CN217009119U - Electrospray ion source capable of automatically adjusting spray position and mass spectrometer - Google Patents
Electrospray ion source capable of automatically adjusting spray position and mass spectrometer Download PDFInfo
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- CN217009119U CN217009119U CN202220204564.7U CN202220204564U CN217009119U CN 217009119 U CN217009119 U CN 217009119U CN 202220204564 U CN202220204564 U CN 202220204564U CN 217009119 U CN217009119 U CN 217009119U
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- 239000007921 spray Substances 0.000 title claims abstract description 44
- 238000005507 spraying Methods 0.000 claims abstract description 30
- 230000001105 regulatory effect Effects 0.000 claims 1
- 150000002500 ions Chemical class 0.000 description 27
- 238000005070 sampling Methods 0.000 description 7
- 230000035945 sensitivity Effects 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 238000004451 qualitative analysis Methods 0.000 description 2
- 238000004445 quantitative analysis Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000012491 analyte Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000000132 electrospray ionisation Methods 0.000 description 1
- 238000010884 ion-beam technique Methods 0.000 description 1
- 238000000752 ionisation method Methods 0.000 description 1
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
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Abstract
The utility model discloses an electrospray ion source capable of automatically adjusting a spraying position, which belongs to the field of mass spectrometers and comprises a shell and a spraying needle, wherein the shell is provided with a cavity, the spraying needle is arranged on the shell and extends into the cavity, the electrospray ion source capable of automatically adjusting the spraying position also comprises a first moving structure, a second moving structure and a lifting structure, the first moving structure is arranged on the shell and provides movement in a first direction for the spraying needle, the second moving structure is arranged on the first moving structure and provides movement in a second direction perpendicular to the first direction for the spraying needle, the lifting structure is arranged on the second moving structure and provides movement in a third direction perpendicular to the first direction and the second direction for the spraying needle, the spraying needle is arranged on the lifting structure, and the spraying needle passes through the first moving structure, the second moving structure and the lifting structure realize automatic position adjustment. The utility model also relates to a mass spectrometer comprising the electrospray ion source capable of automatically adjusting the spray position.
Description
Technical Field
The utility model relates to the technical field of mass spectrometers, in particular to an electrospray ion source capable of automatically adjusting a spraying position.
Background
Mass spectrometry is an essential analytical tool in chemistry, biochemistry, pharmacy, medicine and many related scientific fields. As a high-end tool for quantitative and qualitative analysis of substances, a mass spectrometer is an analysis instrument that ionizes substance particles (atoms, molecules) into ions, separates them by electric field and magnetic field with appropriate stability or change according to space position, time sequence and other modes to realize charge-to-mass ratio, and detects their intensities for qualitative and quantitative analysis.
The mass spectrometer consists of the following systems: sample introduction device, ion source, vacuum system, mass analyzer, detector and data acquisition system.
The ion source provides energy to ionize a sample to be analyzed to form an ion beam consisting of ions with different mass-to-charge ratios (m/z), and the ions are led out, accelerated and focused; electrospray ionization is the most widely applied soft ionization technology in the current atmospheric pressure ionization method, is the first choice method of liquid chromatography-mass spectrometry, and is widely applied to analysis of nonpolar and thermally unstable compounds, such as proteins, nucleic acid polymers and the like. The reasonable design of the electrospray ion source has important and even decisive influence on the sensitivity, the signal-to-noise ratio and the like of the electrospray mass spectrometer.
The sampling efficiency of the electrospray ion source is formed by the ionization efficiency and the transmission efficiency of the electrospray ion source, and the improvement of the mass spectrum sensitivity of the electrospray ion source is directly restricted. Spray needle voltage, solution flow rate, assist gas, temperature, position of the spray needle within the source, analyte physicochemical properties, and interface design all contribute to the sampling efficiency of the ESI source. Wherein, the spray needle voltage, the solution flow rate, the auxiliary gas and the like can influence the spray plume form, the spray plume shape formed under different voltages, and the sampling port can obtain better sensitivity and signal-to-noise ratio from the edge sampling of the plume.
The position of the sampling port is generally relatively fixed, and the relative adjustment of the sampling port and the position of the spray needle can be realized by adjusting the position of the spray needle. Common electrospray ion source in the existing market often adopts the form of differential head to carry out manual fine adjustment to the position of the spray needle relative to the ion source, and the relative regulation of the spray needle and the position of the sampling port can be realized by the regulation mode, but the manual regulation can consume a large amount of time of experimenters, the efficiency is lower, and to the operating personnel with abundant experiences, it is difficult to find a relatively optimal spray needle position.
