CN216823442U

CN216823442U - Vascular tissue impedance testing device

Info

Publication number: CN216823442U
Application number: CN202122884671.7U
Authority: CN
Inventors: 吴飞; 李桂香; 许为康; 谭仲威; 陈军
Original assignee: Institute Of Health Medicine Guangdong Academy Of Sciences
Current assignee: Institute of Biological and Medical Engineering of Guangdong Academy of Sciences
Priority date: 2021-11-23
Filing date: 2021-11-23
Publication date: 2022-06-28
Anticipated expiration: 2031-11-23

Abstract

The utility model discloses a vascular tissue impedance testing device which comprises a single chip microcomputer, a display module, a heating device, a signal acquisition and processing module, a precise linear transmission module, a blasting pressure testing module and a storage module, wherein the single chip microcomputer is connected with the display module; the output end of the signal acquisition processing module is connected with the input end of the singlechip; the output end of the single chip microcomputer is connected with the input end of the display module, the input end of the temperature rising device, the input end of the precise linear transmission module, the input end of the blasting pressure testing module and the input end of the storage module. The vascular tissue impedance testing device is low in cost, convenient to operate and small in error, and can be widely applied to the technical field of medical equipment.

Description

Vascular tissue impedance testing device

Technical Field

The utility model relates to the technical field of medical equipment, in particular to a vascular tissue impedance testing device.

Background

Electrosurgical devices have an important role in tissue cutting and vessel closure. A bipolar vessel sealer is a novel electro-surgical device, and the principle of the bipolar vessel sealer is that by means of physical compression and electric energy influence between two electrodes, protein denaturation occurs to a tissue clamped between the electrodes, and therefore a vessel is sealed. At present, the method is mainly used for separating tissues with more small vessels, such as liver lobes, lung lobes, uterine ligaments and the like in surgical operations. However, such equipment is expensive, needs to be maintained by a specially-assigned person, and has high use cost. The impedance of the vascular tissue can change along with the changes of the temperature, the applied current frequency, the voltage and the like of the bipolar forceps, and the impedance change rule of the tissue is unclear, so that the research, development, popularization and application of energy type vascular welding equipment and in-vitro diagnosis equipment are seriously restricted. The reason is mainly the lack of a test system for researching the change rule of the vascular tissue. The change rule of the blood vessel impedance is to study the dynamic change process of the biological impedance of the biological blood vessel under complex conditions. The blood vessel is fine, the surface has lubricity and good biological elasticity, and the blood vessel is wrapped by organism tissues. In the actual measurement process, the clamping is difficult, and the accurate biological impedance is difficult to obtain. In addition, in the research process, in order to simulate the actual welding closing process, the blood vessel is required to be kept at a certain temperature, current stimulation and pressure, the test conditions are difficult to quantitatively control and research in vitro, the blood vessel welding closing quality is generally evaluated by adopting burst pressure, and the blood vessel clamping measurement by a handheld differential pressure gauge is complicated and has no standard test platform.

At present, a test platform special for testing the impedance change rule of the blood vessel under the complex condition does not exist at home and abroad, the platform is usually independently set up for measuring the impedance of the blood vessel to research the impedance change of blood vessel tissues under the influence of single factors, and the operation has certain randomness in the test process.

SUMMERY OF THE UTILITY MODEL

In view of this, the embodiment of the present invention provides a vascular tissue impedance testing device with low cost, convenient operation and small error.

The utility model provides a vascular tissue impedance testing device which comprises a single chip microcomputer, a display module, a heating device, a signal acquisition and processing module, a precise linear transmission module, a blasting pressure testing module and a storage module, wherein the single chip microcomputer is connected with the display module;

the output end of the signal acquisition processing module is connected with the input end of the singlechip; the output end of the single chip microcomputer is connected with the input end of the display module, the input end of the temperature rising device, the input end of the precise linear transmission module, the input end of the blasting pressure testing module and the input end of the storage module.

