CN216964161U - BA biological fermentation liquid solvent phase removes protein membrane separation purification device - Google Patents

Abstract

The utility model discloses a BA biological fermentation liquid solvent phase protein removal membrane separation and purification device, which belongs to the technical field of biological fermentation and comprises a bottom plate, wherein a fermentation tank is arranged on the upper surface of the bottom plate, the bottom end of the fermentation tank is connected with the input end of a transfer pump through a guide pipe, the lower surface of the transfer pump is lapped with the upper surface of the bottom plate, and the output end of the transfer pump is communicated with the top of a refining tank through a guide pipe. This biological zymotic fluid solvent of BA removes protein film separation purification device mutually, through setting up the motor, the apparatus further comprises a rotating shaft, electronic hydraulic stem, the telescopic link, the scraper blade, the sleeve, bracing piece and puddler, it makes two scraper blades break away from the fermentation cylinder inner wall to drive the litter rebound through the spring after the sleeve breaks away from the interior bottom of fermentation cylinder, make it not influence stirring effect, make this scheme be convenient for clear up the fermentation cylinder inner wall, the extension of control electronic hydraulic stem shortens and to accomplish the cleaning work to the fermentation cylinder, be favorable to subsequent reprocessing when lightening work burden.

Description

BA biological fermentation liquid solvent phase removes protein membrane separation purification device

Technical Field

The utility model belongs to the technical field of biological fermentation, and particularly relates to a BA biological fermentation liquid solvent phase-removing protein membrane separation and purification device.

Background

BA is used as a biological medicine dissolved in a solvent phase only, the biological fermentation process adopts the solvent phases of acetone, ethyl acetate and the like for biological fermentation to form the biological medicine, a finished product contains a large amount of biological cell wall residues, biological protein, lignin, pigments and other impurities in the production process, and in the extraction and purification process, the purification and the protein removal are carried out through once, twice or even multiple times of refining purification, and the high-purity finished product is formed after activated carbon decoloration.

The traditional process comprises the following steps: the feed liquid passes through a fermentation tank, the fermented feed liquid is conveyed to a refining tank through a transfer pump, the fermented feed liquid enters an impurity removal and decoloration tank after protein removal, a decolorant is intercepted by a filtering unit and then enters centrifugal separation for finished product centrifugation, a solvent is removed, so that a first refined and purified finished product is obtained, the first refined and purified feed liquid enters a second refining tank and a second impurity removal and decoloration tank, the second refined and purified finished product enters a second refined finished product centrifuge after passing through a pull-intercept decolorant filter, so that a second refined and purified finished product is obtained, and mother liquor generated by the first refining process and the second refining process enters a mother liquor collection tank.

In the traditional process, in the primary and secondary refining processes, the removal efficiency of impurities such as cell wall residues, biological protein, lignin, pigments and the like is not high, and the impurities have great influence on the back-end biological pharmacy process, so the impurity removal process is very important, and the industry basically requires that the protein content is less than 0.1%. In the refining and purifying process, besides the long production period, a large amount of solvent is needed, the production cost is high, and mother liquor containing a large amount of impurity protein is formed, so that the yield is low, and the production cost is high.

In-process that uses at the fermentation cylinder, the effect of fermentation of stewing is not good, and consuming time is longer, and its jar internal wall adheres to a large amount of bonds after the fermentation finishes simultaneously, is difficult to carry out high-efficient clearance to its inside, is unfavorable for subsequent reprocessing when increasing work burden.

SUMMERY OF THE UTILITY MODEL

Technical problem to be solved

In order to overcome the defects of the prior art, the utility model provides a BA biological fermentation liquid solvent removal protein membrane separation and purification device, which solves the problems that the production period is long, a large amount of solvent is required to be used, the production cost is high, mother liquor containing a large amount of impurity protein is formed, the yield is low, the production cost is high, the standing fermentation effect is poor and the time consumption is long in the process of using a fermentation tank, and meanwhile, a large amount of adhesive is adhered to the inner wall of a tank body after the fermentation is finished, the inside of the tank body is difficult to efficiently clean, the work load is increased, and the subsequent reprocessing is not facilitated.

