CN217423870U - Preparation heparin is crude precipitation dehydration integrative device for sodium - Google Patents
Preparation heparin is crude precipitation dehydration integrative device for sodium Download PDFInfo
- Publication number
- CN217423870U CN217423870U CN202221028804.9U CN202221028804U CN217423870U CN 217423870 U CN217423870 U CN 217423870U CN 202221028804 U CN202221028804 U CN 202221028804U CN 217423870 U CN217423870 U CN 217423870U
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- cylinder
- box
- drying
- dehydration
- box body
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- 230000018044 dehydration Effects 0.000 title claims abstract description 36
- 238000006297 dehydration reaction Methods 0.000 title claims abstract description 36
- 229920000669 heparin Polymers 0.000 title claims abstract description 29
- 238000001556 precipitation Methods 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title abstract description 10
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title description 4
- 229960002897 heparin Drugs 0.000 title description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title description 3
- 229910052708 sodium Inorganic materials 0.000 title description 3
- 239000011734 sodium Substances 0.000 title description 3
- 238000001035 drying Methods 0.000 claims abstract description 44
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 claims abstract description 25
- 229960001008 heparin sodium Drugs 0.000 claims abstract description 23
- 239000012043 crude product Substances 0.000 claims abstract description 21
- 239000000945 filler Substances 0.000 claims description 14
- 238000001125 extrusion Methods 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 5
- 239000000741 silica gel Substances 0.000 claims description 5
- 229910002027 silica gel Inorganic materials 0.000 claims description 5
- 239000002274 desiccant Substances 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 2
- 239000002699 waste material Substances 0.000 abstract description 5
- 239000013049 sediment Substances 0.000 abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 230000000694 effects Effects 0.000 description 4
- 244000309464 bull Species 0.000 description 2
- 238000007791 dehumidification Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
The utility model relates to a pharmacy processing technology field, and a preparation heparin sodium is with crude product precipitation dehydration integrative device is disclosed, the power distribution box comprises a box body, the inside downside of box is equipped with dry board, the top of dry board is equipped with year thing cylinder disc, the fixed cylinder that is equipped with in upper end of box, the output of cylinder rotates and is connected with the connecting block, the connecting block is located the fixed setting of inner bottom of carrying thing cylinder disc, the box is connected with rotary driving mechanism jointly with year thing cylinder disc, the fixed machine box that is equipped with of lateral wall of box, the fixed air heater that is equipped with in inside of machine box, the lateral wall of box and the lower extreme of machine box fixed intercommunication jointly have the air-supply line, the fixed intercommunication in lateral wall upper end of box has the tuber pipe. This application can blow the hot-blast mode through rotatory cooperation fixed point and carry out dehydration to the heparin sodium after the sediment, and drying uniformity is high, effectively improves holistic drying efficiency, and hot-blast circulated use reduces heat energy waste simultaneously.
Description
Technical Field
The application relates to the technical field of pharmaceutical processing, in particular to a crude product precipitation, dehydration and drying integrated device for preparing heparin sodium.
Background
Heparin is a natural anticoagulant substance, and a crude product is relatively easy to obtain in the heparin sodium extraction process, but when the crude product is used for refining a fine product, ethanol is required to be added and precipitated, and dehydration and drying are required after precipitation.
The patent publication No. CN208382737U discloses a crude product precipitation, dehydration and drying integrated device for preparing heparin sodium by a salt hydrolysis method, which comprises a machine shell, a circulating fan, a water pump and a controller, wherein the circulating fan is arranged below one side of the machine shell, the circulating fan is used for supplying air to the interior of a precipitation drying chamber, and the controller is arranged above the front surface of the machine shell; the heparin sodium preparation processingequipment that above-mentioned patent discloses, collect sediment and dehydration in an organic whole, it is through circulating fan cooperation first tuyere and second tuyere to deposit the indoor crude product after the drying of letting in hot-blast pair of sediment and carrying out dehydration, this kind has set up two tuyeres, but it still can only fixed point blow hot-blastly, it is faster to be close to the crude dry dehydration that two tuyeres go out, and keep away from the crude product of two tuyeres one side then dry slower, this kind easily leads to dehydration uneven, holistic dehydration drying efficiency is lower, consequently, a preparation for heparin sodium crude product deposit integrative device of dehydration.
