CN217181700U - Teaching aid model for interaction between initial T cells and adhesion molecules - Google Patents
Teaching aid model for interaction between initial T cells and adhesion molecules Download PDFInfo
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- CN217181700U CN217181700U CN202220408110.1U CN202220408110U CN217181700U CN 217181700 U CN217181700 U CN 217181700U CN 202220408110 U CN202220408110 U CN 202220408110U CN 217181700 U CN217181700 U CN 217181700U
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- 210000001744 T-lymphocyte Anatomy 0.000 title claims abstract description 33
- 230000003993 interaction Effects 0.000 title claims abstract description 23
- 102100022339 Integrin alpha-L Human genes 0.000 claims abstract description 8
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims abstract description 8
- 108010092694 L-Selectin Proteins 0.000 claims abstract description 7
- 102000016551 L-selectin Human genes 0.000 claims abstract description 7
- 102100028688 Putative glycosylation-dependent cell adhesion molecule 1 Human genes 0.000 claims abstract description 7
- 108010012704 sulfated glycoprotein p50 Proteins 0.000 claims abstract description 7
- 210000003556 vascular endothelial cell Anatomy 0.000 claims abstract description 7
- 239000007787 solid Substances 0.000 claims description 15
- 239000002023 wood Substances 0.000 claims description 11
- 239000011324 bead Substances 0.000 claims description 8
- 102000015271 Intercellular Adhesion Molecule-1 Human genes 0.000 claims description 7
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims description 7
- 102000009410 Chemokine receptor Human genes 0.000 claims description 5
- 108050000299 Chemokine receptor Proteins 0.000 claims description 5
- 102000019034 Chemokines Human genes 0.000 claims description 5
- 108010012236 Chemokines Proteins 0.000 claims description 5
- 239000001045 blue dye Substances 0.000 claims description 3
- 239000001046 green dye Substances 0.000 claims description 3
- AJDUTMFFZHIJEM-UHFFFAOYSA-N n-(9,10-dioxoanthracen-1-yl)-4-[4-[[4-[4-[(9,10-dioxoanthracen-1-yl)carbamoyl]phenyl]phenyl]diazenyl]phenyl]benzamide Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C=CC=C2NC(=O)C(C=C1)=CC=C1C(C=C1)=CC=C1N=NC(C=C1)=CC=C1C(C=C1)=CC=C1C(=O)NC1=CC=CC2=C1C(=O)C1=CC=CC=C1C2=O AJDUTMFFZHIJEM-UHFFFAOYSA-N 0.000 claims description 3
- 239000001043 yellow dye Substances 0.000 claims description 3
- 102000016289 Cell Adhesion Molecules Human genes 0.000 claims 2
- 108010067225 Cell Adhesion Molecules Proteins 0.000 claims 2
- 230000000977 initiatory effect Effects 0.000 claims 2
- 230000009471 action Effects 0.000 abstract description 3
- 239000005482 chemotactic factor Substances 0.000 abstract description 3
- 230000002349 favourable effect Effects 0.000 abstract description 2
- 102000005962 receptors Human genes 0.000 abstract description 2
- 108020003175 receptors Proteins 0.000 abstract description 2
- 241001146209 Curio rowleyanus Species 0.000 abstract 2
- 210000004698 lymphocyte Anatomy 0.000 description 10
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 4
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 description 4
- 238000010276 construction Methods 0.000 description 4
- 210000002889 endothelial cell Anatomy 0.000 description 3
- 210000004986 primary T-cell Anatomy 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 210000001165 lymph node Anatomy 0.000 description 2
- 210000005210 lymphoid organ Anatomy 0.000 description 2
- 230000005012 migration Effects 0.000 description 2
- 238000013508 migration Methods 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 102100023935 Transmembrane glycoprotein NMB Human genes 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 210000004081 cilia Anatomy 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000003511 endothelial effect Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 108091007466 transmembrane glycoproteins Proteins 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
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Abstract
The utility model discloses an initial T cell and mutual action teaching aid model that adheres molecule belongs to teaching aid model technical field, including representing initial T cell's first spheroid, represent the first cylinder by being the string of beads form of L-selectin, first cuboid, the combination that second spheroid and head rod that has the arc breach are constituteed, represent the combination that second cuboid and second connecting rod that chemotactic factor receptor comprise the second cuboid that has the arc breach and second connecting rod, represent LFA-1 the combination that comprises third cuboid and the third connecting rod that has the rectangle breach, represent vascular endothelial cell's fillet cuboid, represent GlyCAM-1 the combination that comprises the second cylinder and the fourth connecting rod that are the string of beads form, represent the combination that chemotactic factor comprises third spheroid and fifth connecting rod. The utility model has simple structure, convenient assembly and disassembly, can clearly show the interaction mode of the initial T cell and the adhesion molecule, and is favorable for the learning and memory of the user to the structure.
