CN216792244U

CN216792244U - Gastric function fluorescence immunochromatography detection card

Info

Publication number: CN216792244U
Application number: CN202122732378.9U
Authority: CN
Inventors: 朱汝祥; 谢露; 宋雪峰; 杨博林
Original assignee: Shanghai Changrun Biotechnology Co ltd
Current assignee: Shanghai Changrun Biotechnology Co ltd
Priority date: 2021-11-09
Filing date: 2021-11-09
Publication date: 2022-06-21
Anticipated expiration: 2031-11-09

Abstract

The utility model discloses a gastric function fluorescence immunochromatographic detection card, relating to the technical field of fluorescence immunochromatographic detection cards and comprising the following steps: the top end of the lower clamping shell is provided with an upper clamping shell; and the sampling hole is arranged at the top end of the upper clamping shell. According to the utility model, the upper clamping shell is pulled upwards by arranging the clamping shell mechanism, the upper fixing pin is separated from the lower fixing hole, then the test paper mechanism is placed in the lower clamping shell, the test paper mechanism extrudes the top end of the rubber column, the rubber column rotates, when the test paper mechanism completely moves to the inner part of the lower clamping shell, the rubber column resets and rotates, the test paper mechanism is clamped, then the upper fixing pin at the bottom end of the upper clamping shell is aligned with the lower fixing hole, the upper clamping shell is pushed, the upper clamping shell moves to drive the fixing bulge to move, the fixing bulge moves to fix the test paper mechanism, and the test paper mechanism is favorably fixed in position by the structure, so that the precision of the device is improved.

Description

Gastric function fluorescence immunochromatography detection card

Technical Field

The utility model relates to the technical field of fluorescence immunochromatography detection cards, in particular to a fluorescence immunochromatography detection card for gastric function.

Background

The immunochromatography technology is an analysis method combining the immunological technology and the chromatographic technology developed at the end of the 20 th century, and is based on the principle that a nitrocellulose membrane is used as a solid phase carrier, colloidal gold, fluorescent microspheres and the like are used as tracing markers and are combined with antibodies, under the percolation action or capillary action of a microporous membrane, the combination of the marked antibodies and the antigens or secondary antibodies is traced by utilizing the high specificity of antigen-antibody reaction and the specific color of the colloidal gold or the fluorescent microspheres and excitation spectrum, and red strips or spots visible to the naked eye are displayed or the fluorescence intensity of specific wavelengths is detected by an instrument, so that the qualitative or quantitative analysis of the objects to be detected is realized.

Most of the current test paper strips are composed of a bottom plate, a sample pad, a combination pad, a coating film and a water absorption pad, the structure is complex, the cost is high, fluorescent labeled antibodies are not easy to be uniformly sprayed on the combination pad, the plate-to-plate difference is large, the precision is low, the current card shell needs to be manually marked with numerical values, the recording efficiency is low, and no anti-skid device is arranged outside the card shell.

SUMMERY OF THE UTILITY MODEL

The utility model aims to: in order to solve the problems of low precision of test paper strips, low recording efficiency and incapability of preventing the card shell from skidding, the gastric function fluorescence immunochromatography detection card is provided.

In order to achieve the purpose, the utility model provides the following technical scheme: a gastric function fluorescence immunochromatography detection card comprising:

the top end of the lower clamping shell is provided with an upper clamping shell;

the sampling hole is arranged at the top end of the upper clamping shell;

the detection window is arranged at the top end of the upper clamping shell and is positioned at one end of the sample adding hole;

the clamping shell mechanism is arranged at the bottom end of the upper clamping shell and inside the lower clamping shell and is used for fixing the lower clamping shell and the upper clamping shell;

the test paper mechanism is arranged in the lower clamping shell and is positioned at the bottom end of the detection window and used for qualitatively or quantitatively analyzing the object to be detected.

As a still further scheme of the utility model: the card shell mechanism comprises grafting unit, block unit and auxiliary unit in advance, grafting unit is including setting up the rubber column of card shell inner wall under in advance, the rubber column is provided with a plurality ofly to evenly distributed is in the both sides of card shell inner wall under, just the level of rubber column is a little higher than the height of test paper mechanism.

As a still further scheme of the utility model: the block unit is including setting up the last fixed foot in last card shell bottom, one side of going up fixed foot is provided with fixed arch, the inside of card shell down be provided with last fixed foot assorted fixed orifices down, go up fixed foot, fixed orifices down and be provided with a plurality ofly, and correspond the inside of distributing in last card shell bottom and card shell down.

