CN108175466B - Bronchial fistula plugging instrument - Google Patents
Bronchial fistula plugging instrument Download PDFInfo
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- CN108175466B CN108175466B CN201711382883.7A CN201711382883A CN108175466B CN 108175466 B CN108175466 B CN 108175466B CN 201711382883 A CN201711382883 A CN 201711382883A CN 108175466 B CN108175466 B CN 108175466B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12027—Type of occlusion
- A61B17/12031—Type of occlusion complete occlusion
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12104—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in an air passage
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/1214—Coils or wires
- A61B17/12145—Coils or wires having a pre-set deployed three-dimensional shape
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/1214—Coils or wires
- A61B17/1215—Coils or wires comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
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Abstract
The invention discloses a bronchial fistula plugging instrument which is characterized by comprising a metal net rack woven by nickel-titanium alloy wires, wherein two ligation ends of the metal net rack are respectively provided with a stainless steel sleeve, the metal net rack is in an I-shaped structure, 2-5 layers of high-molecular elastic films are sewed in the metal net rack, the metal net rack comprises a large disk surface and a small disk surface, the large disk surface and the small disk surface are connected through a waist part, the large disk surface and the small disk surface are buckled towards the waist part, and the stainless steel sleeves at the two ends of the metal net rack are arranged in the metal net rack. The invention has enough radial supporting force, can ensure that the fistula orifice is completely blocked, has no residual pores and ensures the success rate of the operation; the axis position adopts the fixed line to tie a knot, pulls two ligature ends of the plugging device to be close to and fixed, realizes the shape of a 'pouring cup' on two sides of the plugging, further enhances the radial supporting force of the waist part of the device and the laminating property of the disc surface and the periphery of the tissue, and avoids the displacement and the falling-off phenomenon of the plugging device.
Description
Technical Field
The invention relates to a bronchial fistula blocking instrument, and belongs to the technical field of medical instruments.
Background
A bronchopleural fistula is an abnormal passage formed between the bronchus and pleura. It can be caused by many reasons, such as tuberculous empyema, lobar pneumonia, lung abscess and postoperative infection. The formation of the chronic empyema is caused by that pus of the chronic empyema erodes adjacent lung tissues and then punctures bronchi, or because lesions in the lung directly invade the thoracic cavity or are ruptured to the pleural cavity to form a fistula, or because of the infection of the empyema caused by thoracocentesis or surgical excision of the empyema. Pus can be coughed out of the bronchus, and in severe cases, a large amount of pus is sucked into the bronchus, so that the patient can be suffocated.
When modern medicine treats the disease, after various complications are effectively controlled, the fistula tract is filled by adopting a technique of injecting glue through a fiberbronchoscope fistula tract to achieve the purpose of treatment. But has the disadvantages that the disease is easy to recur in a short period and needs to be reinjected, and multiple times of reinjection are not suitable. Therefore, the treatment mainly comprises the thoracotomy, and no suitable instrument is clinically used for treating the patient who is not suitable for secondary thoracotomy.
Aiming at the clinical requirements of bronchus pleura fistula plugging, a mushroom-shaped double-disc plugging device is developed. For patients with bronchopleural fistula, the air enters the thoracic cavity through the fistula to cause suppuration in the thoracic cavity, i.e. clinical empyema disease.
In order to treat the patient, the fistula orifice of the bronchus pleura fistula is blocked, but the fistula orifice is connected with the trachea, firstly, the cartilage tissue of the trachea has a blocking effect on the forming of the blocking instrument, and in general, the blocking instrument cannot support the cartilage tissue at the fistula orifice to cause incomplete fistula blockage, so that the operation fails; secondly, because the plugging device is a foreign body to the human body, the stimulation of the foreign body can be caused, the patient can cough/asthma at the initial stage of implantation, at the moment, the tissues around the fistula fluctuate violently, the displacement and the falling of plugging substances are often caused, and the operation failure is caused.
In the process of the bronchial pleural fistula plugging treatment, two difficulties are brought up: 1, the joint performance of the plugging device is good, so that residual pores are ensured after plugging, and residual gas leakage is avoided, otherwise, the operation fails; 2, the plugging device can bear the violent fluctuation of tissues/air pressure near the fistula after being implanted, and does not shift or fall off, otherwise, the operation fails.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: the bronchial fistula plugging instrument has the advantages that the radial supporting force is large, the fistula is completely plugged, the displacement and the dropping are avoided, and the problem of how to treat a patient who is not suitable for secondary thoracotomy to treat bronchial pleura fistula is solved.
