CN217186314U - Guide catheter and ultrasonic catheter - Google Patents

Abstract

The utility model provides a guide catheter and supersound pipe, wherein, guide catheter include the central cavity that extends along guide catheter's extending direction and dispose in at least one subcavity of central cavity periphery, dispose the drainage seal wire in the subcavity, the drainage seal wire is at least including the first section that has first crookedness and the second section that has the second crookedness. The utility model provides a guide catheter disposes the drainage seal wire in guide catheter's subcavity, and the drainage seal wire configuration has the first section of first crookedness and has the second section of second crookedness for the supersound pipe of making by this guide catheter can compromise rigidity and flexibility, with the unobstructed passageway of dosing of formation.

Description

Guide catheter and ultrasonic catheter

Technical Field

The utility model relates to the technical field of medical equipment, more specifically relates to a guide catheter and supersound pipe.

Background

In several medical applications, there are situations where ultrasound energy is used to enhance the effect on various therapeutic compounds, for example, ultrasound catheters are used to deliver ultrasound energy and therapeutic compounds to a treatment site within a patient's body. Such ultrasound catheters typically include an ultrasound assembly configured for generating ultrasound energy and a fluid delivery lumen for delivering a therapeutic compound to a treatment site.

In particular, ultrasound catheters may be used to treat human blood vessels that have been partially or completely occluded by plaque, thrombus, emboli, or other substances that reduce the blood carrying capacity of the vessel. To remove or reduce the obstruction, an ultrasound catheter is used to deliver a solution containing a therapeutic compound directly to the site of the obstruction. The ultrasonic energy generated by the ultrasound assembly enhances the action of the therapeutic compound. Such devices may be used to treat diseases such as peripheral arterial occlusion, deep vein thrombosis, pulmonary embolism, or acute ischemic stroke. In such applications, ultrasonic energy enhances the treatment of the obstruction by therapeutic compounds (such as urokinase, tissue plasminogen activator, recombinant tissue plasminogen activator, and the like).

The existing fluid delivery cavity has high requirements on the rigidity and flexibility of the ultrasonic catheter, if the ultrasonic catheter with higher rigidity is adopted, the fluency of the fluid in the fluid delivery cavity can be ensured, but when the fluid meets a bent part of a blood vessel, the flexibility of the ultrasonic catheter is insufficient; if the ultrasonic catheter with lower rigidity is adopted, when the ultrasonic catheter meets the bent part of the blood vessel, the flexibility of the ultrasonic catheter is satisfied, but the supporting force to the cavity is insufficient, so that the flowability of the medicine in the fluid delivery cavity is influenced.

In view of the above, there is a need for an improved ultrasound catheter in the prior art to solve the above problems.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to disclose a guide catheter and supersound pipe, the rigidity of having solved current supersound pipe and the problem that the pliability need be compromise.

In order to achieve the above object, the utility model provides a guide catheter, include the central cavity that extends along guide catheter's extending direction and dispose in at least one subcavity of central cavity periphery, dispose the drainage seal wire in the subcavity, the drainage seal wire is at least including the first section that has first crookedness and the second section that has the second crookedness.

As a further improvement of the present invention, the ratio of the first curvature to the second curvature is (0.5-0.7): 1.

as a further improvement of the utility model, the ratio range of the lengths of the first section and the second section is (2-4): 1.

as a further improvement of the present invention, the ratio of the lengths of the first section and the second section is 7: 3.

as a further improvement of the utility model, the length of the drainage guide wire accounts for 1/2-2/3 of the length of the guide catheter.

As a further improvement of the present invention, the guide catheter includes a distal end and a proximal end, the first section is disposed at the proximal end of the guide catheter, and the second section extends from the proximal end to the distal end.

As a further improvement, the peripheral configuration of the central cavity is three the sub-cavities are three the sub-cavities use the central cavity as the center and evenly arrange along the hoop.

As a further improvement of the present invention, the sub-cavity extends linearly or spirally.

In order to achieve the above object, the present invention provides an ultrasound catheter, which comprises the above guiding catheter and an ultrasound transducing tube disposed in the central cavity.

