CN217120253U

CN217120253U - Anti-tuberculosis medicine midbody production is with enamel reactor

Info

Publication number: CN217120253U
Application number: CN202220098507.5U
Authority: CN
Inventors: 邓治荣; 宋立波; 彭捷; 张翔; 向世明
Original assignee: Chengdu Better Pharmaceutical Technology Co ltd
Current assignee: Chengdu Better Pharmaceutical Technology Co ltd
Priority date: 2022-01-14
Filing date: 2022-01-14
Publication date: 2022-08-05
Anticipated expiration: 2032-01-14

Abstract

The utility model discloses an enamel reactor for producing an anti-tuberculosis drug intermediate, which comprises a tank body and a tank cover, wherein a stirring pipe is vertically and slidably arranged on the axis of the tank cover, one end of the stirring pipe extends into the tank body and is provided with a cleaning component, the cleaning component comprises a main push rod motor and a plurality of auxiliary push rod motors, the main push rod motor is downwards arranged at the lower side of a partition plate, a telescopic shaft of the main push rod motor extends out of the stirring pipe, the lower end of the stirring pipe is in threaded connection with a first guide sleeve, the telescopic shaft of the main push rod motor is slidably arranged in the first guide sleeve in a penetrating way, the telescopic end of the main push rod motor is provided with a connecting seat, a plurality of push rods are hinged on the side wall of the connecting seat at intervals, a plurality of auxiliary push rod motors are hinged on the side wall of the bottom end of the stirring pipe at intervals, one end of the push rod, which is far away from the connecting seat, is hinged with the outer wall of the auxiliary push rod motor, the telescopic end of the auxiliary push rod motor is provided with a soft brush, manual cleaning is solved, not only the operation is troublesome, but also the enamel layer is easy to be damaged.

Description

Anti-tuberculosis medicine midbody production is with enamel reactor

Technical Field

The utility model relates to a chemical combination reaction equipment field specifically is an enamel reactor is used in production of anti tuberculosis medicine midbody.

Background

PA-824 is declared by Fuxing medicine at home and has the general name Pretomanid. The new drug achieves the effect of inhibiting the tubercle bacillus mainly through a dual action mechanism of inhibiting the synthesis of bacterial protein and the synthesis of cell wall mycolic acid. The antibacterial activity is superior to isoniazid, and the activity to sensitive tubercle bacillus and rifampicin resistant tubercle bacillus is good; has potential curative effect on isolated MDR-TB, and can shorten the treatment period without cross resistance with the prior clinically used antituberculosis drugs.

Mainly use enamel reactor as the container to carry out a series of chemical reactions when preparing PA-824's midbody, and after the chemical combination reaction, need in time clear up attached to the residual debris on the enamel layer, open the lid earlier usually, clear up inside the reation kettle again, in the clearance process, the use of hard, sharp-pointed metal stick is contraindicated, should select the better appurtenance of pliability such as stuff, complete bamboo stick, plastic stick to carry out the debris clearance, there is artifical manual clearance, not only the troublesome poeration, and cause the scheduling problem of damage to the enamel layer easily.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to overcome prior art not enough, provide an anti-tuberculosis medicine midbody production is with enamel reactor, solved the problem of mentioning in the background art.

The purpose of the utility model is realized through the following technical scheme: an enamel reaction kettle for producing an anti-tuberculosis drug intermediate comprises a tank body and a tank cover, wherein a stirring pipe is vertically and slidably arranged on the axis of the tank cover, and one end of the stirring pipe extends into the tank body and is provided with a cleaning assembly;

the cleaning component comprises a main push rod motor and a plurality of auxiliary push rod motors, a baffle plate is arranged in a cavity at one end of the stirring pipe in the tank body, the baffle plate divides the inner cavity of the stirring pipe into an upper part and a lower part, the main push rod motor is downwards arranged in the cavity at the lower side of the baffle plate, the telescopic shaft of the main push rod motor extends out of the stirring pipe, the lower end of the stirring pipe is in threaded connection with a first guide sleeve, the telescopic shaft of the main push rod motor is slidably arranged in the first guide sleeve in a penetrating way, the telescopic end of the main push rod motor is provided with a connecting seat, a plurality of push rods are hinged on the side wall of the connecting seat at intervals, a plurality of auxiliary push rod motors are hinged on the side wall of the bottom end of the stirring pipe at intervals, one end of the push rod, which is far away from the connecting seat, is hinged with the outer wall of the auxiliary push rod motor, and the telescopic end of the auxiliary push rod motor is provided with a soft brush.