Optionally, the device further comprises a power module and a key module;

the power output end of the power supply module is connected with the power input end of the single chip microcomputer, and the output end of the key module is connected with the input end of the single chip microcomputer.

Optionally, the signal acquisition and processing module includes a thermocouple, a pressure sensor and a signal conditioning circuit;

the burst pressure testing module is composed of air pump equipment and a differential pressure meter.

Optionally, the device body is provided with a pressure table, a first pressurizing block, a second pressurizing block, an SD card storage tank, a heat flow grid, a first impedance test clip, a second impedance test clip, a first clamping table, a second clamping table, a first blood vessel clip, an air pump interface end, a heat dissipation grid, an insulating rod, a glass cover and an electrical stimulation signal wire hole.

Optionally, the display module includes a current frequency display screen, a temperature rise display screen, and a voltage display screen.

One technical solution in the above embodiment of the present invention has the following advantages: the embodiment of the utility model comprises a single chip microcomputer, a display module, a temperature rising device, a signal acquisition and processing module, a precise linear transmission module, a blasting pressure testing module and a storage module; the output end of the signal acquisition processing module is connected with the input end of the singlechip; the output end of the single chip microcomputer is connected with the input end of the display module, the input end of the temperature rising device, the input end of the precise linear transmission module, the input end of the blasting pressure testing module and the input end of the storage module. The vascular tissue impedance testing device is low in cost, convenient to operate and small in error.

Drawings

FIG. 1 is a schematic diagram of a frame of an apparatus according to the present invention;

fig. 2 is a schematic structural diagram of the device body according to the present invention.

Detailed Description

Optionally, the device further comprises a power module and a key module;

the burst pressure testing module is composed of an air pump device and a differential pressure meter.

The utility model will be further explained and explained with reference to the drawings and the embodiments in the description.

As shown in fig. 1, the vascular tissue impedance testing device of the present invention includes a single chip, a storage module, a display module, a key module, a power module, a precise linear transmission module, a signal acquisition and processing module, a temperature raising device and a burst pressure testing module.

The single chip microcomputer is responsible for processing and calculating signals and controlling related actuating mechanisms;

the power supply module is responsible for supplying power to the single chip microcomputer and related accessory equipment;

the display module is responsible for displaying numerical values and graphs;

the key module is responsible for generating a test process control signal;

the storage module is responsible for storing relevant test data;

The temperature rising device generates heat convection air to heat the sample to be measured;

the signal acquisition processing module is responsible for amplifying, filtering and transmitting electric signals generated by the surface temperature of the blood vessel acquired by the thermocouple in real time and the pressure applied to the surface of the blood vessel acquired by the pressure sensor to the singlechip;

the precise linear transmission module is responsible for precisely moving the position of the clamping table;

the air pump device in the burst pressure testing module is responsible for introducing preset air pressure into the blood vessel, and the differential pressure gauge in the burst pressure testing module is used for monitoring and recording the change of the pressure in the blood vessel in real time.

Fig. 2(a), (b), and (c) are schematic structural diagrams of the device body provided in this embodiment, and as shown in fig. 2, the meanings of the reference numerals appearing in fig. 2(a), (b), and (c) are explained as follows: wherein, 1 generation is gauge pressure platform; 2 represents a first pressuring block; 3 represents a current frequency display screen; 4 represents a power switch; 5 represents an SD card slot; 6 represents a voltage display screen; 7 represents a blood vessel; 8 represents a heat flow grid; 9 denotes a first impedance test clip; 10 denotes a second holding stage; 11 represents a first vascular clamp; 12 represents the pump interface end; 13 denotes a heat dissipation grid; 14 represents a first warming display screen; 15 represents an insulating rod; 16 represents a second warming display screen; 17 represents a second pressuring block; 18 represents a thermocouple; 19 denotes a first clamping table; 20 denotes a first guide rail; 21 denotes a second impedance test clip; 22 represents a second guide rail; 23 represents a second vascular clamp; 24 represents a glass cover; and 25 represents an impedance test clip and an electrical stimulation signal line hole.

