CN216983320U - Intelligent infusion equipment for hematopoietic stem cell cryoprotectant - Google Patents
Intelligent infusion equipment for hematopoietic stem cell cryoprotectant Download PDFInfo
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- CN216983320U CN216983320U CN202220356036.3U CN202220356036U CN216983320U CN 216983320 U CN216983320 U CN 216983320U CN 202220356036 U CN202220356036 U CN 202220356036U CN 216983320 U CN216983320 U CN 216983320U
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Abstract
The utility model relates to the technical field of hematopoietic stem cell cryoprotectant infusion, in particular to an intelligent infusion device for a hematopoietic stem cell cryoprotectant. The utility model provides a hemopoietic stem cell cryoprotectant intelligence infusion equipment, includes low temperature super-clean bench, cryoprotectant low temperature save set and microcomputer infusion device, and cryoprotectant low temperature save set and microcomputer infusion device set up in low temperature super-clean bench, and low temperature super-clean bench outside is equipped with the cold air compressor, and the cold air compressor is inside UNICOM with cryoprotectant low temperature save set, and microcomputer infusion device and cryoprotectant low temperature save set detachable are connected. The infusion process is carried out in a low-temperature super-clean bench, the infusion process can be guaranteed to be pollution-free, the infusion of the cryoprotectant is controlled through the microcomputer flow rate control valve, the uniform mixing of blood and the cryoprotectant is promoted through the injection pump and the injector, the accuracy of the injection amount can be greatly improved, the operation is simple and convenient, and the labor is saved.
Description
Technical Field
The utility model relates to the technical field of hematopoietic stem cell cryoprotectant infusion, in particular to an intelligent infusion device for a hematopoietic stem cell cryoprotectant.
Background
With the development of life science and the advancement of clinical medical technology, the maintenance of active biological samples is an important requirement in the biological and medical industries, and thus, more and more mechanisms such as cord blood banks, biological sample banks, cell tissue banks and the like mainly for the preservation of cell tissues are promoted. In particular, the preservation of hematopoietic stem cells derived from umbilical cord blood or bone marrow blood is becoming a key to the long-term preservation of hematopoietic stem cells due to the development of a technique for treating malignant diseases such as clinical hematological diseases and autoimmune diseases.
Dimethyl sulfoxide (DMSO) is one of important freezing protective agents for cell and tissue freezing preservation and liquid nitrogen preservation, particularly in the aspect of hematopoietic stem cell preservation, but dimethyl sulfoxide also generates certain toxic and side effects on cells, tissues and organisms, particularly above 4 ℃, and the freezing preservation activity of the cells is seriously influenced. How to reduce the toxic and side effects of dimethyl sulfoxide as a cryoprotectant on cells, the infusion time and the temperature of dimethyl sulfoxide and cell suspension are mainly controlled by adopting the mature automatic injection pump for controlling the infusion time to be 10 minutes at present, the infusion is slowly carried out, and the problem related to temperature control is solved.
SUMMERY OF THE UTILITY MODEL
In order to solve the problem that the absorbed dose and the temperature of the cryoprotectant are not easy to master, the utility model provides an intelligent infusion device for the cryoprotectant of hematopoietic stem cells.
The technical scheme adopted by the utility model for solving the technical problem is as follows: the intelligent infusion equipment for the hematopoietic stem cell cryoprotectant comprises a low-temperature super-clean bench, a cryoprotectant low-temperature storage device and a microcomputer infusion device, wherein the cryoprotectant low-temperature storage device and the microcomputer infusion device are arranged in the low-temperature super-clean bench, a cold air compressor is arranged outside the low-temperature super-clean bench and communicated with the interior of the cryoprotectant low-temperature storage device, and the microcomputer infusion device is detachably connected with the cryoprotectant low-temperature storage device.
As optimization, the low temperature super clean bench include the cabinet body and support, the support upper end with the lower terminal surface of the cabinet body links firmly, cabinet body top is equipped with the freeze-drying subassembly, cabinet body upper surface is equipped with the fresh air inlet, be equipped with high-efficient filter screen on the fresh air inlet, the freeze-drying subassembly with the fresh air inlet through connection, cabinet body bottom is equipped with the exhaust vent, the internal portion of cabinet is equipped with ultraviolet ray disinfection lamp.
