CN213885027U - Purification device based on organic intermediate impurity of medicine - Google Patents
Purification device based on organic intermediate impurity of medicine Download PDFInfo
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- CN213885027U CN213885027U CN202022310190.0U CN202022310190U CN213885027U CN 213885027 U CN213885027 U CN 213885027U CN 202022310190 U CN202022310190 U CN 202022310190U CN 213885027 U CN213885027 U CN 213885027U
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- distillation
- box
- organism
- organic intermediate
- purification device
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- 238000000746 purification Methods 0.000 title claims abstract description 30
- 239000012535 impurity Substances 0.000 title claims abstract description 28
- 239000003814 drug Substances 0.000 title abstract description 8
- 238000004821 distillation Methods 0.000 claims abstract description 39
- 238000001704 evaporation Methods 0.000 claims abstract description 32
- 238000001816 cooling Methods 0.000 claims abstract description 21
- 238000010438 heat treatment Methods 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 26
- 238000003756 stirring Methods 0.000 claims description 20
- 230000008020 evaporation Effects 0.000 claims description 19
- 238000002955 isolation Methods 0.000 claims description 16
- 230000007246 mechanism Effects 0.000 claims description 13
- 238000004090 dissolution Methods 0.000 claims description 11
- 238000007790 scraping Methods 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 4
- 229910000831 Steel Inorganic materials 0.000 claims description 3
- 230000005389 magnetism Effects 0.000 claims description 3
- 239000010959 steel Substances 0.000 claims description 3
- 230000008901 benefit Effects 0.000 abstract description 3
- 238000011084 recovery Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 description 12
- 239000013078 crystal Substances 0.000 description 6
- 239000012153 distilled water Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 238000002425 crystallisation Methods 0.000 description 3
- 230000008025 crystallization Effects 0.000 description 3
- 230000007547 defect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000005485 electric heating Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000011403 purification operation Methods 0.000 description 2
- 206010053615 Thermal burn Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
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Abstract
The utility model discloses a purification device based on medicine organic intermediate impurity, including distillation tank, cage and evaporating dish, through connecting rod fixed connection between distillation tank and the cage, the block is connected between evaporating dish and the cage, fixed mounting has heating wire one on the distillation tank, a chock is installed to the block on the distillation tank, fixed mounting has an inlet tube on the chock, and the inlet tube runs through the chock and extend to the distillation tank bottom in the lump, block two and a dissolving tank are installed to the block on the cage, fixed mounting has a cooler bin on the chock two, fixed mounting has a plurality of cooling plates on the cooler bin, the intercommunication has a distillation column between cooler bin and the distillation tank. Has the advantages that: the purity of the purified organism is improved, the dissolving speed of the organism and the one-time purification amount of the organism are accelerated, the recovery degree of the separated organism is also improved, and the loss of the organism is reduced.
Description
Technical Field
The utility model relates to an impurity purification technical field especially relates to a purification device based on organic midbody impurity of medicine.
Background
The pharmaceutical organic intermediates are actually some chemical raw materials or chemical products used in the process of synthesizing the medicines. The chemical products can be produced in a common chemical plant without the production license of medicines, and the chemical products have limited purity due to simple process and contain more impurities and cannot meet the pharmaceutical required purity, so that an impurity purification device is required to be used for purifying the organic intermediate.
However, the existing impurity purification device dissolves organisms through water to form organic solution, then filters the organic solution, and finally carries out distillation crystallization on the filtered organic solution to finish the purification operation of the organic intermediate, and the purification device has the following defects: 1. the adopted water contains extra impurities, and 2, the dissolved solution needs to be processed by replacing a filtering device when being filtered and manufactured, so that the operation is complicated.
Therefore, a novel purification device for the medical organism impurities can be adopted to solve the defects of the existing device.
SUMMERY OF THE UTILITY MODEL
The utility model aims at solving the problem that the water for dissolving the organism in the prior art can bring extra impurities to the organism and the solution after dissolving filters the complex operation, and the purification device based on the organic intermediate impurity of medicine that provides.
In order to achieve the above purpose, the utility model adopts the following technical scheme:
a purification device based on medical organic intermediate impurities comprises a distillation box, an isolation cover and an evaporation pan, wherein the distillation box is fixedly connected with the isolation cover through a connecting rod, the evaporation pan is connected with the isolation cover in a clamping manner, a heating wire I is fixedly installed on the distillation box, a chock block I is installed on the distillation box in a clamping manner, a water inlet pipe is fixedly installed on the chock block I, the water inlet pipe penetrates through the chock block and extends to the bottom of the distillation box, a chock block II and a dissolving box are installed on the isolation cover in a clamping manner, a cooling box is fixedly installed on the chock block II, a plurality of cooling plates are fixedly installed on the cooling box, a distillation pipe is communicated between the cooling box and the distillation box, a water pipe is communicated between the cooling box and the dissolving box, a stirring mechanism is installed on the dissolving box, and a filter screen is fixedly installed on the dissolving box, and a support rod and a second heating wire are fixedly arranged on the evaporation dish, and a scraping mechanism is arranged between the support rod and the evaporation dish.
