CN216799920U

CN216799920U - External microsome product partial shipment preserves integrated device

Info

Publication number: CN216799920U
Application number: CN202122906667.6U
Authority: CN
Inventors: 郝祝兵; 余斐斐; 孙易; 胡卓汉
Original assignee: Research Institute For Liver Disease Shanghai Co ltd
Current assignee: Research Institute For Liver Disease Shanghai Co ltd
Priority date: 2021-11-25
Filing date: 2021-11-25
Publication date: 2022-06-24
Anticipated expiration: 2031-11-25

Abstract

The utility model discloses an integrated device for subpackaging and storing in-vitro microsome products, which comprises at least one lower box and an upper box covered on the lower box, wherein a hollow cavity is arranged in the lower box, a cold source is placed in the hollow cavity, two hollow grooves sunken downwards are formed in the top of the upper box, a first hollow groove is formed by a bottom support plate and support rods respectively connected with two sides of the support plate, the top ends of the support rods are connected with the top wall of the upper box, a test tube rack is placed in the first hollow groove, a sample adding groove is placed in a second hollow groove, a clamping part is arranged on the outer edge of the top of the sample adding groove, and the sample adding groove is clamped in the hollow groove. According to the integrated device for subpackaging and storing the in-vitro microsome product, the cold source is placed in the lower box, so that the maintenance of a good low-temperature environment of the product in the subpackaging process is guaranteed, the enzymatic activity of the product is further improved, and the like. The sample adding groove and the test tube rack are prepared through the upper box, so that the required laboratory table top operation space is saved, and the split charging of large-batch products can be supported.

Description

External microsome product partial shipment preserves integrated device

Technical Field

The utility model relates to the field of subpackaging and storing devices for in-vitro microsome products, in particular to an in-vitro microsome product subpackaging and storing integrated device.

Background

In the medical field, microsomes such as liver microsomes, intestinal microsomes, and kidney microsomes are subcellular tissues containing different tissue metabolizing enzymes, and are important test systems for evaluating drug metabolism and drug-drug interactions.

Microsomes are subcellular tissues obtained by centrifuging primary cells at different levels, and repeated freezing and thawing can affect the enzyme activity and the product quality of the microsomes and further affect the experimental results. Therefore, the microsomal solution is generally prepared and then transferred to-80 ℃ for storage for subsequent use. According to the conventional use amount, 0.5-1 mL of microsome solution with the protein concentration of 20mg/mL is generally recommended to be stored in each freezing storage tube, so that the use is convenient for each experiment. The microsome is dispensed by rapid processing in a low temperature environment, so that the microsome can maintain high enzyme activity.

At present, the conventional method is to subpackage the microsome solution into test tubes on a test table, and then transfer and refrigerate the test tubes. This operation destroys the enzymatic activity of the microsomes and also requires a large operating floor space.

SUMMERY OF THE UTILITY MODEL

In view of the above disadvantages existing in the storage of the in vitro microsome product at present, the utility model provides an integrated device for subpackaging and storing the in vitro microsome product, which ensures the maintenance of good low-temperature environment of the product in the subpackaging process, further improves the enzyme activity of the product, and the like, and saves the table space at the same time.

In order to achieve the above purpose, the embodiment of the utility model adopts the following technical scheme:

the utility model provides an integrated device is preserved in partial shipment of external microsome product, includes that at least one is down the box and one covers the last box on lower box, establish the cavity in the box down, placed the cold source in it, it sets up two undercut's cavity dead slots to go up the box top, and first cavity dead slot is formed by bottom sprag board and the bracing piece of difference joint support board both sides, the bracing piece top is connected with the interior roof of last box, the test-tube rack has been placed to first cavity dead slot, the test-tube rack is equipped with a plurality of test tube accommodation holes, the test-tube rack is placed in the backup pad, the application of sample groove has been placed to the cavity dead slot in the second, the application of sample groove top is outer along setting up joint portion, the application of sample groove joint is in the cavity dead slot.

According to one aspect of the utility model, the gap formed by the upper box inner wall and the hollow groove is filled with an insulating layer.

According to one aspect of the utility model, the cross section of the sample adding groove is rectangular or square with the same upper and lower sizes.

According to one aspect of the utility model, the clamping portion is a lug or a hem.

According to one aspect of the utility model, the test tube rack is an 81-hole test tube rack.

According to one aspect of the utility model, the cold source is ice or a cold or a freezer.