In order to solve the technical problem, the technical scheme of the invention is to provide a bronchial fistula blocking instrument which is characterized by comprising a metal net rack woven by nickel-titanium alloy wires, wherein two ligation ends of the metal net rack are respectively provided with a stainless steel sleeve, the metal net rack is of an I-shaped structure, 2-5 layers of high-molecular elastic films are sewed in the metal net rack, the metal net rack comprises a large disk surface and a small disk surface, the large disk surface and the small disk surface are connected through a waist, the large disk surface and the small disk surface are buckled towards the waist, and the stainless steel sleeves at the two ends of the metal net rack are trapped in the metal net rack.
Preferably, the two ligation ends of the metal net frame are fixedly connected through a surgical knot tied by a fixing thread, the fixing thread adopts 1-0 to 2-0 suture, and the fixing thread is 1-6 strands.
Preferably, the diameter of the waist is between 4mm and 20mm, the diameter of the large disc surface is between 12mm and 30mm, the diameter of the small disc surface is between 8mm and 24mm, the diameter of the large disc surface is 8mm to 18mm larger than that of the waist, and the diameter of the small disc surface is 6mm to 16mm larger than that of the waist.
Preferably, the metal net rack is formed by weaving 48-144 nickel-titanium alloy wires, and the ratio of the interval between the nickel-titanium alloy wires in the same rotation direction to the wire diameter of the nickel-titanium alloy wires is 1: 1-3: 1; the diameter of the nickel-titanium alloy wire is between 0.10 and 0.30 mm.
Preferably, the waist part is a vertical cylindrical support waist with the height of 1-4mm, and the support waist is in right-angle transition with the large disc surface and the small disc surface respectively.
Preferably, the sizes of the macromolecular elastic films in the large disc surface and the small disc surface are respectively the same as the diameters of the large disc surface and the small disc surface, and the area of the macromolecular elastic film in the waist part is 2/5 to 2/3 of the area of the macromolecular elastic film in the large disc surface; the large dish surface and the small dish surface are respectively provided with 5 layers of high molecular elastic films, and 1 layer of high molecular elastic film is sewed in the waist part close to the large dish surface; the elastic polymer film is sewn on the metal net frame through sewing needles and sutures, the thickness of the sewing needles is 0.2-0.4mm, and the specifications of the sutures are 3-0/4-0/5-0.
Preferably, the edge of the disk surface of the large disk surface is laminated, and the disk surface of the large disk surface is in stepped fit at the inner side of the fistula.
Preferably, the waist is internally provided with an inner net, the nickel-titanium wires of the inner net are thicker than those of the waist, and the inner net is cylindrical with two concave ends.
Preferably, the inner side of the waist part is sewed with a self-expanding bracket through a suture, and the wall thickness of the self-expanding bracket is 0.3mm-0.6 mm.
Preferably, the waist is filled with gel for blocking gas from escaping.
The invention adopts the inverted house gap design, namely the large disc surface is arranged at the outer side of the chest cavity/body, and the small disc surface is arranged at the side of the trachea, so that the invention is more suitable for the airflow exchange dynamics of the trachea and the outer cavity and avoids the falling off of the plugging device caused by the change of air pressure; the design of the stiffened right-angle waist is adopted, so that the deformation of the waist and the forming effect of the disc surface of the occluder are better, and meanwhile, the defect is excessively clamped by a right angle, so that the occluder is more stably fixed; by adopting the design of wire diameter, enough radial supporting force can be provided, the fistula can be completely plugged, no residual pores exist, and the success rate of the operation is ensured; the axis position adopts the fixed line to tie a knot, pulls two ligature ends of the plugging device to be close to and fixed, realizes the shape of a 'pouring cup' on two sides of the plugging, further enhances the radial supporting force of the waist part of the device and the laminating property of the disc surface and the periphery of the tissue, avoids the residual gas leakage and avoids the displacement and the falling-off phenomenon of the plugging device.
The membrane sewing position of the invention can effectively block residual shunt of gas around the membrane, further promote endothelial climbing and accelerate endothelialization. The waist inner layer is enhanced in a double-layer composite manner by adding the inner layer net or the self-expansion cutting bracket, the outer layer net is relatively soft, the irritation to the tissue around the fistula is small, the inner layer is hard, and the radial supporting force of the waist of the plugging device is ensured; and the gel can be filled, and the gel is blocked by the blocking grids and the polymer membrane and cannot overflow, so that the gas is completely blocked from escaping. Meanwhile, the gel is extruded and deformed under the pulling of the fixing line, so that the radial supporting force of the waist part of the plugging device is ensured.
