CN217111734U - Blending device and sample analyzer - Google Patents

Abstract

The utility model relates to a mixing device and a sample analyzer, wherein the mixing device comprises a pot body; the rotating disc can rotate around the central axis of the rotating disc relative to the pot body and is used for containing a reagent, a sample hole matched with the sample tube is further formed in the rotating disc, and the central axis of the sample hole and the central axis of the rotating disc are arranged at intervals; the meshing piece is rotationally matched with the sample hole and can be used for fixing the sample tube, and comprises a driving gear provided with first meshing teeth; the blending mechanism is arranged on the pot body and meshed with the first meshing teeth; when the rotating disc rotates relative to the pot body, the blending mechanism drives the meshing part to rotate, and the meshing part drives the sample tube to rotate around the central axis of the sample hole. When the rotating disc rotates, the sample tube revolves around the central axis of the rotating disc and rotates around the central axis of the sample hole. Under the combined action of revolution and rotation, the uniform mixing effect of the sample in the sample tube can be effectively improved, and the structure is simplified.

Description

Blending device and sample analyzer

Technical Field

The utility model relates to an external diagnosis field especially relates to a mixing device and contain sample analysis appearance of this mixing device.

Background

The sample analyzer mainly uses samples such as serum and plasma, and due to the long separation time of serum and plasma, the demand for the sample analyzer to directly support the whole blood sample is increasing. However, the whole blood sample may cause sedimentation of blood cells after standing for a long time, which may affect the result of the subsequent test. For a traditional sample analyzer, the defect of poor mixing effect of a whole blood sample is usually existed.

SUMMERY OF THE UTILITY MODEL

The utility model provides a technical problem how to improve the mixing effect on simple structure's basis.

A blending apparatus, comprising:

a pan body;

the rotating disc can rotate around the central axis of the rotating disc relative to the pot body and is used for containing a reagent, a sample hole matched with the sample tube is further formed in the rotating disc, and the central axis of the sample hole and the central axis of the rotating disc are arranged at intervals;

a meshing member rotatably engaged with the sample hole and capable of being used to fix the sample tube, the meshing member including a drive gear provided with first meshing teeth; and

the blending mechanism is arranged on the pot body and meshed with the first meshing teeth;

when the rotating disc rotates relative to the pot body, the blending mechanism drives the meshing part to rotate, and the meshing part drives the sample tube to rotate around the central axis of the sample hole.

In one embodiment, the sample hole comprises a first matching hole, the blending mechanism comprises a first gear arranged around the central axis of the rotating disc, and the first gear is meshed with the first meshing teeth corresponding to the first matching hole.

In one embodiment, the sample hole further comprises a second matching hole, the second matching hole is closer to the central line axis of the rotating disc relative to the first matching hole, the blending mechanism further comprises a second gear surrounding the central axis of the rotating disc, and the second gear is meshed with the first meshing teeth corresponding to the second matching hole.

In one embodiment, the number of the first fitting holes is greater than or equal to the number of the second fitting holes.

In one embodiment, the first gear is an internal gear and the second gear is an external gear.

In one embodiment, the reagent box further comprises a reagent box and a third gear, the third gear is arranged around the central axis of the rotating disc, the reagent box comprises a box body and a meshing bottle, a reagent hole is formed in the box body, the central axis of the reagent hole and the central axis of the rotating disc are arranged at intervals, the meshing bottle is matched with the reagent hole in a rotating mode and can contain reagents or sample tubes, and the meshing bottle comprises second meshing teeth meshed with the third gear.

In one embodiment, the third gear is arranged around the blending mechanism.

In one embodiment, the engaging member further includes a fixing sleeve, the fixing sleeve is fixedly connected to the driving gear, and the fixing sleeve is provided with a socket for fixing the sample tube.

In one embodiment, at least one of the following schemes is further included:

the pot body is provided with an open cavity, and the rotating disc is at least partially accommodated in the open cavity;

still include actuating mechanism, actuating mechanism includes pivot, action wheel, follows driving wheel and drive belt, the pivot is connected the rolling disc with from between the driving wheel, the drive belt cover is established the action wheel with follow the driving wheel on.

A sample analyser comprising a mixing device as defined in any one of the preceding claims.