Further, the cavity has been seted up to the auxiliary push rod motor telescopic link, be provided with the spring in the cavity of auxiliary push rod motor telescopic link and slide and be provided with slider and slide bar, the one end of slider with the spring butt, the other end of slider with sliding rod connects, the slide bar extends the telescopic link of auxiliary push rod motor with the pappus brush is connected.

Further, the stirring pipe is kept away from the one end of main push rod motor is connected with rotary joint, rotary joint's one end intercommunication has the high pressure inlet tube, still encircle on the lateral wall of stirring pipe and be provided with a plurality of high pressure nozzle, it is a plurality of high pressure nozzle is located the baffle top and with stirring pipe inner chamber intercommunication.

Further, the stirring pipe is located the outer wall of high pressure nozzle top part and has seted up the spout to the slip cover is equipped with driven gear, the hole has been seted up on the driven gear, it is provided with the button head feather key to slide in the spout, be provided with the lug on the button head feather key, the lug with the hole gomphosis, still be provided with gear motor on the pot cover, gear motor's output is provided with the driving gear, the driving gear with driven gear meshes.

Furthermore, a second guide sleeve is arranged on the tank cover, an internal thread is arranged on the second guide sleeve, an external thread is arranged on the outer wall of the stirring pipe, and the stirring pipe is in threaded connection with the second guide sleeve.

Furthermore, a baffle is sleeved on the stirring pipe above the driven gear, the stirring pipe is arranged on the baffle in a sliding mode, and the baffle is fixed with the tank cover through a connecting plate.

Furthermore, a first thrust ball bearing and a second thrust ball bearing are slidably sleeved on the stirring pipe, the first thrust ball bearing is located between the baffle and the driven gear, and the second thrust ball bearing is located between the driven gear and the second guide sleeve.

Further, jar body bottom is provided with the discharge port, be provided with the valve on the discharge port.

The utility model has the advantages that:

1. promote the connecting seat through main push rod motor and reciprocate, and then control a plurality of inclination of assisting the push rod motor and stirring pipe through push-and-pull push rod, it pushes away the pappus brush on reation kettle's inner wall to recombine and stir the pipe and reciprocate, and then respectively to reation kettle's tank bottoms, lateral wall and cover inner wall wash, it all will manually open the manual washing of cover to have solved at every turn to wash, the manpower has been practiced thrift simultaneously, the work efficiency is promoted, also can wash different positions in the enamel reation kettle.

2. In order to avoid assisting when the push rod motor promotes the pappus brush, the dynamics of brush is too big or assist the push rod motor and extend not enough, through opening the cavity in the telescopic link of assisting the push rod motor, and be provided with the spring in the cavity, it is provided with slider and slide bar to slide, slider and spring butt, the one end that the spring was kept away from to the slider is connected with the slide bar, the connection pappus brush can be dismantled to the slide bar other end, and then make the pappus brush all the time with enamel reactor inner wall butt through the spring.

3. Driven gear passes through the smooth key drive of button head and stirs the pipe and rotate, and then drives whole washing subassembly and rotate inside washing enamel reactor, stirs the pipe simultaneously and when rotating, owing to stirring pipe and second guide pin bushing threaded connection, so stir the pipe and pass through gear motor's positive and negative rotation, and make self rotatory removal about the cover, and then drive and wash subassembly rotatory removal from top to bottom, and then wash enamel reactor inside.

4. When the stirring, through control main push rod motor, promote the connecting seat, and then promote or stimulate through the push rod and assist the push rod motor and rotate on stirring the pipe, finally make a plurality of assistance push rod motors perpendicular with stir the pipe, the rethread rotates the pipe and makes a plurality of assistance push rod motors stir inside mixed liquid.

Drawings

FIG. 1 is a schematic structural view of an enamel reactor for the production of an intermediate of an antituberculotic drug of the present invention;

FIG. 2 is an enlarged view of the point A in FIG. 1;

FIG. 3 is an enlarged view of the point B in FIG. 1;

in the figure, 1, a tank body, 2, a tank cover, 3, a stirring pipe, 4, a main push rod motor, 5, an auxiliary push rod motor, 6, a first guide sleeve, 7, a connecting seat, 8, a push rod, 9, a soft brush, 10, a spring, 11, a sliding block, 12, a sliding rod, 13, a rotary joint, 14, a high-pressure water inlet pipe, 15, a high-pressure spray head, 16, a partition plate, 17, a sliding groove, 18, a round head sliding key, 19, a bump, 20, a driven gear, 21, a speed reduction motor, 22, a driving gear, 23, a second guide sleeve, 24, a baffle, 25, a connecting plate, 26, a first thrust ball bearing, 27, a second thrust ball bearing, 28, a discharge port, 29 and a valve.

