CN217312330U - 3-aminoisoxazole active carbon decoloration heat filter equipment - Google Patents
3-aminoisoxazole active carbon decoloration heat filter equipment Download PDFInfo
- Publication number
- CN217312330U CN217312330U CN202220810291.0U CN202220810291U CN217312330U CN 217312330 U CN217312330 U CN 217312330U CN 202220810291 U CN202220810291 U CN 202220810291U CN 217312330 U CN217312330 U CN 217312330U
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- China
- Prior art keywords
- aminoisoxazole
- reaction kettle
- filter
- bin
- activated carbon
- Prior art date
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 title claims abstract description 56
- RHFWLPWDOYJEAL-UHFFFAOYSA-N 1,2-oxazol-3-amine Chemical compound NC=1C=CON=1 RHFWLPWDOYJEAL-UHFFFAOYSA-N 0.000 title claims abstract description 21
- 229910052799 carbon Inorganic materials 0.000 title claims abstract description 20
- 238000006243 chemical reaction Methods 0.000 claims abstract description 36
- 238000001914 filtration Methods 0.000 claims abstract description 29
- 238000003756 stirring Methods 0.000 claims abstract description 7
- 239000003381 stabilizer Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 abstract description 9
- 239000007788 liquid Substances 0.000 abstract description 5
- 239000000543 intermediate Substances 0.000 abstract description 4
- 238000000926 separation method Methods 0.000 abstract 3
- 238000004042 decolorization Methods 0.000 description 7
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- 239000000047 product Substances 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 238000005192 partition Methods 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical class C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000012450 pharmaceutical intermediate Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
Images
Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/10—Process efficiency
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- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The utility model discloses a 3-aminoisoxazole active carbon decoloration heat filtering device, which belongs to the technical field of medical intermediates and comprises a reaction kettle, wherein the top end of the reaction kettle is fixedly provided with a motor and a feeding hopper which are communicated with the reaction kettle, a separation plate is fixedly arranged in the reaction kettle, a control valve is fixedly arranged on the separation plate, the separation plate divides the inner part of the reaction kettle into a decoloring bin and a filtering bin, the output end of the motor is fixedly connected with a rotating shaft, the rotating shaft extends into the decoloring bin, a stirring blade is fixedly arranged on the rotating shaft, the bottom end of the filtering bin is communicated with a liquid discharge pipe, a first filter plate is fixedly arranged in the filtering bin, a rotating rod is rotatably arranged in the filtering bin, a second filter plate is fixedly arranged on the rotating rod, a worm is rotatably arranged in the reaction kettle, the utility model discloses can not receive active carbon quantity and influence the filtration efficiency to the solvent.
Description
Technical Field
The utility model belongs to the technical field of the pharmaceutical intermediate decoloration, specifically speaking relates to a 3-amino isoxazole active carbon decoloration heat filter equipment.
Background
The active carbon for decolorization is prepared by using high-quality sawdust and the like as raw materials and adopting a zinc chloride method, has the characteristics of developed mesoporous structure, large adsorption capacity, quick filtration and the like, and is often used for decolorization and purification of medical intermediate products.
The 3-aminoisoxazole is an organic synthesis intermediate and a medical intermediate, and is particularly used for the cotinib amine medicament. The 3-aminoisoxazole is colorless to pale yellow liquid, however, when the product is actually prepared and stored for a long time, the product is darker, and usually, the product is decolored by adding activated carbon into an organic solvent, and then, the product is lighter.
When the activated carbon is used for decoloring, 3-aminoisoxazole to be decolored is dissolved in solvents such as dichloromethane and the like, the mixture is poured into a decoloring container after being completely and uniformly dissolved, and decolored activated carbon is added into the container, so that the purposes of decoloring and impurity removal are achieved by utilizing the strong adsorption capacity of the activated carbon. However, when the active carbon is filtered each time, the existing active carbon decolorization device slows down the speed of solvents such as dichloromethane and the like passing through the filter screen because the active carbon is accumulated on the filter screen, and when the accumulation of the active carbon on the filter screen is excessive, the filtering speed is affected, so that the reaction efficiency is low.
SUMMERY OF THE UTILITY MODEL
Too much activated carbon accumulation on aiming at the prior filter screen can influence the problem of the filtering speed, the utility model provides a 3-aminoisoxazole activated carbon decoloration heat filter device.
In order to solve the above problem, the utility model adopts the following technical scheme:
the utility model provides a 3-amino isoxazole active carbon decoloration heat filter equipment, includes reation kettle, reation kettle's top fixed mounting has motor and income hopper, go into the hopper with the reation kettle intercommunication, fixed mounting has the division board in the reation kettle, fixed mounting has the control valve on the division board, the division board will reation kettle's inside is for taking off the look storehouse and filtering the storehouse, the output fixedly connected with axis of rotation of motor, the axis of rotation stretches into in taking off the look storehouse, fixed mounting has the stirring leaf in the axis of rotation, it has the fluid-discharge tube to filter storehouse bottom intercommunication, it has first filter to filter fixed mounting in the storehouse, filter the storehouse internal rotation and install the dwang, fixed mounting has the second filter on the dwang, the worm is installed to the reation kettle internal rotation, the worm with the dwang worm wheel is connected.