The utility model discloses a technical effect of an embodiment is: the central axis of the sample hole and the central axis of the rotating disc are arranged at intervals, and the engaging piece drives the sample tube to rotate around the central axis of the sample hole. When the rotating disc rotates, the sample tube revolves around the central axis of the rotating disc and rotates around the central axis of the sample hole. Under revolution and rotation combined action, can effectively improve the mixing effect of sample in the sample pipe, the device structure need not newly-increased extra drive structure simultaneously for it is structurally simpler. In view of the sample pipe produces the rotation around the central axis of sample hole, sample pipe promptly produces the rotation around self central axis, so both can avoid the risk that sample pipe throws away from the sample hole, also can avoid the risk that the sample throws away from the sample pipe under the centrifugal force effect.

Drawings

Fig. 1 is a schematic perspective view of a blending device according to an embodiment;

FIG. 2 is a schematic perspective view of the blending apparatus shown in FIG. 1 from another viewing angle;

FIG. 3 is a schematic view of a partial perspective structure of the blending apparatus shown in FIG. 1;

FIG. 4 is a schematic perspective cross-sectional view of FIG. 3;

fig. 5 is a schematic perspective sectional view of fig. 3 from another view angle.

Detailed Description

In order to facilitate understanding of the present invention, the present invention will be described more fully hereinafter with reference to the accompanying drawings. The preferred embodiments of the present invention are shown in the drawings. The invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.

It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "inner", "outer", "left", "right" and the like as used herein are for illustrative purposes only and do not represent the only embodiments.

Referring to fig. 1, fig. 2 and fig. 3, a blending device 10 according to an embodiment of the present invention can be used for holding samples and reagents simultaneously, and the blending device 10 includes a pot body 100, a driving mechanism 200, a rotating disc 300, a meshing member 400, and a blending mechanism 500.

In some embodiments, the pan body 100 defines an open cavity 110, and the rotating disc 300 is at least partially received in the open cavity 110, for example, the rotating disc 300 can be completely received in the open cavity 110. The driving mechanism 200 includes a motor 210, a driving wheel 220, a driven wheel 230, a transmission belt 240, a rotating shaft 250 and a bracket 260, the bracket 260 is located outside the open cavity 110, and the motor 210, the driving wheel 220 and the driven wheel 230 are all arranged on the bracket 260. The driving wheel 220 is connected with an output shaft of the motor 210, the driving wheel 220 and the driven wheel 230 are arranged on the bracket 260 at intervals, the diameter of the driven wheel 230 can be larger than that of the driving wheel 220, and the transmission belt 240 is sleeved on the driving wheel 220 and the driven wheel 230. The lower end of the rotating shaft 250 is connected with the driven wheel 230, and the rotating shaft 250 is inserted into the pot body 100 and the upper end thereof is connected with the rotating disc 300. The central axis of the rotary shaft 250 and the central axis of the rotary disk 300 coincide with each other, i.e., the rotary disk 300 is coaxially disposed with the rotary shaft 250. When the motor 210 is started, the rotating disc 300 can be driven by the rotating shaft 250 to rotate, that is, the rotating disc 300 rotates around its central axis.

In some embodiments, the cross-section of the rotating disk 300 may be circular, regular polygonal, or elliptical, among others. The rotating disc 300 is provided with a sample hole 310, the sample hole 310 is used for being matched with a sample tube 20, the sample tube 20 is used for containing a sample, and the central axis of the sample hole 310 and the central axis of the rotating disc 300 both extend in the vertical direction and are parallel to each other, so that the sample hole 310 and the rotating disc 300 are spaced at a certain distance in the horizontal direction. The sample tube 20 can be inserted into the sample hole 310, ensuring that the rotating disc 300 bears the sample tube 20, and the sample tube 20 will follow the rotating disc 300 to revolve around the central axis of the rotating disc 300. The sample hole 310 includes a first fitting hole 311 and a second fitting hole 312, the second fitting hole 312 is closer to the centerline axis of the rotary disk 300 than the first fitting hole 311, the number of the first fitting holes 311 is greater than or equal to the number of the second fitting holes 312, for example, the number of the first fitting holes 311 may be twice the number of the second fitting holes 312.

