CN217366312U - Dressing plaster - Google Patents

Abstract

The utility model discloses a dressing plaster, which is provided with an adhesive tape, a dressing pad, a breathable film and a separable protective layer from bottom to top in sequence; the upper surface of the dressing pad is compounded with freeze-dried powder; the adhesive plaster is provided with air holes. Selecting a dressing pad compounded with freeze-dried powder, wherein the freeze-dried powder contains no water, is not easy to be infected with infectious microbes and stabilizes active ingredients; the air holes arranged on the adhesive plaster and the air permeable film arranged on the adhesive plaster can improve the air permeability of the dressing plaster, so that the dressing plaster is soft and comfortable, and the anaphylactic reaction is reduced.

Description

Dressing plaster

Technical Field

The utility model relates to a medical treatment bandaging article, concretely relates to dressing subsides.

Background

Human Epidermal Growth Factor (EGF) exists in body fluid and various glands widely, but is not suitable for large-scale industrial production, and with the development of genetic engineering technology, biologists successfully utilize Escherichia coli to produce the recombinant human epidermal growth factor (rhEGF) as a host through the genetic recombination technology, so that the industrial production of the rhEGF is realized.

The molecular structure of the gene recombinant human epidermal growth factor (rhEGF) consists of 53 amino acids, the molecular weight is 6201 daltons, disulfide bonds consisting of 6 cysteines are arranged in molecules, 3 intramolecular ring structures are formed, and a receptor binding region necessary for the biological activity is formed. Experimental studies have shown that EGF stimulates the proliferation of a variety of cells, mainly epidermal cells and endothelial cells. Has good curative effect on the repair and healing of the wound surfaces of corneal injury, burn, scald, operation and the like.

At present, the skin repair preparation produced by using rhEGF as a raw material in China has varieties of gel, aqua, dressing and the like, because the rhEGF is a bioactive protein, the activity of the rhEGF in an aqueous solution can be generally only preserved for 7-10 days, a proper protective agent is generally required to be added to a produced product to slow down the inactivation of the rhEGF, but a substance capable of completely avoiding the inactivation of the rhEGF is not found at present, the activity of a growth factor of the product prepared into the gel and the dressing is better than that of the aqua, but the addition of the rhEGF has extremely low content and poor fluidity of the gel and the ointment, the rhEGF is limited to reach an epidermal action part to play a role, the fluidity of the aqua is good, and the activity half-life period is shorter than that of the gel and the ointment.

SUMMERY OF THE UTILITY MODEL

In order to overcome the not enough of prior art, the utility model discloses an aim at provides a dressing subsides, chooses for use the complex dressing pad that has the freeze-dried powder, can effectively maintain the activity of freeze-dried powder, pastes the dressing with the normal saline dropwise add when using, can redissolve the dressing composition of freeze-dried state immediately, and active ingredient is dissolved in water and is directly reachd skin and play a role for impaired skin repair.

The purpose of the utility model is realized by adopting the following technical scheme:

a dressing patch comprises an adhesive tape, a dressing pad, a breathable film and a separable protective layer from bottom to top; the dressing pad is compounded with freeze-dried powder; the adhesive tape is provided with air holes.

The common dressing patch takes a water-soluble polymer material as a matrix skeleton, is rich in 60% of water, achieves the cold compress treatment effect through the physical action of the contained effective components such as menthol and the like and hydrogel, can reduce the joint tissue injury, eliminate swelling pain and reduce the complication of inflammation. But the utility model discloses select for use the complex dressing pad of freeze-dried powder, the dressing subsides do not contain the moisture when not using, and active ingredient is stable, is difficult for dying miscellaneous fungus, does not need to add antiseptic, and is mild to skin and does not have the stimulation. When in use, the protective layer is lifted, then normal saline is dripped into the dressing patch, and the composite freeze-dried powder of the dressing pad is redissolved and then pasted on the skin. Particularly, the utility model discloses a dressing subsides adopt aluminium foil bag sealing package, avoid the active ingredient in the freeze-dried powder to be by the oxidation.

Further, the separable protective layer is an isolation film.

Furthermore, the aperture of the air holes is 0.3-0.5 mm.

Furthermore, the breathable film is a low-density PE film with dense holes, and the aperture is 0.2-0.4 cm. The breathable film can improve the ventilation effect of the dressing patch, reduce the discomfort of the skin after being applied and simultaneously facilitate the exudation of effective active substances. The breathable film should be made of an anti-sticking material to play a role in protection.

Further, the adhesive fabric is a non-woven fabric adhesive fabric or a PU adhesive fabric. The non-woven fabric adhesive plaster or the PU (polyurethane film) adhesive plaster has the characteristics of comfort and softness, and can reduce the anaphylactic reaction of patients. Wherein, the PU adhesive tape is made of transparent material, so that the wound condition can be observed at any time; also has waterproof function.

Further, the dressing pad is one of a non-woven fabric pad, a silk membrane or a cotton wool pad.

