CN216933589U - Device for establishing minimally invasive tracheoesophageal fistula animal model - Google Patents
Device for establishing minimally invasive tracheoesophageal fistula animal model Download PDFInfo
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- CN216933589U CN216933589U CN202120208116.XU CN202120208116U CN216933589U CN 216933589 U CN216933589 U CN 216933589U CN 202120208116 U CN202120208116 U CN 202120208116U CN 216933589 U CN216933589 U CN 216933589U
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Abstract
The utility model provides a device for establishing trachea esophagus fistula animal model under wicresoft, including at least one trachea side magnet, at least one esophagus side magnet and two at least sacculus pipes, wherein trachea side magnet and esophagus side magnet are the cylinder, and the diameter of trachea side magnet is less than the diameter of esophagus side magnet, open the first through-hole that runs through along radial direction in trachea side magnet middle part, open the second through-hole that runs through along radial direction in esophagus side magnet middle part, the sacculus pipe comprises pipe portion and sacculus portion two parts, sacculus portion connects the one end in pipe portion, the size of first through-hole and second through-hole allows the sacculus portion before aerifing to penetrate, and the card is solid after aerifing. The utility model realizes the minimization of wound and the simplest operation, has very small wound to esophagus and trachea in the operation process and has high success rate of model preparation.
Description
Technical Field
The utility model belongs to the technical field of medical instruments, and particularly relates to a device for establishing a minimally invasive tracheoesophageal fistula animal model.
Background
Although not many patients are clinically treated with Tracheoesophageal fistula (TEF), the treatment is difficult. Tracheoesophageal fistulas can be classified as congenital and acquired (acquired). Congenital tracheoesophageal fistula often coexists with esophageal atresia and is caused by abnormal development of embryos. The causative factors of acquired tracheoesophageal fistulae include trauma, foreign body, tumor, infection, and iatrogenic (balloon compression, esophageal stent placement, etc.).
When the tracheoesophageal fistula is small and local infection is light, the tracheoesophageal fistula can be plugged by fibrin glue under a bronchoscope, but the indication is strictly controlled, otherwise, the main bronchus is blocked by the falling of the fibrin glue to cause a fatal event. For patients with large fistula and serious infection and tissue edema around the fistula, a stent method, a tracheoesophageal fistula incision respective repair method, a gastric or colonic esophageal replacement method by repairing tracheal defects with double valves of esophagus, a tracheoesophageal replacement method by repairing tracheal defects with posterior esophageal valves and colocolic replacement, a tracheoesophageal fistula open-set and esophageal diversion method and the like can be considered. Tracheoesophageal fistulas, once found without active treatment, can lead to aspiration pneumonia with serious complications and even death.
The tracheoesophageal fistula animal model is the basis for researching and innovating the treatment method. At present, the preparation of the tracheoesophageal fistula animal model mainly comprises a drug induction method and an operation method. The drug induction method is suitable for rats and is mainly used for researching the generation mechanism and possible influencing factors of the trachea and esophagus differentiated pancreas and intestine in the embryonic development process. The operation method is to establish fistula between trachea and esophagus by means of surgical operation, and the model prepared with the method is mainly used in exploratory research of various clinical innovative operation modes.
Although the operation method can establish the tracheoesophageal fistula animal model, the operation is complex, the operation wound is large, the success rate is low, meanwhile, the normal anatomical structure of the tracheoesophageal gap is destroyed by the model making operation, the adhesion around the fistula is severe during the second-stage repair operation, the tissue infection edema is obvious, the tolerance of the experimental animal to the second-stage repair operation is poor, and the difference between the experimental animal and the clinically acquired tracheoesophageal fistula case is large. At present, no special instrument or device for preparing the tracheoesophageal fistula animal models of experimental dogs, experimental rabbits and experimental pigs exists. Therefore, it is very important to explore a device and a method for preparing the minimally invasive tracheoesophageal fistula animal model.
Disclosure of Invention
In order to overcome the defects of the prior art, the utility model aims to provide a device for establishing a minimally invasive tracheoesophageal fistula animal model.
In order to achieve the purpose, the utility model adopts the technical scheme that:
a device for establishing a minimally invasive tracheoesophageal fistula animal model comprises at least one trachea side magnet 1, at least one esophagus side magnet 2 and at least two balloon catheters 3, wherein the trachea side magnet 1 and the esophagus side magnet 2 are both cylinders, elliptic cylinders or cuboids, the diameter of the trachea side magnet 1 is smaller than that of the esophagus side magnet 2, a first through hole 11 penetrating through the trachea side magnet 1 is formed in the middle of the trachea side magnet 1 along the radial direction, a second through hole 21 penetrating through the esophagus side magnet 2 along the radial direction is formed in the middle of the esophagus side magnet 2, the balloon catheters 3 are composed of a catheter portion 31 and a balloon portion 32, the balloon portion 32 is connected to one end of the catheter portion 31, and the first through hole 11 and the second through hole 21 are sized to allow the balloon portion 32 before inflation to penetrate through and are clamped after inflation.