Referring to fig. 3, 4 and 5, in some embodiments, the engagement member 400 is rotatably engaged with the sample hole 310, i.e., the engagement member 400 is engaged with both the first engagement hole 311 and the second engagement hole 312. When the sample tube 20 is inserted in the sample well 310, the sample tube 20 will be connected with the engagement member 400 and the central axis of the sample tube 20 coincides with the central axis of the sample well 310. The engaging member 400 includes a fixing sleeve 410 and a driving gear 420, the fixing sleeve 410 and the driving gear 420 can be fixedly connected to each other, the fixing sleeve 410 is provided with a socket 411, and when the sample tube 20 is received in the sample hole 310, the lower end of the sample tube 20 is inserted into the socket 411. The driving gear 420 is provided with a first meshing tooth 421, and obviously, the first meshing tooth 421 is an external gear tooth. The first engagement tooth 421 may be located outside the sample hole 310. In the case that the driving gear 420 and the fixing sleeve 410 rotate in the sample hole 310, the fixing sleeve 410 will drive the sample tube 20 to rotate in the sample hole 310 in view of the sample tube 20 being inserted into the insertion hole 411 of the fixing sleeve 410, and at this time, the sample tube 20 will rotate around its central axis.

In some embodiments, the blending mechanism 500 includes a first gear 510 and a second gear 520, it being apparent that the first gear 510 is an internal gear and the second gear 520 is an external gear. The first gear 510 and the second gear 520 are both circular and both are disposed around the central axis of the rotary disk 300, and the first gear 510 is disposed around the second gear 520, i.e., the first gear 510 is further away from the central axis of the rotary disk 300 relative to the second gear 520, so that the first gear 510 corresponds to the first mating hole 311, and the second gear 520 corresponds to the second mating hole 312. Both the first gear 510 and the second gear 520 can be fixed on the pot body 100 and received in the open cavity 110, so that the first gear 510 and the first meshing tooth 421 of the driving gear 420 corresponding to the first matching hole 311 are meshed with each other due to the rotating matching of the first matching hole 311 with the meshing piece 400. Similarly, the second gear 520 is engaged with the first engaging tooth 421 of the driving gear 420 corresponding to the second fitting hole 312 in view of the engagement member 400 rotatably fitted in the second fitting hole 312. In other embodiments, the first gear 510 may be replaced with an external gear and the second gear 520 may be replaced with an internal gear.

When the rotating disk 300 is rotated by the rotation shaft 250 when the sample tube 20 is accommodated in the sample hole 310, the sample tube 20 rotates along with the rotating disk 300, and the sample tube 20 revolves around the central axis of the rotating disk 300. On the other hand, for the sample tube 20 in the first matching hole 311, the first gear 510 is meshed with the first meshing tooth 421 on the meshing member 400 matched with the first matching hole 311, so that the first gear 510 drives the meshing member 400 to rotate relative to the first matching hole 311, and thus drives the sample tube 20 accommodated in the first matching hole 311 to rotate, that is, the sample tube 20 rotates around its central axis. Similarly, for the sample tube 20 in the second matching hole 312, the second gear 520 is engaged with the first engaging tooth 421 on the engaging member 400 matched with the second matching hole 312, so that the second gear 520 drives the engaging member 400 to rotate relative to the second matching hole 312, and thus the sample tube 20 accommodated in the second matching hole 312 is driven to rotate, i.e. the sample tube 20 rotates around its central axis. The first gear 510 may be an internal gear and the second gear 520 may be an external gear.

Therefore, for the sample tube 20 of the sample hole 310, when the rotary disk 300 rotates, the sample tube 20 will rotate and revolve at the same time. For example, when the rotary disk 300 rotates clockwise, the sample tube 20 will revolve clockwise, and at the same time, the sample tube 20 will rotate counterclockwise; when the rotary disk 300 rotates counterclockwise, the sample tube 20 will revolve counterclockwise, and the sample tube 20 will rotate clockwise. Under the combined action of revolution and rotation, the sample in the sample tube 20 is disturbed to form uniform mixing, and particularly for a whole blood sample, the uniform mixing mode can effectively prevent blood cells from generating precipitation. The rotating shaft 250 can drive the rotating disc 300 to rotate clockwise or counterclockwise all the time; the rotary disk 300 may also be driven to rotate clockwise for a certain period of time and counterclockwise for the next time, in short, the rotary disk 300 produces periodic alternating clockwise and counterclockwise rotations.