SUMMERY OF THE UTILITY MODEL
In order to overcome the defects of the prior art, the utility model provides an electrospray ion source capable of automatically adjusting the position of spray.
In order to overcome the defects of the prior art, the utility model also aims to provide a mass spectrometer of an electrospray ion source, which can automatically adjust the spray position.
One of the purposes of the utility model is realized by adopting the following technical scheme:
an electrospray ion source capable of automatically adjusting a spraying position comprises a shell and a spraying needle, wherein the shell is provided with a cavity, the spraying needle is installed on the shell and extends into the cavity, the electrospray ion source capable of automatically adjusting the spraying position further comprises a first moving structure, a second moving structure and a lifting structure, the first moving structure is installed on the shell and provides movement in a first direction for the spraying needle, the second moving structure is installed on the first moving structure and provides movement in a second direction perpendicular to the first direction for the spraying needle, the lifting structure is installed on the second moving structure and provides movement in a third direction perpendicular to the first direction and the second direction for the spraying needle, the spraying needle is installed on the lifting structure, and the spraying needle passes through the first moving structure, The second moving structure and the lifting structure realize automatic position adjustment.
Furthermore, the first moving structure comprises a first driving part and a first moving platform, the first driving part is fixed on the casing, the first moving platform is slidably mounted on the casing and connected with the output end of the first driving part, and the first driving part drives the first moving platform to move relative to the casing.
Furthermore, the first moving structure further comprises a first sliding rail, the first sliding rail is fixed on the shell, and the first moving platform is slidably mounted on the first sliding rail.
Furthermore, the number of the first slide rails is two, and the two first slide rails are arranged in parallel.
Furthermore, the second moving structure comprises a second driving piece and a second moving platform, the second driving piece is fixed on the first moving platform, the second moving platform is movably installed on the first moving platform, and the output end of the second driving piece is connected with the second moving platform.
Furthermore, the second moving structure further comprises a second sliding rail, the second sliding rail is fixed on the first moving platform, and the second moving platform is slidably mounted on the second sliding rail.
Furthermore, the number of the second slide rails is two, and the two second slide rails are arranged in parallel.
Furthermore, the lifting structure comprises a fixed sleeve, a movable sleeve and a lifting driving piece, wherein the fixed sleeve is fixed on the second movable platform, the movable sleeve is slidably mounted on the fixed sleeve, and the lifting driving piece is fixed on the fixed sleeve and connected with the output end of the lifting driving piece and the movable sleeve.
Further, the fixed sleeve and the movable sleeve are positioned on the same straight line and perpendicular to the second movable platform.
The second purpose of the utility model is realized by adopting the following technical scheme:
a mass spectrometer comprising an electrospray ion source as claimed in any preceding claim capable of automatically adjusting the position of the spray.
Compared with the prior art, the electrospray ion source capable of automatically adjusting the spraying position further comprises a first moving structure, a second moving structure and a lifting structure, wherein the first moving structure is mounted on the shell and provides movement in a first direction for the spraying needle, the second moving structure is mounted on the first moving structure and provides movement in a second direction perpendicular to the first direction for the spraying needle, the lifting structure is mounted on the second moving structure and provides movement in a third direction perpendicular to the first direction and the second direction for the spraying needle, the spraying needle is mounted on the lifting structure, and the spraying needle realizes automatic adjustment of the position through the first moving structure, the second moving structure and the lifting structure.
Drawings
Fig. 1 is a perspective view of an electrospray ion source of the present application capable of automatically adjusting spray position;
FIG. 2 is a perspective view of a portion of the electrospray ion source of FIG. 1 capable of automatically adjusting spray position;
fig. 3 is a perspective cross-sectional view of the electrospray ion source of fig. 1 capable of automatically adjusting the spray position.
