CN115440572B - Mass spectrometry device and method - Google Patents
Mass spectrometry device and method Download PDFInfo
- Publication number
- CN115440572B CN115440572B CN202211383346.5A CN202211383346A CN115440572B CN 115440572 B CN115440572 B CN 115440572B CN 202211383346 A CN202211383346 A CN 202211383346A CN 115440572 B CN115440572 B CN 115440572B
- Authority
- CN
- China
- Prior art keywords
- moving
- spring
- guide
- piece
- cam
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000004949 mass spectrometry Methods 0.000 title claims abstract description 37
- 238000000034 method Methods 0.000 title claims abstract description 15
- 239000004020 conductor Substances 0.000 claims description 12
- 239000000126 substance Substances 0.000 claims description 11
- 238000001514 detection method Methods 0.000 claims description 8
- 230000003068 static effect Effects 0.000 claims description 3
- 150000002500 ions Chemical class 0.000 description 38
- 239000007788 liquid Substances 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000004308 accommodation Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000002306 biochemical method Methods 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Images
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0022—Portable spectrometers, e.g. devices comprising independent power supply, constructional details relating to portability
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0027—Methods for using particle spectrometers
- H01J49/0031—Step by step routines describing the use of the apparatus
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Electrochemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
The invention provides a mass spectrometry device and a method, wherein the mass spectrometry device comprises an ion source, a bracket and a shell, the ion source comprises a capillary tube, an electrode and a fixed block, the capillary tube is arranged on the fixed block, and the electrode is arranged in the capillary tube; further comprising: the guide unit is fixed in the shell and is provided with a first guide piece allowing the fixed block to pass through; the first moving piece on the second guide piece is pushed by the fixed block to move forward and push the second moving piece to move upward, and the first moving piece is provided with a limiting groove which allows the second moving piece to be clamped into and blocks the first moving piece to move reversely; the second moving piece is movably connected with a cam rotating around the first rotating shaft and is arranged on the third guide piece; the first moving piece is blocked by the first spring from moving forwards, one end of the second spring is fixed, and the other end of the second spring is connected with the cam; the first protrusion of the third moving member is driven to push the second protrusion of the cam to rotate clockwise and counterclockwise for a certain period of time. The invention has the advantages of automation and the like.
Description
Technical Field
The present invention relates to mass spectrometry, and more particularly, to a mass spectrometry device and method.
Background
At present, in the clinical field, mass spectrometry is more sensitive, higher in accuracy and less in sample consumption compared with biochemical methods and immunological methods. However, the application of the current clinical mass spectrometry faces two major challenges, namely, the restriction of the admission of inspection items and the charging system, and the poor automation, repeatability and stability of the mass spectrometry.
The technical difficulty to be solved at present is to realize the quantitative function of a mass spectrometer, and a quantitative ion source cannot be opened when the quantitative mass spectrometer is required to be developed. Most ion sources on the market are very convenient to use at present, but the quantitative requirement cannot be met, and fatigue exists after multiple batches of sample injection. For example, after a large amount of PDESI samples are injected, the hand of a user is very fatigued due to pushing in and pulling out the consumable many times. In addition, although the PDESI guide rail type sample injection is convenient to operate, the guide rail needs to be disassembled before and after storage and transportation, and after the guide rail is installed, the guide rail is exposed in the air for a long time, and dust and other impurities are easy to enter a cavity of the vacuum enclosure.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention provides a mass spectrometry device.
The purpose of the invention is realized by the following technical scheme:
the mass spectrometry device comprises an ion source, a bracket and a shell, wherein the ion source comprises a capillary tube, an electrode and a fixed block, the capillary tube is arranged on the fixed block, and the electrode is arranged in the capillary tube; the mass spectrometry apparatus further comprises:
a guide unit fixed in the housing and having a first guide allowing the fixed block to pass therethrough;
the first moving part is arranged on the second guide part and pushed by the fixed block to move forward and push the second moving part to move upwards, and the first moving part is provided with a limiting groove which allows the second moving part to be clamped in and blocks the first moving part to move reversely;
the second moving piece is movably connected with the cam rotating around the first rotating shaft and arranged on the third guide piece;
the first spring blocks the first moving part to move positively, one end of the second spring is fixed, and the other end of the second spring is connected with the cam;
a third moving member, the first projecting portion of the third moving member being driven to push the second projecting portion of the cam to rotate clockwise and counterclockwise for a certain period of time.