Detailed Description

The technical solution of the present invention will be described in further detail with reference to the accompanying drawings, but the protection scope of the present invention is not limited to the following description, and the indicated orientation or positional relationship is based on the orientation or positional relationship shown in the drawings, and is only for convenience of description and simplification of description, and does not indicate or imply that the indicated device or element must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.

In the description of the present invention, it should be noted that, unless explicitly stated or limited otherwise, the terms "mounted," "connected" and "disposed" are to be interpreted broadly, and may be, for example, fixedly connected, disposed, detachably connected, disposed, or integrally connected and disposed; the utility model discloses in provide only supply the reference with the model of electrical apparatus. For those skilled in the art, different types of electrical appliances with the same function can be replaced according to actual use conditions, and for those skilled in the art, the specific meaning of the above terms in the present invention can be understood in specific situations.

Referring to fig. 1 to 3, the present invention provides a technical solution: as shown in fig. 1, an enamel reactor for the production of an intermediate of an antituberculosis drug comprises a tank body 1 and a tank cover 2, wherein a stirring pipe 3 is vertically arranged on the axis of the tank cover 2 in a sliding manner, and one end of the stirring pipe 3 extends into the tank body 1 and is provided with a cleaning component;

the cleaning assembly comprises a main push rod motor 4 and a plurality of auxiliary push rod motors 5, a partition plate 16 is arranged in a cavity at one end of the stirring pipe 3, which is positioned in the tank body 1, the partition plate 16 divides the inner cavity of the stirring pipe 3 into an upper part and a lower part, the main push rod motor 4 is downwards arranged in the cavity at the lower side of the partition plate 16, a telescopic shaft of the main push rod motor 4 extends out of the stirring pipe 3, the lower end of the stirring pipe 3 is in threaded connection with a first guide sleeve 6, the telescopic shaft of the main push rod motor 4 is slidably arranged in the first guide sleeve 6, the telescopic end of the main push rod motor 4 is provided with a connecting seat 7, a plurality of push rods 8 are hinged on the side wall of the connecting seat 7 at intervals, a plurality of auxiliary push rod motors 5 are hinged on the side wall at the bottom end of the stirring pipe 3 at intervals, one end of each push rod 8, which is far away from the connecting seat 7, is hinged with the outer wall of each auxiliary push rod motor 5, and a soft brush 9 is arranged at the telescopic end of each auxiliary push rod motor 5; as shown in figure 1, in the concrete implementation, during the stirring, the main push rod motor 4 is controlled to push the connecting seat 7, the auxiliary push rod motor 5 is pushed or pulled to rotate on the stirring pipe 3 through the push rod 8, finally, the auxiliary push rod motors 5 are perpendicular to the stirring pipe 3, the stirring pipe 3 is rotated to enable the auxiliary push rod motors 5 to stir the internal mixed liquid, when the interior of the enamel reaction kettle needs to be cleaned after the reaction is finished, the main push rod motor 4 pushes the connecting seat 7 to move up and down, the push-pull push rod 8 is used for controlling the inclination angles of the auxiliary push rod motors 5 and the stirring pipe 3, the auxiliary push rod motor is combined to push the soft brush 9 to the inner wall of the reaction kettle, and the stirring pipe moves up and down, so as to respectively clean the bottom, the side wall and the inner wall of the tank cover of the reaction kettle, and solve the problem that the manual cleaning of the tank cover 2 needs to be manually opened every time of cleaning, and save manpower, the working efficiency is improved, and different parts in the enamel reaction kettle can be cleaned.

The auxiliary push rod motor 5 is provided with a cavity in an expansion link, a spring 10, a sliding block 11 and a sliding rod 12 are arranged in the cavity of the expansion link of the auxiliary push rod motor 5 in a sliding manner, one end of the sliding block 11 is abutted against the spring 10, the other end of the sliding block 11 is connected with the sliding rod 12, and the sliding rod 12 extends out of the expansion link of the auxiliary push rod motor 5 to be connected with the soft hairbrush 9; as shown in fig. 1 and 2, during the concrete implementation, because enamel reactor is inside mostly irregular, the unevenness, in order to avoid assisting push rod motor 5 when promoting pappus brush 9, the dynamics of brush is too big or assist push rod motor 5 and extend not enough, through opening the cavity in the telescopic link of assisting push rod motor 5, and be provided with spring 10 in the cavity, it is provided with slider 11 and slide bar 12 to slide, slider 11 and spring 10 butt, the one end that spring 10 was kept away from to slider 10 is connected with slide bar 12, connection pappus brush 9 can be dismantled to the slide bar 12 other end, and then make pappus brush 9 all the time with enamel reactor inner wall butt through spring 10.