SUMMERY OF THE UTILITY MODEL
The purpose of this application is in order to solve among the prior art can only fix a point and blow hot-blastly, and the crude drying dehydration that is close to two tuyeres and goes out is very fast, and the crude of keeping away from two tuyeres one side then dry slower, and this kind easily leads to dehydration uneven, the lower problem of holistic dehydration drying efficiency, and the preparation for heparin sodium crude precipitate dehydration drying integrated device that provides.
In order to achieve the purpose, the following technical scheme is adopted in the application:
the utility model provides a preparation crude product for sodium heparin deposits dry integrative device of dehydration, the power distribution box comprises a box body, the inside downside of box is equipped with dry board, the top of dry board is equipped with carries thing cylinder dish, the fixed cylinder that is equipped with in upper end of box, the output of cylinder rotates and is connected with the connecting block, the connecting block is located the fixed setting of inner bottom of carrying thing cylinder dish, the box is connected with rotary driving mechanism with carrying thing cylinder dish jointly, the fixed machine box that is equipped with of lateral wall of box, the fixed air heater that is equipped with in inside of machine box, the lateral wall of box and the fixed intercommunication of the lower extreme of machine box jointly have the air-supply line, the fixed intercommunication in lateral wall upper end of box has the tuber pipe.
By adopting the technical scheme, the dehydration drying can be carried out by rotating the rotary matching fixed-point hot air blowing mode, the drying uniformity is high, and the overall drying efficiency is effectively improved.
Preferably, a cylinder is arranged above the box body, a rotating rod is fixedly arranged in the cylinder, spiral extrusion blades are fixedly sleeved on the rod wall of the rotating rod, dry fillers are filled in the cylinder, the air outlet pipe is communicated with the cylinder, and one end, far away from the air outlet pipe, of the cylinder is connected with a return pipe together with the machine box.
By adopting the technical scheme, the hot air can be recycled after being dehumidified and dried, the waste of heat energy is reduced, and the effect of dehumidifying and drying the hot air is improved by adopting a spiral flowing mode.
Preferably, rotary driving mechanism connects in the ring gear of year thing mould dish lateral wall upper end including fixed cover, the fixed driving motor that is equipped with of inner wall of box, driving motor's output is connected with the actuating lever, the rod end fixedly connected with drive gear of actuating lever, and drive gear and ring gear mesh are connected.
By adopting the technical scheme, the carrying disc can be driven to rotate at a constant speed.
Preferably, an inlet pipe is fixedly inserted into one side of the upper end of the cylinder, a material changing pipe is fixedly communicated with the lower side of one end, close to the air outlet pipe, of the cylinder, and sealing covers are connected to pipe ends of the inlet pipe and the material changing pipe in a threaded connection mode.
By adopting the technical scheme, the rotating rod can be rotated to drive the spiral extrusion blade to rotate, so that the dry filler in the cylinder can be discharged through the material changing pipe, and the convenience of material changing can be improved through the arrangement.
Preferably, a control valve is arranged inside the air inlet pipe.
By adopting the technical scheme, the ethanol can be prevented from flowing backwards into the air inlet pipe.
Preferably, the upper end of the cylinder is provided with an observation port, a transparent plate is fixedly arranged in the observation port, and the drying filler is made of allochroic silica gel drying agent.
By adopting the technical scheme, people can observe the color change condition of the color-changing silica gel drying agent through the transparent plate, so that whether the drying filler is replaced or not can be determined.
Preferably, the fixed cover of lateral wall of drum has connect two and has supported the curb plate, two it all lies in the fixed setting in upper end of drum to support the curb plate.
By adopting the technical scheme, the stable support of the box body to the cylinder can be ensured.
Compared with the prior art, the application provides a preparation crude product for sodium heparin deposits integrative device of dehydration, possesses following beneficial effect:
1. this preparation heparin is crude product for sodium deposits integrative device of dehydration, through the box that is equipped with, drying plate, carry thing cylinder dish, cylinder, connecting block, rotary driving mechanism, air heater, machine box, air-supply line and go out mutually supporting of tuber pipe, can be used for heparin sodium crude product to deposit and the dehydration uses, and when carrying out dehydration, can blow hot-blast mode through the rotation fit fixed point and carry out dehydration, drying uniformity is high, effectively improves holistic drying efficiency.
