CN217348878U - Sealing device of detection kit - Google Patents

Abstract

The application relates to a sealing device of a detection kit, and belongs to the technical field of medical consumables. The sealing device comprises a sealing cover for sealing an opening of a detection kit and a sealing gasket arranged on the sealing cover, wherein a sealing assembly used for sealing a sample pool and an exhaust column is arranged on the sealing gasket, and a reinforcing assembly used for reinforcing the tightness of connection between the sealing cover and the detection kit is arranged between the sealing cover and the detection kit. This application makes sealed lid and detect reagent box zonulae occludens through strengthening the subassembly, avoids the external environment to the destruction risk that reaction environment in the reaction tank brought, has avoided the reaction liquid in the reaction tank to leak the entering air moreover equally to produce the risk of nucleic acid aerosol polluted environment.

Description

Sealing device of detection kit

Technical Field

The application relates to the field of medical consumables, in particular to a sealing device of a detection kit.

Background

In Vitro diagnosis, i.e., ivd (in Vitro diagnosis), refers to products and services for determining diseases or body functions by detecting human body samples (blood, body fluids, tissues, etc.) in addition to the human body to obtain clinical diagnosis information. Generally, the consumables and the devices required for the in vitro diagnostic process require the professional to operate in a special laboratory or medical institution, which is expensive and takes a long time to wait for the analysis.

Moreover, in some specific use scenarios, the in vitro diagnostic test that is conventionally performed according to the above procedures still faces a great challenge, such as: remote areas with insufficient medical resources; occasions of acute infectious disease outbreaks; the patients with inconvenient actions at home and the like cannot really meet the use requirements.

Taking a nucleic acid detection kit based on an amplification method as an example, through reagent optimization, a detection card box and a matched instrument of a one-step method (direct amplification method) have appeared, so that the manual operation link is greatly simplified, and the requirements of the specific scene are basically met. However, in order to precisely control the liquid, there is still a case that the sample to be detected and the amplification product are sealed by using a gas-permeable material (such as a filter membrane, a filter element, etc.), and the above-mentioned gas-permeable material cannot completely avoid the problem that the aerosol pollutes the environment due to the leakage of the amplification product.

If the environment is polluted, the subsequent detection result is easy to generate a false positive phenomenon, and can cause serious interference to the real and accurate diagnosis of the detection mechanism in time. Once misjudged, not only medical resources are wasted, but also normal progress of social life can be influenced.

SUMMERY OF THE UTILITY MODEL

In order to help improve the leakproofness of the detection kit in the detection process, the application provides a sealing device of the detection kit.

The application provides a sealing device of detect reagent box adopts following technical scheme:

the utility model provides a sealing device of detect reagent box, is including being used for shutoff detect reagent box open-ended sealed lid and installing sealed the sealed pad on the lid, be provided with on the sealed pad and be used for carrying out the seal assembly sealed to sample cell and exhaust post, be provided with between sealed lid and the detect reagent box and be used for strengthening sealed lid and detect reagent box and be connected the reinforcement subassembly of compactness.

Through adopting above-mentioned technical scheme, cover sealed lid at the detect reagent box opening part, sealed side of filling up and the tip butt of sample cell and exhaust post, seal sample cell and exhaust post, sealed lid is through consolidating subassembly and detect reagent box zonulae occludens, sealed lid is difficult for deviating from the detect reagent box opening, and then make sealed the pad closely seal sample cell and exhaust post, avoid the destruction risk that external environment brought the reaction environment in the reaction cell, and avoided the reaction liquid in the reaction cell to leak the entering air outward equally, thereby produce the risk of nucleic acid aerosol polluted environment.

Optionally, the sealing cover includes an end cover and an inner ring fixed on a side surface of the end cover, and an outer circumferential side wall of the inner ring is used for abutting against an inner circumferential wall of the detection kit.

Through adopting above-mentioned technical scheme, the periphery wall of inner ring offsets with detect reagent box's internal perisporium, can further improve the area of contact of sealed lid and detect reagent box, improves the frictional force between sealed lid and the detect reagent box, makes sealed lid and detect reagent box be difficult for breaking away from, ensures the leakproofness of sealed lid and detect reagent box.

Optionally, the reinforcing assembly comprises an inner ring limiting convex strip arranged on the outer periphery of the inner ring, and the inner ring limiting convex strip is used for being abutted against the inner peripheral wall of the detection kit.

Through adopting above-mentioned technical scheme, the spacing sand grip of inner ring can further improve the frictional force of inner ring and detect reagent box, the leakproofness of the sealed lid of guarantee.