With reference to the schematic structural diagram of fig. 2, the vascular tissue impedance testing apparatus according to the embodiment of the present invention has the following working principle:

as shown in fig. 2, the vascular tissue impedance testing device structure includes a pressure table (as shown by the mark 1 in fig. 2 (b)), a pressure applying block 1 (as shown by the mark 2 in fig. 2 (b)), a current frequency display screen (as shown by the mark 3 in fig. 2 (b)), a power switch (as shown by the mark 4 in fig. 2 (b)), an SD card slot (as shown by the mark 6 in fig. 2 (b)), a voltage display screen (as shown by the mark 6 in fig. 2 (b)), a blood vessel (as shown by the mark 7 in fig. 2 (b)), a heat flow grid (as shown by the mark 8 in fig. 2 (b)), an impedance testing clip 1 (as shown by the mark 9 in fig. 2 (b)), a holding table 2 (as shown by the mark 10 in fig. 2 (b)), a blood vessel clip 1 (as shown by the mark 11 in fig. 2 (b)), an air pump interface end (as shown by the mark 12 in fig. 2 (b)), a heat dissipation grid (as shown by the mark 13 in fig. 2 (b)), a temperature increasing display screen 1 (as shown by the mark 14 in fig. 2 (b)), a temperature display screen (14, 2(b) An insulating rod (as marked 15 in fig. 2 (b)), a temperature-raising display screen 2 (as marked 16 in fig. 2 (b)), a pressurizing block 2 (as marked 17 in fig. 2 (c)), a thermocouple (as marked 18 in fig. 2 (c)), a holding table 1 (as marked 19 in fig. 2 (c)), a guide rail 1 (as marked 20 in fig. 2 (c)), an impedance test clip 2 (as marked 21 in fig. 2 (c)), a guide rail 2 (as marked 22 in fig. 2 (c)), a blood vessel clip 2 (as marked 23 in fig. 2 (c)), a glass cover (as marked 24 in fig. 2 (a)), an impedance test clip, and an electrical stimulation signal line hole (as marked 25 in fig. 2 (a)).

The vascular tissue impedance testing device mainly comprises a single chip microcomputer, a storage module, a display module, a power supply module, a precise linear transmission module, a signal acquisition and processing module, a heating device and a blasting pressure testing module, wherein the precise linear transmission module, the pressurizing module, a constant-temperature heating module, the blasting pressure testing module and the signal acquisition and processing module are used, and requirements of different testing tasks can be met through calling and combining LCR impedance testers, high-frequency power supplies and other devices of different modules.

As shown in fig. 2(c), the single chip microcomputer is responsible for processing and calculating signals and controlling related actuating mechanisms; the power supply module is responsible for supplying power to the singlechip and related accessory equipment; the display module is responsible for displaying numerical values; the storage module is responsible for storing relevant test data; the key module comprises a start key, a record key and a stop key.

As shown in fig. 2(c), the precise linear transmission module moves up and down the pressurizing block 1 (fig. 2(b)2) and the pressurizing block 2 (fig. 2(c)17) under the driving of the servo motor to realize the operation of pressing and holding the blood vessel. The clamping table 1 (fig. 2(c)19) and the clamping table 2 (fig. 2(b)10) are driven on the guide rail by a servo motor and move on the guide rail 1 (fig. 2(c)20), so that the distance between the two clamping tables is adjusted. The pressure table (figure 2(b)1) is controlled by a single chip microcomputer AT89s51 in the guide rail 2 (figure 2(c)22) to be driven by a servo motor to realize accurate positioning.