In the purification device based on the medical organic intermediate impurities, a discharge pipe is communicated between the dissolution box and the evaporation pan, penetrates through the bottom of the isolation cover and extends into the evaporation pan, and a one-way valve is fixedly mounted below the discharge pipe.
In the above purification device based on pharmaceutical organic intermediate impurities, the stirring mechanism includes a motor and a stirring rod, the dissolution tank is fixedly provided with a motor, the driving end of the motor is fixedly provided with a stirring rod, and the lower end of the stirring rod penetrates through the dissolution tank and extends into the dissolution tank.
In foretell purification device based on organic midbody impurity of medicine, scraping mechanism includes scraper blade, push rod and magnet, slidable mounting has two scraper blades on the branch, and equal fixed mounting has a magnet on two scraper blades, and two magnets keep away from scraper blade one end magnetism opposite, two all rotate on the scraper blade and install a push rod, and the common fixed mounting in two push rod upper portions has a telescopic link, fixed mounting has one and two magnet matched with dog on the branch.
In the purification device based on the medical organic intermediate impurities, a first hopper is fixedly arranged on the second stopper, and a second hopper matched with the first hopper is fixedly arranged on the dissolution box.
In the purification device based on the pharmaceutical organic intermediate impurities, the end face of the scraper is shaped like an arc, and the scraper is made of a steel paste material.
Compared with the prior art, the utility model discloses the advantage lies in:
1. through the cooperation of distillation case, heating wire and distillation tube for the water that dissolves the organism required use becomes purer through the distillation, avoids bringing extra impurity to lead to the reduction of the organism purity after the crystallization in giving organic solution.
2. The cooperation through motor, stirring rod is used for the dissolving speed of organism, simultaneously through the stirring for the bubble of aquatic is in time discharged, has increased the solubility of organism, thereby has increased the organism's of once purification volume, and the cooperation through the filter screen simultaneously uses still can carry out direct filtration operation to organic solution.
3. Through the cooperation use of scraper blade, magnet, push rod and dog for the organism crystal of adhesion on the evaporating dish after the evaporation crystallization is drawed more easily, will have practiced thrift the loss of organism, has practiced thrift pharmaceutical cost.
To sum up, the utility model provides the high purity of the organism of purification for the volume of the once purification of the solution rate of organism and organism has still improved and has collected the degree to appearing the organism, has reduced the loss of organism.
Drawings
FIG. 1 is a schematic structural diagram of a purification apparatus based on pharmaceutical organic intermediate impurities according to the present invention;
FIG. 2 is an enlarged view of portion A of FIG. 1;
FIG. 3 is an enlarged view of portion B of FIG. 1;
fig. 4 is a schematic structural diagram of the isolation cover in fig. 1.
In the figure: the device comprises a distillation box 1, a first plug block 2, a first electric heating wire 3, a water inlet pipe 4, a distillation tube 5, a separation cover 6, a connecting rod 7, a second plug block 8, a first hopper 9, a cooling box 10, a cooling plate 11, a water pipe 12, a dissolution box 13, a motor 14, a second hopper 15, a stirring rod 16, a filter screen 17, a one-way valve 18, an evaporation pan 19, a support rod 20, a scraper 21, a push rod 22, a magnet 23 and a second electric heating wire 24.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
Referring to fig. 1-4, a purification device based on pharmaceutical organic intermediate impurities comprises a distillation box 1, an isolation cover 6 and an evaporation pan 19, wherein the distillation box 1 is fixedly connected with the isolation cover 6 through a connecting rod 7, the evaporation pan 19 is connected with the isolation cover 6 in a clamping manner, a heating wire I3 is fixedly arranged on the distillation box 1, a plug block I2 is fixedly arranged on the distillation box 1 in a clamping manner, a water inlet pipe 4 is fixedly arranged on the plug block I2, the water inlet pipe 4 penetrates through the plug block I2 and extends to the bottom of the distillation box 1, and a plug block II 8 and a dissolving box 13 are arranged on the isolation cover 6 in a clamping manner;
the following points are notable:
1. the advantage of setting up chock 2 and chock two 8 is that the risk that the distilled water vapour causes the scald to the personnel of periphery is prevented.
2. The first and second blocks 2 and 8 are made of rubber material, and are designed commonly and will not be described in detail.
3. The heating wire I3 is communicated with an external controller, and the controller can adopt a common plc controller.