Drawings
Figure 1 is a schematic view of a bronchial stoma occlusion device;
fig. 2 is a schematic view showing a large disc surface of a bronchial fistula blocking instrument with a stack of the disc surface edges;
fig. 3 is a schematic view of the bronchial stoma occluding device with an inner mesh in the waist;
figure 4 is a schematic view of a bronchial stoma occluding device with a self-expanding stent in the waist;
fig. 5 is a schematic illustration of the filling of gel in the waist of a bronchial stoma occluding device;
fig. 6 is a schematic view of the small disc surface of the tracheal side of the bronchial stoma occluding instrument with an internally threaded ligating steel sleeve.
Detailed Description
In order to make the invention more comprehensible, preferred embodiments are described in detail below with reference to the accompanying drawings.
Example 1
The invention relates to a bronchial fistula blocking instrument, which comprises a metal net rack 1 woven by nickel-titanium alloy wires, a medical suture, a high-molecular elastic film and a tightening wire, and is shown in figure 1. The two ligation ends of the metal net rack 1 are kneaded and fixed by a stainless steel sleeve 2, the metal net rack 1 is made into an I-shaped structure as shown in figure 1, and 2-5 layers of high molecular elastic films are sewed in the metal net rack 1 by medical sutures. The metal net rack 1 comprises a large disk surface 4 and a small disk surface 5, and the large disk surface 4 is connected with the small disk surface 5 through a waist 3.
The tightening line is formed by a suture line passing through the metal net rack 1 and the macromolecule elastic film and knotting the stainless steel sleeves 2 at the two ends of the metal net rack 1 to form an annular loop.
The large disc surface 4 is arranged at the outer side of the chest cavity/body, and the small disc surface 5 is arranged at the side of the trachea, so that the design is more suitable for the airflow exchange dynamics of the trachea and the outer cavity, and the blockage device is prevented from falling off due to the change of air pressure; wherein the ligation steel sleeve of the large disc surface 4 is provided with internal threads and can be connected with a conveying device to be matched with a sheath tube for conveying and releasing.
The diameter of the waist 3 is between 4mm and 20mm, the diameter of the large disc surface 4 is between 12mm and 30mm, the diameter of the small disc surface 5 is between 8mm and 24mm, the diameter of the large disc surface 4 is 8mm to 18mm larger than that of the waist 3, the diameter of the small disc surface 5 is 6mm to 16mm larger than that of the waist 3, and the large disc surface 4 and the small disc surface 5 are buckled towards the waist 3.
The invention is woven by 48-144 nickel-titanium alloy wires, the wires of the nickel-titanium alloy wires are arranged as close as possible, namely the ratio of the interval between the nickel-titanium alloy wires in the same rotation direction to the wire diameter of the nickel-titanium alloy wires is 1: 1 to 3: 1;
the diameter of the used nickel-titanium alloy wire is 0.10-0.30mm, is thicker than that of the traditional niti wire weaving device, can provide stronger supporting performance, and ensures that the occluder is not easy to deform;
the waist part 3 is a vertical cylindrical support waist with the height of 1-4 mm. The support waist is in right-angle transition with the large dish surface 4 and the small dish surface 5 respectively, so that the support waist can be ensured to be well formed, and the dish surfaces are not easy to deform.
The ligation steel sleeves (namely the stainless steel sleeves 2) at the two ends of the metal net rack 1 are sunken in the metal net rack 1, so that the clamping performance of the large disk surface 4 and the small disk surface 5 is increased, and the wine pouring cup shape is formed, and the plugging device is prevented from shifting and falling off.
The use can block gaseous polymer elastic membrane, for example PTFE, PEEK etc. have certain elastic film material, can guarantee that gaseous not leak through the diaphragm, guarantee simultaneously that the pinhole space that the diaphragm produced can elastic recovery closure in the sewing process.
The sizes of the macromolecular elastic films in the large disc surface 4 and the small disc surface 5 are respectively the same as the diameters of the large disc surface 4 and the small disc surface 5, and the area of the macromolecular elastic film in the waist part 3 is 2/5-2/3 of the area of the macromolecular elastic film in the large disc surface 4; the position of the film is shown in figure 1, 5 layers of high molecular elastic films are respectively arranged on the large disc surface 4 and the small disc surface 5, and 1 layer of high molecular elastic film is sewed in the waist part 3 near the large disc surface 4.
The seam position of the 3-layer seam film can effectively block residual shunting of gas around the film sheet, further promote endothelial climbing and accelerate endothelialization.