Furthermore, the thickness of the dressing pad is 0.5-1.0 mm.

Further, the dressing pad has an area of one of 30 × 50mm, 40 × 80mm or 80 × 120 mm.

Still further, the dressing pad and the air permeable membrane are the same in size, and the size of the adhesive plaster is larger than the area of the dressing pad.

Further, the freeze-dried powder is gene recombinant human epidermal growth factor freeze-dried powder (rhEGF). The freeze-dried powder of the gene recombinant human epidermal growth factor is sterile freeze-dried powder which is prepared by preparing rhEGF and other auxiliary materials into liquid medicine, enabling a dressing pad to adsorb the liquid medicine, freezing the liquid medicine into a solid state in a sterile environment, vacuumizing, gradually heating and subliming and drying water.

Compared with the prior art, the beneficial effects of the utility model reside in that:

the dressing patch of the utility model selects the dressing pad compounded with freeze-dried powder, the freeze-dried powder contains no water and is not easy to be infected with infectious microbes, and the activity of growth factors in the freeze-dried powder is kept; the air holes arranged on the adhesive plaster and the air permeable film arranged on the adhesive plaster can improve the air permeability of the dressing plaster, so that the dressing plaster is soft and comfortable, and the anaphylactic reaction is reduced.

Drawings

FIG. 1 is a schematic view of the layered structure of the dressing of example 1;

FIG. 2 is a schematic view of the construction of the dressing patch of example 1;

in the figure: 1. rubberized fabric; 2. a rubber surface layer; 3. a dressing pad; 4. a protective layer; 5. a gas permeable membrane; 6. and (4) air holes.

Detailed Description

The present invention will be further described with reference to the accompanying drawings and the detailed description, and it should be noted that the embodiments or technical features described below can be arbitrarily combined to form a new embodiment without conflict.

Example 1

A dressing patch is provided with an adhesive plaster 1, a dressing pad 3, a breathable film 5 and a separable protective layer 4 from bottom to top in sequence as shown in figures 1-2; the dressing pad 3 is compounded with freeze-dried powder; the adhesive plaster 1 is provided with an air hole 6. The surface of the adhesive plaster 1 contacted with the dressing pad 3 is called an adhesive surface layer 2, and the area of the adhesive plaster 1 is larger than that of the dressing pad 3.

The common dressing patch takes a water-soluble polymer material as a matrix skeleton, is rich in 60% of water, achieves the cold compress treatment effect through the physical action of the contained effective components such as menthol and the like and hydrogel, can reduce the injury of joint tissues, eliminate swelling pain and reduce the complication of inflammation.

The utility model discloses select for use compound dressing pad 3 of freeze-dried powder, will contain active ingredient rhEGF freeze-dried powder and other dressings to adsorb at carrier (non-woven fabrics, cotton wool or silk membrane), then carry out freeze-drying, can furthest protect rhEGF's activity like this, simultaneously, dressing pad 3 does not contain the moisture when not using, is difficult for dying miscellaneous fungus, need not add antiseptic, and is gentle to skin and does not have the stimulation, and active substance obtains the protection. When in use, the protective layer 4 is lifted, and then normal saline (1 cm) is dripped on the dressing ² 0.5mL), and the freeze-dried powder compounded by the dressing pad 3 is redissolved and then attached to the skin. Particularly, the dressing paste of the utility model adopts the aluminum foil bag package with moisture insulation and sealing performance, and active ingredients in the freeze-dried powder are prevented from being oxidized.

Further, the detachable protective layer 4 is a PET release film.

Furthermore, the aperture of the air holes 6 is 0.3-0.5 mm.

Further, the breathable film 5 is a low-density PE film with dense holes, and the hole diameter is 0.2-0.4 cm. The air-permeable film 5 can improve the air permeability of the dressing patch, reduce the discomfort of the skin after the dressing patch is applied and facilitate the permeation of the effective components.

Still further, the material of adhesive tape 1 is non-woven fabrics or PU. The adhesive plaster 1 made of non-woven fabric or the adhesive plaster 1 made of PU (polyurethane film) has the characteristics of comfort and softness, and can reduce the anaphylactic reaction of patients. The PU is made of transparent materials, so that the wound condition can be observed at any time; also has waterproof function.

Further, the dressing pad 3 is one of a non-woven fabric pad, a silk membrane or a cotton pad.

Still further, the dressing pad 3 has a thickness of 0.5 to 1.0 mm.

Further, the area of the dressing pad 3 is one of 30 × 50mm, 40 × 80mm or 80 × 120 mm.

Still further, the dressing pad 3 and the air permeable membrane 5 are the same size, and the size of the adhesive plaster 1 is larger than the area of the dressing pad 3.

Still further, the freeze-dried powder is gene recombinant human epidermal growth factor (rhEGF) freeze-dried powder.