(II) technical scheme

In order to achieve the purpose, the utility model provides the following technical scheme: a BA biological fermentation liquid solvent phase removal protein membrane separation and purification device comprises a bottom plate, wherein a fermentation tank is arranged on the upper surface of the bottom plate, the bottom end of the fermentation tank is connected with the input end of a transfer pump through a guide pipe, the lower surface of the transfer pump is in lap joint with the upper surface of the bottom plate, the output end of the transfer pump is communicated with the top of a refining tank through a guide pipe, the lower surface of the refining tank is in lap joint with the upper surface of the bottom plate, a mother liquid discharge valve is arranged at the bottom end of the refining tank, the top of the refining tank is communicated with the top of an impurity removal tank through a guide pipe, the lower surface of the impurity removal tank is in lap joint with the upper surface of the bottom plate, the bottom end of the impurity removal tank is connected with the input end of a circulating pump through a guide pipe, the lower surface of the circulating pump is in lap joint with the upper surface of the bottom plate, the output end of the circulating pump is communicated with a separation membrane device through a guide pipe, and the lower surface of the separation membrane device is in lap joint with the upper surface of the bottom plate, the slag discharge valve is arranged on the right side of the separation membrane device, the right side face of the separation membrane device is communicated with the centrifuge through a guide pipe, the lower surface of the centrifuge is fixedly connected with the upper surface of the bottom plate, and a finished product discharge valve is arranged on one side of the centrifuge.

The utility model discloses a fermentation tank, including drive assembly, pivot, the outer wall of pivot, the output of drive assembly and the top fixed connection of pivot, the outer wall of pivot is provided with a plurality of puddler, the equal fixedly connected with of the left and right sides face of pivot clears up the subassembly, and two clearance subassemblies are located the left and right sides of fermentation tank inner wall respectively, the bottom of pivot and supporting component's top fixed connection, the left and right sides face of supporting component all articulates through the round pin axle has the bracing piece, the other end of bracing piece is articulated through one side of round pin axle and clearance subassembly.

As a further scheme of the utility model: the driving assembly comprises a motor, the upper surface of the motor body is fixedly connected with the lower surface of the fixing plate, the lower surface of the fixing plate is fixedly connected with the upper surface of the fermentation tank through the electric hydraulic rod, and the output shaft of the motor is fixedly connected with the top end of the rotating shaft.

As a further scheme of the utility model: the outer wall of pivot has cup jointed sealed bearing, sealed bearing joint is in the piston board, the piston board sets up in the slide cartridge, the top at the fermentation cylinder of slide cartridge joint, piston board and sleeve are the rectangle design.

As a further scheme of the utility model: the cleaning assembly comprises a scraper, the upper side of the right side face of the scraper is fixedly connected with the left end of the telescopic rod, and the right end of the telescopic rod is fixedly connected with the outer wall of the rotating shaft.

As a further scheme of the utility model: the supporting component comprises a sliding rod, the top end of the sliding rod is fixedly connected with the bottom end of the rotating shaft, the sliding rod is connected in the sleeve in a sliding mode, the left side face and the right side face of the sleeve are hinged to the two supporting rods through pin shafts, the lower surface of the inner wall of the sleeve is fixedly connected with the bottom end of the sliding rod through springs, and the bottom of the sleeve is designed in a spherical mode.

As a further scheme of the utility model: one side of the scraper close to the inner wall of the fermentation tank is designed in an arc shape, and the lower part of the right side surface of the scraper is hinged with the left end of the supporting rod through a pin shaft.