The invention also aims to provide a mass spectrometry method, and the aim is realized by the following technical scheme:
a method of mass spectrometry comprising the steps of:
(A1) Under the drive of external force, the fixed block of the ion source moves forwards on the first guide piece of the guide unit and enters the shell;
(A2) The fixed block pushes the first moving piece to move on the second guide piece in the forward direction, the first spring is extruded by the first moving piece, and meanwhile, the first moving piece pushes the second moving piece to move on the third guide piece in the upward direction; the second moving piece pushes the cam to rotate clockwise, so that a second spring connected with the cam deviates from a balance position;
(A3) When the ion source moves to a set position, under the action of a second spring, the cam rotates anticlockwise to push a second moving part to move downwards, the second moving part is clamped into the limiting groove of the first moving part, and the first moving part is static;
(A4) The third moving piece moves downwards, the first protruding part of the third moving piece pushes the second protruding part of the cam to move downwards from top to bottom, the cam rotates anticlockwise, the second spring deviates from the balance position, the first protruding part moves to the lower side of the second protruding part, the second spring deviating from the balance position drives the cam to rotate clockwise, and the second spring returns to the balance position;
(A5) The ion source ionizes a substance to be detected and sends the substance to be detected to the mass spectrometer for detection;
(A6) The third moving piece moves upwards, the first bulge pushes the second bulge to move upwards, the cam rotates clockwise, the second spring deviates from a balance position, the second moving piece moves upwards and is separated from the limiting groove, and the first spring pushes the first moving piece to move reversely on the second guide piece, so that the ion source is automatically pushed to exit the shell; a second spring, offset from the rest position, drives the cam to rotate counterclockwise, returning the second spring to the rest position.
Compared with the prior art, the invention has the beneficial effects that:
1. automation;
the ion source is taken as a consumable, when the ion source is pushed into the shell, the ion source is automatically clamped along with the downward movement of the movable door, and after the detection is finished, the ion source is automatically pushed out along with the upward movement of the movable door, so that the operation burden of a user is reduced when repeated operation is carried out on multiple batches, the use feeling of an operator is greatly improved, and the efficiency is improved;
2. the efficiency is high;
the movable door and the high-voltage sequential discharge structure realize independent high-voltage discharge detection of batches of capillaries in the quantitative ion source, and quickly and efficiently finish sample detection;
3. the portability is good;
the guide rail unit adopts the foldable design, when needing to use, will be in the second part of casing and rotate out to utilize the slider to keep the level, after the use, take out the slider in the first part, rotatory second part, the second part is folding to get into in the casing, has realized the fast switch-over, saves space, portable.
Drawings
The present disclosure will become more readily understood with reference to the accompanying drawings. As is readily understood by those skilled in the art: these drawings are only for illustrating the technical solutions of the present invention and are not intended to limit the scope of the present invention. In the figure:
FIG. 1 is a schematic diagram of an operating state of a mass spectrometry apparatus according to an embodiment of the present invention;
FIG. 2 is a schematic structural diagram of a mass spectrometry apparatus according to an embodiment of the present invention;
FIG. 3 is a schematic diagram of a rear side structure of a mass spectrometry apparatus according to an embodiment of the present invention;
FIG. 4 is a schematic view of the internal structure of a mass spectrometry apparatus according to an embodiment of the present invention;
FIG. 5 is a schematic view of another internal structure of a mass spectrometry apparatus according to an embodiment of the present invention;
fig. 6 is a schematic view of a horizontal state structure of a guide unit according to an embodiment of the present invention;
fig. 7 is a schematic view showing a structure of a turning state of a guide unit according to an embodiment of the present invention;
FIG. 8 is a schematic illustration of an inoperative state of a mass spectrometry apparatus according to an embodiment of the invention.
Detailed Description
Fig. 1-8 and the following description depict alternative embodiments of the invention to teach those skilled in the art how to make and use the invention. Some conventional aspects have been simplified or omitted for the purpose of explaining the technical solution of the present invention. Those skilled in the art will appreciate that variations or substitutions from these embodiments will be within the scope of the invention. Those skilled in the art will appreciate that the features described below can be combined in various ways to form multiple variations of the invention. Thus, the present invention is not limited to the following alternative embodiments, but is only limited by the claims and their equivalents.