2. This preparation heparin is integrative device of crude product precipitation dehydration for sodium mutually supports through drum, bull stick, spiral extrusion leaf, dry filler and the back flow that is equipped with, can carry out circulation after the hot-blast drying dehumidification and use, reduces the heat energy waste, and through spiral drying's mode, can improve the dry dehumidification effect to the hot-blast back flow.
The device in not relate to the part all the same with prior art or can adopt prior art to realize, this application can blow hot-blast mode through rotatory cooperation fixed point and carry out dehydration to the heparin sodium after the sediment, drying uniformity is high, effectively improves holistic drying efficiency, but hot-blast recycling reduces heat energy waste simultaneously.
Drawings
FIG. 1 is a schematic structural diagram of an integrated device for precipitation, dehydration and drying of crude heparin sodium product according to the present application;
FIG. 2 is an enlarged view of the portion A in FIG. 1;
fig. 3 is a schematic perspective view of the cylinder of fig. 1.
In the figure: 1. a box body; 2. drying the plate; 3. carrying a round net plate; 4. a cylinder; 5. connecting blocks; 6. a case; 7. a hot air blower; 8. an air inlet pipe; 9. an air outlet pipe; 10. a cylinder; 11. a rotating rod; 12. spirally extruding the leaves; 13. a return pipe; 14. a gear ring; 15. a drive motor; 16. a drive gear; 17. a feed pipe; 18. changing a material pipe; 19. a transparent plate; 20. supporting the side plates.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments.
Rotatory actuating mechanism connects in the ring gear 14 of carrying 3 lateral walls upper ends of thing net dish including fixed cover, the fixed driving motor 15 that is equipped with of inner wall of box 1, driving motor 15's output is connected with the actuating lever, the rod end fixedly connected with drive gear 16 of actuating lever, and drive gear 16 is connected with the ring gear 14 looks meshing, driving motor 15 works, can make the actuating lever rotate, thereby can drive gear 16 and rotate, rotate with drive ring gear 14, thereby can drive and carry thing disc 3 and rotate.
The control valve is arranged inside the air inlet pipe 8, and through the arrangement, the ethanol can be prevented from flowing backwards into the air inlet pipe 8.
The fixed grafting in upper end one side of drum 10 has inlet pipe 17, drum 10 is close to the fixed intercommunication of the one end downside of play tuber pipe 9 and has the reloading pipe 18, the equal threaded connection of the pipe end of inlet pipe 17 and reloading pipe 18 has sealed lid, can put in dry filler to drum 10 inside through inlet pipe 17, through rotating bull stick 11, can drive spiral extrusion leaf 12 and rotate, thereby can discharge the dry filler of drum 10 inside through reloading pipe 18, through this kind of setting, can improve the convenience of reloading.
The viewing aperture has been seted up to the upper end of drum 10, and the fixed transparent plate 19 that is equipped with in inside of viewing aperture, and the dry filler is made for the silica gel drier that discolours, and through this kind of setting, people can observe the condition of discolouring of silica gel drier through transparent plate 19 to can decide whether to change the dry filler.
The outer side wall of the cylinder 10 is fixedly sleeved with two supporting side plates 20, the two supporting side plates 20 are both located at the upper end of the cylinder 10 and are fixedly arranged, and through the arrangement, the stable support of the box body 1 on the cylinder 10 can be ensured.
In the application, when in use, the heparin sodium crude product is uniformly placed in the carrying circular net disc 3, then the carrying circular net disc 3 is moved downwards to a proper position through the connecting block 5 by the air cylinder 4, at the moment, the ethanol is added and deposited overnight, after the deposition, the redundant ethanol is discharged, then the hot air blower 7 is started, hot air can be delivered to the interior of the box body 1 through the air inlet pipe 8, the flowing hot air can be utilized to dehydrate and dry the heparin sodium, the subsequent hot air is discharged through the air outlet pipe 9, and when the hot air blower 7 is started, simultaneously, the driving motor 15 is started, the driving motor 15 can drive the driving gear 16 to rotate through the driving rod, thereby driving the gear ring 14 to rotate, and then can drive year thing rotary screen dish 3 at the uniform velocity, the hot-blast that discharges through air-supply line 8 at this moment can carry out dehydration to heparin sodium from carrying thing rotary screen dish 3 week side, and drying effect is good.
The above description is only for the preferred embodiments of the present application, but the scope of the present application is not limited thereto, and any person skilled in the art should be considered to be within the scope of the present application, and all equivalent substitutions and changes according to the technical solutions and the inventive concepts of the present application should be covered by the scope of the present application.