In the figure: 10. a housing; 11. a cavity; 20. a first moving structure; 21. a first slide rail; 22. a first driving member; 23. a first mobile platform; 30. a second moving structure; 31. a second slide rail; 32. a second driving member; 33. a second mobile platform; 40. a lifting structure; 41. fixing the sleeve; 42. a lifting drive member; 43. moving the sleeve; 50. and (4) a spray needle.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present, secured by intervening elements. When a component is referred to as being "connected" to another component, it can be directly connected to the other component or intervening components may also be present. When an element is referred to as being "disposed on" another element, it can be directly disposed on the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and the like are used herein for purposes of illustration only.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the utility model herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the utility model. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
Fig. 1 to 3 show an electrospray ion source capable of automatically adjusting a spray position according to the present invention, which includes a housing 10, a first moving structure 20, a second moving structure 30, a lifting structure 40, and a spray needle 50.
The housing 10 is a hollow structure, and a cavity 11 is formed inside the housing 10.
The first moving structure 20 includes a first slide rail 21, a first driving member 22, and a first moving platform 23.
The first slide rail 21 is fixed to the outer surface of the housing 10. The number of the first slide rails 21 is two, and the two first slide rails 21 are parallel to each other. The first driver 22 is fixed to the outer surface of the housing 10. In this embodiment, the first driving member 22 is a motor. The first driving member 22 is located between the two first sliding rails 21. The first moving platform 23 is slidably mounted between the two first slide rails 21, and the output end of the first driving member 22 is fixedly connected to the first moving platform 23.
The second moving structure 30 includes a second slide rail 31, a second driving member 32 and a second moving platform 33.
The second slide rail 31 is fixed to the first moving platform 23. The number of the second slide rails 31 is two, and the two second slide rails 31 are parallel to each other. The second slide rail 31 is perpendicular to the first slide rail 21. The second driving member 32 is fixed to the first moving platform 23. In this embodiment, the second driving member 32 is a motor. The second driving member 32 is located between the two second sliding rails 31. The second moving platform 33 is slidably mounted between the two second sliding rails 31.
The lifting structure 40 includes a fixed socket 41, a lifting driving member 42, and a movable socket 43.
The fixed sleeve 41 is fixed to the second moving platform 33. The movable sleeve 43 is slidably mounted to the fixed sleeve 41. The movable sleeve 43 and the fixed sleeve 41 are located on the same straight line. The lifting driving member 42 is fixed to the fixed sleeve 41, and the output end of the lifting driving member 42 is fixedly connected to the movable sleeve 43. In this embodiment, the lift drive 42 is a motor.
The spray needle 50 is fixedly mounted to the traveling sleeve 43, with the end of the spray needle 50 extending into the cavity 11.
When the electrospray ion source capable of automatically adjusting the position of the spray is used, the first driving part 22 of the first moving structure 20 drives the spray needle 50 to move along the first direction when the position of the spray needle 50 needs to be adjusted. The second driving member 32 of the second moving structure 30 drives the spray needle 50 to move in a second direction perpendicular to the first direction. The lifting driving member 42 of the lifting structure 40 drives the spraying needle 50 to move along a third direction perpendicular to the first direction and the second direction.
Through the design, the design of automatically adjusting the position of the spray needle 50 reduces the inconvenience caused by manual adjustment, and saves the time of experimenters; the ion source optimization control system is matched, the ion source parameter optimization time is shortened, and the method has great significance for improving the sensitivity of the instrument.
The application also relates to a mass spectrometer comprising the electrospray ion source capable of automatically adjusting the spray position.
The above examples only show some embodiments of the present invention, and the description thereof is more specific and detailed, but not to be construed as limiting the scope of the utility model. It should be noted that, for those skilled in the art, variations and modifications can be made without departing from the spirit of the utility model, and all equivalent modifications and changes can be made to the above embodiments according to the essential technology of the utility model, which falls into the protection scope of the utility model.
Claims (10)
1. The utility model provides an electrospray ion source that can automatically regulated spraying position, includes casing and spraying needle, the casing is equipped with the cavity, the spraying needle install in the casing stretches into the cavity, its characterized in that: the electrospray ion source capable of automatically adjusting the spray position further comprises a first moving structure, a second moving structure and a lifting structure, wherein the first moving structure is mounted on the housing and provides movement in a first direction for the spray needle, the second moving structure is mounted on the first moving structure and provides movement in a second direction perpendicular to the first direction for the spray needle, the lifting structure is mounted on the second moving structure and provides movement in a third direction perpendicular to the first direction and the second direction for the spray needle, the spray needle is mounted on the lifting structure, and the spray needle realizes automatic adjustment of the position through the first moving structure, the second moving structure and the lifting structure.