Example 1:
fig. 1-2 schematically show the construction of a mass spectrometry apparatus according to embodiment 1 of the present invention, which, as shown in fig. 1-2, comprises:
the ion source 3 comprises a capillary tube, an electrode and a fixed block, wherein the capillary tube is arranged on the fixed block, and the electrode is arranged in the capillary tube;
a guide unit 2, the guide unit 2 being fixed in the housing 1 and having a first guide allowing the fixed block to pass therethrough;
a first moving part 53 and a second guiding part 54, as shown in fig. 3, the first moving part 53 on the second guiding part 54 is pushed by the fixed block to move forward and push the second moving part 45 to move upward, the first moving part 53 has a limiting groove for allowing the second moving part 45 to be clamped in and blocking the first moving part 53 to move reversely;
a cam 49 and a second moving member 45, the second moving member 45 being movably connected to the cam 49 rotating about the first rotation axis and provided on the third guide;
a first spring 57 and a second spring 50, wherein the first spring 57 prevents the first moving part 53 from moving in the forward direction, one end of the second spring 50 is fixed, and the other end of the second spring is connected with the cam 49, so that the cam 49 is in a balance position;
a third moving member 47, a first projecting portion of said third moving member 47 is driven to push a second projecting portion of said cam 49 to rotate clockwise and counterclockwise for a certain period of time.
In order to isolate the ion source 3 in an operating state, as shown in fig. 1, the mass spectrometer further includes:
a movable door 6 and a first driving unit, wherein the movable door 6 is arranged on the housing 1, and the first driving unit drives the movable door 6 to move up and down to isolate the ion source 3 in the housing 1;
and the connecting piece is connected with the first driving unit and the third moving piece 47, and the movable door 6 and the third moving piece 47 synchronously move under the driving of the first driving unit.
In order to selectively ionize the substance to be detected in each capillary of the ion source 3, further, the number of the capillaries is two or more, as shown in fig. 4, and the mass spectrometry apparatus further includes:
a first set of contacts, which are arranged at the rear side of the moving door 6, but are respectively connected with the electrodes in the capillaries after the moving door 6 moves downwards;
the second group of contacts correspond to the first group of contacts one by one and are electrically connected;
a conductor 42 and a second driving unit, under the driving of the second driving unit, the conductor 42 connected with an external power supply is selectively connected with any one of the second group of contacts.
In order to provide guidance for translation of the ion source 3 and to facilitate accommodation into the housing 1, further, as shown in fig. 6 to 7, the guide unit 2 includes:
a first portion 9, said first portion 9 being fixed to said carriage and having internally a first set of channels 16 allowing the entrance and exit of the slider;
a second portion 10 and a slide, said second portion 10 being arranged at the end of said first portion 9 by means of a rotating shaft, having internally a second set of channels 15 allowing the passage of said slide; the first guide is a guide groove respectively arranged at the upper side of the first part 9 and the second part 10;
a handle 12, the handle 12 being connected to the slider.
In order to facilitate the movement of the slider, further, as shown in fig. 7, the lower side of the second portion 10 has a groove in which the handle 12 is disposed.
The mass spectrometry method comprises the following steps:
(A1) Under the drive of external force, the fixed block of the ion source 3 moves forwards on the first guide piece of the guide unit 2 and enters the shell 1;
(A2) The fixed block pushes the first moving part 53 to move forward on the second guide 54, the first spring 57 is pressed by the first moving part 53, and simultaneously, the first moving part 53 pushes the second moving part 45 to move upward on the third guide; the second moving member 45 pushes the cam 49 to rotate clockwise so that the second spring 50 connected to the cam 49 is deviated from the equilibrium position;
(A3) When the ion source 3 moves to a set position, the cam 49 rotates anticlockwise under the driving of the second spring 50 to push the second moving part 45 to move downwards, the second moving part 45 is clamped in the limiting groove of the first moving part 53, and the first moving part 53 is static;
(A4) The third moving part 47 moves downwards, the first protrusion of the third moving part 47 pushes the second protrusion of the cam 49 downwards from top to bottom, the cam 49 rotates anticlockwise, the second spring 50 deviates from the equilibrium position, the first protrusion moves to the lower side of the second protrusion, the second spring 50 deviating from the equilibrium position drives the cam 49 to rotate clockwise, and the second spring 50 returns to the equilibrium position;
(A5) The ion source 3 ionizes a substance to be detected and sends the substance to a mass spectrometer for detection;
(A6) The third moving part 47 moves upwards, the first protrusion pushes the second protrusion to move upwards, the cam 49 rotates clockwise, the second spring 50 deviates from the equilibrium position, the second moving part 45 moves upwards and is separated from the limiting groove, the first spring 57 pushes the first moving part 53 to move reversely on the second guiding part 54, so as to automatically push the ion source 3 to exit the housing 1; the cam 49 is driven to rotate counterclockwise by the second spring 50 which is deviated from the equilibrium position, and the second spring 50 returns to the equilibrium position.
In order to isolate the ion source 3 in the operating state, further, in step (A4), the first driving unit drives the moving door 6 to move downward, isolating the ion source 3 within the housing 1;
meanwhile, the first driving unit drives the third moving member 47 to move downward;
in step (A6), the first driving unit drives the third moving member 47 to move up.