The pressurizing module is used for controlling the movement and the positioning of the precise linear transmission module by the single chip microcomputer AT89s51, then adjusting the distance between the two ends of the clamping mechanism and clamping a blood vessel AT the fixed end, adjusting the position of the pressure clamping mechanism to plug the blood vessel into the pressure clamping mechanism, adjusting the pressure clamping speed and the pressing distance of the pressurizing block 2 (figure 2(c)17) according to experimental requirements, realizing the pressurization of blood vessel tissues, simulating the clamping of a jaw, and converting and inputting the pressure detected by the pressure sensor into the single chip microcomputer for displaying and storing through the signal acquisition processing module.

The constant temperature heating module mainly comprises a temperature rising device and a temperature rising display screen (figure 2(b)16), a heat flow grid diagram 2(b)8 and a heat dissipation grid (figure 2(b)13), wherein the temperature rising device and the temperature rising display screen are composed of a single chip microcomputer, a thermocouple (figure 2(c)18) and a signal acquisition circuit: the heating device is mainly characterized in that a heating pipe element is started and disconnected by a single chip microcomputer through MOS (metal oxide semiconductor) pipe control, the temperature is displayed on a heating display screen 1 (fig. 2(b)14) after the heating temperature is set, a thermocouple collects the surface temperature of a blood vessel in real time, the surface temperature enters the single chip microcomputer for AD conversion through a signal collecting and processing module and then is displayed on the heating display screen 2 (fig. 2(b)16), and the heating pipe element generates heat in a water tank and heats a sample to be measured through heat flow grids and convection air.

The explosion pressure testing module is characterized in that a single chip microcomputer AT89s51 sends signals to a left impedance testing clamp and a right impedance testing clamp (an impedance testing clamp 1, an impedance testing clamp 2 (a clamp 2, a clamp c and a clamp 21)) of a clamping mechanism, an air pump device is connected with an air pump interface end (a clamp 2, a clamp b and a clamp c and a clamp 2, the air pump device inflates a blood vessel under the control of the single chip microcomputer, and a differential pressure gauge is connected to one end of the blood vessel and used for monitoring and recording the change of pressure in the blood vessel in real time.

The signal acquisition processing module is composed of an electric signal amplifying and filtering conditioning circuit which is composed of a thermocouple, a pressure sensor, an amplifier, a capacitor, a resistor and the like.

The operation of the vascular tissue impedance measurement device according to the embodiment of the present invention will be described in further detail below.

In the embodiment, the isolated New Zealand rabbit blood vessel is used for researching the impedance rule of the blood vessel tissue, the blood vessel is placed in a refrigerator for cold storage and preservation for 12 hours after impurities such as blood in a lumen are removed by cleaning, the tissue is cleaned by normal saline before the experiment, thick connective tissue containing fat on the surface of the blood vessel is removed, and the surface of a sample is smooth and clean to ensure that the contact performance is good. The rabbit blood vessel with the length of 40 +/-0.5 mm and the diameter of 5.11 +/-0.1 mm is adopted to carry out the research on the impedance rule by using the vascular tissue impedance testing device disclosed by the utility model, and the method comprises the following steps:

1. current frequency-vessel impedance measurement procedure:

inserting an SD card into a card slot (figure 2(b)6), turning on a power switch (figure 2(b)4), starting to heat to the operating room temperature (26 ℃), opening a glass cover (figure 2(a)24), initializing to set an LCR tester and a high-frequency power supply, selecting an insulating rod (figure 2(b)15) with a proper size and inserting the insulating rod into a blood vessel to be tested, moving up and down through a pressurizing block 1 (figure 2(b)2) and a pressurizing block 2 (figure 2(c)17) to press the blood vessel, clamping the blood vessel (figure 2(b)7) at a fixed end, setting an electric signal frequency parameter, clamping two ends of the high-frequency power supply on a blood vessel clamp to be tested (a blood vessel clamp 1 (figure 2(b)11) and a blood vessel clamp 2 (figure 2(c)23)), clamping an impedance tester on two-end impedance testing clamps (an impedance testing clamp 1, a figure 2(b)9 and an impedance testing clamp 2 (figure 2(c)21) of the blood vessel to be tested, the glass cover (fig. 2(a)24) is covered to prevent external interference, the impedance of the vascular tissue changes under the stimulation of current (the signal frequency is adjusted in an increasing mode) with the collection frequency range of 200 KHz, and the data is automatically stored in the SD card (fig. 2(b) 6).