Preferably, the cryoprotectant low-temperature preservation device is arranged inside the cabinet body, the cold air compressor is arranged at the lower part of the cabinet body, the lower part of the cabinet body is connected with the air inlet pipe and the air outlet pipe, and the cold air compressor is communicated with the interior of the cryoprotectant low-temperature preservation device through the air inlet pipe.
As optimizing, cryoprotectant low temperature save set include bin, the king of ice case, cold air box and support column, the king of ice case set up in inside the cold air box, the bin set up in the king of ice incasement portion, support column through connection in cold air box bottom, the support column is equipped with two sets ofly, two sets of support column lower extreme respectively with the air-supply line is connected with play tuber pipe detachable, and the quantity of support column is 2 in every group support column, the cold air box passes through support column through connection with the air-supply line and play tuber pipe.
As the optimization, the lateral wall of the king ice box on the dense ventilation hole that is equipped with, king ice box inboard bottom one side is equipped with the plastics baffle, the slope of plastics baffle sets up, the bin bottom is the wedge, the bin set up in between plastics baffle and the king ice box, plastics baffle upside is equipped with protectant temperature sensor, king ice box bottom opposite side all is equipped with the bottom connector with the cold air chest bottom corresponds the position, the bin bottom is connected with the outrigger, the bottom connector is used for holding the outrigger and passes through.
As optimization, the refrigerator king outside and cold wind incasement inboard between be equipped with and walk the wind interval, the support column top with walk the inside through connection in wind interval, the refrigerator king top with the cold wind roof portion corresponds the position and is equipped with the top connector, the storage box top is equipped with the liquid feeding pipe, the top connector is used for holding the liquid feeding pipe, top connector upside is connected with the three-layer filter screen lid, the liquid feeding pipe set up in the three-layer filter screen lid is inboard.
Preferably, the microcomputer infusion device comprises a connecting pipe, a microcomputer flow rate control valve, an injector, an injection pump, an anti-backflow kettle and a shaking table, the microcomputer flow rate control valve is arranged in the middle of the connecting pipe, the end part of the connecting pipe on one side of the microcomputer flow rate control valve is detachably connected with the outer end of the outer extension pipe, the end part of the connecting pipe on the other side of the microcomputer flow rate control valve is detachably connected with the anti-backflow kettle, the connecting pipe between the anti-backflow kettle and the microcomputer flow rate control valve is connected with the injector, the injection pump is connected with the injector, the shaking table is used for placing a blood collection bag, and the other end of the anti-backflow kettle is connected with the blood collection bag.
As optimization, an indicating cotton plug is arranged inside one end, close to the connecting pipe, of the backflow prevention kettle, and a blood sample temperature sensor is arranged on the shaking table.
The beneficial effect of this scheme is: an intelligent infusion device for hematopoietic stem cell cryoprotectant has the following benefits:
the infusion process is carried out in a low-temperature super-clean bench, so that the pollution-free infusion process can be ensured, the infusion of the cryoprotectant is controlled by a microcomputer flow rate control valve, the uniform mixing of blood and the cryoprotectant is promoted by an injection pump and an injector, the accuracy of the injection amount can be greatly improved, the operation is simple and convenient, and the errors caused by manual operation are greatly reduced;
carry out the cooling to the cryoprotectant through cold air compressor to at the inside temperature sensor that sets up of the king-box of ice, can carry out real time monitoring to the temperature of cryoprotectant, just can inject when the temperature of cryoprotectant meets the requirements, prevent that the temperature of cryoprotectant from reaching the requirement, influence the cryopreservation quality of stem cell.
Drawings
FIG. 1 is a schematic isometric view of the present invention.
FIG. 2 is a schematic top view of the present invention.
FIG. 3 is a schematic axial view of the cut-away structure A-A of FIG. 2 according to the present invention.
Fig. 4 is an enlarged view of a portion a of fig. 3 according to the present invention.
FIG. 5 is a schematic axial view of a cryoprotectant storage apparatus of the present invention.
FIG. 6 is a schematic bottom view of the cryoprotectant storage apparatus of the present invention.
FIG. 7 is a schematic view of the cut-away structure A-A of FIG. 6 according to the present invention.