Whereas the first mating hole 311 is farther from the central axis of the rotary disk 300 than the second mating hole 312, the greater the arc length that the sample tube 20 in the first mating hole 311 experiences with respect to the sample tube 20 in the second mating hole 312 for the same angle of rotation of the rotary disk 300, the greater the number of revolutions of the sample tube 20 in the first mating hole 311 with respect to the sample tube 20 in the second mating hole 312. Therefore, when the rotating disc 300 rotates once, the sample in the sample tube 20 in the first fitting hole 311 has a relatively strong mixing effect with respect to the sample in the sample tube 20 in the second fitting hole 312. Therefore, the selective matching between the sample tube 20 and the first matching hole 311 and the second matching hole 312 can be adjusted according to the actually required blending effect of various samples.

In some embodiments, the mixing apparatus 10 further comprises a reagent kit 600 and a third gear 700, wherein the reagent kit 600 can contain both the homogeneous reagent in the form of a solution and the solid-phase reagent in the form of a suspension, and in fact, the solid-phase reagent has magnetic particles suspended therein. The third gear 700 is disposed around the central axis of the rotary disk 300 and the third gear 700 is disposed around the kneading mechanism 500, and it is apparent that the third gear 700 is more distant from the central axis of the rotary disk 300 than both the first gear 510 and the second gear 520. The reagent kit 600 comprises a kit body 610 and an engagement bottle 620, wherein a reagent hole 611 is formed in the kit body 610, the central axis of the reagent hole 611 coincides with the central axis of the engagement bottle 620, the central axis of the reagent hole 611 and the central axis of the rotary disk 300 are arranged at intervals, the reagent hole 611 can be far away from the central axis of the rotary disk 300 relative to the sample hole 310, the engagement bottle 620 is in rotating fit with the reagent hole 611 and can contain a reagent or contain a sample tube 20, and the reagent contained in the engagement bottle 620 can be a solid-phase reagent. The engaging bottle 620 includes a second engaging tooth 621, the second engaging tooth 621 is an external gear, and the second engaging tooth 621 is engaged with the third gear 700. The third gear 700 may be an internal gear. In other embodiments, the third gear 700 may be replaced with an outer gear.

For the engaging bottle 620 in the reagent hole 611, when the rotating shaft 250 drives the rotating disk 300 to rotate, on one hand, the engaging bottle 620 will follow the rotating disk 300 to rotate, so that the engaging bottle 620 revolves around the central axis of the rotating disk 300. On the other hand, the second engaging tooth 621 and the third gear 700 are engaged with each other, so that the engaged bottle 620 is rotated about its central axis. Therefore, the rotation of the rotary disk 300 may bring the engaged bottle 620 to rotate and revolve at the same time. Under the combined action of revolution and rotation, when the solid phase reagent with suspended magnetic particles is contained in the engagement bottle 620, the solid phase reagent is disturbed and uniformly mixed, so that the magnetic particles are uniformly suspended in the solid phase reagent, and the magnetic particles are prevented from being precipitated. When the engagement bottle 620 does not contain the solid-phase reagent, the idle engagement bottle 620 can be fully utilized, so that the sample tube 20 containing the sample is inserted into the engagement bottle 620, the sample tube 20 rotates and revolves along with the engagement bottle 620, and the samples in the sample tube 20 are effectively ensured to be uniformly mixed. Therefore, by inserting the sample tubes 20 into the engagement bottles 620, the number of sample tubes 20 that can be carried on the entire rotating disk 300 can be increased reasonably, so that the entire mixing device 10 can mix more samples.

If the sample tube 20 is adopted to generate a back-and-forth shaking and mixing mode in a certain gap, when the shaking amplitude is small, an ideal mixing effect cannot be achieved; when the shaking amplitude is large, the sample tube 20 is thrown out of the shaking position. If the sample tube 20 adopts an eccentric oscillation mode for blending, when the shaking eccentricity is small, an ideal blending effect cannot be achieved; when the shaking eccentricity is large, the sample in the sample tube 20 will be thrown out by the centrifugal force.