Description
Technical Field
The utility model relates to an initial T cell and mutual action teaching aid model that adheres molecule belongs to teaching aid model technical field.
Background
Lymphocytes, after maturation in the central lymphoid organs, colonize peripheral lymphoid organs by the bloodstream and perform a variety of biological functions throughout the body and in organs, tissues and sites of inflammation. Lymphocyte homing (homing) is a special form of lymphocyte migration, including lymphocyte recirculation and migration of lymphocytes to sites of inflammation. The molecular basis is the interaction of a Lymphocyte Homing Receptor (LHR) expressed on lymphocytes with a vascular addressen expressed on endothelial cells. In this process, primary T cell surface L-selectin in combination with high endothelial veno peripheral lymph node addressens (Cly-CAM and CD34) mediates primary adhesion; chemokines on vascular endothelial cells stimulate the corresponding chemokine receptors on naive T cells to activate the LFA-1 molecule; binding of activated LFA-1 to ICAM-1 results in the passage of lymphocytes out of vascular endothelial cells into human lymph nodes.
In the existing teaching, the interaction between the initial T cell and the adhesion molecule can only be shown by a schematic plan view, the schematic plan view and the courseware can not satisfy the requirement that the learner can fully understand the interaction between the initial T cell and the adhesion molecule, and the interaction state between the initial T cell and the adhesion molecule can not be shown in front of the learner by a concrete and image state, so that the learner can not understand and memorize easily, and the teaching difficulty of the lecturer is increased.
SUMMERY OF THE UTILITY MODEL
[ problem ] to
The utility model discloses the problem that solves is: in the existing teaching, the interaction between the initial T cell and the adhesion molecule can only be shown by a schematic plan view, the schematic plan view and the courseware can not satisfy the requirement that the learner can fully understand the interaction between the initial T cell and the adhesion molecule, and the interaction state between the initial T cell and the adhesion molecule can not be shown in front of the learner by a concrete and image state, so that the learner can not understand and memorize easily, and the teaching difficulty of the lecturer is increased.
[ solution ]
The utility model provides an initial T cell and the interact teaching aid model that adheres molecule, this teaching aid model simple structure, three-dimensional show, the initial T cell of show that can be more clear and the interact's that adheres molecule state are favorable to the learner to the understanding and the memory of cilia, have also reduced the professor's degree of difficulty simultaneously.
The teaching aid model for the interaction of the initial T cells and the adhesion molecules comprises a first sphere representing the initial T cells, a first bead-shaped cylinder representing the L-selectin, and a first cuboid, the combination of the second sphere with the arc-shaped notch and the first connecting rod represents a combination of the second cuboid with the arc-shaped notch and the second connecting rod of a chemokine receptor, the combination of the third cuboid with the rectangular notch and the third connecting rod of LFA-1, the rounded cuboid of a vascular endothelial cell, the combination of the second cylinder with the bead-shaped fourth connecting rod of GlyCAM-1, the combination of the third sphere with the fifth connecting rod of the chemokine, the combination of the fourth cuboid with the sixth connecting rod of ICAM-1, and the combination of the third cylinder with the bead-shaped seventh connecting rod of CD 34.
The utility model discloses an in an embodiment, the first spheroid passes through the first connecting rod and the integral connection that is formed by the first cylinder that is the beading, first cuboid and the second spheroid that has the arc breach, and the first spheroid passes through the second connecting rod to be connected with the second cuboid that has the arc breach, and the first spheroid passes through the third connecting rod to be connected with the third cuboid that has the rectangle breach.
The utility model discloses an in the embodiment, the fillet cuboid passes through the fourth connecting rod and is connected with the second cylinder that is the beading, and the fillet cuboid passes through fifth connecting rod and is connected with the third spheroid, and the fillet cuboid passes through the sixth connecting rod and is connected with the fourth cuboid, and the fillet cuboid passes through the seventh connecting rod and is connected with the third cylinder that is the beading.