As a further improvement of the present invention, the ultrasonic transducing device is disposed in the ultrasonic transducing tube body along a plurality of ultrasonic transducing devices arranged at intervals along the extending direction of the guiding catheter, and the ultrasonic transducing device includes a first transducer and a second transducer arranged back to back.

Compared with the prior art, the beneficial effects of the utility model are that:

the utility model provides a guide catheter disposes the drainage seal wire in guide catheter's subcavity, and the drainage seal wire configuration has the first section of first crookedness and has the second section of second crookedness for the supersound pipe of making by this guide catheter can compromise rigidity and flexibility, in order to form unobstructed passageway of dosing.

Drawings

Fig. 1 is a schematic view of components of a tubular body portion of an ultrasound catheter provided by the present invention;

fig. 2 is a schematic view of components of a proximal end of an ultrasound catheter provided by the present invention;

fig. 3 is a schematic perspective view of an embodiment of a guide catheter provided by the present invention;

fig. 4 is a schematic cross-sectional view of a guiding catheter according to the present invention;

fig. 5 is a schematic perspective view of another embodiment of a guide catheter provided by the present invention;

fig. 6 is a schematic view of a guide wire according to the present invention.

Detailed Description

The present invention is described in detail with reference to the embodiments shown in the drawings, but it should be understood that these embodiments are not intended to limit the present invention, and those skilled in the art should understand that the functions, methods, or structural equivalents or substitutions made by these embodiments are within the scope of the present invention.

It should be understood that, in the present application, the terms "longitudinal", "transverse", "length", "thickness", "upper", "lower", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. indicate orientations or positional relationships based on those shown in the drawings, which are only for convenience of describing the present technical solution and simplifying the description, but do not indicate or imply that the designated jig or component must have a specific orientation, be configured and operated in a specific orientation, and thus, should not be construed as limiting the present technical solution.

It is desirable to provide an ultrasound catheter having various features and advantages, examples of which include the ability to apply ultrasound energy to a treatment site. In other embodiments, the catheter has the ability to deliver therapeutic compounds to a treatment site. Embodiments of ultrasound catheters having certain of these features and advantages are described herein. Methods of using such ultrasound catheters are also described herein.

The ultrasound catheter described herein may be used to enhance the therapeutic effect of a therapeutic compound at a treatment site within a patient. As used herein, the term "therapeutic compound" is broadly, but not limited to, a drug, a medicament, a dissolved compound, genetic material, an anti-cancer drug, or any other substance capable of affecting physiological function. For applications in which a human blood vessel has been partially or completely occluded by plaque, thrombus, embolus, or other substance that reduces the blood carrying capacity of the vessel, suitable therapeutic compounds include, but are not limited to, aqueous solutions containing heparin, urohormone, streptokinase.

Certain features and aspects of the ultrasound catheter disclosed herein may also be used in applications where the ultrasound energy itself provides a therapeutic effect. Examples of such therapeutic effects include preventing or reducing stenosis and/or restenosis; tissue ablation, abrasion, or fragmentation; promote temporary or permanent physiological changes in intracellular or intercellular structures; and cleaving the micro-balloon or microbubble for therapeutic compound delivery.

The ultrasound catheters described herein may be configured for application of ultrasound energy over a substantial length of a body lumen, such as, for example, in a lower extremity artery. In other embodiments, the catheter may be configured to treat pulmonary embolism ("PE"), which may occur when a large blood clot blocks a large blood vessel leading from the heart to the lungs. However, it should be appreciated that certain features and aspects of the present disclosure may be applied to catheters configured to be inserted into other vessels or cavities, such as small brain vessels, solid tissues, ductal systems, and body cavities.

Fig. 1 schematically illustrates an ultrasound catheter 10 configured for use in a large vessel of a patient's anatomy. For example, the ultrasound catheter 10 shown in fig. 1 may be used to treat long-segment peripheral arterial occlusions, such as those in the vasculature of the legs. Alternatively, in other examples, the ultrasound catheter 10 shown in fig. 1 may be used to treat pulmonary emboli, the ultrasound catheter 10 being configured to be introduced into a large blood vessel (e.g., pulmonary artery) of a patient leading from the heart to the lungs. In one embodiment of use, the femoral venous access may be used to place the ultrasound catheter 10 into such a vessel. In such embodiments, the ultrasound catheter 10 may be advanced through the femoral access site, through the heart, and into the pulmonary artery. The size of the ultrasound catheter 10 is adjusted based on the particular application for which the ultrasound catheter 10 is to be used.

