CN217390958U - Mouse virus enema device - Google Patents
Mouse virus enema device Download PDFInfo
- Publication number
- CN217390958U CN217390958U CN202220230124.9U CN202220230124U CN217390958U CN 217390958 U CN217390958 U CN 217390958U CN 202220230124 U CN202220230124 U CN 202220230124U CN 217390958 U CN217390958 U CN 217390958U
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- China
- Prior art keywords
- enema
- tube
- injection port
- virus
- head
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 241000792859 Enema Species 0.000 title claims abstract description 99
- 239000007920 enema Substances 0.000 title claims abstract description 99
- 229940095399 enema Drugs 0.000 title claims abstract description 99
- 241000700605 Viruses Species 0.000 title claims abstract description 37
- 238000002347 injection Methods 0.000 claims abstract description 40
- 239000007924 injection Substances 0.000 claims abstract description 40
- 239000003814 drug Substances 0.000 claims abstract description 23
- 239000004800 polyvinyl chloride Substances 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 5
- 230000008595 infiltration Effects 0.000 abstract description 3
- 238000001764 infiltration Methods 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 24
- 210000000436 anus Anatomy 0.000 description 11
- 230000006378 damage Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 210000001072 colon Anatomy 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000005662 Paraffin oil Substances 0.000 description 2
- 208000036142 Viral infection Diseases 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229920000915 polyvinyl chloride Polymers 0.000 description 2
- 230000009385 viral infection Effects 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 208000029549 Muscle injury Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Images
Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The utility model discloses a mouse virus enema device, include: enema tubes and stopcocks; the tail of the enema tube is provided with an injector interface, the head of the enema tube is provided with an injection port, and the tube body is internally provided with a medicine channel communicated with the injection port; the utility model discloses a enema tube, including pipe head, pipe body, stopper, pipe head, pipe body surface is provided with the scale, the zero scale mark of scale is located the tube head is most advanced, the stopcock contains chock plug and stopper body, the diameter of stopper body with the internal diameter of enema tube matches. The utility model discloses technical scheme has following beneficial effect for prior art: the virus utilization rate is improved, the virus loss and possible pollution opportunities are reduced, and the virus infiltration range is enlarged; the depth of the catheter entering is directly determined, and experimental errors are reduced.
Description
Technical Field
The utility model relates to the field of medical equipment, concretely relates to mouse virus enema device.
Background
In some non-clinical experimental researches on gastrointestinal diseases, a mouse intestinal inflammation or tumor model is often required to be established, and experimental animals are also subjected to enema to verify the curative effect of a targeted drug. With the development of optogenetic and chemogenetic techniques in gastroenterology in recent years, experiments sometimes required specific and highly effective viral infection of cells of the intestinal tract. Viral infection and enteral administration, although possible by means of an enema, require more elaborate enema procedures and higher equipment requirements due to the low virus dose and the high price. At present, no special virus enema device exists. The enema tube in the prior art has the following disadvantages: 1. homemade catheter tips are often not blunt enough, resulting in damage or perforation of the mouse intestinal tissue; 2. the tip of the enema catheter is usually large in inner diameter, the dosage of the virus is usually less than 200ul, and a large amount of virus is lost when the enema is performed by sucking the virus; 3. the enema catheter is not provided with a graduated scale for prompting the distance from the front section of the catheter to the anus, so that the medicine infiltration site is easy to be undefined; 4. the anus is clamped or closed by a self-made rubber and the anus plug can cause mechanical damage to the anus and the leakage problem, and the operation needs to pull out the catheter and then pull out and insert the anus of the experimental animal again, so that secondary damage is easily caused.
Therefore, how to design a novel enema device is a technical problem which needs to be solved by the technical personnel in the field at present.
Disclosure of Invention
In order to solve the technical problems, the main object of the present invention is to provide a mouse virus enema device to improve the virus utilization rate, reduce the virus loss, and improve the accuracy of the experiment.