In order to selectively ionize the substances to be tested in the capillaries of the ion source 3, further, in the step (A4), after the movable door 6 moves downwards, the first group of contacts at the rear side of the movable door 6 are respectively connected with the electrodes in the capillaries of the ion source 3;
in the step (A5), under the driving of the second driving unit, the conductor 42 connected to the external power supply is selectively connected to any one of the second set of contacts, which correspond to and are electrically connected to the first set of contacts one to one, so that the external power supply is selectively connected to the electrodes in the capillary and ionizes the substance to be measured in the capillary.
For convenience of extension (in an operating state) and storage (in a non-operating state), further, the mass spectrometry method further includes a step (A0) before the step (A1) and a step (A7) after the step (A6):
(A0) The guide unit 2 includes a first part 9 and a second part 10, and the second part 10, which is located in the housing 1 and connected to the first part 9, is rotated in a forward direction such that the second part 10 is exposed and its upper side is horizontal; the first guide member comprises guide grooves on the upper sides of the first and second portions 9 and 10;
pushing the slide in the second portion 10, which enters the first set of channels 16 of the first portion, so that the upper side of said second portion 10 remains horizontal, as shown in figures 1, 7;
(A7) Pulling the slide, which exits the first set of channels 16 of the first portion 9;
the second part 10 is rotated in the opposite direction and enters the housing 1 and is fixed, as shown in fig. 8.
Example 2:
an application example of the mass spectrometry apparatus and method according to embodiment 1 of the present invention.
In the present application example, as shown in fig. 1, the movable door 6 and the guide unit 2 are respectively provided on the front side of the housing 1, and the ion source 3 is provided on the guide unit 2 at the time of detection;
as shown in fig. 2-3, the second guide 54 is fixed to the spring holder 58 by a guide rod and inserted into the housing 1 from a guide hole 55 at the rear side of the housing 1; the rear side of the housing 1 is also provided with a spring mounting hole 56, and a first spring 57 is inserted into the spring mounting hole 56 and blocked by a spring pressing plate 58; the first moving part 53 is positioned in the housing 1 and is arranged on the second guide part 54, and the first spring 57 is positioned between the first moving part 53 and the spring pressure plate 58;
the first moving member 53 has a positioning groove for allowing the second moving member 45 to be inserted therein, and the bottom of the second moving member 45 has a slope whose distance from the second guide 54 is gradually increased from the front side to the rear side of the housing 1; the second moving member 45 is in the third guide so that the second moving member 45 can only move vertically; one end of the second moving part 45 is movably connected with a cam 49 through a connecting rod 46, and a clamp spring 48 is arranged at the connecting position; the cam 49 is arranged on a rotating shaft, the rotating shaft is arranged on a fixed module 52, and the fixed module 52 is fixed on the bracket; the second spring 50 is a tension spring, one end of the second spring is fixed on the fixed pin 51, and the other end of the second spring is fixed on the cam 49, so that the cam 49 is in a balance position; the third moving member 47 has a first protrusion, the cam 49 has a second protrusion, and the third moving member 47 and the moving door 6 are synchronously linked under the driving of the first driving unit to realize vertical movement, so that the first protrusion part is located at the upper side and the lower side of the second protrusion part at certain time;
as shown in fig. 4 to 5, in the second driving unit, the conductor 42 is disposed on the high voltage connection plate 43 and is fixedly connected with the first stopper 44; the first motor 39 is fixed on the motor adapter plate 38 and is connected with the high-voltage connecting plate 43 through a first conversion module, so that the rotation of the first motor 39 is converted into the vertical movement of the high-voltage connecting plate, and the first photoelectric switch 41 is used for determining the zero position of the first limiting sheet 44 (namely, the conductor 42); the rear side of the moving gate 6 has three contacts (first set of contacts) corresponding to the three electrodes of the ion source 3, respectively; the high-pressure plate 35 has three contacts (a second group of contacts) in the vertical direction, and the first group of contacts and the second group of contacts are in one-to-one correspondence and are electrically connected; selectively connecting any one of the second set of contacts, i.e. selectively connecting the conductor 42 to any one of the electrodes in the ion source 3, when the first motor 39 drives the conductor 42 to move vertically;
in the first driving unit, a second motor 28 is fixed on a motor adapter plate 27, a flange 25 is connected with a second limiting sheet 26, a moving door 6 connecting plate 29 and a moving door 6 adapter plate 32, and the second motor 28 is connected with the flange 25 through a second conversion module to convert the rotation of the second motor 28 into the vertical movement of the flange 25; the adapter plate 32 of the movable door 6 is connected with the third moving piece 47, and the connecting plate 29 of the movable door 6 is connected with the movable door 6 and is positioned on the vertical linear guide rail 30; the second photoelectric switch 37 is fixedly connected with the motor adapter plate 27 and is used for determining the zero position of the second limiting sheet 26, namely determining the zero position of the movable door 6;