According to one aspect of the utility model, the height of the hollow groove is smaller than the height of the inner cavity formed by the connection of the upper box and the lower box.

According to one aspect of the utility model, the upper surface of the lower case is peripherally provided with a groove, and the groove is embedded with the upper case.

According to one aspect of the utility model, the upper case and the lower case are made of polyurethane.

According to one aspect of the utility model, the material of the sample loading slot is polyvinyl chloride or polypropylene.

The implementation of the utility model has the advantages that: by the scheme, the subpackaging and the preservation of the microsome products are integrated, and the sample moving step and time during subpackaging and preservation are effectively saved. Place the cold source in the lower box, guaranteed the maintenance of product at the good low temperature environment of partial shipment in-process, further, it also fills in the clearance that goes up box inner wall and hollow groove and has had the heat preservation, and then has improved product quality such as product enzyme activity. In addition, the integrated device saves the required laboratory table board operation space and can support the large-batch product subpackaging. Simultaneously, the upper and lower box can superpose, can dismantle, the cleaning and disinfection of being convenient for, and test-tube rack and application of sample groove all are connected with last box demountable installation, convenient washing, simple operation.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to these drawings without creative efforts.

Fig. 1 is an appearance schematic diagram of an integrated device for subpackaging and storing an in-vitro microsome product according to the utility model.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

As shown in FIG. 1, a lower case 1, an upper case 2, a test tube rack 3, a sample addition slot 4, a case wall 5, and a test tube hole 6.

As shown in figure 1, the integrated device for subpackaging and preserving the microsome products outside the body is divided into an upper layer of box and a lower layer of box which are the same in size, wherein the upper layer of box and the lower layer of box which are the same in size can be overlapped and can be detached, and the boxes are similar to food boxes. The upper and lower two-layer box can be connected in an embedded manner or in a clamping manner, and a groove is arranged on the periphery of the upper surface of the lower box 1 and is embedded with the upper box 2. The lower box 1 may be a three-dimensional rectangle with a hollow cavity formed therein, or may be other shapes, such as a three-dimensional square or a circle with a hollow cavity formed therein. Wherein 1 open-top of lower box comprises the heat preservation material, has placed the cold source in it, plays the effect of heat preservation box, the cold source can be ice-cube or cold-storage agent package or refrigerator, the ice-cube is directly placed in the box, the cold-storage agent package can paste and place wherein, conveniently gets and puts. The heat insulation material is polyurethane. The upper box 2 is provided with a sample adding groove 4 and a test tube rack 3, and the upper box 2 forms a split charging layer. Go up 2 tops of box and set up two undercut's cavity grooves, the height in cavity groove is less than the height of the inner chamber that upper and lower box connected and form. First cavity groove is formed by the bottom sprag board and the bracing piece of joint support both sides respectively, the bracing piece top is connected with last box inside roof, test-tube rack 3 has been held to first cavity inslot, test-tube rack 3 is equipped with a plurality of test tube accommodation holes, test-tube rack 3 directly places in the backup pad, handheld test-tube rack both ends can be accomplished and get and put the simple operation. The test-tube rack 3 comprises a bottom beam, a mounting plate horizontally arranged is arranged above the bottom beam, and test tube holes 6 for placing test tubes are formed in the mounting plate. In this embodiment, the test tube rack is an 81-hole test tube rack. Other test tube racks, such as 72-hole or 90-hole racks, may also be used as the case may be. The application of sample groove 4 has been placed to the cavity inslot in the second, 4 tops of application of sample groove are along setting up joint portion outward, 4 joints of application of sample groove are in the cavity inslot. The clamping part is a hanging lug or a folded edge. When the test-tube rack 3 and the sample adding groove 4 are detachably arranged in the hollow groove, the clamping parts are clamped on the box wall 5, the taking and the placing are convenient, and the test-tube rack 3 is directly stored to the ultra-low temperature refrigerator after the sub-packaging is completed, so that the space is saved.

The sample adding groove 4 is formed by integrally molding a base and a hollow inner cavity supported on the base. The cross section of the inner cavity can be set to be a closing structure with two sides inclined towards the middle, and the closing part at the bottommost part is of an arc transition structure. In this embodiment, the cross section of the hollow inner cavity is configured to be the same in size from top to bottom, and can be rectangular or square, that is, the cross section of the sample adding slot 4 is rectangular or square with the same size from top to bottom. Therefore, the solution can be conveniently and quickly distributed in the gun, and the operation time is saved.