Optionally, the reinforcing assembly further comprises a box body limiting convex strip arranged on the inner peripheral wall of the detection kit, and one side, close to the bottom of the detection kit, of the box body limiting convex strip is abutted to the inner ring limiting convex strip.

Through adopting above-mentioned technical scheme, the spacing sand grip joint of inner ring is at the spacing sand grip downside of box body, further improves the inseparable degree that inner ring and detect reagent box are connected, further improves the leakproofness and reduces the sealed risk that the lid deviates from detect reagent box.

Optionally, sealed lid includes the end cover and fixes the outer loop in end cover side, sealed the pad is located the outer loop, the outer loop with it wears to locate the box body seal groove in to reserve between the sealed pad to have the week side that supplies the box body.

Through adopting above-mentioned technical scheme, outer loop and detect reagent box's outer wall rigid contact, sealed pad and detect reagent box's inner wall flexible contact, both ensured the leakproofness between sealed lid and the detect reagent box, can improve the convenience of sealed lid and detect reagent box equipment again.

Optionally, the reinforcing component comprises a buckle connecting portion arranged on the outer peripheral wall of the outer ring, a buckle groove is formed in the buckle connecting portion, and the outer peripheral wall of the detection kit is provided with a buckle portion capable of being clamped in the buckle groove.

Through adopting above-mentioned technical scheme, utilize buckle portion joint in the buckle inslot, can effectively improve the intensity that outer loop and test kit box body are connected, and then the outer loop is more difficult for breaking away from in the test kit in the testing process, further strengthens sealed effect of filling up to sample cell and exhaust post.

Optionally, the sealing assembly comprises a collection canister sealing lug having a side for abutting against the inlet end of the sample cell and an exhaust column sealing lug for abutting against the end of the exhaust column.

By adopting the technical scheme, the opening end parts of the sample pool and the exhaust column at the corresponding positions are sealed by the bumps, so that the sealing effect of each position is favorably improved in a targeted manner.

Optionally, a sample cell sealing groove is formed in the side surface of the collecting cylinder sealing projection, and the end of the sample cell penetrates through the sample cell sealing groove.

Through adopting above-mentioned technical scheme, further seal the entry to the sample cell, improve the leakproofness to the sample cell entry, guarantee sealed effect.

Optionally, an exhaust column sealing groove is formed in the side surface of the exhaust column sealing bump, and the end of the exhaust column penetrates through the exhaust column sealing groove.

By adopting the technical scheme, the port of the exhaust column is sealed, so that a sample to be detected and the external environment are further isolated, and the accuracy of a nucleic acid detection result is improved.

Optionally, the side of sealed lid is provided with the setting element, sealed pad passes through the setting element and can dismantle with sealed lid and be connected.

By adopting the technical scheme, the sealing gasket is positioned and fixed by the positioning piece, the sealing gasket is detachably connected with the sealing gasket, respective products can be produced in the actual production process respectively, and the sealing gasket is assembled subsequently, so that the production and the manufacturing are facilitated, and the manufacturing efficiency of the products is improved.

Optionally, a connecting strip is connected between the sealing cover and the detection kit.

Through adopting above-mentioned technical scheme, sealed lid links together through connecting strip and detect reagent box, can improve the convenience that the personnel carried or took detect reagent box.

In summary, the present application includes at least one of the following beneficial technical effects:

1. the sealed intercommunication that can block box body inside and external environment of sealing up, sealed pad simultaneously also can be isolated to sample cell and exhaust column and external environment, and through consolidating the subassembly again simultaneously, can effectively improve the compactness that sealed lid is connected with detect reagent box, reduces the risk that sealed lid and detect reagent box break away from, the leakproofness in the guarantee testing process.

2. Through setting up different reinforcement assemblies, reinforcement assembly can effectively improve the compactness that sealed lid and test kit are connected on the one hand, and on the other hand does not influence simultaneously sealed lid and test kit's dismantlement and is connected, has improved the convenience of using yet.

Drawings

Fig. 1 is an exploded view of a case and a base cover sheet in the related art.

Fig. 2 is a sectional view of a part of the structure of a cartridge in the related art.

Fig. 3 is an exploded view of a part of the structure of example 1 of the present application.

Fig. 4 is a schematic structural diagram of another positioning element according to embodiment 1 of the present application.

Fig. 5 is a schematic structural diagram of another exhaust column sealing bump according to embodiment 1 of the present application.

Fig. 6 is a schematic structural diagram of embodiment 2 of the present application.