as shown in fig. 6-7, in the guide unit 2, the first portion 9 is fixed to the support and internally has a first set of channels 16 allowing the entrance and exit of the slide; the second portion 10 is arranged at the end of the first portion 9 by means of a rotating shaft 11, internally provided with a second set of channels 15 allowing the passage of the slider; the first guide parts are guide grooves which are respectively arranged at the upper sides of the first part 9 and the second part 10; the lower side of the second part 10 has a recess in which the handle 12 is arranged and connected to the slide in the second set of channels 15; the second part 10 has grooves 14 on both sides, and correspondingly, the bracket has protrusions for being snapped into the grooves 14, so as to fix the rotated second part 10 in the housing 1;
the mass spectrometry method of the embodiment of the present invention, that is, the operating method of the mass spectrometry apparatus of the embodiment of the present invention, includes the following steps:
(A0) Forward rotating the second portion 10, which is inside the casing 1 and connected to the first portion 9, the projection coming out of the groove 14, so that said second portion 10 is exposed with its upper side horizontal; the first guide member comprises guide grooves on the upper sides of the first and second portions 9 and 10;
the operator pushes the handle 12 in the recess and thus the slide in the second portion 10, which enters the first set of channels 16 of the first portion, so that the upper side of said second portion 10 remains horizontal, as shown in fig. 1;
moving the ion source 3 to enable the bottom ends of the three capillaries to enter liquid to be detected, and enabling part of the liquid to be detected to enter the capillaries so as to dip the liquid to be detected;
moving the ion source 3 to separate the capillary from the liquid to be detected, and placing the ion source 3 in a guide groove of a guide unit 2;
(A1) Under the drive of external force, the fixed block of the ion source 3 moves forwards on the first guide piece of the guide unit 2 and enters the shell 1;
(A2) The fixed block pushes the first moving part 53 to move forward on the second guide 54, the first spring 57 is pressed by the first moving part 53, and at the same time, the first moving part 53 pushes the second moving part 45 to move upward on the third guide; the second moving member 45 pushes the cam 49 to rotate clockwise by the link 46, so that the second spring 50 connected to the cam 49 is deviated from the equilibrium position;
(A3) When the ion source 3 moves to a set position, the cam 49 rotates counterclockwise under the driving of the elastic force of the second spring 50 to push the second moving part 45 to move downward, the bottom of the second moving part 45 is clamped into the limiting groove of the first moving part 53, and the first moving part 53 is stationary;
(A4) The first driving unit drives the movable door 6 and the third moving part 47 to synchronously move downwards vertically, specifically, the second motor 28 rotates, so that the connecting plate 29 of the movable door 6 is driven to move downwards and upwards on the linear guide rail 30, the adapter plate 32 of the movable door 6 drags the movable door 6 and the third moving part 47 to move downwards and vertically until the second photoelectric opening 37 detects the second limiting sheet 26, at this time, the movable door 6 moves to a zero point position, the first group of contacts at the rear side of the movable door 6 are respectively connected with electrodes in each capillary of the ion source 3, and the second motor 28 stops rotating to isolate the ion source 3 in the housing 1;
as the third moving part 47 moves downwards, the first protrusion of the third moving part 47 pushes the second protrusion of the cam 49 downwards from top to bottom, the cam 49 rotates anticlockwise, the second spring 50 deviates from the equilibrium position, and when the first protrusion moves to the lower side of the second protrusion, the second spring 50 deviating from the equilibrium position drives the cam 49 to rotate clockwise, and the second spring 50 returns to the equilibrium position;
(A5) Under the drive of the second driving unit, that is, the first motor 39 drives the conductor 42 to move vertically, so that the conductor 42 connected with an external power supply is selectively connected with any one of the contacts in the second group, that is, the external power supply is selectively connected with the electrodes in the capillary, the substance to be detected in the capillary is ionized, and the ions are sent to the mass spectrometer for detection;
(A6) The first driving unit drives the movable door 6 and the third moving part 47 to synchronously move upwards vertically, in a specific way, the second motor 28 rotates, so that the connecting plate 29 of the movable door 6 is driven to move upwards on the linear guide rail 30, the adapter plate 32 of the movable door 6 drags the movable door 6 and the third moving part 47 to move upwards vertically, and the first set of contacts are separated from the electrodes;
as the third moving part 47 moves upwards, the first protrusion pushes the second protrusion to move upwards, the cam 49 rotates clockwise, the second spring 50 deviates from the equilibrium position, the second moving part 45 moves upwards and is separated from the limiting groove, the first protrusion moves to the upper side of the second protrusion, and the first spring 57 pushes the first moving part 53 to move reversely on the second guide 54, so as to automatically push the ion source 3 to exit the housing 1; the cam 49 is driven to rotate anticlockwise by the second spring 50 which deviates from the equilibrium position, and the second spring 50 returns to the equilibrium position;
(A7) Pulling the slide by means of the handle 12, the slide exiting the first set of channels 16 of the first portion 9;
the second portion 10 is rotated in the reverse direction into the housing 1 to be protruded to be caught in the groove 14, thereby fixing the second portion 10, and the decorative plate 59 is inserted into the lower side of the moving door 6 to prevent dust from being introduced into the housing 1, as shown in fig. 8.