As shown in fig. 1, the ultrasound catheter 10 may include a multi-component, elongated, flexible guide catheter 11 and an ultrasound transducing tube 14 disposed within the guide catheter 11, wherein the guide catheter 11 has a distal end 12 and a proximal end 13. To more clearly illustrate the structure of the ultrasound transducing tube 14, the ultrasound transducing tube 14 is shown in fig. 1 as extending out of the distal end 12 of the guide catheter 11. The guide catheter 11 and other components of the ultrasound catheter 10 may be manufactured according to any of a variety of techniques well known in the art of catheter manufacturing. Suitable materials and dimensions can be readily selected based on the natural and anatomical dimensions of the treatment site, as well as based on the desired percutaneous access site.

For example, in some embodiments, the distal end 12 of the guide catheter 11 may comprise a material having sufficient flexibility, kink resistance, rigidity, and structural support to push the ultrasound transducer tube 14 through the patient's vasculature to the treatment site. Examples of such materials include, but are not limited to, polytetrafluoroethylene, polyethylene, polyamide, polyurethane, silicone, and other similar materials. In certain example aspects, the proximal end 13 of the guide catheter 11 is reinforced by braiding, netting, or other configurations to provide increased kink resistance and pushability.

As shown in fig. 1 and 3, the cross-sectional shape of the guide catheter 11 may be circular, square, or other irregular shapes. In some embodiments configured for treating thrombi in arteries of lower extremities, the guide catheter 11 has an outer diameter between about 0.15cm and about 0.19 cm. In another embodiment, the guide catheter 11 has an outer diameter of about 0.18 cm. In certain embodiments, the length of the guide catheter 11 is from 10cm to 200cm, preferably from 60 to 160cm, for example, preferably from 106cm to 135cm, the specific length being determined according to the length required for the treatment.

The ultrasound transducing tube 14 may comprise a material that is thinner or more acoustically transparent than the material of the proximal end 13 of the guiding catheter 11. Thinner materials generally have greater acoustic transmission than thicker materials. Suitable materials for the ultrasound transducing body 14 may include, but are not limited to, high or low density polyethylene, urethane, nylon, and the like. In certain modified embodiments, the ultrasonic transducing tube body 14 may be formed of the same material or the same thickness of material as the proximal end 13.

Referring to FIG. 2, to provide access to the interior of the guide catheter 11, fluid may be injected into the proximal end 13 of the ultrasound catheter 10 through a plurality of injection ports 15. In some embodiments, the proximal end 13 of the ultrasound catheter 10 is provided with a plurality of infusion ports 15, and the infusion ports 15 may include drug inlet ports, saline inlet ports, and the like. In some embodiments, to provide electrical connection to the ultrasound transducing tube 14, the ultrasound catheter 10 may further include a cable (not shown), which may include a connector (not shown) to a control system (not shown). In some embodiments, the cable may be connected to the ultrasound catheter 10 at the proximal end 13 through a proximal access port (not labeled).

As shown in fig. 3 and 4, the guiding catheter 11 includes a central cavity 110 extending along the extending direction (i.e. the longitudinal direction a) of the guiding catheter 11, and at least one sub-cavity disposed at the periphery of the central cavity 110, and a drainage wire is disposed in the sub-cavity to satisfy the requirements of rigidity and flexibility of the guiding catheter 11.

For example, in the present embodiment, three sub-cavities are arranged at the periphery of the central cavity 110, including a first sub-cavity 112, a second sub-cavity 113, and a third sub-cavity 114. The first sub-chamber 112, the second sub-chamber 113 and the third sub-chamber 114 all extend in the extending direction (i.e. the longitudinal direction a) of the guide conduit 11, and are uniformly arranged in a circumferential direction with the central chamber 110 as the center. During treatment, the central cavity 110 is used for configuring the ultrasonic transduction tube 14 and injecting a medicament, and the first sub-cavity 112, the second sub-cavity 113 and the third sub-cavity 114 are used for configuring a thermocouple and injecting physiological saline, the medicament and the like.