In an embodiment of the present invention, the first ball body is a solid wood structure, and the first ball body has three connecting holes.
The utility model discloses an in an embodiment, first cylinder, second spheroid, second cuboid and third cuboid are wooden solid construction and have all seted up a connecting hole.
The utility model discloses an in an embodiment, the fillet cuboid is wooden solid construction, and its one side has four connecting holes.
The utility model discloses an in an embodiment, second cylinder, third spheroid, fourth cuboid and third cylinder are wooden solid construction and have all seted up a connecting hole.
In an embodiment of the present invention, the first connecting rod, the second connecting rod, the third connecting rod, the fourth connecting rod, the fifth connecting rod, the sixth connecting rod and the seventh connecting rod are all wood solid structures, and have the same size and the same diameter as the aperture of the connecting hole; the length of the second cylinder is larger than that of the third cylinder.
In an embodiment of the present invention, the arc-shaped notch of the second sphere corresponds to the second cylinder or the third cylinder; the arc-shaped notch of the second cuboid corresponds to the third cuboid; the rectangular notch of the third cuboid corresponds to the fourth cuboid.
In one embodiment of the present invention, the surfaces of the first cylinder, the first cuboid, the second sphere, the second cylinder and the third cylinder are coated with green dye; the surfaces of the third cuboid and the fourth cuboid are coated with blue dye; the surfaces of the second cylinder and the third sphere are coated with yellow dye.
[ advantageous effects ]
1. The utility model discloses show initial T cell and the interact who adheres the molecule with three-dimensional structural style, vividly show the connection action relation between each part, make the learner be convenient for the recognition and understanding, greatly reduced the lecture degree of difficulty.
2. The utility model comprises a sphere representing lymphocyte, a first cylinder representing L-selectin and formed by beads, the combination body comprises a first cuboid, a second sphere with an arc-shaped notch and a first connecting rod, a combination body which is used for representing a chemokine receptor and consists of the second cuboid with the arc-shaped notch and a second connecting rod, a combination body which is used for representing LFA-1 and consists of a third cuboid with a rectangular notch and a third connecting rod, a rounded cuboid which is used for representing vascular endothelial cells, a combination body which is used for representing GlyCAM-1 and consists of a second cylinder with a saw-toothed end and a fourth connecting rod, a combination body which is used for representing a chemokine and consists of the first sphere and a fifth connecting rod, a combination body which is used for representing ICAM-1 and consists of the fourth cuboid and a sixth connecting rod, and a combination body which is used for representing CD34 and consists of a third cylinder with a bead string and a seventh connecting rod. The display is vivid in a real three-dimensional structure, and a visual and deep understanding is given to people.
3. The utility model discloses initial T cell and the interact that adheres the molecule, each subassembly can demonstrate alone or assemble into an organic whole, including the concrete position and the interrelationship of various structures, convenient teaching strengthens user's study and memory simultaneously.
Drawings
FIG. 1 is a schematic view showing the structural resolution of the teaching aid model for the interaction between the initial T cell and the adhesion molecule of the present invention.
FIG. 2 is a schematic diagram of the structural resolution of the original T cell of the present invention.
FIG. 3 is a schematic view showing the structural resolution of the endothelial cell surface adhesion molecule of the present invention.
In the figure, 1, a first sphere; 2. a first cylinder; 3. a first cuboid; 4. a second sphere; 5. a first connecting rod; 6. a second cuboid; 7. a second connecting rod; 8. a third cuboid; 9. a third connecting rod; 10. a round corner cuboid; 11. a second cylinder; 12. a fourth connecting rod; 13. a third sphere; 14. a fifth connecting rod; 15. a fourth cuboid; 16. a sixth connecting rod; 17. a third cylinder; 18. a seventh connecting rod; 19. and (4) connecting the holes.
Detailed Description
To achieve the above objects, features and advantages and in accordance with the purpose of the invention, as embodied and broadly described herein, the present invention will be described in detail with reference to the accompanying drawings.