The device comprises a cabinet body, a support, a cold air compressor, an air inlet, an air outlet, an air inlet, a plastic partition plate, a protective agent temperature sensor, a support, an air outlet, an air inlet pipe, an air outlet pipe, a storage tank, a cold air box, a support column, a vent hole, a plastic partition plate, a protective agent temperature sensor, a protective pipe 15, an outer extension pipe, a bottom connecting port, a cold air interval, a top connecting port, a liquid adding pipe, a three-layer filter screen cover, a connecting pipe 21, a connecting pipe, a microcomputer flow rate control valve 22, a syringe 23, a syringe, a 24, an injection pump, a 25, an anti-backflow kettle, a 26, a shaking table, a 27, a blood collection bag, a 28 and a blood sample temperature sensor.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations. Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the utility model, as claimed, but is merely representative of selected embodiments of the utility model. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings or orientations or positional relationships that the products of the present invention are conventionally placed in use, and are only for convenience of describing the present invention and simplifying the description, but do not indicate or imply that the device or element to which the description refers must have a specific orientation, be constructed in a specific orientation, and be operated, and thus should not be construed as limiting the present invention. Furthermore, the terms "first," "second," "third," and the like are used solely to distinguish one from another and are not to be construed as indicating or implying relative importance.
As shown in fig. 1, the intelligent infusion device for the cryoprotectant of the hematopoietic stem cells comprises a low-temperature super-clean bench, a cryoprotectant low-temperature storage device and a microcomputer infusion device, wherein the cryoprotectant low-temperature storage device and the microcomputer infusion device are arranged in the low-temperature super-clean bench, a cold air compressor 3 is arranged outside the low-temperature super-clean bench, the cold air compressor 3 is communicated with the interior of the cryoprotectant low-temperature storage device, and the microcomputer infusion device is detachably connected with the cryoprotectant low-temperature storage device.
As shown in fig. 3, the low temperature super clean bench include the cabinet body 1 and support 2, 2 upper ends of support with the lower terminal surface of the cabinet body 1 links firmly, 1 top of the cabinet body is equipped with the freeze drying subassembly, 1 upper surface of the cabinet body is equipped with inlet opening 4, be equipped with high-efficient filter screen on the inlet opening 4, the freeze drying subassembly with inlet opening 4 through connection, 1 bottom of the cabinet body is equipped with exhaust vent 5, 1 inside ultraviolet ray disinfection lamp that is equipped with of the cabinet body.
As shown in fig. 3, the cryoprotectant low-temperature preservation device is arranged inside the cabinet body 1, the cold air compressor 3 is arranged at the lower part of the cabinet body 1, the lower part of the cabinet body 1 is connected with an air inlet pipe 6 and an air outlet pipe 7, and the cold air compressor 3 is communicated with the interior of the cryoprotectant low-temperature preservation device through the air inlet pipe 6.
Cryoprotectant low temperature save set include bin 8, ice king box 9, cold air box 10 and support column 11, ice king box 9 set up in inside cold air box 10, bin 8 set up in inside ice king box 9, support column 11 through connection in cold air box 10 bottom, support column 11 is equipped with two, two support column 11 lower extremes respectively with air-supply line 6 and play tuber pipe 7 detachable are connected, cold air box 10 passes through support column 11 through connection with air-supply line 6 and play tuber pipe 7.
As shown in fig. 3 and 7, the lateral wall of ice king box 9 on the close ventilation hole 12 that is equipped with, ice king box 9 inboard bottom one side is equipped with plastics baffle 13, the slope of plastics baffle 13 sets up, storage box 8 bottom is the wedge, storage box 8 set up in between plastics baffle 13 and the ice king box 9, plastics baffle 13 upside is equipped with protectant temperature sensor 14, ice king box 9 bottom opposite side and cold air box 10 bottom correspond the position and all are equipped with bottom connector 16, storage box 8 bottom is connected with outrigger 15, bottom connector 16 is used for holding outrigger 15 and passes through.
As shown in fig. 7, ice king 9 outside and cold wind box 10 inboard between be equipped with and walk wind interval 17, support column 11 top with walk the inside through connection of wind interval 17, ice king 9 top with the corresponding position in cold wind box 10 top is equipped with top connector 18, storage box 8 top is equipped with liquid feeding pipe 19, top connector 18 is used for holding liquid feeding pipe 19, top connector 18 upside is connected with three-layer filter screen cover 20, liquid feeding pipe 19 set up in three-layer filter screen cover 20 is inboard. The bottom of the storage tank 8 is gradually folded from the upper right to the lower, so that the cryoprotectant can flow out conveniently.