In an embodiment, as shown in fig. 5, the guide conduit 11' comprises a central cavity 110' extending in the extension direction (i.e. the longitudinal direction a) of the guide conduit 11', the periphery of the central cavity 110' being configured with three sub-cavities, comprising a first sub-cavity 112', a second sub-cavity 113' and a third sub-cavity 114 '. The first sub-cavity 112', the second sub-cavity 113' and the third sub-cavity 114 'are arranged around the central cavity 110' and extend spirally along the longitudinal direction a. In other alternative embodiments, only one of the first sub-cavity 112', the second sub-cavity 113' and the third sub-cavity 114' may be helical, or two of them may be helical, and the others may be linear, so long as mutual interference among the three sub-cavities is avoided.

The number and shape of the sub-cavities disposed in the guide duct 11 are not limited, and for example, the guide duct 11 may have a curved shape, since the degree of curvature may affect the flow rate of the drug.

Further, a drainage guide wire is disposed in the subcavity of the guide catheter 11. The lengths of the drainage guide wires configured in different sub-cavities can be equal or different. Since an excessively long drainage wire affects the softness of the distal end 13 of the guide catheter 11, the speed of releasing the drug, and the like, the entire guide catheter 11 does not need to be covered with the drainage wire. The inventor finds that when the length of the drainage guide wire is between 1/2 and 2/3 of the length of the guide catheter 11, the optimal drainage effect can be achieved, when the guide catheter 11 is squeezed, the medicine channel can be supported, the medicine channel is guaranteed not to be blocked, and meanwhile, the guide catheter 11 can be prevented from being twisted. And limited by the space size of the sub-cavity, the maximum diameter of the drainage guide wire is not more than 0.5mm, and preferably about 0.1 mm.

For example, referring to fig. 3 and 5, a first drainage wire 112a is disposed in the first subcavity 112, a second drainage wire 113a is disposed in the second subcavity 113, and a third drainage wire 114a is disposed in the third drainage wire 114, respectively. One end of each of the first, second and third drainage guidewires 112a, 113a, 114a is disposed at the distal end 12 of the guide catheter 11, and the other end of each of the first, second and third drainage guidewires 112a, 113a, 114a extends toward the proximal end 13 of the guide catheter 11. The first drainage guidewire 112a, the second drainage guidewire 113a, and the third drainage guidewire 114a all have different lengths.

The drainage guide wire can be made of stainless steel or high molecular polymer. Further, each of the drainage guidewires 112a, 113a, 114a includes at least a first segment 1121a having a first curvature and a second segment 1122a having a second curvature. That is, the first section 1121a is configured at the proximal end 13, and the second section 1122a extends from the proximal end 13 to the distal end 12.

For example, referring to FIG. 6, an example of a drainage guidewire 112a includes a first segment 1121a having a first curvature and a second segment 1122a having a second curvature. The ratio of the lengths of the first segment 1121a and the second segment 1122a preferably ranges from (2-4): 1, for example, the ratio of the lengths of the first and second sections 1121a and 1122a is 7: 3.

here, the degree of curvature (e.g., the first and/or second degree of curvature) may mean a degree of curvature in the axial length direction. A relatively high degree of curvature (e.g. a second degree of curvature) may mean a relatively large degree of curvature, such that the deformation is large, whereas a relatively low degree of curvature (e.g. a first degree of curvature) may mean a relatively small degree of curvature, such that the deformation is small. For example, the ratio of the first curvature to the second curvature is (0.5-0.7): 1.

if a drainage guide wire with a small bending degree is adopted, the rigidity of the whole guide catheter 11 is too high, and the requirement of flexibility is not met. Meanwhile, if the drainage guide wire with larger curvature is adopted (the flexibility is better), the guide catheter 11 is not beneficial to supporting the sub-cavity when meeting the bending part, so that the medicine is not beneficial to flowing through the cavity. Experiments show that when the ratio of the length of the first bending to the length of the second bending is 7: 3, the rigidity and the flexibility of the guide catheter 11 can be effectively considered, so that the ultrasonic catheter 10 made of the guide catheter 11 can be considered both the rigidity and the flexibility so as to be suitable for ultrasonic interventional therapy.