(III) advantageous effects

Compared with the prior art, the utility model has the beneficial effects that:

1. the BA biological fermentation liquid solvent phase removal protein membrane separation and purification device comprises a motor, a rotating shaft, an electric hydraulic rod, a telescopic rod, scraping plates, a sleeve, supporting rods and a stirring rod, wherein the motor can rotate through the rotating shaft and the stirring rod when working, the fermentation effect is improved through a dynamic fermentation mode, the electric hydraulic rod is controlled to be shortened to drive the motor and the rotating shaft to move downwards when cleaning the inner wall of a fermentation tank, the rotating shaft drives the sleeve to be contacted with the bottom in the fermentation tank through a slide rod, the two supporting rods deflect and support the two scraping plates in the process of extruding the sleeve to be fully attached to the inner wall of the fermentation tank, the scraping plates are driven to clean the inner wall of the fermentation tank in the working process of the motor, the electric hydraulic rod is controlled to extend to drive the rotating shaft to move upwards after the sleeve is separated from the bottom in the fermentation tank, the slide rod is driven to move upwards through a spring to separate the two scraping plates from the inner wall of the fermentation tank, make it not influence stirring effect, make this scheme be convenient for clear up the fermentation cylinder inner wall, the extension of control electronic hydraulic stem shortens and to accomplish the cleaning work to the fermentation cylinder, is favorable to subsequent reprocessing when lightening work burden.

2. This BA biological fermentation liquid solvent removes protein membrane separation purification device mutually, through setting up the fermentation cylinder, the transfer pump, the refining jar, the edulcoration jar, the circulating pump, separation membrane device and centrifuge, the feed liquid after the fermentation cylinder fermentation is carried to the refining jar through the transfer pump, get into the edulcoration jar again after removing the albumen, the material after removing the albumen through once refine gets into special selectivity separation membrane device through the circulating pump, with the albumen, impurity and material and solvent separation, obtain high-quality product after centrifuge separation solvent, this technology has higher separation precision, can need not to produce mother liquor in the smart process simultaneously, reduce the loss of material, production cycle and manufacturing cost have been shortened, the finished product quality is higher, the process is more simple and convenient.

3. This biological zymotic fluid solvent of BA removes protein film separation purification device mutually, through setting up the litter, a spring, the telescopic link, piston plate and slide cylinder, the sleeve downstream and with the fermentation cylinder in the contact of bottom after, the spring effectively plays certain supporting role, make difficult appearance card dead unable rotatory condition behind scraper blade and the contact of fermentation cylinder inner wall, improve the clearance effect of scraper blade, the setting of telescopic link is effectively spacing to the scraper blade, prevent its skew position, improve the stability that the scraper blade removed, piston plate and the slide cylinder of rectangle through setting up the rectangle, seal bearing card is in the piston plate, it drives puddler and scraper blade and rotates not influence the pivot when making motor and pivot reciprocate, be favorable to the stirring work of puddler and the clearance work of scraper blade, certain leakproofness is played in addition in effect, the fermentation effect is improved.

Drawings

FIG. 1 is a schematic cross-sectional view of a solid body according to the present invention;

FIG. 2 is a schematic perspective sectional view of a fermenter according to the present invention;

FIG. 3 is a perspective view of the driving assembly of the present invention;

FIG. 4 is a schematic perspective view of a cleaning assembly of the present invention;

FIG. 5 is a perspective view of the support assembly of the present invention;

in the figure: 1. a base plate; 2. a fermentation tank; 3. a drive assembly; 301. a motor; 302. a fixing plate; 303. an electro-hydraulic lever; 4. a transfer pump; 5. a refining tank; 6. a mother liquor drain valve; 7. an impurity removal tank; 8. a circulation pump; 9. a separation membrane device; 10. a slag discharge valve; 11. a centrifuge; 12. a finished product discharge valve; 13. a rotating shaft; 14. a stirring rod; 15. a slide cylinder; 16. a piston plate; 17. sealing the bearing; 18. cleaning the assembly; 181. a squeegee; 182. a telescopic rod; 19. a support assembly; 191. a slide rod; 192. a sleeve; 193. a spring; 20. a support rod.