In order to heat the solution of the decolorization reaction at a constant temperature, preferably, a constant temperature rod is fixedly installed in the decolorization bin.
In order to reduce heat loss, further, a sealing cover is rotatably arranged on the feeding hopper.
In order to observe whether the decoloring reaction is completed or not through the transparent window, preferably, the reaction kettle is fixedly provided with the transparent window, and the position of the transparent window is matched with the position of the decoloring bin.
In order to open the rotary cover plate, the activated carbon between the first filter plate and the second filter plate can be taken out, preferably, the reaction kettle is rotatably provided with the rotary cover plate, and the position of the rotary cover plate is matched with that of the first filter plate.
In order to enable the device to be horizontally placed, the bottom end of the reaction kettle is preferably fixedly provided with leveling feet.
Compared with the prior art, the utility model provides a 3-amino isoxazole active carbon decoloration heat filter equipment, the utility model discloses possess following beneficial effect:
the part that does not relate to in the device all is the same with prior art or can adopt prior art to realize, the utility model discloses an division board keeps apart reation kettle, and the top is decoloration reaction storehouse, and the below is for filtering the storehouse, and after the decoloration reaction of top was accomplished, open the control valve, let solvent and active carbon granule get into and filter the storehouse, rotate the worm, let it drive dwang and second filter, the active carbon granule clamp that will float in the solvent between first filter and second filter for the filtration efficiency to the solvent can not influenced by active carbon quantity, and easy operation just can accomplish the filtration of active carbon granule, with this improvement production efficiency.
Drawings
FIG. 1 is a schematic diagram of the overall structure of a 3-aminoisoxazole activated carbon decolorization heat filter device of the present invention;
FIG. 2 is a schematic diagram of the internal structure of the 3-aminoisoxazole activated carbon decolorizing heat filtering device of the present invention;
FIG. 3 is a schematic diagram of the first filter plate and the second filter plate of the 3-aminoisoxazole activated carbon decolorizing heat filtering device of the present invention;
FIG. 4 is a schematic view of a three-dimensional structure of a 3-aminoisoxazole activated carbon decolorization heat filter device of the present invention.
In the figure: 1. a reaction kettle; 101. a decolorizing bin; 102. a filtering bin; 2. feeding into a hopper; 201. sealing the cover; 3. a motor; 301. a rotating shaft; 302. stirring blades; 4. a separator plate; 5. a control valve; 6. rotating the rod; 7. a first filter plate; 8. a second filter plate; 9. a worm; 10. rotating the cover plate; 11. a transparent window; 12. a liquid discharge pipe; 13. leveling the support leg; 14. a thermostatic bar.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments.
In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention.
Example (b):
referring to fig. 1-4, a 3-aminoisoxazole activated carbon decolorizing heat filtering device comprises a reaction kettle 1, wherein a motor 3 and a feed hopper 2 are fixedly mounted at the top end of the reaction kettle 1, the feed hopper 2 is communicated with the reaction kettle 1, a partition plate 4 is fixedly mounted in the reaction kettle 1, a control valve 5 is fixedly mounted on the partition plate 4, the partition plate 4 divides the inner part of the reaction kettle 1 into a decolorizing bin 101 and a filtering bin 102, an output end of the motor 3 is fixedly connected with a rotating shaft 301, the rotating shaft 301 extends into the decolorizing bin 101, a stirring blade 302 is fixedly mounted on the rotating shaft 301, a liquid discharge pipe 12 is communicated with the bottom end of the filtering bin 102, a first filtering plate 7 is fixedly mounted in the filtering bin 102, a rotating rod 6 is rotatably mounted in the filtering bin 102, a second filtering plate 8 is fixedly mounted on the rotating rod 6, a worm 9 is rotatably mounted in the reaction kettle 1, and the worm 9 is connected with a worm wheel 6.
A constant temperature rod 14 is fixedly arranged in the decolorizing bin 101, and a sealing cover 201 is rotatably arranged on the feeding hopper 2. The reaction in the decoloring bin 101 is heated through the thermostatic bar 14, the reaction rate of the decoloring reaction is guaranteed, and the cover 201 prevents air from rotating impurities to influence the purity of the decoloring solvent.
A transparent window 11 is fixedly arranged on the reaction kettle 1, the position of the transparent window 11 is matched with the position of the decoloring bin 101, whether the decoloring reaction is finished or not is observed through the transparent window 11, if so, the control valve 5 is opened, and if not, the control valve continues to wait.
