CN217230596U

CN217230596U - Multichannel asynchronous full-automatic polypeptide synthesizer

Info

Publication number: CN217230596U
Application number: CN202220811865.6U
Authority: CN
Inventors: 刘龙龙; 罗永健; 贺青海
Original assignee: Changsha Dilun Biotechnology Co ltd
Current assignee: Changsha Dilun Biotechnology Co ltd
Priority date: 2022-04-07
Filing date: 2022-04-07
Publication date: 2022-08-19
Anticipated expiration: 2032-04-07

Abstract

The utility model relates to a chemical synthesis technical field, the utility model discloses an asynchronous full-automatic polypeptide synthesizer of multichannel, include: a plurality of sets of reactors for polypeptide synthesis; the main shafts are in one-to-one correspondence with the reactors and are respectively connected with the corresponding reactors and used for driving the reactors to rotate; the motors are in one-to-one correspondence with the main shafts and are respectively connected with the corresponding main shafts to provide power for the main shafts; and the mounting bracket is used for mounting the multiple groups of reactors, the multiple spindles and the multiple motors.

Description

Multichannel asynchronous full-automatic polypeptide synthesizer

Technical Field

The utility model relates to the technical field of chemical synthesis, in particular to a multichannel asynchronous full-automatic polypeptide synthesizer.

Background

The description of the background art pertaining to the present invention is provided for the purpose of illustration and understanding only, and is not intended to be construed as an admission that the applicant specifically believes or is believed to be the prior art in the filing date of the first filing date of the present invention.

The synthesis is a synthesis process which takes resin (solid phase medium of artificial synthesis) as a carrier, repeatedly adds amino acid under certain reaction conditions, and performs chemical reaction. The existing multi-channel equipment is synchronously finished, the reactors of the existing multi-channel equipment are on the same carrier, if the existing multi-channel equipment needs to rotate together, liquid can not be fed and discharged in the rotating process, so that the synthesis time is too long, and the synthesis processes of all the reactors need to be synchronously finished

SUMMERY OF THE UTILITY MODEL

The embodiment of the utility model provides an aim at providing an asynchronous full-automatic polypeptide synthesizer of multichannel, the utility model discloses an asynchronous full-automatic polypeptide synthesizer of multichannel can realize the asynchronous work of a plurality of passageways.

A multi-channel asynchronous full-automatic polypeptide synthesizer comprises:

a plurality of sets of reactors for polypeptide synthesis;

the main shafts are in one-to-one correspondence with the reactors and are respectively connected with the corresponding reactors and used for driving the reactors to rotate;

the motors are in one-to-one correspondence with the main shafts and are respectively connected with the corresponding main shafts to provide power for the main shafts;

and the mounting bracket is used for mounting the multiple groups of reactors, the multiple spindles and the multiple motors.

Further, the number of the reactors is 2, the number of the spindles is 2, and the number of the motors is 2.

Further, the reactor is a 200ml reactor.

Furthermore, the motors are respectively controlled and can work asynchronously.

Borrow by above-mentioned scheme, the utility model discloses possess following beneficial effect at least:

the device has multiple channels, and the multiple channels can be completed automatically and asynchronously; the reactors are arranged on different main shafts, the different main shafts are controlled by independent motors, and each group of reactors can be rotationally mixed at any time. When one group of reactors rotate and mix, the other group of reactors can normally feed and discharge liquid, and several groups of reactors can also rotate simultaneously, so that the synthesis time can be reduced, and different processes can be adopted, and the synthesis efficiency can be improved. Different synthesis processes can be synchronously verified on equipment, and the verification speed of the processes can be accelerated, so that a better synthesis process can be obtained.

Drawings

In order to more clearly illustrate the technical solution of the present invention, the drawings used in the description of the embodiments are briefly introduced as follows:

FIG. 1 is a schematic structural view of the multi-channel asynchronous full-automatic polypeptide synthesizer of the present invention;

FIG. 2 is a front view of FIG. 1;

FIG. 3 is a side view of FIG. 1;

FIG. 4 is a top view of FIG. 1;

FIG. 5 is a schematic view of a reactor according to an embodiment.

Detailed Description

The present invention will be described in further detail with reference to the following examples, which should be understood by those skilled in the art to understand the technical solutions of the present invention more easily, and should not be taken as a limitation of the protection scope of the present invention.

In the following description, the terms "first" and "second" are used for descriptive purposes only and are not intended to indicate or imply relative importance. The following description provides embodiments of the invention, which may be combined or substituted for various embodiments, and is intended to include all possible combinations of the same and/or different embodiments described herein. Thus, if one embodiment includes feature A, B, C and another embodiment includes feature B, D, the invention should also be construed as including embodiments that include all other possible combinations of one or more of A, B, C, D, even though such embodiments may not be explicitly recited in the following text.