In this embodiment, the specific steps of the dressing patch are as follows:

1) preparing a dressing solution containing rhEGF;

2) calculating the corresponding dressing liquid dosage according to the total size of the dressing pad 3, and putting the dressing pad 3 into the dressing liquid to be adsorbed until the dressing liquid is saturated;

3) vacuum freeze-drying the dressing pad 3 in the step 2);

4) and (4) sticking the dressing pad 3 obtained in the step 3) on the adhesive surface layer 2 of the adhesive tape 1, and then covering the air-permeable membrane 5 on the dressing pad 3 to obtain the dressing plaster. Wherein, the ventilated membrane 5 adopts an anti-sticking material (PE membrane with dense holes), plays the roles of isolation, ventilation and protection, and finally covers an isolation membrane;

5) and then the dressing paste is put into an aluminum foil bag, sealed and packaged.

Comparative example 1

The dressing of comparative example 1 differs from example 1 in that: the dressing pad 3 of the comparative example 1 is compounded with rhEGF hydrogel, and the content of rhEGF and the dosage of other auxiliary materials are the same as those of the example 1.

Performance testing

1. Comparison of stability

The dressings of example 1 and comparative example 1 were stored at room temperature (temperature 20 to 30 ℃ C., humidity 30 to 40%) for 0 month (in-line assay), 1 month, 3 months, 6 months, and 12 months, respectively, and the activity of epidermal growth factor (rhEGF) was assayed by MTT method, and the results are shown in Table 1.

Table 1 stability test data of the dressing of example 1 and the dressing of comparative example 1

2. Comparison of results of use

66 volunteers were selected and divided into two groups, and the dressing patches of example 1 and comparative example 1 were used, respectively. The age interval of the volunteers is 20-40 years, and the skin damage types are as follows: repairing small-range epidermis and dermis injuries such as mechanical wounds, scalds and bedsores; the damaged part is as follows: back, limbs, head and face. Volunteers with similar age, skin damage type and damaged part were divided into two groups on average. During the period of using the dressing patch of example 1 or the dressing patch of comparative example 1, the volunteers did not take or apply other drugs until the wound on the skin healed, and the number of healing days and the number of dressing changes were recorded, as shown in table 2.

Table 2 data of the result of use of the dressing of example 1 and the dressing of comparative example 1

Grouping	Average healing days (heaven)	Dressing change label (second)
			Example 1	46.3	44.6
Comparative example 1	62.2	65.7

As can be seen from table 1, the dressing pad 3 in the dressing patch of example 1 was compounded with the lyophilized powder, so that the activity of rhEGF was only reduced by 1.48% even after 12 months of storage, ensuring that the rhEGF active substance sufficiently reached the site of action, and exerting high-efficiency action. And the dressing paste of the comparative example 1 is compounded with the hydrogel which is not subjected to freeze-drying treatment, so that the activity of rhEGF stored for 12 months is reduced by 47.51%, and the activity loss is serious. The dressing pad 3 composite freeze-dried powder of the embodiment 1 can improve the fluidity and ensure the activity of the effective component (rhEGF), and the product does not contain chemical components such as preservatives which are irritating to the skin, has the functions of moisturizing and inhibiting bacteria on the damaged skin part, simultaneously can quickly reach the surface of the affected skin by the epidermal active factor (rhEGF), has high efficiency and no loss of activity, and has quick response, stability and no stimulation to the growth recovery of the damaged skin.

As can be seen from Table 2, the skin healing time and the number of dressing changes were superior to those of example 1 in the volunteers who used the dressing of example 1. The dressing of example 1 is shown to accelerate the repair of damaged skin.

The above embodiments are only preferred embodiments of the present invention, and the protection scope of the present invention cannot be limited thereby, and any insubstantial changes and substitutions made by those skilled in the art based on the present invention are all within the protection scope of the present invention.

Claims (10)

1. A dressing patch is characterized in that an adhesive tape, a dressing pad, a breathable film and a separable protective layer are sequentially arranged from bottom to top; the dressing pad is compounded with freeze-dried powder; the adhesive tape is provided with air holes.

2. The dressing of claim 1, wherein the protective layer is a release film, and the release film is a PET release film.

3. The dressing of claim 1, wherein the pore size of the air-permeable pores is 0.3-0.5 mm.

4. The dressing patch according to claim 1, wherein the air permeable membrane is a low-density PE membrane with dense pores, and the pore diameter is 0.2-0.4 cm.

5. The casting patch of claim 1, wherein the adhesive is a non-woven or PU adhesive.

6. The dressing patch of claim 1 wherein said dressing pad is one of a nonwoven pad, a silk film, or a cotton pad.

7. The dressing of claim 1 wherein said dressing pad has a thickness of 0.5mm to 1.0 mm.

8. The dressing patch of claim 1 wherein said dressing pad has an area of one of 30 x 50mm, 40 x 80mm or 80 x 120 mm.

9. The dressing patch according to claim 1, wherein said dressing pad and said gas permeable membrane are the same size, and said adhesive is larger in size than the area of said dressing pad.

10. The dressing patch of claim 1, wherein the lyophilized powder is a gene recombinant human epidermal growth factor lyophilized powder.

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