Detailed Description

The technical solution of the present patent will be described in further detail with reference to the following embodiments.

As shown in fig. 1 to 5, the present invention provides a technical solution: a BA biological fermentation liquid solvent phase removal protein membrane separation and purification device comprises a bottom plate 1, wherein a fermentation tank 2 is arranged on the upper surface of the bottom plate 1, the bottom end of the fermentation tank 2 is connected with the input end of a transfer pump 4 through a conduit, the lower surface of the transfer pump 4 is lapped with the upper surface of the bottom plate 1, the output end of the transfer pump 4 is communicated with the top of a refining tank 5 through a conduit, the lower surface of the refining tank 5 is lapped with the upper surface of the bottom plate 1, the bottom end of the refining tank 5 is provided with a mother liquid discharge valve 6, the top of the refining tank 5 is communicated with the top of an impurity removal tank 7 through a conduit, the lower surface of the impurity removal tank 7 is lapped with the upper surface of the bottom plate 1, the bottom end of the impurity removal tank 7 is connected with the input end of a circulating pump 8 through a conduit, the lower surface of the circulating pump 8 is lapped with the upper surface of the bottom plate 1, the output end of the circulating pump 8 is communicated with a separation membrane device 9 through a conduit, and the lower surface of the separation membrane device 9 is lapped with the upper surface of the bottom plate 1, a slag discharge valve 10 is arranged on the right side of the separation membrane device 9, the right side surface of the separation membrane device 9 is communicated with a centrifuge 11 through a guide pipe, the lower surface of the centrifuge 11 is fixedly connected with the upper surface of the bottom plate 1, and a finished product discharge valve 12 is arranged on one side of the centrifuge 11.

The output of drive assembly 3 and the top fixed connection of pivot 13, the outer wall of pivot 13 is provided with a plurality of puddler 14, the equal fixedly connected with clearance subassembly 18 of the left and right sides face of pivot 13, two clearance subassemblies 18 are located the left and right sides of fermentation cylinder 2 inner wall respectively, the bottom of pivot 13 and the top fixed connection of supporting component 19, supporting component 19's the left and right sides face all articulates through the round pin axle has bracing piece 20, the other end of bracing piece 20 is articulated through one side of round pin axle and clearance subassembly 18.

Specifically, as shown in fig. 1, fig. 2 and fig. 4, the driving assembly 3 includes a motor 301, the upper surface of the body of the motor 301 is fixedly connected with the lower surface of a fixing plate 302, the lower surface of the fixing plate 302 is fixedly connected with the upper surface of the fermentation tank 2 through an electric hydraulic rod 303, the output shaft of the motor 301 is fixedly connected with the top end of a rotating shaft 13, the outer wall of the rotating shaft 13 is sleeved with a sealing bearing 17, the sealing bearing 17 is clamped in a piston plate 16, the rectangular piston plate 16 and a rectangular sliding cylinder 15 are arranged, the sealing bearing 17 is clamped in the piston plate 16, so that the rotating shaft 13 is not influenced to drive the stirring rod 14 and the scraper 181 to rotate while the motor 301 and the rotating shaft 13 move up and down, the stirring operation of the stirring rod 14 and the cleaning operation of the scraper 181 are facilitated, a certain sealing performance is effectively achieved, the fermentation effect is improved, the piston plate 16 is arranged in the sliding cylinder 15, the sliding cylinder 15 is clamped at the top of the fermentation tank 2, piston plate 16 and sleeve 192 are the rectangle design, clearance subassembly 18 includes scraper blade 181, through setting up scraper blade 181, litter 191 drives sleeve 192 and fermentation cylinder 2 bottom contact, the in-process of extrusion sleeve 192 makes two bracing pieces 20 take place to deflect and support two scraper blades 181, make its and fermentation cylinder 2 inner wall fully laminate, drive scraper blade 181 in the motor 301 working process and clear up fermentation cylinder 2 inner wall, thereby and effectively realize carrying out the mesh of clearing up the fermentation cylinder 2 inner wall, the top of scraper blade 181 right flank and telescopic link 182's left end fixed connection, the right-hand member of telescopic link 182 and the outer wall fixed connection of pivot 13, through setting up telescopic link 182, telescopic link 182's setting is effectively spacing to scraper blade 181, prevent its skew position, improve the stability that scraper blade 181 removed.