As shown in fig. 3 and 4, the microcomputer infusion device comprises a connecting tube 21, a microcomputer flow rate control valve 22, a syringe 23, an injection pump 24, an anti-backflow pot 25 and a shaking table 26, wherein the microcomputer flow rate control valve 22 is arranged in the middle of the connecting tube 21, the end of the connecting tube 21 on one side of the microcomputer flow rate control valve 22 is detachably connected with the outer end of the outer extension tube 15, the end of the connecting tube 21 on the other side of the microcomputer flow rate control valve 22 is detachably connected with the anti-backflow pot 25, the connecting tube 21 between the anti-backflow pot 25 and the microcomputer flow rate control valve 22 is connected with the syringe 23, the injection pump 24 is connected with the syringe 23, the shaking table 26 is used for placing a blood collection bag 27, and the other end of the anti-backflow pot 25 is connected with the blood collection bag 27.
As shown in FIGS. 3 and 4, an indicating cotton plug is arranged inside one end of the backflow prevention pot 25 close to the connecting pipe 21, and a blood sample temperature sensor 28 is arranged on the shaking table 26.
When the device is used specifically, the method comprises the following steps:
opening the three-layer filter screen cover 20, adding the cryoprotectant into the storage tank 8 through the liquid feeding pipe 19, closing the three-layer filter screen cover 20, and inserting the storage tank 8 into the upper ends of the air inlet pipe 6 and the air outlet pipe 7 through the support columns 11;
one end of a connecting pipe 21 is connected with the outer end of the outer extension pipe 15, a syringe 23 is arranged on the injection pump 14 and is connected with the connecting pipe 21, and the other end of the connecting pipe 21 is connected with a backflow prevention pot 25;
opening the low-temperature ultra-clean bench, the ultraviolet lamp and the cold air compressor 3 30min in advance;
when the temperature of the storage tank 8 detected by the protective agent temperature sensor 14 is 2 ℃, connecting the other end of the anti-backflow pot 25 with the cord blood freezing bag 27, flatly laying the cord blood on the shaking table 26, and turning on a switch of the shaking table 26;
when the temperature detection device in the low-temperature super clean bench detects that the temperature in the low-temperature super clean bench is less than 4 ℃, and the blood sample temperature sensor 28 on the shaking table 26 detects that the temperature of the umbilical cord blood cryopreservation bag 27 is less than 4 ℃, the microcomputer flow rate control valve 22 carries out infusion cryopreservation protective agent according to the amount of the umbilical cord blood;
after the infusion of the protective agent with cryopreservation is finished, the microcomputer flow rate control valve 22 is closed, and the injection pump 24 repeatedly pushes and pulls the injector 23, so that the umbilical cord blood is repeatedly mixed in the umbilical cord blood cryopreservation bag 27 and the anti-reflux kettle 25;
after infusion is completed, the cord blood cryopreservation bag 27 is taken down, and the anti-reflux kettle 20 is removed.
The above embodiments are only specific cases of the present invention, and the scope of the present invention includes but is not limited to the product forms and types of the above embodiments, and any suitable changes or modifications of the intelligent infusion device for hematopoietic stem cell cryoprotectant according to the claims of the present invention and those of ordinary skill in the art should fall within the scope of the present invention.
Claims (8)
1. The utility model provides a hemopoietic stem cell cryoprotectant intelligence infusion equipment which characterized in that: the low-temperature preservation device for the cryoprotectant and the microcomputer infusion device are arranged in the low-temperature ultra-clean platform, a cold air compressor is arranged outside the low-temperature ultra-clean platform and communicated with the interior of the low-temperature preservation device for the cryoprotectant, and the microcomputer infusion device is detachably connected with the low-temperature preservation device for the cryoprotectant.
2. The intelligent infusion device of hematopoietic stem cell cryoprotectant according to claim 1, wherein: the low-temperature super-clean bench comprise a cabinet body and a support, the upper end of the support is fixedly connected with the lower end face of the cabinet body, a freeze drying assembly is arranged at the top of the cabinet body, an air inlet hole is formed in the upper surface of the cabinet body, a high-efficiency filter screen is arranged on the air inlet hole, the freeze drying assembly is in through connection with the air inlet hole, an air outlet hole is formed in the bottom of the cabinet body, and an ultraviolet disinfection lamp is arranged inside the cabinet body.