As a still further scheme of the utility model: the auxiliary unit is including setting up the two-dimensional code on last calorie of shell top, the two-dimensional code is located the one end that the application of sample hole kept away from the detection window, the one end that the application of sample hole was kept away from to the detection window is provided with skid proof block, skid proof block is located the top of last calorie of shell.

As a still further scheme of the utility model: the test paper mechanism comprises a sample unit, a test unit and a collection unit, wherein the sample unit comprises a sample pad arranged in a lower clamping shell, a bottom plate is arranged at the bottom end of the sample pad, and a plurality of lower fixing holes are formed in the outer side of the bottom plate.

As a still further scheme of the utility model: the test unit comprises a coating film which is arranged at the top end of the lower clamping shell and located at one end of the sample pad, a plurality of detection lines are arranged at the top end of the coating film and evenly distributed at the top end of the coating film, and a quality control line is arranged at one end of the coating film and located at the detection line.

As a still further scheme of the utility model: the collecting unit is including setting up the pad that absorbs water on the bottom plate top, the pad that absorbs water is located the one end that quality control line kept away from the detection line, just the one end that the pad that absorbs water is close to quality control line is provided with the hydrophobic layer.

Compared with the prior art, the utility model has the beneficial effects that:

1. by arranging the clamping shell mechanism, the upper clamping shell is pulled upwards firstly, the upper fixing pin is separated from the lower fixing hole, then the test paper mechanism is placed in the lower clamping shell, the test paper mechanism extrudes the top end of the rubber column, the rubber column rotates, when the test paper mechanism completely moves into the lower clamping shell, the rubber column resets and rotates, the test paper mechanism is clamped, then the upper fixing pin at the bottom end of the upper clamping shell is aligned with the lower fixing hole and pushes the upper clamping shell, the upper clamping shell moves to drive the fixing bulge to move, the fixing bulge moves and fixes the test paper mechanism, and the test paper mechanism is favorably operated at a fixed position by the structure, so that the precision of the device is improved;

2. by arranging the test paper mechanism, the object to be detected moves to the detection line from the sample adding hole to the sample pad and then moves to the detection line through the sample pad, the object to be detected is combined with the antibody by taking the nitrocellulose membrane in the detection line as a solid phase carrier and taking colloidal gold, fluorescent microspheres and the like as tracer markers, under the percolation action or capillary action of the microporous membrane, the combination of the labeled antibody and the antigen or the secondary antibody is traced by utilizing the high specificity of the antigen-antibody reaction and the specific color and excitation spectrum of the colloidal gold or the fluorescent microsphere, then the object to be detected is collected by a water absorption pad, and a macroscopic red strip or spot is displayed by a detection window, or the fluorescence intensity of specific wavelength is detected by an instrument, thereby realizing qualitative or quantitative analysis of the object to be detected, and the two-dimensional code through going up card shell top records the testing result to the problem of device emergence landing has been avoided through skid proof block's setting.

Drawings

FIG. 1 is a schematic view of the structure of the present invention;

FIG. 2 is an exploded view of the housing-engaging mechanism of the present invention;

FIG. 3 is an exploded view of a complementary structure of the jamming mechanism of the present invention;

FIG. 4 is a schematic structural diagram of a test strip mechanism of the present invention.

In the figure: 1. a lower clamping shell; 2. mounting a clamping shell; 3. two-dimensional codes; 4. an anti-slip bump; 5. a sample application hole; 6. detecting a window; 7. an upper fixing leg; 8. a lower fixing hole; 9. a rubber column; 10. a fixing projection; 11. a base plate; 12. a sample pad; 13. a coating film; 14. a water absorbent pad; 15. detecting lines; 16. and (4) a quality control line.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by a person skilled in the art of the present fluorescence immunochromatographic assay card without creative efforts shall fall within the protection scope of the present invention.

In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance. In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "disposed" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be specifically understood by those of ordinary skill in the art of the present fluorescence immunochromatographic assay card. The following describes an embodiment of the present invention based on its overall structure.

Referring to fig. 1 to 4, in an embodiment of the present invention, a gastric function fluorescence immunochromatography detection card includes:

the top end of the lower clamping shell 1 is provided with an upper clamping shell 2;

the sampling hole 5 is formed in the top end of the upper clamping shell 2;

the detection window 6 is arranged at the top end of the upper clamping shell 2 and is positioned at one end of the sample adding hole 5;

the clamping shell mechanism is arranged at the bottom end of the upper clamping shell 2 and inside the lower clamping shell 1 and is used for fixing the lower clamping shell 1 and the upper clamping shell 2;

the test paper mechanism is arranged in the lower clamping shell 1 and is positioned at the bottom end of the detection window 6 and used for qualitatively or quantitatively analyzing the object to be detected.