Example 1
A teaching aid model for interaction between primary T cells and adhesion molecules is shown in figure 1, and comprises a first sphere 1 representing the primary T cells, a combination of a first cylinder 2 in a bead shape, a first cuboid 3, a second sphere 4 with an arc-shaped notch and a first connecting rod 5 representing L-selectin, a combination of a second cuboid 6 with an arc-shaped notch and a second connecting rod 7 representing a chemokine receptor, a combination of a third cuboid 8 with a rectangular notch and a third connecting rod 9 representing LFA-1 (lymphocyte function-related molecule), a rounded cuboid 10 representing vascular endothelial cells, a combination of a second cylinder 11 in a bead shape and a fourth connecting rod 12 representing GlyCAM-1 (glycosylation-dependent cell adhesion molecule-1), a combination of a third sphere 13 and a fifth connecting rod 14 representing a chemokine, a combination consisting of a fourth cuboid 15 and a sixth connecting rod 16 representing ICAM-1 (intercellular adhesion molecule-1), and a combination consisting of a third beaded cylinder 17 and a seventh connecting rod 18 representing CD34 (highly glycosylated type I transmembrane glycoprotein).
As shown in fig. 1 or fig. 2, the first sphere 1 is connected with the whole body formed by the first cylinder 2 in bead shape, the first cuboid 3 and the second sphere 4 with arc-shaped gap through the first connecting rod 5, the first sphere 1 is connected with the second cuboid 6 with arc-shaped gap through the second connecting rod 7, the first sphere 1 is connected with the third cuboid 8 with rectangular gap through the third connecting rod 9, and the above structures jointly form the initial T cell with L-selectin, chemotactic factor and LFA-1 on the surface.
As shown in FIG. 1 or FIG. 3, the rounded rectangular parallelepiped 10 is connected to the beaded second cylinder 11 through the fourth connecting rod 12, connected to the third sphere 13 through the fifth connecting rod 14, connected to the fourth rectangular parallelepiped 15 through the sixth connecting rod 16, and connected to the beaded third cylinder 17 through the seventh connecting rod 18, and the above structures together constitute the endothelial cell having GlyCAM-1, ICAM-1, and CD34 on the surface.
Further, the first sphere 1 is a solid wood structure, and three connecting holes 19 are formed in the first sphere 1.
Further, first cylinder 2, second spheroid 4, second cuboid 6 and third cuboid 8 are wooden solid construction and have all seted up a connecting hole 19.
Further, the round rectangular parallelepiped 10 is a solid wood structure, and one side of the round rectangular parallelepiped has four connecting holes 19.
Further, the second cylinder 11, the third sphere 13, the fourth cuboid 15 and the third cylinder 17 are all wood solid structures and are all provided with a connecting hole 19.
Further, the first connecting rod 5, the second connecting rod 7, the third connecting rod 9, the fourth connecting rod 12, the fifth connecting rod 14, the sixth connecting rod 16 and the seventh connecting rod 18 are all wood solid structures, and have the same size and the same diameter as the aperture of the connecting hole 19.
Further, the second cylinder 11 has a length greater than that of the third cylinder 17.
Further, the arc-shaped gap of the second sphere 4 corresponds to the second cylinder 11 or the third cylinder 17; the arc-shaped gap of the second cuboid 6 corresponds to the third sphere 13; the rectangular notch of the third cuboid 8 corresponds to the fourth cuboid 15.
Further, the surfaces of the first cylinder 2, the first cuboid 3, the second sphere 4, the second cylinder 11 and the third cylinder 17 are coated with green dye; the surfaces of the third cuboid 8 and the fourth cuboid 15 are coated with blue dyes; the surfaces of the second cylinder 11 and the third sphere 13 are coated with yellow dye.
The protection scope of the present invention is not limited to the above embodiments, and any modifications, equivalent replacements, and improvements that can be made by a person skilled in the art within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A teaching aid model for interaction of initial T cells and adhesion molecules is characterized by comprising a first sphere (1) representing the initial T cells, a combination body which represents L-selectin and consists of a first cylinder (2) in a bead shape, a first cuboid (3), a second sphere (4) with an arc-shaped notch and a first connecting rod (5), a combination body which represents a chemokine receptor and consists of a second cuboid (6) with an arc-shaped notch and a second connecting rod (7), a combination body which represents LFA-1 and consists of a third cuboid (8) with a rectangular notch and a third connecting rod (9), a rounded cuboid (10) representing vascular endothelial cells, a combination body which represents GlyCAM-1 and consists of a second cylinder (11) and a fourth connecting rod (12) in a bead shape, and a combination body which represents chemokines and consists of a third sphere (13) and a fifth connecting rod (14), a combination body which is composed of a fourth cuboid (15) and a sixth connecting rod (16) and represents ICAM-1, and a combination body which is composed of a third cylinder (17) and a seventh connecting rod (18) which are in a bead shape and represent CD 34.