In this embodiment, lower box 1 designs into the box that keeps warm, has guaranteed the product in the maintenance of the good low temperature environment of partial shipment in-process, and then has improved product quality such as product enzyme activity. Go up the box and be prepared with detachable application of sample groove 4 and test-tube rack 3, saved required laboratory table surface operating space, can support the large batch to carry out the product partial shipment.

In this embodiment, the gap formed by the inner wall of the upper box 2 and the hollow groove is filled with a thermal insulation layer, and the upper box 2 is also made of a thermal insulation material, such as polyurethane. Can further maintain good low-temperature environment and improve the product quality such as the enzyme activity of the product.

In this embodiment, the material of the sample adding slot 4 is polyvinyl chloride, and may also be polypropylene. The upper layer and the lower layer of the device can be detached before use, so that the device is convenient to clean and disinfect.

The integrated device is preserved in partial shipment of external microsome product of this embodiment is when using, at first put into ice-cube or cold-storage agent package precooling at lower box 1 after, then superpose box 2, install application of sample groove 4 and 81 hole test-tube rack 3 again, the frozen tube is put into upper test-tube rack 3 for use, the microsome solution that obtains has separated adds upper application of sample groove 4, adopt the calandria to divide the microsome solution in application of sample groove 4 to the frozen tube fast partial shipment, accomplish the partial shipment after, can directly move upper test-tube rack 3 to-80 ℃ ultra-low temperature refrigerator or storage box with the frozen tube and preserve. The upper and lower layers can also be transferred to a low-temperature refrigerator for preservation.

The implementation of the utility model has the advantages that: by the scheme, the subpackaging and the preservation of the microsome products are integrated, and the sample moving step and time during subpackaging and preservation are effectively saved. The lower box is internally provided with a cold source, so that the maintenance of a good low-temperature environment of the product in the split charging process is ensured, and further, a heat-insulating layer is filled in a gap formed by the inner wall of the upper box and the hollow groove, so that the product quality such as the activity of the enzyme is improved. In addition, the integrated device saves the required laboratory table board operation space and can support the large-batch product subpackaging. Simultaneously, the upper and lower box can superpose, can dismantle, the cleaning and disinfection of being convenient for, and test-tube rack and application of sample groove all are connected with last box demountable installation, convenient washing, simple operation.

The above description is only an embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention disclosed herein are intended to be covered by the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.

Claims

1. The utility model provides an integrated device is preserved in external microsome product partial shipment, includes at least one box down and one covers the last box on the box down, its characterized in that, establish cavity in the box down, placed the cold source in it, it sets up two undercut's cavity grooves to go up the box top, and first cavity groove is formed by bottom support board and the bracing piece of joint support both sides respectively, the bracing piece top is connected with last box roof, the test-tube rack has been held in the first cavity inslot, the test-tube rack is equipped with a plurality of test tube accommodation holes, the test-tube rack is placed in the backup pad, the application of sample groove has been placed in the cavity inslot in the second, application of sample groove top is outer along setting up joint portion, application of sample groove joint is in the cavity inslot.

2. The integrated device for split charging and storage of in vitro microsome products as claimed in claim 1, wherein the gap formed by the inner wall of the upper box and the hollow groove is filled with an insulating layer.

3. The integrated device for split charging and storage of in vitro microsome products as claimed in claim 1, wherein the section of the sample loading slot is rectangular or square with the same upper and lower sizes.

4. The integrated device for split charging and storage of in vitro microsome product as claimed in claim 1, wherein the clamping portion is a lug or a folded edge.

5. The integrated device for split charging and preservation of in vitro microsomal products according to claim 1, wherein the test tube rack is an 81-hole test tube rack.

6. The integrated device for subpackaging and preserving of extra-corporeal microsomal products as claimed in claim 1, wherein the cooling source is ice cubes or a coolant pack or a refrigerator.

7. An in vitro microsome product dispensing and storing integrated device as claimed in any one of claims 1 to 6, wherein the height of the hollow groove is smaller than the height of the inner cavity formed by the connection of the upper and lower cases.

8. The integrated device for split charging and storage of a microsomal product from outside of the body as claimed in claim 7, wherein the periphery of the upper surface of the lower box is provided with a groove, and the groove is engaged with the upper box.

9. The integrated device for dispensing and storing an in vitro microsome product according to claim 8, wherein the upper case and the lower case are made of polyurethane.

10. The integrated device for split charging and storage of in vitro microsome product of claim 9, wherein the material of the sample loading slot is polyvinyl chloride or polypropylene.