The reaction kettle 1 is rotatably provided with a rotating cover plate 10, the position of the rotating cover plate 10 is matched with the position of the first filter plate 7, the rotating cover plate 10 is rotated to open, and the activated carbon particles between the first filter plate 7 and the second filter plate 8 are taken out from the filter bin 102.
Leveling support legs 13 are fixedly arranged at the bottom end of the reaction kettle 1, and the device is horizontally arranged through the leveling support legs 13, so that the reaction can be normally carried out.
The utility model is applied to the field of medical intermediates, by closing the control valve 5, the solution and the active carbon which need to be decolored are poured into the decoloring bin 101 from the reaction kettle 1, the constant temperature rod 14 and the motor 3 are started, the constant temperature rod 14 is used for heating at constant temperature, the stirring is carried out by the stirring blade 302, whether the decoloring reaction is finished or not is observed through the transparent window 11, after the decoloring reaction is finished, the worm 9 is rotated, the first filter plate 7 and the second filter plate 8 are tightly attached, the control valve 5 is opened, the solvent and the active carbon particles enter the filtering bin 102, the worm 9 is rotated, the second filter plate 8 is rotated by 360 degrees, the second filter plate 8 is rotated from one side of the first filter plate 7 to the other side, so as to clamp the active carbon particles floating in the solvent between the first filter plate 7 and the second filter plate 8, the valve on the liquid discharge pipe 12 is opened, the solution after the decoloring reaction is discharged, the rotating cover plate 10 is opened, the activated carbon granules are removed from the filter silo 102.
The above, only be the concrete implementation of the preferred embodiment of the present invention, but the protection scope of the present invention is not limited thereto, and any person skilled in the art is in the technical scope of the present invention, according to the technical solution of the present invention and the utility model, the concept of which is equivalent to replace or change, should be covered within the protection scope of the present invention.
Claims (6)
1. The utility model provides a 3-amino isoxazole active carbon decoloration hot filtration device, which comprises a reaction kettle (1), the top fixed mounting of reation kettle (1) has motor (3) and goes into hopper (2), go into hopper (2) with reation kettle (1) intercommunication, fixed mounting has division board (4) in reation kettle (1), fixed mounting has control valve (5) on division board (4), division board (4) will reation kettle (1) the inside for taking off look storehouse (101) and filtering storehouse (102), the output end fixed connection of motor (3) has axis of rotation (301), axis of rotation (301) stretch into take off look storehouse (101) in, fixed mounting has stirring leaf (302) on axis of rotation (301), filtering storehouse (102) bottom intercommunication has fluid-discharge tube (12), filtering storehouse (102) interior fixed mounting has first filter (7), filter storehouse (102) internal rotation and install dwang (6), fixed mounting has second filter (8) on dwang (6), worm (9) are installed to reation kettle (1) internal rotation, worm (9) with dwang (6) worm wheel connection.
2. The 3-aminoisoxazole activated carbon decolorizing heat filtration device according to claim 1, characterized in that a thermostatic bar (14) is fixedly installed in the decolorizing bin (101).
3. 3-aminoisoxazole activated carbon decoloration heat filter device according to claim 2, characterized in that the feeding hopper (2) is rotatably provided with a cover (201).
4. The 3-aminoisoxazole activated carbon decoloration heat filter device according to claim 1, characterized in that a transparent window (11) is fixedly arranged on the reaction kettle (1), and the position of the transparent window (11) is matched with the position of the decoloration bin (101).
5. 3-aminoisoxazole activated carbon decoloration heat filter device according to claim 1, characterized in that rotating cover plate (10) is installed on the reaction kettle (1) in a rotating way, and the position of the rotating cover plate (10) matches with the position of the first filter plate (7).
6. 3-aminoisoxazole activated carbon decoloration heat filter device according to claim 1, characterized in that, the bottom of reation kettle (1) is fixed with leveling stabilizer blade (13).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220810291.0U CN217312330U (en) | 2022-04-09 | 2022-04-09 | 3-aminoisoxazole active carbon decoloration heat filter equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220810291.0U CN217312330U (en) | 2022-04-09 | 2022-04-09 | 3-aminoisoxazole active carbon decoloration heat filter equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN217312330U true CN217312330U (en) | 2022-08-30 |
Family
ID=82946984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202220810291.0U Active CN217312330U (en) | 2022-04-09 | 2022-04-09 | 3-aminoisoxazole active carbon decoloration heat filter equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN217312330U (en) |
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2022
- 2022-04-09 CN CN202220810291.0U patent/CN217312330U/en active Active
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20231124 Address after: 116400 memorial archway Village, Qingdui Town, Zhuanghe City, Dalian City, Liaoning Province (Room 404, the back building of the town government office building) Patentee after: Hengjin Biotechnology (Dalian) Co.,Ltd. Address before: 201512 room 404, unit 2, building 1, no.688 Qiushi Road, Jinshanwei Town, Jinshan District, Shanghai Patentee before: SHANGHAI TBBMED Co.,Ltd. |