The film material is sewn on the plugging device by using a sewing needle with the thickness of 0.2-0.4mm and a 3-0/4-0/5-0 suture, and the thread hole is controlled to be the minimum size, so that the pore space of the needle eye is prevented from being expanded by air pressure.
As shown in figure 1, the two ligation ends of the plugging device are knotted by using a fixing line, the two ligation ends of the plugging device are pulled to be close to and fixed, the shape of a 'wine pouring cup' on the two sides of the plugging device is realized, the radial supporting force of the waist 3 of the device is further enhanced due to the inward sinking of the shape of the 'wine pouring cup' on the waist 3, the waist 3 is more tightly attached to the defect, the attachment degree of the disk surface and the tissue of the plugging device is enhanced simultaneously, and the residual gas leakage at the edge of the disk surface is avoided. Meanwhile, the design that the suture is knotted and the ligation steel sleeves at the two ends are tightened reduces the risk of displacement and falling off of the plugging device, 1-0, 2-0 or 3-0 suture is adopted as the fixing thread, 1-6 strands of the fixing thread can be adopted, and the thread ends are fixed by surgical knots.
Example 2
As shown in fig. 2, the edge of the large disc surface 4 has a stacking phenomenon, i.e. the thickness of the disc surface is increased, which can prevent the edge of the disc surface from wearing the peripheral tissues of the fistula and reduce the stimulation to the human body. Simultaneously, the thickening quotation (being the quotation of big quotation 4) can be the ladder laminating in the inside of fistula, further guarantees the leakproofness of shutoff.
The rest is the same as in example 1.
Example 3
As shown in figure 3, the invention is compositely reinforced by an inner layer net and an outer layer net, the inner layer net is formed by weaving thicker nickel-titanium wires, namely, the nickel-titanium wires of the inner layer net are thicker than those of the waist part 3, and the shape of the inner layer net is a cylinder with two concave ends. The outer layer net (the nickel-titanium wires woven into the metal net rack 1) of the embodiment is relatively soft, the irritation to the peripheral tissues of the fistula is small, and the inner layer net is hard, so that the radial supporting force of the waist of the plugging device is ensured.
Meanwhile, the shape memory retraction of the inner net is also beneficial to the approaching and fixing of the two ends of the plugging device, so that the shape of a 'pouring cup' on the two sides of the plugging device is realized, the radial supporting force of the waist part 3 and the fitting property of the disc surface and the periphery of the tissue are further enhanced, and the displacement and the falling-off phenomenon of the plugging device are avoided.
The rest is the same as in example 1.
Example 4
As shown in figure 4, a cutting self-expanding bracket is sewn on the inner side of the waist part 3 by using a suture, the wall thickness of the self-expanding bracket is 0.3mm-0.6mm, the inner layer and the outer layer are compounded to enhance the waist support property, meanwhile, the outer layer net is relatively soft, the stimulation to the peripheral tissues of the fistula is small, the inner layer bracket is hard, the radial support force of the waist part of the plugging device is ensured, and simultaneously, the outer layer net can be driven by the pores of the inner layer bracket (namely the self-expanding bracket) to be clamped into the wall of the fistula, so that the plugging.
The rest is the same as in example 1.
Example 5
As shown in figure 5, the waist part 3 of the invention is filled with gel, the gel has a plugging grid and the barrier of the polymer membrane can not overflow, and the gas can be prevented from escaping. After the gel is filled, the fixing wires are used for tightening the steel sleeves at the two ends of the plugging device, the axis position of the plugging device forms an inverted wine cup shape, the gel is extruded to be completely deformed and fit with the fistula, complete plugging of gas is realized, and meanwhile, the radial supporting force of the waist of the plugging device is further ensured.
The rest is the same as in example 1.
Example 6
As shown in figure 6, the conveying method of the invention is transtracheal interventional conveying, namely, the small disc surface 5 at the trachea side is provided with a ligation steel sleeve with internal threads, can be connected with a conveying device and is matched with a sheath tube to carry and release through a trachea.
The rest is the same as in example 1.