Claims (8)
1. A mass spectrometry apparatus comprising an ion source, a holder and a housing, the ion source comprising a capillary, an electrode and a fixed block, the capillary being disposed on the fixed block, the electrode being disposed within the capillary; the method is characterized in that: the mass spectrometry apparatus further comprises:
a guide unit fixed in the housing and having a first guide allowing the fixed block to pass therethrough;
the first moving part on the second guide part is pushed by the fixed block to move forward and push the second moving part to move upwards, and the first moving part is provided with a limiting groove which allows the second moving part to be clamped in and blocks the first moving part to move reversely;
the second moving piece is movably connected with the cam rotating around the first rotating shaft and arranged on the third guide piece;
the first spring blocks the first moving part to move positively, one end of the second spring is fixed, and the other end of the second spring is connected with the cam;
a third moving member, the first projecting portion of which is driven to push the second projecting portion of the cam to rotate clockwise and counterclockwise for a certain period of time;
the movable door is arranged on the shell, and the first driving unit drives the movable door to move up and down to isolate the ion source in the shell;
and the connecting piece is connected with the first driving unit and the third moving piece, and the movable door and the third moving piece synchronously move under the driving of the first driving unit.
2. The mass spectrometry apparatus of claim 1, wherein the first drive unit comprises:
the motor is fixed on the bracket;
the adapter plate is connected with the third moving piece, and the connecting plate is arranged on the vertical linear guide rail and connected with the movable door; the motor drives the connecting plate and the adapter plate to vertically move.
3. The mass spectrometry apparatus of claim 1, wherein the number of capillaries is two or more, the mass spectrometry apparatus further comprising:
the first group of contacts are arranged on the rear side of the movable door, and are respectively connected with the electrodes in the capillary tubes after the movable door moves downwards;
the second group of contacts correspond to the first group of contacts one by one and are electrically connected;
the conductor and the second driving unit are driven by the second driving unit, and the conductor connected with an external power supply is selectively connected with any one of the second group of contacts.
4. The mass spectrometry apparatus of claim 1, wherein the guide unit comprises:
a first portion fixed to the bracket and having a first set of channels therein to allow the slider to enter and exit;
the second part is arranged at the end part of the first part through a rotating shaft, and a second group of channels allowing the sliding piece to pass through are arranged inside the second part; the first guide part is a guide groove which is respectively arranged at the upper sides of the first part and the second part;
a handle connected to the slider.
5. The mass spectrometry apparatus of claim 4, wherein the underside of the second portion has a recess, the handle being disposed within the recess.
6. A method of mass spectrometry comprising the steps of:
(A1) Under the drive of external force, the fixed block of the ion source moves forwards on the first guide piece of the guide unit and enters the shell;
the first driving unit drives the movable door to move downwards to isolate the ion source in the shell; meanwhile, the first driving unit drives the third moving part to move downwards;
(A2) The fixed block pushes the first moving piece to move on the second guide piece in the forward direction, the first spring is extruded by the first moving piece, and meanwhile, the first moving piece pushes the second moving piece to move on the third guide piece in the upward direction; the second moving piece pushes the cam to rotate clockwise, so that a second spring connected with the cam deviates from a balance position;
(A3) When the ion source moves to a set position, under the action of a second spring, the cam rotates anticlockwise to push a second moving part to move downwards, the second moving part is clamped in the limiting groove of the first moving part, and the first moving part is static;
(A4) The third moving piece moves downwards, the first protruding part of the third moving piece pushes the second protruding part of the cam downwards from top to bottom, the cam rotates anticlockwise, the second spring deviates from the balance position, the first protruding part moves to the lower side of the second protruding part, the second spring deviating from the balance position drives the cam to rotate clockwise, and the second spring returns to the balance position;
(A5) The ion source ionizes a substance to be detected and sends the substance to be detected to the mass spectrometer for detection;
(A6) The third moving piece moves upwards, the first bulge pushes the second bulge to move upwards, the cam rotates clockwise, the second spring deviates from a balance position, the second moving piece moves upwards and is separated from the limiting groove, and the first spring pushes the first moving piece to move reversely on the second guide piece, so that the ion source is automatically pushed to exit the shell; a second spring which deviates from the balance position drives the cam to rotate anticlockwise, and the second spring returns to the balance position;
the first driving unit drives the third moving part to move upwards.