FIG. 7 is a schematic sectional view showing the closure cap and the case of example 2 of the present application when they are engaged.

Description of reference numerals: 10. a box body; 11. a sample cell; 12. a reaction tank; 13. freeze-drying the balls; 14. an exhaust column; 15. an exhaust hole; 16. a bottom cover sheet; 17. a box body positioning edge; 18. a fastening part; 20. a sealing cover; 21. an end cap; 22. an inner ring; 23. a handle part is buckled; 24. an outer ring; 25. a snap connection; 26. a fastening groove; 30. a gasket; 31. a positioning cylinder; 32. positioning a groove; 33. a box body sealing groove; 41. the collecting cylinder seals the lug; 42. the exhaust column sealing projection; 43. a sample cell sealing groove; 44. an exhaust column seal groove; 51. an inner ring limiting convex strip; 52. a box body limiting convex strip; 60. a connecting strip; 71. a positioning column; 72. positioning blocks; 73. a cylindrical portion; 74. a rectangular portion.

Detailed Description

The present application is described in further detail below with reference to figures 1-7.

In the correlation technique, disclose a detect reagent box, refer to fig. 1 and 2, including cylindrical box body 10, box body 10 is cavity and one end is equipped with the opening, is equipped with cuvette 11 in the box body 10, and the bottom of box body 10 is provided with a plurality of reaction tanks 12 that are linked together with cuvette 11, all has the freeze-drying ball 13 in advance in every reaction tank 12, contains amplification components such as primer, enzyme, dNTP in the freeze-drying ball 13, can take place the amplification reaction of target sequence with the preservative solution and the sample that awaits measuring that get into reaction tank 12. The outer bottom surface of the box body 10 is further provided with a bottom cover 16 to seal the downward opening of the reaction tank 12, so that the preservation solution and the sample to be tested can smoothly enter the reaction tank 12.

The upper part of the reaction tank 12 is communicated with a columnar exhaust column 14, an exhaust hole 15 which is vertically communicated is formed in the exhaust column 14, and the height of the reaction tank 12 is smaller than that of the exhaust column 14.

The detection kit is implemented according to the following principle: the preserving fluid and the sample to be tested are injected into the sample cell 11, flow into the reaction cell 12 under the action of gravity, and then move upwards under the action of capillary force and enter the exhaust hole 15 of the exhaust column 14.

After the preserving fluid and the sample to be detected enter the reaction tank 12 to react with the freeze-dried balls 13, the kit is sent to a detection instrument for detection, the kit is heated in the detection process, the preserving fluid and the sample to be detected in the reaction tank 12 can perform amplification reaction of a target sequence with the freeze-dried balls 13 which are prestored in the reaction tank 12 and contain amplification components such as primers, enzymes and dNTP, and the amplification result of the reaction tank 12 is detected and judged to obtain a detection result. For example, if the amplification result of one of the reaction cells 12 is positive, the result can be determined to be positive.

The embodiment of the application discloses sealing device of a detection kit.

Example 1

Referring to fig. 3, the sealing device comprises a sealing cover 20 and a sealing gasket 30 mounted on an end surface of the sealing cover 20, wherein a sealing component for sealing the sample cell 11 and the exhaust column 14 is arranged on the sealing gasket 30, and a reinforcing component for reinforcing the tightness of the connection between the sealing cover 20 and the box body 10 is arranged between the sealing cover 20 and the box body 10.

Referring to fig. 3, the sealing cover 20 includes an end cover 21 and an inner ring 22 fixed on a side surface of the end cover 21, a connecting strip 60 is disposed between the end cover 21 and the box body 10, the connecting strip 60 is made of a flexible material, and the connecting strip 60 can be bent to buckle the end cover 21 and the box body 10 together. One side of the end cover 21 far away from the connecting strip 60 is provided with a handle part 23, and the handle part 23 is used for facilitating the personnel to disassemble and assemble the end cover 21 and the box body 10.

Wherein, a positioning element is arranged on the side surface of the end cover 21 and inside the inner ring 22, and the sealing gasket 30 is connected with the end cover 21 through the positioning element. Referring to fig. 3, in one embodiment, the positioning element is provided as a positioning column 71, the positioning columns 71 are provided as four, the four positioning columns 71 are annularly provided, the positioning cylinder 31 adapted to the positioning columns 71 is provided on the side surface of the sealing gasket 30, the positioning columns 71 are inserted into the positioning cylinder 31, and the sealing gasket 30 and the end cover 21 are detachably connected by using the positioning cylinder 31 and the positioning columns 71.