A rotary joint 13 is connected to one end, far away from the main push rod motor 4, of the stirring pipe 3, one end of the rotary joint 13 is communicated with a high-pressure water inlet pipe 14, a plurality of high-pressure spray heads 15 are further arranged on the side wall of the stirring pipe 3 in a surrounding mode, and the high-pressure spray heads 15 are located above the partition plate 16 and are communicated with the inner cavity of the stirring pipe 3; as shown in fig. 1-3, in the specific implementation, when cleaning the inside of the enamel reactor, the static high-pressure water inlet pipe 14 and the rotating stirring pipe 3 are communicated through the rotary joint 13, because the inside of the stirring pipe 3 is divided into an upper part and a lower part through the partition plate 16, the occupied proportion of the space of the lower part is very small, the bottom of the cavity body of the upper part, namely, the side wall of the top part of the partition plate 16 is surrounded by a plurality of high-pressure spray nozzles 15, the plurality of high-pressure spray nozzles 15 are communicated with the inner cavity of the stirring pipe 3 at the top of the partition plate 16, and then high-pressure water is pumped in and sprayed out through the plurality of high-pressure spray nozzles 15, so as to flush the inside of the enamel reactor, and further flush the substances brushed by the soft brush 9.

The outer wall of the stirring pipe 3 above the high-pressure spray head 15 is provided with a sliding groove 17, the stirring pipe is slidably sleeved with a driven gear 20, the driven gear 20 is provided with a hole, a round-head sliding key 18 is slidably arranged in the sliding groove 17, a convex block 19 is arranged on the round-head sliding key 18, the convex block 19 is embedded with the hole, the tank cover 2 is also provided with a speed reducing motor 21, the output end of the speed reducing motor 21 is provided with a driving gear 22, the driving gear 22 is meshed with the driven gear 20, the tank cover 2 is provided with a second guide sleeve 23, the second guide sleeve 23 is provided with an internal thread, the outer wall of the stirring pipe 3 is provided with an external thread, the stirring pipe 3 is in threaded connection with the second guide sleeve 23, the stirring pipe 3 above the driven gear 20 is sleeved with a baffle plate 24, the stirring pipe 3 is slidably arranged on the baffle plate 24, the baffle plate 24 is fixed with the tank cover 2 through a connecting plate 25, and the stirring pipe 3 is slidably sleeved with a first thrust ball bearing 26 and a second thrust ball bearing 27, the first thrust ball bearing 26 is positioned between the baffle plate 24 and the driven gear 20, and the second thrust ball bearing 27 is positioned between the driven gear 20 and the second guide sleeve 23; as shown in fig. 1 and 3, in practical application, the reduction motor 21 drives the driven gear 20 to rotate through the driving gear 22, the driven gear 20 is slidably sleeved on the stirring pipe 3, the driven gear drives the stirring pipe 3 to rotate through the round-head sliding key 18, and further drives the whole cleaning assembly to rotate to clean the interior of the enamel reactor, meanwhile, when the stirring pipe 3 rotates, because the stirring pipe 3 is in threaded connection with the second guide sleeve 23, the stirring pipe 3 rotates forward and backward through the reduction motor 21, so that the stirring pipe itself rotates up and down on the tank cover 2, and further drives the cleaning assembly to rotate up and down, and further cleans the interior of the enamel reactor, when the stirring pipe 3 moves up and down and rotates, the driven gear 20 does not move relative to the tank cover 2, the driven gear 20 is disposed between the baffle plate 24 and the second guide sleeve 23, and is in rotational abutment with the baffle plate 24 and the second guide sleeve 23 through the first thrust ball bearing 26 and the second thrust ball bearing 27 respectively, the driven gear is prevented from directly abutting and rubbing against the baffle plate 24 and the second guide sleeve 23.

A discharge port 28 is arranged at the bottom of the tank body 1, and a valve 29 is arranged on the discharge port 28; when the reaction is completed or the cleaning is completed, the compound in the tank body or the cleaned impurities are discharged by opening the valve 29 on the discharge port 28.

The foregoing is illustrative of the preferred embodiments of the present invention, and it is to be understood that the invention is not limited to the precise forms disclosed herein, and that various other combinations, modifications, and environments may be resorted to, falling within the scope of the invention as defined by the appended claims. But that modifications and variations may be effected by those skilled in the art without departing from the spirit and scope of the invention, which is to be limited only by the claims appended hereto.