7. The method of mass spectrometry of claim 6, wherein in step (A4), after the moving gate is moved downward, the first set of contacts on the rear side of the moving gate are connected to the electrodes in the capillaries of the ion source, respectively;
in the step (A5), under the driving of the second driving unit, the conductor connected to the external power supply is selectively connected to any one of a second set of contacts, and the second set of contacts corresponds to and is electrically connected to the first set of contacts one to one, so that the external power supply is selectively connected to the electrodes in the capillary and ionizes the substance to be measured in the capillary.
8. The method of mass spectrometry of claim 6, further comprising step (A0) before step (A1) and step (A7) after step (A6):
(A0) The guide unit includes a first part and a second part, and the second part which is arranged in the shell and connected with the first part is rotated in a positive direction, so that the second part is exposed and the upper side of the second part is horizontal; the first guide part comprises guide grooves on the upper sides of the first part and the second part;
pushing a slide in the second portion, the slide entering the channel of the first portion such that the upper side of said second portion remains horizontal;
(A7) Pulling the slide, the slide exiting the channel of the first portion;
the second part rotates in the opposite direction, enters the shell and is fixed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211383346.5A CN115440572B (en) | 2022-11-07 | 2022-11-07 | Mass spectrometry device and method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211383346.5A CN115440572B (en) | 2022-11-07 | 2022-11-07 | Mass spectrometry device and method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115440572A CN115440572A (en) | 2022-12-06 |
| CN115440572B true CN115440572B (en) | 2023-03-10 |
Family
ID=84252531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211383346.5A Active CN115440572B (en) | 2022-11-07 | 2022-11-07 | Mass spectrometry device and method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115440572B (en) |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202259158U (en) * | 2011-09-22 | 2012-05-30 | 上海大学 | Small and portable time-of-flight mass spectrometer |
| CN106206238A (en) * | 2016-08-30 | 2016-12-07 | 聚光科技(杭州)股份有限公司 | Change wimble device and method |
| CN210467763U (en) * | 2019-10-21 | 2020-05-05 | 清谱（上海）分析仪器有限公司 | Sample introduction device for portable mass spectrum |
| CN111883414A (en) * | 2020-07-15 | 2020-11-03 | 宁波华仪宁创智能科技有限公司 | Replacement device and automatic sampling system |
| CN113514593A (en) * | 2020-04-09 | 2021-10-19 | 中国科学院上海药物研究所 | Multi-channel capillary chromatographic column electrospray ion source device |
| CN113740412A (en) * | 2021-11-08 | 2021-12-03 | 宁波华仪宁创智能科技有限公司 | Mass spectrometry system and method based on automatic sample introduction |
| CN215118826U (en) * | 2020-12-31 | 2021-12-10 | 南京信路申医药科技有限公司 | Sample introduction device of mass spectrometer |
| CN114400175A (en) * | 2021-12-01 | 2022-04-26 | 宁波大学 | Mass spectrometry system and method |
| CN217009119U (en) * | 2022-01-25 | 2022-07-19 | 天津国科医工科技发展有限公司 | Electrospray ion source capable of automatically adjusting spray position and mass spectrometer |
| CN115083882A (en) * | 2022-08-19 | 2022-09-20 | 中科润生康泰(苏州)医学检验实验室有限公司 | Device for mass spectrum reduction of sample injection capillary pollution |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6825466B2 (en) * | 2002-08-01 | 2004-11-30 | Automated Biotechnology, Inc. | Apparatus and method for automated sample analysis by atmospheric pressure matrix assisted laser desorption ionization mass spectrometry |
| US10686266B2 (en) * | 2016-08-30 | 2020-06-16 | Honeywell International Inc. | Cam driven, spring loaded grounding clamp |
| CN116798849A (en) * | 2017-12-22 | 2023-09-22 | 英国质谱公司 | Ion source rapid exchange device and ion transmission device |
| JP7258799B2 (en) * | 2020-02-27 | 2023-04-17 | 株式会社日立ハイテク | Ion source, mass spectrometer, ion source control method |
| CN112750679A (en) * | 2020-12-31 | 2021-05-04 | 杭州谱育科技发展有限公司 | Mass spectrometry system and method |
-
2022