2. The initial T cell and adhesion molecule interaction teaching aid model according to claim 1, wherein the first sphere (1) is connected to the whole formed by the first beaded cylinder (2), the first cuboid (3) and the second arc-notched sphere (4) through a first connecting rod (5), the first sphere (1) is connected to the second arc-notched cuboid (6) through a second connecting rod (7), and the first sphere (1) is connected to the third arc-notched cuboid (8) through a third connecting rod (9).
3. The initial T cell and adhesion molecule interaction teaching aid model as claimed in claim 2, wherein the rounded rectangular parallelepiped (10) is connected to the beaded second cylinder (11) through a fourth connecting rod (12), the rounded rectangular parallelepiped (10) is connected to the beaded third cylinder (13) through a fifth connecting rod (14), the rounded rectangular parallelepiped (10) is connected to the fourth rectangular parallelepiped (15) through a sixth connecting rod (16), and the rounded rectangular parallelepiped (10) is connected to the beaded third cylinder (17) through a seventh connecting rod (18).
4. The interaction teaching aid model of initiating T cells and adhesion molecules as claimed in claim 3, wherein the first sphere (1) is a solid wood structure, and three connecting holes (19) are formed in the first sphere (1).
5. The interaction teaching aid model of initial T cells and adhesion molecules as claimed in claim 4, wherein the first cylinder (2), the second sphere (4), the second cuboid (6) and the third cuboid (8) are all wood solid structures and are provided with a connecting hole (19).
6. The initial T cell adhesion molecule interaction teaching aid model according to claim 5, wherein the rounded rectangular parallelepiped (10) is a wood solid structure with four connecting holes (19) on one side.
7. The interaction teaching aid model of initiating T cells and adhesion molecules as claimed in claim 6, wherein the second cylinder (11), the third sphere (13), the fourth cuboid (15) and the third cylinder (17) are all wood solid structures and are provided with a connecting hole (19).
8. The initial T cell and adhesion molecule interaction teaching aid model according to claim 7, wherein the first connecting rod (5), the second connecting rod (7), the third connecting rod (9), the fourth connecting rod (12), the fifth connecting rod (14), the sixth connecting rod (16) and the seventh connecting rod (18) are all wood solid structures, and have the same size and the same diameter as the hole diameter of the connecting hole (19); the length of the second cylinder (11) is larger than that of the third cylinder (17).
9. The initial T-cell adhesion molecule interaction teaching aid model according to claim 8, wherein the arc-shaped gap of the second sphere (4) corresponds to the second cylinder (11) or the third cylinder (17); the arc-shaped gap of the second cuboid (6) corresponds to the third sphere (13); the rectangular gap of the third cuboid (8) corresponds to the fourth cuboid (15).
10. The initial T cell adhesion molecule interaction teaching aid model according to claim 9, wherein the surfaces of the first cylinder (2), the first cuboid (3), the second sphere (4), the second cylinder (11) and the third cylinder (17) are coated with green dye; blue dyes are coated on the surfaces of the third cuboid (8) and the fourth cuboid (15); the surfaces of the second cylinder (11) and the third sphere (13) are coated with yellow dye.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220408110.1U CN217181700U (en) | 2022-02-25 | 2022-02-25 | Teaching aid model for interaction between initial T cells and adhesion molecules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220408110.1U CN217181700U (en) | 2022-02-25 | 2022-02-25 | Teaching aid model for interaction between initial T cells and adhesion molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN217181700U true CN217181700U (en) | 2022-08-12 |
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| CN202220408110.1U Expired - Fee Related CN217181700U (en) | 2022-02-25 | 2022-02-25 | Teaching aid model for interaction between initial T cells and adhesion molecules |
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| Country | Link |
|---|---|
| CN (1) | CN217181700U (en) |
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- 2022-02-25 CN CN202220408110.1U patent/CN217181700U/en not_active Expired - Fee Related
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