2. Temperature-vascular impedance measurement procedure:

inserting an SD card into the card slot (figure 2(b)6), opening a power switch (figure 2(b)4), starting heating to the operating room temperature (26 ℃), selecting an insulating rod with a proper size to be inserted into a blood vessel to be tested, moving up and down through a pressurizing block 1 (figure 2(b)2) and a pressurizing block 2 (figure 2(c)17) to clamp the blood vessel, clamping the blood vessel (figure 2(b)7) at a fixed end, clamping two ends of a high-frequency power supply on the blood vessel clamp to be tested (the blood vessel clamp 1 (figure 2(b)11) and the blood vessel clamp 2 (figure 2(c)23)), clamping an LCR impedance tester on the impedance testing clamp (the impedance testing clamp 1, figure 2(b)9 and the impedance testing clamp 2 (figure 2(c)21) at two ends of the blood vessel, covering a constant-temperature glass cover (figure 2(a)24), setting constant-temperature heating parameters to heat the blood vessel to be tested (figure 2(b)7), the set temperature is displayed on a temperature-rising display screen 1 (fig. 2(b)14), a thermocouple (fig. 2(c)18) directly measures the surface temperature of the blood vessel and feeds back the temperature-rising device in real time to keep the temperature constant, an acquisition constant current source sets the impedance change of the blood vessel tissue with the temperature range of 26-65 ℃ under 350KHz (the minimum frequency of the influence of the imaginary part of the impedance in the experiment) sine wave stimulation, the temperature data is displayed on the temperature-rising display screen 2 (fig. 2(b)16), and the data is automatically stored in an SD card (fig. 2(b) 6).

3. Pressure-vessel impedance measurement procedure:

turning on a power switch (figure 2(b)4), starting heating to the operating room temperature (26 ℃), opening a glass cover (figure 2(a)24), initializing and setting an impedance tester, moving up and down through a pressurizing block 1 (figure 2(b)2) and a pressurizing block 2 (figure 2(c)17) to clamp a blood vessel, clamping the blood vessel (figure 2(b)7) at a fixed end, clamping an LCR impedance tester on an impedance test clamp (impedance test clamp 1, figure 2(b)9 and an impedance test clamp 2 (figure 2(c)21) at two ends of the blood vessel, adjusting the clamping speed and the pressing distance according to the pressure range (0-14N) required by the experiment, and storing pressure and impedance data.

4. Voltage-vessel impedance measurement procedure:

turning on a power switch (figure 2(b)4), starting heating to the operating room temperature (26 ℃), opening a glass cover, selecting an insulating rod with a proper size to be inserted into a blood vessel to be tested, moving up and down through a pressurizing block 1 (figure 2(b)2) and a pressurizing block 2 (figure 2(c)17) to clamp the blood vessel, clamping the blood vessel (figure 2(b)7) at a fixed end, clamping an LCR impedance tester on an impedance test clamp (an impedance test clamp 1, figure 2(b)9 and an impedance test clamp 2 (figure 2(c)21) at two ends of the blood vessel, setting the stimulation frequency of a high-frequency power supply to be 350KHz (the virtual impedance part influences the minimum frequency in the experiment), clamping two ends of the high-frequency power supply on the blood vessel clamps (the blood vessel clamp 1 (figure 2(b)11) and the blood vessel clamp 2(c)23) at two ends of the blood vessel to be tested, continuously and gradually pressurizing, covering the glass cover to prevent external interference, the impedance change of the blood vessel in the voltage range from 20-400V is collected, and the impedance data is automatically stored in the SD card.