For the blending device 10 in the above embodiment, the rotating disc 300 drives the sample tube 20 to simultaneously perform revolution and rotation for blending, and in the blending process, the sample tube 20 rotates around the central axis of the sample tube 20, so that on one hand, a large gap between the sample tube 20 and the rotating disc 300 can be eliminated, and the hidden trouble that the sample tube 20 is thrown out due to the large gap can be prevented. On the other hand, the rotation of the sample tube 20 can eliminate the centrifugal force, and the sample is prevented from being thrown out of the sample tube 20 on the basis of ensuring higher uniform mixing effect.

Above-mentioned mixing device 10 can make rolling disc 300 be used for holding and carrying sample and reagent simultaneously, also makes sample and reagent carry out the mixing simultaneously, makes rolling disc 300 unite two into one with the mixing function to the delivery of sample, reagent then, and need not to increase other drivers except actuating mechanism 200, so can play the effect of simplifying mixing device 10 structure.

The utility model also provides a sample analyzer, this sample analyzer include above-mentioned mixing device 10, through setting up this mixing device 10 for whole sample analyzer can improve the mixing effect to the sample on the basis of simplifying the structure.

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above-mentioned embodiments only represent some embodiments of the present invention, and the description thereof is specific and detailed, but not to be construed as limiting the scope of the present invention. It should be noted that, for those skilled in the art, without departing from the spirit of the present invention, several variations and modifications can be made, which are within the scope of the present invention. Therefore, the protection scope of the present invention should be subject to the appended claims.

Claims (10)

1. A blending device, which is characterized by comprising:

a pan body;

the rotating disc can rotate around the central axis of the rotating disc relative to the pot body and is used for containing a reagent, a sample hole matched with the sample tube is further formed in the rotating disc, and the central axis of the sample hole and the central axis of the rotating disc are arranged at intervals;

a meshing member rotatably engaged with the sample hole and capable of being used to fix the sample tube, the meshing member including a drive gear provided with first meshing teeth; and

the blending mechanism is arranged on the pot body and meshed with the first meshing teeth;

when the rotating disc rotates relative to the pot body, the blending mechanism drives the meshing part to rotate, and the meshing part drives the sample tube to rotate around the central axis of the sample hole.

2. The blending device of claim 1, wherein the sample aperture comprises a first mating aperture, and the blending mechanism comprises a first gear disposed around a central axis of the rotatable disk, the first gear intermeshed with the first meshing tooth corresponding to the first mating aperture.

3. The blending device of claim 2, wherein the sample aperture further comprises a second mating aperture that is closer to the centerline axis of the rotatable disk than the first mating aperture, the blending mechanism further comprises a second gear disposed around the centerline axis of the rotatable disk, the second gear intermeshes with the first meshing teeth corresponding to the second mating aperture.

4. The blending device of claim 3, wherein the number of the first mating holes is greater than the number of the second mating holes; or,

the number of the first matching holes is less than that of the second matching holes; or,

the number of the first fitting holes is equal to the number of the second fitting holes.

5. The blending device of claim 3, wherein the first gear is an internal gear and the second gear is an external gear.

6. The blending device according to claim 1, further comprising a reagent box and a third gear, wherein the third gear is arranged around the central axis of the rotating disc, the reagent box comprises a box body and a meshing bottle, the box body is provided with a reagent hole, the central axis of the reagent hole and the central axis of the rotating disc are arranged at intervals, the meshing bottle is rotatably matched with the reagent hole and can contain a reagent or a sample containing tube, and the meshing bottle comprises a second meshing tooth meshed with the third gear.

7. The blending apparatus of claim 6, wherein the third gear is disposed around the blending mechanism.

8. The blending device according to claim 1, wherein the engaging member further comprises a fixing sleeve, the fixing sleeve is fixedly connected with the driving gear, and the fixing sleeve is provided with a jack for fixing the sample tube.

9. The blending device of claim 1, further comprising at least one of the following:

the pot body is provided with an open cavity, and the rotating disc is at least partially accommodated in the open cavity;

still include actuating mechanism, actuating mechanism includes pivot, action wheel, follows driving wheel and drive belt, the pivot is connected the rolling disc with from between the driving wheel, the drive belt cover is established the action wheel with follow the driving wheel on.

10. A sample analyzer comprising the mixing apparatus of any one of claims 1 to 9.

Images