Referring to fig. 4, in another embodiment, the positioning element is a positioning block 72, the positioning block 72 includes a cylindrical portion 73 and a rectangular portion 74, the cylindrical portion 73 and the rectangular portion 74 are integrally formed, the positioning groove 32 is formed on one side of the sealing gasket 30 away from the sealing assembly, and the positioning block 72 is inserted into the positioning groove 32, so that the sealing gasket 30 and the end cover 21 are detachably connected. The removable connection of the gasket 30 to the end cap 21 may be achieved in other ways in other embodiments.

Referring to fig. 3, the sealing assembly includes a collection cylinder sealing protrusion 41 disposed at the center of the sealing pad 30 and a plurality of exhaust pillar sealing protrusions 42 annularly disposed on the periphery of the collection cylinder sealing protrusion 41, a sample cell sealing groove 43 is disposed at the center of the collection cylinder sealing protrusion 41, when the sealing cap 20 is fastened to the case 10, the end of the sample cell 11 is inserted into the sample cell sealing groove 43, and the outer peripheral wall of the end of the sample cell 11 abuts against the inner wall of the sample cell sealing groove 43, so as to improve the sealing performance of the opening of the sample cell 11.

When the sealing cover 20 is fastened with the box body 10, the end face of the exhaust column sealing lug 42 is abutted against the end part of the exhaust column 14, the exhaust column 14 is sealed by the exhaust column sealing lug 42, and the area of the end face of the exhaust column sealing lug 42 is larger than that of the end part of the exhaust column 14, so that the applicability of the exhaust column sealing lug 42 is improved.

In order to further improve the sealing effect on the exhaust column 14, in another embodiment, referring to fig. 5, an exhaust column sealing groove 44 is formed in the center of the exhaust column sealing protrusion 42, the end of the exhaust column 14 is inserted into the exhaust column sealing groove 44, and the end of the exhaust column 44 abuts against the inner groove wall of the exhaust column sealing groove 44.

This application scheme is sealed the entry and the exhaust column 14 of sample cell 11 alone, can further avoid external environment to the reaction environment's in the reaction tank 12 destruction risk, thereby has avoided the reaction liquid in the reaction tank 12 to leak the risk that gets into the air and produce nucleic acid aerosol polluted environment equally.

In order to further improve the sealing effect of the sealing gasket 30 on the sample cell 11 and the exhaust column 14, the present application is provided with a reinforcing component. Referring to fig. 3, the reinforcing member includes an inner ring limit protrusion 51 provided at the outer periphery of the inner ring 22 and a case limit protrusion 52 provided at the inner peripheral wall of the case 10. When sealed lid 20 and box body 10 lock, the capping of end cover 21 and the top side butt of box body 10, the inner ring 22 is worn to locate in the box body 10, the outer wall butt of inner ring 22 and the outer wall butt of box body 10, the spacing sand grip 51 of inner ring is located the below of the spacing sand grip 52 of box body this moment, the spacing sand grip 52 of box body is close to one side of the box bottom of box body 10 and the side butt of the spacing sand grip 51 of inner ring, utilize the spacing sand grip 51 of inner ring and the spacing sand grip 52 of box body to improve the inseparability that inner ring 22 and box body 10 are connected, and then improve the sealed effect of 30 to sample cell 11 and exhaust column 14.

The implementation principle of the sealing device of the detection kit in the embodiment of the application is as follows: in preserving liquid and the sample that awaits measuring dripped into cuvette 11, it flows into reaction tank 12 to preserve liquid and the sample that awaits measuring under the effect of gravity, later go up and get into in exhaust column 14 under the effect of capillary force, when treating the partial filling liquid in exhaust column 14 or being full of liquid, use end cover 21 to seal the opening of box body 10, the opening of collecting vessel sealing lug 41 to cuvette 11 is further sealed, exhaust column sealing lug 42 is further sealed to exhaust column 14, the tight degree of being connected of sealed lid 20 and box body 10 is further improved to the spacing sand grip of inner ring 51 and the spacing sand grip 52 of box body, reduce the phenomenon that sealed lid 20 and box body 10 leakproofness weaken because of being heated in the testing process, improve the sealed effect of sealed lid 20 and box body 10, guarantee the accuracy of testing result.

Example 2

Referring to fig. 6 and 7, the present embodiment is different from embodiment 1 in that the sealing cover has a different structure of connecting with the case, and in the present embodiment, the sealing cover 20 includes an end cover 21 and an outer ring 24 fixed on a side surface of the end cover 21. The top side of box body 10 integrated into one piece has box body location limit 17, and sealed pad 30 is located outer loop 24, is formed with box body seal groove 33 between the perisporium of sealed pad 30 and the inner wall of outer loop 24, and box body location limit 17 wears to locate in box body seal groove 33, and the annular side of outer loop 24 and the top side butt of box body 10, and sealed pad 30 wears to locate in box body 10, and the perisporium of sealed pad 30 and the inner wall butt of box body 10.