In order to achieve the purpose, the utility model adopts the following technical scheme to solve the problem.
A mouse virus enema device comprising: enema tubes and tube stoppers; the tail of the enema tube is provided with an injector interface, the head of the enema tube is provided with an injection port, and the tube body of the enema tube is internally provided with a medicine channel communicated with the injection port; the utility model discloses a enema tube, including enema tube, zero scale mark, stopcock, stopper body, enema tube's pipe shaft surface is provided with the scale, the zero scale mark of scale is located the tube head is most advanced, the stopcock contains chock plug and stopper body, the diameter of stopper body with the internal diameter of enema tube matches.
Furthermore, the tube head of the enema tube is hemispherical, and the injection port is positioned at the position where the hemisphere of the tube head of the enema tube is connected with the cylindrical section of the tube body.
Furthermore, a cutting mark line is arranged on the tube body of the enema tube and is positioned at the 3.5-4.5cm mark line of the graduated scale.
Further, the cutting mark line is positioned at the 4cm graduation line of the graduated scale.
Furthermore, an injection port marking line along the length direction is arranged on the outer surface of the tube body of the enema tube, and the injection port marking line and the injection port are coplanar and are positioned on the same side of the enema tube as the injection port.
Furthermore, the inner diameter of the medicine channel is 0.5-1mm, the inner diameter of the medicine channel is gradually reduced from the tube body to the tube head, and the aperture of the injection port is 0.4-0.6 mm.
Furthermore, the inner diameter of the medicine channel at the tube body section is 1mm, the inner diameter of the medicine channel at the tube head is 0.5mm, and the aperture of the injection port is 0.5 mm.
Furthermore, the material of enema tube is polyvinyl chloride PVC, the pipe shaft surface is provided with round circumferential attenuate groove, attenuate the groove and be located the 4cm scale mark department of scale.
Furthermore, two binding ropes are arranged on the plug head, and the length of each binding rope is 10-20 cm.
Furthermore, the material of stopcock is rubber, the length of stopcock body is 3 cm.
The utility model discloses technical scheme has following beneficial effect for prior art: the virus utilization rate is improved, the virus loss amount and possible pollution opportunities are reduced, and the virus infiltration range is enlarged; the depth of the catheter entering is directly determined, and experimental errors are reduced.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the embodiments or the prior art descriptions will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the structures shown in the drawings without creative efforts.
FIG. 1 is a perspective view of an embodiment of an enema tube of the mouse virus enema device of the present invention;
FIG. 2 is a perspective view of a plug of the mouse viral enema device of the present invention;
FIG. 3 is a cross-sectional view showing an example of the enema tube of the mouse virus enema device of this invention;
FIG. 4 is a sectional view showing the body of the mouse viral enema device of the present invention after the plug is inserted into the body.
In the above figures:
1, enema tube; 101 an injector interface; 102 an injection port; 103 a drug channel; 104 a graduated scale; 105 thinning grooves; 106 injection port marking lines;
2, pipe plug; 201 plug head; 202 is plugged into the body.
Detailed Description
In order to make the above objects, features and advantages of the present invention more comprehensible, embodiments accompanied with figures are described in detail below.
In the following description, specific details are set forth in order to provide a thorough understanding of the present invention. The invention can be implemented in a number of other ways than those described herein, and those skilled in the art will be able to make similar generalizations without departing from the spirit of the invention. The invention is therefore not to be limited by the specific embodiments disclosed below.
Referring to fig. 1, a mouse virus enema device includes: an enema tube 1 and a tube plug 2; the tail of the enema tube 1 is provided with an injector interface 101, the head of the enema tube 1 is provided with an injection port 102, and the tube body is internally provided with a medicine channel 103 communicated with the injection port 102; the pipe shaft surface of enema pipe 1 is provided with scale 104, the zero scale mark of scale 104 is located enema pipe 1's tube head tip, stopcock 2 contains chock plug 201 and chock plug 202, the diameter of chock plug 202 with enema pipe 1's internal diameter matches.