The trachea side magnet 1 and the esophagus side magnet 2 are made of neodymium iron boron permanent magnet materials, samarium cobalt materials, aluminum cobalt nickel materials or ferrite materials, and titanium nitride, nickel copper nickel, epoxy resin or parylene coatings are arranged on the surfaces of the trachea side magnet 1 and the esophagus side magnet.
The sizes of the trachea side magnet 1 and the esophagus side magnet 2 are determined according to experimental animals (such as experimental rabbits, experimental dogs and experimental pigs) and the required sizes of fistula orifices of the tracheoesophageal fistula, the maximum size cannot exceed the diameters of the trachea and the esophagus of the experimental animals, and the maximum size is preferably 1/2 with the diameters respectively smaller than the diameters of the trachea and the esophagus.
Compared with the prior art, the utility model has the beneficial effects that:
(1) the minimally invasive and the most simple operation are realized, the esophageal side magnet and the tracheal side magnet can be very easily placed into the esophagus and the trachea by using the balloon catheter, and the trauma to the esophagus and the trachea during the operation process is very small.
(2) After the magnet in the esophagus and the trachea is placed, only the magnetic squeezing is needed to form the fistula by itself, the experimental animal is convenient to manage in the period, and the model preparation success rate is high;
(3) after the magnet is left for 5-10 days, the magnet can automatically fall off and enter the esophagus, a tracheoesophageal fistula is formed, and the magnet is finally discharged out of the body through the digestive tract. During the process, whether the magnet falls off into the digestive tract can be judged by X rays.
(4) By utilizing the magnetic element, the size of the fistula of the tracheoesophageal fistula can be controlled according to the experimental requirement by selecting the proper diameter of the magnet at the trachea side; the establishment position of the fistula can be conveniently controlled according to the experimental requirements.
(5) The diameter of the esophagus side magnet is larger than that of the trachea side magnet, so that after the fistula is established, the magnet can only enter the esophagus and cannot fall into the trachea.
Drawings
FIG. 1 is a schematic view of the structure of the trachea side magnet of the present invention.
Fig. 2 is a schematic diagram of the structure of the esophageal side magnet of the utility model.
FIG. 3 is a schematic view of the balloon catheter structure of the present invention.
FIG. 4 is a schematic view showing a state where the air bag portion of the present invention enters the second through hole.
Fig. 5 is a schematic view showing a state after the esophageal side magnet of the present invention enters the esophagus.
Fig. 6 is a schematic view showing the state of the esophageal side magnet and the tracheal side magnet of the present invention after they enter the esophagus and the trachea, respectively.
Fig. 7 is a schematic view showing the state in which the esophageal side magnet and the tracheal side magnet of the present invention are attracted to each other.
FIG. 8 is a schematic view showing the attraction of the esophageal and tracheal magnets after removal of the balloon catheter in accordance with the present invention.
Fig. 9 is a schematic diagram of the status of the esophageal side magnet and the tracheal side magnet entering into the esophagus and the tracheoesophageal fistula building.
Detailed Description
The embodiments of the present invention will be described in detail below with reference to the drawings and examples.
The utility model relates to a device for establishing a minimally invasive tracheoesophageal fistula animal model, which comprises:
at least one trachea-side magnet 1: the shape of the cylinder, the elliptic cylinder or the cuboid is, in this embodiment, a cylinder is selected, and a first through hole 11 penetrating through the middle of the cylinder is formed in the radial direction, as shown in fig. 1.
At least one esophageal side magnet 2: the magnet 2 is a cylinder, an elliptic cylinder or a cuboid, the embodiment selects a cylinder, and a second through hole 21 is formed in the middle of the cylinder along the radial direction, as shown in fig. 2, the diameter of the magnet 2 on the esophagus side is larger than that of the magnet 1 on the trachea side.
At least two balloon catheters 3: the balloon portion 32 is connected to one end of the catheter portion 31, and the balloon portion 32 is inflated by the catheter portion 31, as shown in fig. 3, and the balloon catheter 3 may be a currently available vasodilator balloon catheter.
The sizes of the trachea side magnet 1 and the esophagus side magnet 2 are determined according to the sizes of experimental animals (such as experimental rabbits, experimental dogs and experimental pigs) and the required fistula orifice of the tracheoesophageal fistula, the maximum size cannot exceed the diameters of the trachea and the esophagus of the experimental animals, and the maximum size is preferably 1/2 with the diameters respectively smaller than the diameters of the trachea and the esophagus.
The first through hole 11 and the second through hole 22 are sized to allow the balloon portion 32 to freely pass therethrough when not inflated, and to be firmly clamped in the first through hole 11 or the second through hole 22 after being inflated, and the balloon portion 32 can be smoothly withdrawn from the first through hole 11 or the second through hole 22 after the balloon portion 32 is deflated. Fig. 4 shows a state where the bag portion 32 is fitted into the second through hole 21.