Claims (7)
1. A crude product precipitation, dehydration and drying integrated device for preparing heparin sodium, which comprises a box body (1), it is characterized in that a drying plate (2) is arranged at the lower side in the box body (1), a carrying round net disc (3) is arranged above the drying plate (2), a cylinder (4) is fixedly arranged at the upper end of the box body (1), the output end of the cylinder (4) is rotationally connected with a connecting block (5), the connecting block (5) is fixedly arranged at the inner bottom of the carrying round net plate (3), the box body (1) and the carrying round net disc (3) are connected with a rotary driving mechanism together, a machine box (6) is fixedly arranged on the outer side wall of the box body (1), an air heater (7) is fixedly arranged in the machine box (6), the side wall of the box body (1) and the lower end of the machine box (6) are jointly and fixedly communicated with an air inlet pipe (8), an air outlet pipe (9) is fixedly communicated with the upper end of the side wall of the box body (1).
2. The integrated device for precipitation, dehydration and drying of crude products for preparing heparin sodium according to claim 1, wherein a cylinder (10) is arranged above the box body (1), a rotating rod (11) is fixedly arranged inside the cylinder (10), spiral extrusion blades (12) are fixedly sleeved on the rod wall of the rotating rod (11), dry fillers are filled inside the cylinder (10), the air outlet pipe (9) is communicated with the cylinder (10), and one end of the cylinder (10) far away from the air outlet pipe (9) and the machine box (6) are jointly connected with a return pipe (13).
3. The integrated device for precipitation, dehydration and drying of crude products for preparing heparin sodium according to claim 1, wherein the rotary driving mechanism comprises a gear ring (14) fixedly sleeved on the upper end of the outer side wall of the carrying circular net disc (3), a driving motor (15) is fixedly arranged on the inner wall of the box body (1), the output end of the driving motor (15) is connected with a driving rod, the rod end of the driving rod is fixedly connected with a driving gear (16), and the driving gear (16) is meshed with the gear ring (14) for connection.
4. The integrated device for precipitation, dehydration and drying of crude products for preparing heparin sodium according to claim 2, wherein a feeding pipe (17) is fixedly inserted into one side of the upper end of the cylinder (10), a material changing pipe (18) is fixedly communicated with the lower side of one end of the cylinder (10) close to the air outlet pipe (9), and the pipe ends of the feeding pipe (17) and the material changing pipe (18) are respectively in threaded connection with a sealing cover.
5. The integrated device for crude precipitation, dehydration and drying of heparin sodium according to claim 1, wherein a control valve is arranged inside the air inlet pipe (8).
6. The integrated device for precipitation, dehydration and drying of crude products for preparing heparin sodium according to claim 2, wherein an observation port is opened at the upper end of the cylinder (10), a transparent plate (19) is fixedly arranged inside the observation port, and the drying filler is made of allochroic silica gel drying agent.
7. The integrated device for precipitation, dehydration and drying of crude products for preparing heparin sodium according to claim 2, wherein two supporting side plates (20) are fixedly sleeved on the outer side wall of the cylinder (10), and both the two supporting side plates (20) are fixedly arranged at the upper end of the cylinder (10).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221028804.9U CN217423870U (en) | 2022-04-29 | 2022-04-29 | Preparation heparin is crude precipitation dehydration integrative device for sodium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221028804.9U CN217423870U (en) | 2022-04-29 | 2022-04-29 | Preparation heparin is crude precipitation dehydration integrative device for sodium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN217423870U true CN217423870U (en) | 2022-09-13 |
Family
ID=83184497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202221028804.9U Active CN217423870U (en) | 2022-04-29 | 2022-04-29 | Preparation heparin is crude precipitation dehydration integrative device for sodium |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN217423870U (en) |
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2022
- 2022-04-29 CN CN202221028804.9U patent/CN217423870U/en active Active
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: 224200 Jiangsu Yancheng City Dongtai coastal economic zone port area two road 20 Patentee after: Jiangsu Wanli Biotechnology Co.,Ltd. Country or region after: China Address before: 224200 Jiangsu Yancheng City Dongtai coastal economic zone port area two road 20 Patentee before: JIANGSU WANLI BIOTECHNOLOGY Co.,Ltd. Country or region before: China |
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| CP03 | Change of name, title or address |