Further, the head of the enema tube 1 is hemispherical, and the injection port 102 is located at a position where the hemisphere of the head is connected with the cylindrical section of the tube body.
Furthermore, a cutting mark line is arranged on the tube body of the enema tube 1 and is positioned at the 3.5-4.5cm mark line of the graduated scale 104. Further, the cutting mark line is located at a 4cm graduation line of the scale 104.
In the above embodiment, since the total length of the colon of the mouse is about 8-10cm and the physiological bend is formed at the position 4cm inward from the anus, the graduated scale 104 is arranged on the tube body of the enema tube 1, and the depth of the enema tube 1 inserted into the anus of the mouse can be visually observed in the operation process. The head of the enema tube 1 is hemispherical, so that the enema tube 1 can be conveniently inserted into the anus of a mouse, and the injury to the mouse is reduced.
Further, an injection port marking line 106 is arranged on the outer surface of the tube body of the enema tube 1 along the length direction, and the injection port marking line 106 is coplanar with the injection port 102 and is positioned on the same side of the enema tube 1 as the injection port 102. Since the colon of the mouse has physiological reentry in vivo, the injection port mark line 106 on the same side as the injection port 102 is arranged on the tube body, so that the injection port 102 can be conveniently controlled to face the physiological reentry direction after the enema tube 1 is inserted into the colon of the mouse.
Furthermore, the inner diameter of the medicine channel is 0.5-1mm, the inner diameter of the medicine channel is gradually reduced from the tube body to the tube head, and the aperture of the injection port is 0.4-0.6 mm. Preferably, the inner diameter of the medicine channel at the tube body section is 1mm, the inner diameter of the medicine channel at the tube head is 0.5mm, and the aperture of the injection port is 0.5 mm.
Because the amount of virus injected into a mouse is small, if the pipe diameter of the medicine channel 103 is too large, air bubbles can be generated, virus is lost, and the measurement is inaccurate, therefore, preferably, the inner diameter of the medicine channel at the pipe body section is 1mm, the inner diameter of the medicine channel 103 is gradually reduced towards the direction of the injection port 102, the inner diameter of the medicine channel at the pipe head is 0.5mm, and the hole diameter of the injection port is 0.5 mm. .
Further, enema tube 1's material is polyvinyl chloride (PVC), the pipe shaft surface is provided with round circumferential attenuate groove 105, attenuate groove 105 and be located the 4cm scale mark department of scale 104. In the above embodiment, polyvinyl chloride (PVC) is selected for use as the material of the enema tube 1, and since polyvinyl chloride (PVC) has certain hardness, the circumferential thinning groove 105 of one circle is arranged on the outer surface of the tube body, so that the enema tube 1 can be broken off without using tools after the enema is finished.
Further, two binding ropes are arranged on the plug head 201, and the length of each binding rope is 10-20 cm. The binding rope is used for fixing the pipe plug 2 and the enema pipe 1 on the mouse after the enema of the mouse is finished. Because the pipe plug 2 is matched with the inner diameter of the enema pipe 1, the enema pipe does not need to be pulled out after the enema is finished, and the pipe plug can be directly combined with the enema pipe, so that secondary anus muscle injury is reduced.
Further, the pipe plug 2 is made of rubber, and the length of the plug body is 3 cm.