2. An electrospray ion source capable of automatically adjusting spray position according to claim 1, characterized by: the first moving structure comprises a first driving piece and a first moving platform, the first driving piece is fixed on the shell, the first moving platform is slidably installed on the shell and connected with the output end of the first driving piece, and the first driving piece drives the first moving platform to move relative to the shell.
3. An electrospray ion source capable of automatically adjusting spray position according to claim 2, characterized in that: the first moving structure further comprises a first sliding rail, the first sliding rail is fixed on the shell, and the first moving platform is slidably mounted on the first sliding rail.
4. An electrospray ion source capable of automatically adjusting spray position according to claim 3, characterized in that: the quantity of first slide rail is two, two first slide rail parallel arrangement.
5. An electrospray ion source capable of automatically adjusting spray position according to claim 2, characterized in that: the second moving structure comprises a second driving piece and a second moving platform, the second driving piece is fixed on the first moving platform, the second moving platform is movably installed on the first moving platform, and the output end of the second driving piece is connected with the second moving platform.
6. An electrospray ion source capable of automatically adjusting spray position according to claim 5, characterized in that: the second moving structure further comprises a second sliding rail, the second sliding rail is fixed on the first moving platform, and the second moving platform is slidably mounted on the second sliding rail.
7. An electrospray ion source capable of automatically adjusting spray position according to claim 6, characterized in that: the quantity of second slide rail is two, two second slide rail parallel arrangement.
8. An electrospray ion source capable of automatically adjusting spray position according to claim 5, characterized in that: the lifting structure comprises a fixed sleeve, a movable sleeve and a lifting driving piece, the fixed sleeve is fixed on the second movable platform, the movable sleeve is slidably mounted on the fixed sleeve, and the lifting driving piece is fixed on the fixed sleeve and the output end of the lifting driving piece is connected with the movable sleeve.
9. An electrospray ion source capable of automatically adjusting spray position according to claim 8, characterized in that: the fixed sleeve and the movable sleeve are positioned on the same straight line and are perpendicular to the second movable platform.
10. A mass spectrometer, characterized by: the mass spectrometer comprising an electrospray ion source as recited in any of claims 1-9 capable of automatically adjusting spray position.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220204564.7U CN217009119U (en) | 2022-01-25 | 2022-01-25 | Electrospray ion source capable of automatically adjusting spray position and mass spectrometer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220204564.7U CN217009119U (en) | 2022-01-25 | 2022-01-25 | Electrospray ion source capable of automatically adjusting spray position and mass spectrometer |
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| CN217009119U true CN217009119U (en) | 2022-07-19 |
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| CN202220204564.7U Active CN217009119U (en) | 2022-01-25 | 2022-01-25 | Electrospray ion source capable of automatically adjusting spray position and mass spectrometer |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115440572A (en) * | 2022-11-07 | 2022-12-06 | 宁波华仪宁创智能科技有限公司 | Mass spectrometry device and method |
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- 2022-01-25 CN CN202220204564.7U patent/CN217009119U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115440572A (en) * | 2022-11-07 | 2022-12-06 | 宁波华仪宁创智能科技有限公司 | Mass spectrometry device and method |
| CN115440572B (en) * | 2022-11-07 | 2023-03-10 | 宁波华仪宁创智能科技有限公司 | Mass spectrometry device and method |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: 300300 building 4, No. 16, Wujing Road, Dongli Development Zone, Dongli District, Tianjin Patentee after: Tianjin Guoke Medical Technology Development Co.,Ltd. Country or region after: China Address before: Building 4, No.16 Wujing Road, development zone, Dongli District, Tianjin Patentee before: TIANJIN GUOKE YIGONG TECHNOLOGY DEVELOPMENT Co.,Ltd. Country or region before: China |
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| CP03 | Change of name, title or address | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20240407 Address after: 300300 building 4, No. 16, Wujing Road, Dongli Development Zone, Dongli District, Tianjin Patentee after: Tianjin Guoke Medical Technology Development Co.,Ltd. Country or region after: China Patentee after: Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences Address before: 300300 building 4, No. 16, Wujing Road, Dongli Development Zone, Dongli District, Tianjin Patentee before: Tianjin Guoke Medical Technology Development Co.,Ltd. Country or region before: China |
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| TR01 | Transfer of patent right |