In the utility model, the trachea side magnet 1 and the esophagus side magnet 2 can be both processed by neodymium iron boron permanent magnet material, samarium cobalt material, aluminum cobalt nickel material and ferrite material, and the surfaces can be treated by titanium nitride, nickel copper nickel, epoxy resin, parylene and other coating layers.
The specific operation path for establishing the minimally invasive tracheoesophageal fistula animal model by using the method is as follows:
as shown in fig. 5, the experimental animal is anesthetized and fixed in the supine position, the laryngeal part of the pharynx is exposed, the saccule part 32 is inserted into the second through hole 21, then the saccule part is inflated and fixed, and the magnetic body 2 at the side of the esophagus is sent to the proper position of the esophagus 4 by using the catheter part 31 (the positioning can be carried out under the X-ray).
As shown in fig. 6, the balloon portion 32 of the other balloon catheter 3 is inserted into the first through hole 11, and then inflated and fixed, and the trachea-side magnet 1 is fed to a suitable position of the trachea 5 by the catheter portion 31 (positioning can be performed under X-ray).
As shown in fig. 7, the esophageal magnet 2 and the tracheal magnet 1 are attracted by the magnetic force.
As shown in fig. 8, the balloon catheter 3 is withdrawn by deflation, and only the indwelling esophageal side magnet 2 and the tracheal side magnet 1 are located in the esophagus 4 and the trachea 5, respectively.
As shown in fig. 9, after 5 to 10 days, the esophageal side magnet 2 and the tracheal side magnet 1 are attracted tightly to each other to make a stoma, and a tracheoesophageal fistula 6 is established. Because the size of fistula is equal to the diameter of the trachea side magnet 1, and the esophagus side magnet 2 is larger than the trachea side magnet 1, the mutually attracted esophagus side magnet 2 and trachea side magnet 1 fall off into the esophagus 4 and cannot enter the trachea 5, so that the drainage is facilitated.
Claims (4)
1. A device for establishing a minimally invasive tracheoesophageal fistula animal model is characterized by comprising at least one trachea side magnet (1), at least one esophagus side magnet (2) and at least two balloon catheters (3), wherein the trachea side magnet (1) and the esophagus side magnet (2) are both cylinders, elliptic cylinders or cuboids, the diameter of the trachea side magnet (1) is smaller than that of the esophagus side magnet (2), a first through hole (11) penetrating through the trachea side magnet (1) is formed in the middle of the trachea side magnet (1) along the radial direction, a second through hole (21) penetrating through the esophagus side magnet (2) is formed in the middle of the esophagus side magnet (2) along the radial direction, each balloon catheter (3) is composed of a catheter part (31) and a balloon part (32), the balloon part (32) is connected to one end of the catheter part (31), and the first through hole (11) and the second through hole (21) are of sizes which allow the balloon part (32) before inflation to penetrate, and is clamped and fixed after being inflated.
2. The device for establishing the minimally invasive tracheoesophageal fistula animal model according to claim 1, wherein the trachea-side magnet (1) and the esophagus-side magnet (2) are made of neodymium-iron-boron permanent magnet materials, samarium-cobalt materials, aluminum-cobalt-nickel materials or ferrite materials, and titanium nitride, nickel-copper-nickel, epoxy resin or parylene coatings are arranged on the surfaces of the trachea-side magnet (1) and the esophagus-side magnet (2).
3. The device for establishing the minimally invasive tracheoesophageal fistula animal model according to claim 1, wherein the sizes of the trachea side magnet (1) and the esophagus side magnet (2) are determined according to the experimental animal and the required stoma size of the tracheoesophageal fistula, and the maximum size cannot exceed the diameter of the trachea and the esophagus of the experimental animal.
4. The device for establishing the minimally invasive tracheoesophageal fistula animal model according to claim 1, wherein the diameters of the trachea-side magnet (1) and the esophagus-side magnet (2) are respectively less than 1/2 of the trachea and the esophagus diameters of the experimental animal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120208116.XU CN216933589U (en) | 2021-01-26 | 2021-01-26 | Device for establishing minimally invasive tracheoesophageal fistula animal model |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120208116.XU CN216933589U (en) | 2021-01-26 | 2021-01-26 | Device for establishing minimally invasive tracheoesophageal fistula animal model |
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| Publication Number | Publication Date |
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| CN216933589U true CN216933589U (en) | 2022-07-12 |
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| CN202120208116.XU Active CN216933589U (en) | 2021-01-26 | 2021-01-26 | Device for establishing minimally invasive tracheoesophageal fistula animal model |
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2021
- 2021-01-26 CN CN202120208116.XU patent/CN216933589U/en active Active
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