Specifically, as shown in fig. 1, fig. 3 and fig. 5, the supporting component 19 includes a sliding rod 191, the top end of the sliding rod 191 is fixedly connected with the bottom end of the rotating shaft 13, the sliding rod 191 is slidably connected in a sleeve 192, the left side surface and the right side surface of the sleeve 192 are hinged to the two supporting rods 20 through a pin shaft, the lower surface of the inner wall of the sleeve 192 is fixedly connected with the bottom end of the sliding rod 191 through a spring 193, after the sleeve 192 moves downward and contacts with the bottom in the fermentation tank 2, the spring 193 effectively plays a certain supporting role, so that the scraping plate 181 is not easily jammed and cannot rotate after contacting with the inner wall of the fermentation tank 2, the cleaning effect of the scraping plate 181 is improved, the bottom of the sleeve 192 is designed to be spherical, the side of the scraping plate 181 close to the inner wall of the fermentation tank 2 is designed to be arc, and the lower part of the right side surface of the scraping plate 181 is hinged to the left end of the supporting rod 20 through a pin shaft.

The working principle of the utility model is as follows:

s1, when the separation and purification process is carried out, the feed liquid is fermented by the fermentation tank 2, the motor 301 can rotate through the rotating shaft 13 and the stirring rod 14 when working, the fermented feed liquid is conveyed to the refining tank 5 through the transfer pump 4, enters the impurity removal tank 7 after protein removal, the material after primary refining, protein removal and protein removal enters the special selective separation membrane device 9 through the circulating pump 8, protein, impurities, the material and the solvent are separated, and the solvent is separated by the centrifuge 11 to obtain a high-quality product;

s2, when the inner wall of the fermentation tank 2 needs to be cleaned, the electric hydraulic rod 303 is controlled to be shortened to drive the motor 301 and the rotating shaft 13 to move downwards, the rotating shaft 13 drives the sleeve 192 to contact with the bottom in the fermentation tank 2 through the sliding rod 191, the two support rods 20 deflect and support the two scrapers 181 in the process of extruding the sleeve 192, so that the two support rods are fully attached to the inner wall of the fermentation tank 2, and the scraper 181 is driven to clean the inner wall of the fermentation tank 2 in the working process of the motor 301;

s3, after the cleaning is finished, the electric hydraulic rod 303 is controlled to extend to drive the rotating shaft 13 to move upwards, so that the piston plate 16 moves upwards in the sliding cylinder 15, the sleeve 192 is separated from the bottom in the fermentation tank 2, then the spring 193 drives the sliding rod 191 to move upwards, the sleeve 192 returns to the initial position, the two support rods 20 approach to each other and are separated from the inner wall of the fermentation tank 2 along with the movement of the sleeve 192, and the stirring rod 14 can perform stirring work again.

In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood by those of ordinary skill in the art through specific situations.

Although the preferred embodiments of the present patent have been described in detail, the present patent is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present patent within the knowledge of those skilled in the art.