Simultaneously, the reinforcing component is including fixing the buckle connecting portion 25 at the periphery wall of outer loop 24, and buckle groove 26 has been seted up to the inboard of buckle connecting portion 25, and the lateral wall that connecting strip 60 was kept away from to box body 10 is fixed with clamping part 18, and when sealed lid 20 was buckled with box body 10, clamping part 18 joint realized that sealed lid 20 is connected with the reinforcement of box body 10 in clamping groove 26.

The difference between this embodiment and embodiment 1 lies in that this embodiment utilizes buckle connecting portion 25 and buckle portion 18 can further improve the inseparability that sealed lid 20 is connected with box body 10 to sealed lid 20 is difficult for taking off with box body 10 more, has ensured the leakproofness of testing kit in the testing process, also is favorable to personnel's dismouting sealed lid 20 and box body 10 simultaneously, has improved the convenience of operation.

The above embodiments are preferred embodiments of the present application, and the protection scope of the present application is not limited by the above embodiments, so: all equivalent changes made according to the structure, shape and principle of the present application shall be covered by the protection scope of the present application.

Claims (11)

1. A sealing device of a detection kit is characterized in that: including being used for shutoff box body (10) open-ended sealed lid (20) and installing sealed pad (30) on sealed lid (20), be provided with on sealed pad (30) and be used for carrying out the seal assembly who seals up cuvette (11) and exhaust column (14), be provided with between sealed lid (20) and box body (10) and be used for strengthening sealed lid (20) and box body (10) and be connected the reinforcement subassembly of compactness.

2. The sealing device for a test kit according to claim 1, wherein: the sealing cover (20) comprises an end cover (21) and an inner ring (22) fixed on the side face of the end cover (21), and the peripheral side wall of the inner ring (22) is used for being abutted against the inner peripheral wall of the box body (10).

3. The sealing device for a test kit according to claim 2, wherein: the reinforcing assembly comprises an inner ring limiting convex strip (51) arranged on the periphery of the inner ring (22), and the inner ring limiting convex strip (51) is used for being abutted against the inner peripheral wall of the box body (10).

4. The sealing device for a test kit according to claim 3, wherein: the reinforcing assembly further comprises a box body limiting convex strip (52) arranged on the inner peripheral wall of the box body (10), and one side, close to the box bottom of the box body (10), of the box body limiting convex strip (52) is abutted to the inner ring limiting convex strip (51).

5. The sealing device for a test kit according to claim 1, wherein: sealed lid (20) include end cover (21) and fix outer ring (24) of end cover (21) side, sealed pad (30) are located outer ring (24), outer ring (24) with it wears to locate box body seal groove (33) in to reserve between sealed pad (30) to have the week side that supplies box body (10).

6. The sealing device for a test kit according to claim 5, wherein: the reinforcing component comprises a buckle connecting part (25) arranged on the outer peripheral wall of the outer ring (24), a buckle groove (26) is formed in the buckle connecting part (25), and a buckle part (18) capable of being clamped in the buckle groove (26) is arranged on the outer peripheral wall of the box body (10).

7. The sealing device for a test kit according to claim 1, wherein: the sealing assembly comprises a collecting cylinder sealing lug (41) and an exhaust column sealing lug (42), wherein the side face of the collecting cylinder sealing lug (41) is used for being abutted with the inlet end of the sample pool (11), and the exhaust column sealing lug (42) is used for being abutted with the end of the exhaust column (14).

8. The sealing device for a test kit according to claim 7, wherein: and a sample cell sealing groove (43) for the end part of the sample cell (11) to penetrate through is formed in the side surface of the collecting cylinder sealing lug (41).

9. The sealing device for a test kit according to claim 7 or 8, wherein: and an exhaust column sealing groove (44) for the end part of the exhaust column (14) to penetrate through is formed in the side surface of the exhaust column sealing convex block (42).

10. The sealing device for a test kit according to claim 1, wherein: the side of the sealing cover (20) is provided with a positioning piece, and the sealing gasket (30) is detachably connected with the sealing cover (20) through the positioning piece.

11. The sealing device for a test kit according to claim 1, wherein: a connecting strip (60) is connected between the sealing cover (20) and the box body (10).

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