- 2022-11-07 CN CN202211383346.5A patent/CN115440572B/en active Active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202259158U (en) * | 2011-09-22 | 2012-05-30 | 上海大学 | Small and portable time-of-flight mass spectrometer |
| CN106206238A (en) * | 2016-08-30 | 2016-12-07 | 聚光科技(杭州)股份有限公司 | Change wimble device and method |
| CN210467763U (en) * | 2019-10-21 | 2020-05-05 | 清谱（上海）分析仪器有限公司 | Sample introduction device for portable mass spectrum |
| CN113514593A (en) * | 2020-04-09 | 2021-10-19 | 中国科学院上海药物研究所 | Multi-channel capillary chromatographic column electrospray ion source device |
| CN111883414A (en) * | 2020-07-15 | 2020-11-03 | 宁波华仪宁创智能科技有限公司 | Replacement device and automatic sampling system |
| CN215118826U (en) * | 2020-12-31 | 2021-12-10 | 南京信路申医药科技有限公司 | Sample introduction device of mass spectrometer |
| CN113740412A (en) * | 2021-11-08 | 2021-12-03 | 宁波华仪宁创智能科技有限公司 | Mass spectrometry system and method based on automatic sample introduction |
| CN114400175A (en) * | 2021-12-01 | 2022-04-26 | 宁波大学 | Mass spectrometry system and method |
| CN217009119U (en) * | 2022-01-25 | 2022-07-19 | 天津国科医工科技发展有限公司 | Electrospray ion source capable of automatically adjusting spray position and mass spectrometer |
| CN115083882A (en) * | 2022-08-19 | 2022-09-20 | 中科润生康泰(苏州)医学检验实验室有限公司 | Device for mass spectrum reduction of sample injection capillary pollution |
Also Published As
| Publication number | Publication date |
|---|---|
| CN115440572A (en) | 2022-12-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9741552B2 (en) | Triple quadrupole mass spectrometry coupled to trapped ion mobility separation | |
| CN207036761U (en) | A kind of full-automatic point sample instrument | |
| US8785848B2 (en) | Parallel ion mass and ion mobility analysis | |
| US20100200746A1 (en) | Intelligently controlled spectrometer methods and apparatus | |
| US3941567A (en) | Device for the analysis of microscopic objects by laser pyrolysis and chromatography in the gaseous phase | |
| CN115440572B (en) | Mass spectrometry device and method | |
| CN111122751A (en) | Full-automatic turret type solid phase micro-extraction, headspace and liquid sample introduction integrated device | |
| CN210954069U (en) | Automatic enzyme-linked immunoassay analyzer | |
| CN217009119U (en) | Electrospray ion source capable of automatically adjusting spray position and mass spectrometer | |
| CN111879843B (en) | Method for detecting drugs in hair | |
| CN112730859B (en) | Automatic enzyme-linked immunoassay appearance | |
| CN117497398A (en) | Mass spectrometry apparatus and method | |
| CN111883414A (en) | Replacement device and automatic sampling system | |
| CN109270157B (en) | Sampling device based on induction electric spray and mass spectrometry method | |
| CN113514592B (en) | Movable type electrospray ion source accurate positioning device with chromatographic valve linked | |
| CN115312371A (en) | Sampling device of triple quadrupole mass spectrometer | |
| CN203870114U (en) | Active type micro-fluidic chip sampling device | |
| CN212060105U (en) | Movable electrospray ion source accurate positioning device linked with chromatographic valve | |
| CN115206768A (en) | Laser adjusting assembly for mass spectrum detection | |
| CN219758169U (en) | Sample feeding disc of gas chromatography mass spectrometer | |
| CN115436451A (en) | Single cell mass spectrometry systems and methods | |
| CN113514593A (en) | Multi-channel capillary chromatographic column electrospray ion source device | |
| CN217484167U (en) | Online sample mobile device for laser multi-energy spectrum analyzer | |
| CN211206535U (en) | Reagent card tray mechanism of automatic enzyme-linked immunoassay analyzer | |
| CN220730050U (en) | Raman spectrum detection device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: West side of 1st floor, 1st floor, Building A, No. 288 Jingu Middle Road (East), Yinzhou District, Ningbo City, Zhejiang Province, 315000 Patentee after: CHINA INNOVATION INSTRUMENT Co.,Ltd. Country or region after: China Address before: Room 304, D Building, Kexin Building, 655 Xueshi Road, Yinzhou District, Ningbo City, Zhejiang Province, 315000 Patentee before: CHINA INNOVATION INSTRUMENT Co.,Ltd. Country or region before: China |
|
| CP03 | Change of name, title or address |