Claims (6)

1. The utility model provides a BA biological fermentation liquid solvent removes protein membrane separation purification device, includes bottom plate (1), its characterized in that: the upper surface of the bottom plate (1) is provided with a fermentation tank (2), the bottom end of the fermentation tank (2) is connected with the input end of a transfer pump (4) through a guide pipe, the lower surface of the transfer pump (4) is in lap joint with the upper surface of the bottom plate (1), the output end of the transfer pump (4) is communicated with the top of a refining tank (5) through a guide pipe, the lower surface of the refining tank (5) is in lap joint with the upper surface of the bottom plate (1), the bottom end of the refining tank (5) is provided with a mother liquor discharge valve (6), the top of the refining tank (5) is communicated with the top of an impurity removal tank (7) through a guide pipe, the lower surface of the impurity removal tank (7) is in lap joint with the upper surface of the bottom plate (1), the bottom end of the impurity removal tank (7) is connected with the input end of a circulation pump (8) through a guide pipe, the lower surface of the circulation pump (8) is in lap joint with the upper surface of the bottom plate (1), the output end of the circulating pump (8) is communicated with the separation membrane device (9) through a guide pipe, the lower surface of the separation membrane device (9) is overlapped with the upper surface of the bottom plate (1), a slag discharge valve (10) is arranged on the right side of the separation membrane device (9), the right side surface of the separation membrane device (9) is communicated with a centrifugal machine (11) through a guide pipe, the lower surface of the centrifugal machine (11) is fixedly connected with the upper surface of the bottom plate (1), and a finished product discharge valve (12) is arranged on one side of the centrifugal machine (11);

the output of drive assembly (3) and the top fixed connection of pivot (13), the outer wall of pivot (13) is provided with a plurality of puddler (14), the equal fixedly connected with of the left and right sides face of pivot (13) clears up subassembly (18), and two clearance subassemblies (18) are located the left and right sides of fermentation cylinder (2) inner wall respectively, the bottom of pivot (13) and the top fixed connection of supporting component (19), the left and right sides face of supporting component (19) all articulates through the round pin axle has bracing piece (20), the other end of bracing piece (20) is articulated through the round pin axle and one side of clearance subassembly (18).

2. The device for separating and purifying BA biological fermentation broth solvent deproteinized membrane as claimed in claim 1, wherein: drive assembly (3) include motor (301), the upper surface of motor (301) fuselage and the lower fixed surface of fixed plate (302) are connected, the lower surface of fixed plate (302) passes through electronic hydraulic stem (303) and is connected with the upper surface fixed of fermentation cylinder (2), the output shaft of motor (301) and the top fixed connection of pivot (13).

3. The device for separating and purifying BA biological fermentation broth solvent phase deproteinization membrane as claimed in claim 2, wherein: the outer wall of pivot (13) has cup jointed sealed bearing (17), sealed bearing (17) joint is in piston board (16), piston board (16) set up in slide cartridge (15), slide cartridge (15) joint is at the top of fermentation cylinder (2), piston board (16) and sleeve (192) are the rectangle design.

4. The device for separating and purifying BA biological fermentation broth solvent deproteinized membrane as claimed in claim 1, wherein: the cleaning assembly (18) comprises a scraper (181), the upper part of the right side face of the scraper (181) is fixedly connected with the left end of a telescopic rod (182), and the right end of the telescopic rod (182) is fixedly connected with the outer wall of the rotating shaft (13).

5. The device for separating and purifying BA biological fermentation broth solvent deproteinized membrane as claimed in claim 4, wherein: the supporting component (19) includes litter (191), the top of litter (191) and the bottom fixed connection of pivot (13), litter (191) sliding connection is in sleeve (192), the left and right sides face of sleeve (192) all is articulated with two bracing pieces (20) through the round pin axle, the lower surface of sleeve (192) inner wall passes through the bottom fixed connection of spring (193) and litter (191), the bottom of sleeve (192) is spherical design.

6. The device for separating and purifying BA biological fermentation broth solvent deproteinized membrane as claimed in claim 4, wherein: one side of the scraper (181) close to the inner wall of the fermentation tank (2) is arc-shaped, and the lower part of the right side surface of the scraper (181) is hinged with the left end of the support rod (20) through a pin shaft.

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