Claims

1. The enamel reaction kettle for the production of the intermediate of the antituberculosis drug is characterized by comprising a tank body (1) and a tank cover (2), wherein a stirring pipe (3) is vertically arranged on the axis of the tank cover (2) in a sliding manner, and one end of the stirring pipe (3) extends into the tank body (1) and is provided with a cleaning assembly;

the cleaning assembly comprises a main push rod motor (4) and a plurality of auxiliary push rod motors (5), a partition plate (16) is arranged in a cavity at one end, located in the tank body (1), of the stirring pipe (3), the partition plate (16) divides the inner cavity of the stirring pipe (3) into an upper part and a lower part, the main push rod motor (4) is downwards arranged in the cavity at the lower side of the partition plate (16), a telescopic shaft of the main push rod motor (4) extends out of the stirring pipe (3), a first guide sleeve (6) is in threaded connection with the lower end of the stirring pipe (3), the telescopic shaft of the main push rod motor (4) is slidably arranged in the first guide sleeve (6), a connecting seat (7) is arranged at the telescopic end of the main push rod motor (4), a plurality of push rods (8) are hinged on the side wall of the connecting seat (7) at intervals, a plurality of auxiliary push rod motors (5) are hinged on the side wall at the bottom end of the stirring pipe (3) at intervals, one end of the push rod (8) far away from the connecting seat (7) is hinged with the outer wall of the auxiliary push rod motor (5), and a soft brush (9) is arranged at the telescopic end of the auxiliary push rod motor (5).

2. The enamel reactor for the intermediate production of antituberculous drugs according to claim 1, wherein the telescopic rod of the auxiliary push rod motor (5) is provided with a cavity, a spring (10) and a sliding block (11) and a sliding rod (12) are slidably arranged in the cavity of the telescopic rod of the auxiliary push rod motor (5), one end of the sliding block (11) is abutted against the spring (10), the other end of the sliding block (11) is connected with the sliding rod (12), and the sliding rod (12) extends out of the telescopic rod of the auxiliary push rod motor (5) to be connected with the soft brush (9).

3. The enamel reactor for the production of the intermediate of the antituberculous drugs according to claim 2, wherein a rotary joint (13) is connected to one end of the stirring pipe (3) far away from the main push rod motor (4), one end of the rotary joint (13) is communicated with a high-pressure water inlet pipe (14), a plurality of high-pressure nozzles (15) are arranged on the side wall of the stirring pipe (3) in a surrounding manner, and the plurality of high-pressure nozzles (15) are positioned above the partition plate (16) and are communicated with the inner cavity of the stirring pipe (3).

4. The enamel reactor for producing intermediate of antituberculous drugs according to claim 3, wherein the stirring tube (3) is provided with a sliding groove (17) on the outer wall of the upper part of the high pressure nozzle (15), and is slidably sleeved with a driven gear (20), the driven gear (20) is provided with a hole, a round-head sliding key (18) is slidably arranged in the sliding groove (17), a convex block (19) is arranged on the round-head sliding key (18), the convex block (19) is embedded with the hole, the tank cover (2) is further provided with a speed reduction motor (21), the output end of the speed reduction motor (21) is provided with a driving gear (22), and the driving gear (22) is engaged with the driven gear (20).

5. The enamel reactor for the intermediate production of antituberculous drugs according to claim 4, wherein the second guide sleeve (23) is arranged on the pot cover (2), the second guide sleeve (23) is internally threaded, the outer wall of the stirring pipe (3) is externally threaded, and the stirring pipe (3) is in threaded connection with the second guide sleeve (23).

6. The enamel reactor for producing intermediate of antituberculous drugs as claimed in claim 5, wherein a baffle (24) is sleeved on the stirring pipe (3) above the driven gear (20), the stirring pipe (3) is slidably arranged on the baffle (24), and the baffle (24) is fixed with the tank cover (2) through a connecting plate (25).

7. The enamel reactor for the production of the intermediate of the antituberculous drugs according to claim 6, wherein the stirring tube (3) is slidably sleeved with a first thrust ball bearing (26) and a second thrust ball bearing (27), the first thrust ball bearing (26) is located between the baffle plate (24) and the driven gear (20), and the second thrust ball bearing (27) is located between the driven gear (20) and the second guide sleeve (23).

8. The enamel reactor for the production of the intermediate of antituberculous drugs as claimed in claim 7, wherein the bottom of the tank body (1) is provided with a discharge port (28), and the discharge port (28) is provided with a valve (29).