5. The blood vessel bursting pressure measuring process comprises the following steps:

turning on a power switch (figure 2(b)4), moving up and down through a pressurizing block 1 (figure 2(b)2) and a pressurizing block 2 (figure 2(c)17) to realize the operation of clamping the blood vessel, fixing one end of a blood vessel figure 2(b)7 on a clamping mechanism and locking, fixing the other end of the blood vessel figure at one end of a digital differential pressure gauge device, connecting an air pump device at an air pump interface end (figure 2(b)12), setting the speed of air flow blowing into the blood vessel, covering a glass cover, setting a heating parameter to be constant temperature to be near the body temperature (37.5 ℃), and recording pressure change data in the blood vessel by the digital differential pressure gauge in real time.

In summary, compared to the prior art, the present invention can realize the following functions:

1. the utility model can clamp blood vessels in any range through a special mechanical structure;

2. the utility model can adjust the clamping position to adapt to blood vessels with different lengths;

3. the utility model can simulate various environmental temperatures;

4. the utility model can simulate the clamping action of a doctor;

5. the utility model can realize long-time blood vessel impedance measurement and result storage;

6. the utility model can simulate the stimulation of electric signals with various frequencies and voltages;

7. the utility model can meet different vessel impedance testing tasks through the combination and integration of different modules.

The utility model is used as a vascular tissue impedance testing device, realizes the integration of various environmental conditions such as temperature, frequency, voltage, pressure and the like and the device standardization, researchers only need to process blood vessels in advance and assemble the blood vessels into the device, and relevant equipment is connected into a testing system, so that the impedance rule research of the blood vessels under the operation environment of the electrosurgical equipment can be conveniently simulated and realized, the device is portable and easy to use, has small error, provides a convenient and easy-to-use vascular impedance rule research system for researchers of energy type vascular closure equipment, improves the test efficiency, can accelerate the research on the change and mechanism of the vascular impedance under the high-frequency electrosurgical operation environment, and accelerates the research, development, transformation, application and popularization of high-frequency vascular closure operation equipment.

For the step numbers in this embodiment, they are set for convenience of illustration only, the order between the steps is not limited at all, and the execution order of each step in the embodiment can be adaptively adjusted according to the understanding of those skilled in the art.

While the preferred embodiments of the present invention have been illustrated and described, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the utility model as defined by the appended claims.

Claims

1. A vascular tissue impedance testing device, characterized by: the system comprises a singlechip, a display module, a heating device, a signal acquisition and processing module, a precise linear transmission module, a blasting pressure testing module and a storage module;

the output end of the signal acquisition processing module is connected with the input end of the single chip microcomputer; the output end of the single chip microcomputer is connected with the input end of the display module, the input end of the temperature rising device, the input end of the precise linear transmission module, the input end of the bursting pressure testing module and the input end of the storage module.

2. The vascular tissue impedance testing device of claim 1, wherein: the device also comprises a power module and a key module;

3. The vascular tissue impedance testing device of claim 1, wherein:

the signal acquisition processing module comprises a thermocouple, a pressure sensor and a signal conditioning circuit;

4. A vascular tissue impedance testing device according to any one of claims 1 to 3, wherein: the device body is provided with a pressure table, a first pressurizing block, a second pressurizing block, an SD card storage tank, a heat flow grid, a first impedance test clamp, a second impedance test clamp, a first clamping table, a second clamping table, a first blood vessel clamp, an air pump interface end, a heat dissipation grid, an insulating rod, a glass cover and an electrical stimulation signal wire hole.

5. A vascular tissue impedance testing device according to any one of claims 1 to 3, wherein: the display module comprises a current frequency display screen, a heating display screen and a voltage display screen.