Claims (6)
1. A bronchial fistula plugging instrument is characterized by comprising a metal net rack (1) woven by nickel-titanium alloy wires, wherein two ligation ends of the metal net rack (1) are respectively provided with a stainless steel sleeve (2), the metal net rack (1) is of an I-shaped structure, 2-5 layers of high-molecular elastic films are sewed in the metal net rack (1), the metal net rack (1) comprises a large disk surface (4) and a small disk surface (5), the large disk surface (4) and the small disk surface (5) are connected through a waist (3), the large disk surface (4) and the small disk surface (5) are buckled towards the waist (3), and the stainless steel sleeves (2) at two ends of the metal net rack (1) are sunk into the metal net rack (1); the metal net rack (1) is formed by weaving 48-144 nickel-titanium alloy wires, and the ratio of the interval between the nickel-titanium alloy wires in the same rotation direction to the wire diameter of the nickel-titanium alloy wires is 1: 1 to 3: 1; the diameter of the nickel-titanium alloy wire is between 0.10 and 0.30 mm; the waist part (3) is a vertical cylindrical support waist with the height of 1-4mm, and the support waist is in right-angle transition with the large disc surface (4) and the small disc surface (5) respectively; an inner net is arranged in the waist part (3), the nickel-titanium wires of the inner net are thicker than those of the waist part (3), and the inner net is cylindrical with two concave ends; the waist part (3) is filled with gel for blocking gas from escaping.
2. The bronchial fistula plugging device according to claim 1, wherein the two ligated ends of the metal mesh frame (1) are fixedly connected by means of a surgical knot using a fixation thread, the fixation thread being 1-0 to 2-0 sutures, and the fixation thread being 1-6 strands.
3. The bronchial fistula plugging device of claim 1, wherein the diameter of the waist portion (3) is between 4mm and 20mm, the diameter of the greater disc surface (4) is between 12mm and 30mm, the diameter of the smaller disc surface (5) is between 8mm and 24mm, the diameter of the greater disc surface (4) is 8mm to 18mm larger than that of the waist portion (3), and the diameter of the smaller disc surface (5) is 6mm to 16mm larger than that of the waist portion (3).
4. The bronchial fistula plugging device of claim 1, wherein the dimensions of the polymeric elastic films in the large disc surface (4) and the small disc surface (5) are respectively the same as the diameters of the large disc surface (4) and the small disc surface (5), and the area of the polymeric elastic film in the waist portion (3) is 2/5 to 2/3 of the area of the polymeric elastic film in the large disc surface (4); the large dish surface (4) and the small dish surface (5) are respectively provided with 5 layers of high molecular elastic films, and 1 layer of high molecular elastic film is sewed in the waist part (3) close to the large dish surface (4); the macromolecule elastic film is sewed on the metal net rack (1) through sewing needles and sutures, the thickness of the sewing needles is 0.2-0.4mm, and the specification of the sutures is 3-0/4-0/5-0.
5. The bronchial fistula plugging device of claim 1, wherein the disc surface edges of the large disc surface (4) are stacked, and the disc surface of the large disc surface (4) is in stepped fit inside the fistula.
6. A bronchial stoma occlusion device according to claim 1, characterized in that a self-expanding scaffold with a wall thickness of 0.3mm to 0.6mm is sewn on the inside of the waist (3) by means of a suture.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711382883.7A CN108175466B (en) | 2017-12-20 | 2017-12-20 | Bronchial fistula plugging instrument |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711382883.7A CN108175466B (en) | 2017-12-20 | 2017-12-20 | Bronchial fistula plugging instrument |
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| CN108175466A CN108175466A (en) | 2018-06-19 |
| CN108175466B true CN108175466B (en) | 2020-06-09 |
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| CN201711382883.7A Active CN108175466B (en) | 2017-12-20 | 2017-12-20 | Bronchial fistula plugging instrument |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109498074A (en) * | 2019-01-04 | 2019-03-22 | 上海形状记忆合金材料有限公司 | Method Wholly-degradable plugging device dedicated driving means and its connect with plugging device |
| CN112656474B (en) * | 2019-10-15 | 2022-09-02 | 先健科技(深圳)有限公司 | Plugging device |
| CN111317869B (en) * | 2020-02-29 | 2021-12-31 | 福建医科大学附属第二医院 | Injectable hydrogel for treating bronchial pleural fistula |
| WO2022252463A1 (en) * | 2021-06-03 | 2022-12-08 | 上海形状记忆合金材料有限公司 | Implantable instrument having vertical double-concave structure |
| CN117357188A (en) * | 2023-12-07 | 2024-01-09 | 上海欣吉特生物科技有限公司 | Tissue ligation system and use method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103654883B (en) * | 2013-12-06 | 2017-01-04 | 深圳市先健生物材料技术有限公司 | The stopper of with locking mechanism |
| CN103705274B (en) * | 2013-12-20 | 2017-03-29 | 先健科技(深圳)有限公司 | Plugging device |
| CN106037862B (en) * | 2016-07-12 | 2019-07-23 | 上海形状记忆合金材料有限公司 | Variable waist designs occluder for left auricle |
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