As shown in fig. 1 and 3, the ultrasound transducing tube 14 is disposed in the central cavity 110 and extends along the extending direction (i.e., the longitudinal direction a) of the guiding catheter 11, a guide wire 24 extending along the longitudinal direction a is disposed in the ultrasound transducing tube 14, and a plurality of ultrasound transducing devices 20 are connected to the guide wire 24. For example, 8-16 sets of ultrasound transducing devices 20, preferably 12 sets of ultrasound transducing devices 20, may be disposed on the guidewire 24. The side wall of the central cavity 110 may be configured with a thread structure 111, and under the guiding action of the thread structure 111, the ultrasound transducing tube 14 can be conveniently and smoothly introduced into the lesion.

The ultrasonic transducer device 20 may include an ultrasonic therapy transducer and an ultrasonic imaging transducer to allow real-time monitoring of the progress of the therapy for the convenience of guiding the physician in further actions. The ultrasonic therapy transducer and the ultrasonic imaging transducer are respectively and electrically connected with corresponding control signal leads and are used for controlling different central frequencies of the ultrasonic therapy transducer and the ultrasonic imaging transducer. The therapeutic ultrasound transducer and the imaging ultrasound transducer are preferably mounted in a back-to-back arrangement.

When supersound pipe 10 got into the blood vessel, can be earlier by the formation of image information of supersound formation of image transducer observation thrombus, then judge the position and the size of thrombus by the formation of image information condition, then carry out ultrasonic therapy transducer and thrombus and carry out accurate coordination, and then avoided ultrasonic therapy transducer to fail to set up at the thrombus position, reduced treatment.

The utility model provides a guide catheter disposes the drainage seal wire in guide catheter's subcavity, and the drainage seal wire configuration has the first section of first crookedness and has the second section of second crookedness for the supersound pipe of making by this guide catheter can compromise rigidity and flexibility, with the unobstructed passageway of dosing of formation.

The above list of details is only for the practical implementation of the present invention, and they are not intended to limit the scope of the present invention, and all equivalent implementations or modifications that do not depart from the technical spirit of the present invention should be included in the scope of the present invention.

Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.

Claims (10)

1. The guide catheter is characterized by comprising a central cavity extending along the extension direction of the guide catheter and at least one sub-cavity arranged on the periphery of the central cavity, wherein a drainage guide wire is arranged in the sub-cavity, and the drainage guide wire at least comprises a first section with first bending degree and a second section with second bending degree.

2. The guide catheter of claim 1, wherein the ratio of the first curvature to the second curvature is (0.5-0.7): 1.

3. the guide catheter of claim 1, wherein the ratio of the first and second segment lengths ranges from (2-4): 1.

4. the guide catheter of claim 3, wherein the ratio of the first segment length to the second segment length is 7: 3.

5. the guide catheter of claim 1, wherein the length of the drainage guidewire is 1/2-2/3 of the guide catheter length.

6. The guide catheter of claim 1, comprising a distal end and a proximal end, the first section being configured at the proximal end of the guide catheter, the second section extending from the proximal end to the distal end.

7. The guide catheter of claim 1, wherein the periphery of the central lumen defines three of the sub-lumens, and wherein the three sub-lumens are circumferentially and uniformly arranged about the central lumen.

8. The guide catheter of claim 1, wherein the subcavities extend linearly or helically.

9. An ultrasound catheter comprising the guide catheter of any one of claims 1-8, and an ultrasound transducing tube disposed within the central lumen.

10. An ultrasound catheter according to claim 9, wherein a plurality of ultrasound transducing means are arranged at intervals along the extension of the guiding catheter within the ultrasound transducing body, the ultrasound transducing means comprising a first transducer and a second transducer arranged back to back.

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