4. A first hopper 9 is fixedly arranged on the second chock 8, and a second hopper 15 matched with the first hopper 9 is fixedly arranged on the dissolving tank 13, and the parts are used for facilitating the supply of organisms during multiple purifications.
A cooling box 10 is fixedly arranged on the second chock block 8, and a plurality of cooling plates 11 are fixedly arranged on the cooling box 10;
the above is noteworthy for the following two points:
1. the cooling plate 11 is provided to increase the liquefaction rate of the distilled water vapor, thereby increasing the dissolution rate of the organism.
2. The cooling plate 11 is a conventional cooling device and is specifically described herein.
A distillation pipe 5 is communicated between the cooling box 10 and the distillation box 1, a water pipe 12 is communicated between the cooling box 10 and the dissolving box 13, and a stirring mechanism is arranged on the dissolving box 13;
the above is noteworthy for the following two points:
1. a discharge pipe is communicated between the dissolving tank 13 and the evaporating dish 19 and penetrates through the bottom of the isolation hood 6 and extends into the evaporating dish 19, a one-way valve 18 is fixedly installed below the discharge pipe, and the part has the function of preventing the problem that water vapor generated by evaporation flows back into the dissolving tank 13 through the discharge pipe I and the discharge pipe II to be cooled when organic solution evaporation operation is carried out, so that the evaporation efficiency is improved.
2. The stirring mechanism comprises a motor 14 and a stirring rod 16, wherein the motor 14 is fixedly arranged on the dissolving tank 13, the stirring rod 16 is fixedly arranged at the driving end of the motor 14, and the lower end of the stirring rod 16 penetrates through the dissolving tank 13 and extends into the dissolving tank 13, so that the effect of the stirring mechanism is to increase the solubility of organisms in distilled water and accelerate the dissolving speed of the organisms, and the once purification amount of the organisms is increased.
3. The motor can adopt a Y20-M60 motor.
A filter screen 17 is fixedly arranged on the dissolving box 13, a support rod 20 and a second heating wire 24 are fixedly arranged on the evaporating dish 19, and a scraping mechanism is arranged between the support rod 20 and the evaporating dish 19;
the above is noteworthy in several points:
1. the scraping mechanism comprises scraping plates 21, push rods 22 and magnets 23, two scraping plates 21 are arranged on the support rod 20 in a sliding mode, magnets 23 are arranged on the two scraping plates 21 and are fixedly arranged, one end of each scraping plate 21 is opposite in magnetism, one push rod 22 is arranged on each scraping plate 21 in a rotating mode, a telescopic rod is fixedly arranged on the upper portions of the two push rods 22 jointly, a stop block matched with the two magnets 23 is fixedly arranged on the support rod 20, the part of.
2. The end face of the scraper 21 is in an outer arc shape, and the scraper 21 is made of a steel pasting material, so that the scraper 21 can scrape off organism crystals adhered to the lower part of the evaporation pan 19, and the collection difficulty of the organism crystals is reduced.
3. The second heating wire 24 is communicated with an external controller, and the controller can adopt a common pl controller.
The utility model discloses in, add appropriate amount of water in the first step through inlet tube 4 to distillation box 1, make heating wire 3 heat the distillation to the water in distillation box 1 through external control ware, the steam after the distillation passes through in 5 entering cooler bins 10 of distillation tube, cools off liquefaction formation distilled water to steam through cooling plate 11 in the cooler bins 10, and the distilled water passes through water pipe 12 and gets into in dissolving the case 13 to this completion operation of adding water.
Secondly, organism is added into the dissolving tank 13 through the first hopper 9 and the second hopper 15, the motor 14 is turned on, the motor 14 rotates to drive the stirring rod 16 fixedly connected with the driving end of the motor to rotate, the molten liquid is stirred through the stirring rod 16, and the solubility of the organism is increased, so that the dissolving operation is completed.
Thirdly, by opening the check valve 18, the organism solution in the dissolving tank 13 is filtered by the filter screen 17, most impurities in the organism solution are filtered and adsorbed, the filtered organism solution enters the evaporating dish 19 through the discharge pipe, and then the heating wire II 24 is started to evaporate the organism solution in the evaporating dish 19, so that organisms are precipitated, thereby finishing the purification operation of the organisms.
And fourthly, simultaneously pressing the two push rods 22 downwards, wherein the push rods 22 downwards move to have downward acting force on the scraper 21, so that the scraper 21 downwards moves, the scraper 21 is contacted with the punched side wall of the evaporation dish 19 to scrape off the organism crystals precipitated and adhered on the side wall of the evaporation dish 19, when the scraper 21 moves to the lowest part, the stop block upwards pushes the two magnets 23 to separate the two magnets 23, after the two magnets 23 are separated, the push rods 22 continuously downwards press the scraper 21, and at the moment, the scraper 21 rotates to scrape off the organism crystals precipitated and adhered on the lower inner wall of the evaporation dish 19, so that the scraping operation of the organism crystals is completed.