3. The intelligent infusion device of hematopoietic stem cell cryoprotectant according to claim 2, wherein: the low-temperature preservation device for the cryoprotectant is arranged inside the cabinet body, the cold air compressor is arranged on the lower portion of the cabinet body, the lower portion of the cabinet body is connected with the air inlet pipe and the air outlet pipe, and the cold air compressor is communicated with the inside of the low-temperature preservation device for the cryoprotectant through the air inlet pipe.
4. The intelligent infusion device of hematopoietic stem cell cryoprotectant according to claim 3, wherein: cryoprotectant low temperature save set include bin, the king of ice case, cold air box and support column, the king of ice case set up in inside the cold air box, the bin set up in the king of ice incasement portion, support column through connection in the cold air box bottom, the support column is equipped with two sets ofly, two sets of support column lower extreme respectively with the air-supply line is connected with play tuber pipe detachable, the quantity of support column is 2 in every group support column, the cold air box passes through support column through connection with the air-supply line and goes out the tuber pipe.
5. The intelligent infusion device of the hematopoietic stem cell cryoprotectant according to claim 4, wherein: lateral wall of ice king box on the close ventilation hole that is equipped with, ice king box inboard bottom one side is equipped with the plastics baffle, the slope of plastics baffle sets up, the bin bottom is the wedge, the bin set up in between plastics baffle and the ice king box, plastics baffle upside is equipped with protectant temperature sensor, ice king box bottom opposite side corresponds the position with the cold air chest bottom and all is equipped with the bottom connector, the bin bottom is connected with the outrigger, the bottom connector is used for holding the outrigger and passes through.
6. The intelligent infusion device of hematopoietic stem cell cryoprotectant according to claim 5, wherein: the refrigerator comprises a refrigerator body, a refrigerator door, a cold air box, a supporting column top, a top connector, a liquid feeding pipe, a three-layer filter screen cover and a liquid feeding pipe, wherein a wind-running interval is arranged between the outer side of the refrigerator door and the inner side of the cold air box, the supporting column top is connected with the inside through connection of the wind-running interval, the top connector is connected with the top connector corresponding to the position of the top of the cold air box, the top connector is provided with the liquid feeding pipe, the top connector is used for accommodating the liquid feeding pipe, the upper side of the top connector is connected with the three-layer filter screen cover, and the liquid feeding pipe is arranged on the inner side of the three-layer filter screen cover.
7. The intelligent infusion device of the hematopoietic stem cell cryoprotectant according to claim 6, wherein: the microcomputer infusion device comprises a connecting pipe, a microcomputer flow rate control valve, an injector, an injection pump, an anti-backflow kettle and a shaking table, wherein the microcomputer flow rate control valve is arranged in the middle of the connecting pipe, the end part of the connecting pipe on one side of the microcomputer flow rate control valve is detachably connected with the outer end of the outer extension pipe, the end part of the connecting pipe on the other side of the microcomputer flow rate control valve is detachably connected with the anti-backflow kettle, the connecting pipe between the anti-backflow kettle and the microcomputer flow rate control valve is connected with the injector, the injection pump is connected with the injector, the shaking table is used for placing a blood collection bag, and the other end of the anti-backflow kettle is connected with the blood collection bag.
8. The intelligent infusion device of hematopoietic stem cell cryoprotectant according to claim 7, wherein: the anti-return kettle is close to the inside instruction cotton plug that is equipped with of one end of connecting pipe, be equipped with blood specimen temperature sensor on the shaking table.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220356036.3U CN216983320U (en) | 2022-02-22 | 2022-02-22 | Intelligent infusion equipment for hematopoietic stem cell cryoprotectant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220356036.3U CN216983320U (en) | 2022-02-22 | 2022-02-22 | Intelligent infusion equipment for hematopoietic stem cell cryoprotectant |
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| Publication Number | Publication Date |
|---|---|
| CN216983320U true CN216983320U (en) | 2022-07-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202220356036.3U Active CN216983320U (en) | 2022-02-22 | 2022-02-22 | Intelligent infusion equipment for hematopoietic stem cell cryoprotectant |
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| CN (1) | CN216983320U (en) |
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- 2022-02-22 CN CN202220356036.3U patent/CN216983320U/en active Active
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