With reference to fig. 1-4, a multi-channel asynchronous full-automatic polypeptide synthesizer comprises:

a plurality of groups of reactors 1, wherein the reactors 1 are used for polypeptide synthesis;

the reactor comprises a plurality of main shafts (3, 4), wherein the main shafts (3, 4) correspond to the reactors 1 one by one, and the main shafts (3, 4) are respectively connected with the corresponding reactors 1 and are used for driving the reactors 1 to rotate;

the motor driving device comprises a plurality of motors (5 and 6), wherein the motors (5 and 6) correspond to main shafts (3 and 4) one by one, and the motors (5 and 6) are respectively connected with the corresponding main shafts (3 and 4) to provide power for the main shafts (3 and 4);

and the mounting bracket 2 is used for mounting the multiple groups of reactors 1, the multiple spindles (3, 4) and the multiple motors.

In some embodiments of the present invention, the number of reactors 1 is 2, the number of spindles (3, 4) is 2, and the number of motors is 2.

In some embodiments of the present invention, the reactor 1 is a 200ml reactor.

In some embodiments of the present invention, the motors are controlled separately, and asynchronous operation can be performed.

The utility model discloses do not do the restriction to the structure of reactor, can choose for use the field commonly used reactor can, in some embodiments, as shown in fig. 5, a reactor is the cylinder, and its size can be according to the reaction volume setting. The reactor comprises a reactor body 201 and a temperature controller 202, a carrier layer 203 is arranged in an inner pipeline of the reactor, a raw material feeding port and an inlet valve are arranged at the front end of the inner pipeline, the inner pipeline is provided with a discharging port and an outlet valve, the temperature controller 202 can be selected and is arranged outside the reactor body, a temperature sensor 204 is arranged in the reactor, and the temperature controller 202 is connected with the sensor 204 to acquire temperature data and control the temperature. It can be understood that the temperature controller can be connected and receive temperature signal with temperature sensor, controls the surface temperature of micro-reactor through control scheme and heating refrigeration module, and then controls the temperature of the inside fluid of micro-reactor and solid carrier layer, heats or refrigerates the micro-reactor, thereby uses the temperature of accurate quick control chemical reaction with temperature sensor cooperation.

It will be appreciated that mesh screens (not shown) may also be provided in the reactor body at the inlet and outlet of the piping.

In some embodiments, the carrier layer fill rate is 5-10%.

It can be understood that the material of the screen is inert material, which will not affect the reaction system.

It should be noted here that the number of each group of reactors is not limited, and may be 3 as shown in the figure, or may be other numbers, each group may be directly fixed on the main shaft in the case of a single reactor, a plurality of reactors may be fixed together by the fixing device in the case of a plurality of reactors, and then the fixing device is fixed on the main shaft, the type and power of the motor are not limited, the specific form of the main shaft, the length of the main shaft, and the like are not limited, as long as the reactor can be driven to rotate.

The device has multiple channels, and the multiple channels can be completed automatically and asynchronously; the reactors are on different spindles, the different spindles are controlled by separate motors, and each group of reactors can be rotationally mixed at any time. When one group of reactors rotate and mix, the other group of reactors can normally feed and discharge liquid, and several groups of reactors can also rotate simultaneously, so that the synthesis time can be reduced, and different processes can be adopted, and the synthesis efficiency can be improved. Different synthesis processes can be synchronously verified on equipment, and the verification speed of the processes can be accelerated, so that a better synthesis process can be obtained.

The applicant researches that the mixing is carried out in a reactor rotation and nitrogen bubbling mode, the problems of crushing and wall hanging of the synthetic resin can be effectively solved, and the synthesis efficiency is improved to a great extent.

The working principle is as follows:

the synthesis is a synthesis process which takes resin (solid phase medium of artificial synthesis) as a carrier, repeatedly adds amino acid under certain reaction conditions, and performs chemical reaction.

The synthesizer is integrally composed of a main body, transmission equipment, a power device and a software system. A novel mixing mode; the reactor was driven to rotate with stirring using a motor. The rotation of the motor and the synthesis and mixing of the materials are controlled by program software. The first set of reactors is fed first. After the first group of reactors are filled with liquid. The first set of reactors began to rotate while the second set of reactors began to feed liquid. When the second group finishes feeding liquid, the rotation is started. By cycling in this manner, the first set of reactors can be synthesized at a different time than the second set of reactors. Thereby achieving asynchronous synthesis.

The above description is only for the purpose of illustrating preferred embodiments of the present invention and is not to be construed as limiting the present invention, since various modifications and changes will be apparent to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A multi-channel asynchronous full-automatic polypeptide synthesizer is characterized by comprising:

a plurality of sets of reactors for polypeptide synthesis;

2. The multi-channel asynchronous fully automatic polypeptide synthesizer of claim 1 characterized in that the number of reactors is 2, the number of spindles is 2 and the number of motors is 2.

3. The multi-channel asynchronous full-automatic polypeptide synthesizer as claimed in claim 1, wherein the reactor is a 200ml reactor.

4. The multi-channel asynchronous full-automatic polypeptide synthesizer as claimed in claim 1, wherein the motors are controlled individually to operate asynchronously.