Exemplary, the following is a method of use using a mouse enema device:
1. firstly, connecting the tail end of an enema tube with an injector, extending an injection port below the liquid level of paraffin oil, pulling a piston of the injector backwards to suck the paraffin oil into the enema tube, discharging bubbles, and lubricating the front end of the enema tube by 5cm by using glycerol;
2. after anesthesia, the mice were placed flat with the abdomen facing up. The injection port is aligned with the virus liquid, and the syringe is pulled backwards to absorb a proper amount of virus liquid;
3. slowly pushing the enema tube into the anus of the mouse at a position of 3-5 cm, and paying attention to the fact that the mark line of the injection port needs to correspond to the right side of the mouse;
4. slowly pushing the virus into the intestinal tract, staying for 1min, and then slowly pulling the enema tube outwards until the injection port at the tail end is 1-2 cm away from the anus;
5. breaking the catheter along the dotted line, rapidly plugging the opening of the catheter with a matched pipe plug, fixing the catheter on a mouse with a binding rope, and pulling out the enema tube together with the pipe plug after 30 min.
Although the invention has been described in detail in this specification by way of general description and specific embodiments, it will be apparent to those skilled in the art that modifications and improvements can be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (10)
1. A mouse virus enema device, comprising: an enema tube (1) and a tube plug (2); an injector interface (101) is arranged at the tail of the enema tube (1), an injection port (102) is arranged at the tube head of the enema tube (1), and a medicine channel (103) communicated with the injection port (102) is arranged in the tube body of the enema tube (1); the utility model discloses a enema tube, including enema tube (1), pipe shaft, stopcock (2), the diameter of stopcock (202) with the internal diameter of enema tube (1) matches, the pipe shaft surface of enema tube (1) is provided with scale (104), the zero scale mark of scale (104) is located the tube head is most advanced, stopcock (201) and stopcock body (202) are contained in stopcock (2).
2. A mouse virus enema device according to claim 1, wherein the head of the enema tube (1) is hemispherical shaped and the injection port (102) is located at a position where the hemispherical shape of the head meets the cylindrical section of the body of the enema tube (1).
3. A mouse virus enema device according to claim 2, wherein the body of the enema tube (1) is provided with cut-off marking lines at the 3.5-4.5cm graduation lines of the graduated scale (104).
4. A mouse virus enema device according to claim 3, wherein the shear mark line is located at the 4cm scale line of the scale (104).
5. A mouse virus enema device according to claim 1, wherein the outer surface of the body of the enema tube (1) is provided with an injection port marking line (106) along the length direction, the injection port marking line (106) being coplanar with the injection port (102) and located on the same side of the enema tube (1) as the injection port (102).
6. A mouse virus enema device according to claim 2, wherein the inner diameter of the medicine passage (103) is 0.5 to 1mm, the inner diameter of the medicine passage (103) is gradually reduced from the tube body to the tip, and the diameter of the injection port (102) is 0.4 to 0.6 mm.
7. A mouse virus enema device according to claim 6, wherein the inner diameter of the medicine passage (103) at the body section is 1mm, the inner diameter of the medicine passage (103) at the tip is 0.5mm, and the hole diameter of the injection port (102) is 0.5 mm.
8. The mouse virus enema device according to claim 1, wherein the material of the enema tube (1) is polyvinyl chloride (PVC), a circumferential thinning groove (105) is formed in the outer surface of the tube body of the enema tube (1), and the thinning groove (105) is located at the 4cm graduation line of the graduated scale (104).
9. A mouse virus enema device according to claim 1, wherein two binding strings are provided on the plug head (201), and the length of the binding strings is 10-20 cm.
10. A mouse virus enema device according to claim 1, wherein the tube plug (2) is made of rubber, and the length of the plug body is 3 cm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220230124.9U CN217390958U (en) | 2022-01-27 | 2022-01-27 | Mouse virus enema device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220230124.9U CN217390958U (en) | 2022-01-27 | 2022-01-27 | Mouse virus enema device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN217390958U true CN217390958U (en) | 2022-09-09 |
Family
ID=83137147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202220230124.9U Expired - Fee Related CN217390958U (en) | 2022-01-27 | 2022-01-27 | Mouse virus enema device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN217390958U (en) |
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2022
- 2022-01-27 CN CN202220230124.9U patent/CN217390958U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20220909 |
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| CF01 | Termination of patent right due to non-payment of annual fee |