The above, only be the concrete implementation of the preferred embodiment of the present invention, but the protection scope of the present invention is not limited thereto, and any person skilled in the art is in the technical scope of the present invention, according to the technical solution of the present invention and the utility model, the concept of which is equivalent to replace or change, should be covered within the protection scope of the present invention.
Claims (6)
1. The purification device based on the medical organic intermediate impurities comprises a distillation box (1), an isolation cover (6) and an evaporation dish (19), and is characterized in that the distillation box (1) is fixedly connected with the isolation cover (6) through a connecting rod (7), the evaporation dish (19) is connected with the isolation cover (6) in a clamping manner, a heating wire I (3) is fixedly installed on the distillation box (1), a plug block I (2) is installed on the distillation box (1) in a clamping manner, a water inlet pipe (4) is fixedly installed on the plug block I (2), the water inlet pipe (4) penetrates through the plug block I (2) and extends to the bottom of the distillation box (1), a plug block II (8) and a dissolving box (13) are installed on the isolation cover (6) in a clamping manner, a cooling box (10) is fixedly installed on the plug block II (8), and a plurality of cooling plates (11) are fixedly installed on the cooling box (10), the utility model discloses a solar energy water heater, including cooler bin (10), distillation case (1), cooling box (10) and dissolving case (13) between intercommunication have a distillation column (5), and cooler bin (10) and dissolve and to communicate between case (13) have a water pipe (12), dissolve and install rabbling mechanism on case (13), and dissolve and go up fixed mounting on case (13) and have a filter screen (17), evaporating dish (19) are gone up fixed mounting and are had a branch (20) and two (24) of heating wire, and install between branch (20) and evaporating dish (19) and scrape the material mechanism.
2. A purification apparatus for pharmaceutical organic intermediate impurities based on claim 1, wherein a discharge pipe is connected between the dissolving tank (13) and the evaporating dish (19), and the discharge pipe penetrates through the bottom of the isolation cover (6) and extends into the evaporating dish (19), and a one-way valve (18) is fixedly installed below the discharge pipe.
3. The purification device based on pharmaceutical organic intermediate impurities as claimed in claim 1, wherein the stirring mechanism comprises a motor (14) and a stirring rod (16), the dissolution tank (13) is fixedly provided with the motor (14), the driving end of the motor (14) is fixedly provided with the stirring rod (16), and the lower end of the stirring rod (16) penetrates through the dissolution tank (13) and extends into the dissolution tank (13).
4. The purification device based on pharmaceutical and organic intermediate impurities as claimed in claim 1, wherein the scraping mechanism comprises two scrapers (21), a push rod (22) and a magnet (23), the support rod (20) is slidably provided with the two scrapers (21), the two scrapers (21) are fixedly provided with the magnet (23), the two magnets (23) are opposite in magnetism at the ends far away from the scrapers (21), the two scrapers (21) are rotatably provided with the push rod (22), the upper parts of the two push rods (22) are fixedly provided with a telescopic rod, and the support rod (20) is fixedly provided with a stopper matched with the two magnets (23).
5. A purification apparatus based on pharmaceutical organic intermediate impurities as claimed in claim 1, wherein a first hopper (9) is fixedly installed on the second stopper block (8), and a second hopper (15) matched with the first hopper (9) is fixedly installed on the dissolution tank (13).
6. The purification device based on pharmaceutical organic intermediate impurities as claimed in claim 4, wherein the shape of the end face of the scraper (21) is arc-shaped, and the scraper (21) is made of steel paste.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202022310190.0U CN213885027U (en) | 2020-10-16 | 2020-10-16 | Purification device based on organic intermediate impurity of medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202022310190.0U CN213885027U (en) | 2020-10-16 | 2020-10-16 | Purification device based on organic intermediate impurity of medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN213885027U true CN213885027U (en) | 2021-08-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202022310190.0U Expired - Fee Related CN213885027U (en) | 2020-10-16 | 2020-10-16 | Purification device based on organic intermediate impurity of medicine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN213885027U (en) |
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2020
- 2020-10-16 CN CN202022310190.0U patent/CN213885027U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 9 / F, building a, 108 Yuxin Road, Suzhou Industrial Park, Jiangsu Province Patentee after: Suzhou Zhongke new drug basket Biomedical Technology Co.,Ltd. Address before: 9 / F, building a, 108 Yuxin Road, Suzhou Industrial Park, Jiangsu Province Patentee before: Suzhou New Medicine Basket Biomedical Technology Co.,Ltd. |
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| CP01 | Change in the name or title of a patent holder | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20210806 |
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| CF01 | Termination of patent right due to non-payment of annual fee |