Please refer to fig. 2, the clamping mechanism is composed of a pre-connecting unit, a clamping unit and an auxiliary unit, the pre-connecting unit includes a plurality of rubber columns 9 disposed on the inner wall of the lower clamping shell 1, the rubber columns 9 are uniformly distributed on two sides of the inner wall of the lower clamping shell 1, and the horizontal height of the rubber columns 9 is slightly higher than the height of the test paper mechanism, so that the test paper mechanism can be operated at a fixed position, and the precision of the device detection can be improved.

Please refer to fig. 2 and 3, the engaging unit includes an upper fixing pin 7 disposed at the bottom end of the upper engaging shell 2, a fixing protrusion 10 is disposed at one side of the upper fixing pin 7, a lower fixing hole 8 matched with the upper fixing pin 7 is disposed in the lower engaging shell 1, the upper fixing pin 7 and the lower fixing hole 8 are disposed in plural and correspondingly distributed in the bottom end of the upper engaging shell 2 and the lower engaging shell 1, and the engaging unit is advantageous for engaging and fixing the upper engaging shell 2 and the lower engaging shell 1.

Please refer to fig. 1 again, the auxiliary unit includes two-dimensional code 3 disposed on the top of the upper card shell 2, the two-dimensional code 3 is located at one end of the sampling hole 5 far away from the detection window 6, the end of the detection window 6 far away from the sampling hole 5 is provided with an anti-skid block 4, the anti-skid block 4 is located on the top of the upper card shell 2, and the structure is favorable for rapidly recording the detection result and preventing the device from slipping.

Please refer to fig. 4, the test paper mechanism is composed of a sample unit, a testing unit and a collecting unit, the sample unit includes a sample pad 12 disposed inside the lower card housing 1, a bottom plate 11 is disposed at the bottom end of the sample pad 12, and a plurality of lower fixing holes 8 are disposed at the outer side of the bottom plate 11, so that the structure is beneficial for the object to be tested to pass through the sample adding hole 5 and reach the sample pad 12, thereby facilitating the subsequent detection step.

Please refer to fig. 4, the testing unit includes a coating film 13 disposed at the top end of the lower clamping shell 1 and located at one end of the sample pad 12, a detecting line 15 is disposed at the top end of the coating film 13, the detecting lines 15 are uniformly distributed at the top end of the coating film 13, a quality control line 16 is disposed at the top end of the coating film 13 and located at one end of the detecting line 15, and the structure is favorable for detecting the object to be detected.

Please refer to fig. 4, the collecting unit includes a water absorption pad 14 disposed on the top of the bottom plate 11, the water absorption pad 14 is disposed on one end of the quality control line 16 far away from the detection line 15, and a hydrophobic layer is disposed on one end of the water absorption pad 14 close to the quality control line 16, so as to facilitate collecting operation of the detected object to be detected and avoid the object to be detected from overflowing and leaking.

The working principle of the utility model is as follows: when the test paper mechanism is placed in the clamping shell mechanism, the upper clamping shell 2 is pulled upwards firstly, the upper fixing pin 7 is separated from the lower fixing hole 8, then the test paper mechanism is placed in the lower clamping shell 1, the test paper mechanism extrudes the top end of the rubber column 9, the rubber column 9 rotates, when the test paper mechanism completely moves to the interior of the lower clamping shell 1, the rubber column 9 resets and rotates, the test paper mechanism is clamped, then the upper fixing pin 7 at the bottom end of the upper clamping shell 2 is aligned with the lower fixing hole 8, the upper clamping shell 2 is pushed, the upper clamping shell 2 moves to drive the fixing bulge 10 to move, the fixing bulge 10 moves and fixes the test paper mechanism, the structure is favorable for carrying out fixed position operation on the test paper mechanism, thereby improving the precision of the device, carrying out sample adding operation from the sample adding hole 5 to the interior of the clamping shell mechanism, detecting lines from the sample adding hole 5 to the sample pad 12, and then moving towards the sample pad 12, the substance to be detected is used as a solid phase carrier through a nitrocellulose membrane in a detection line 15, colloidal gold, fluorescent microspheres and the like are used as tracer markers and are combined with antibodies, under the percolation action or the capillary action of a microporous membrane, the combination of the labeled antibodies and the antigens or the secondary antibodies is traced by utilizing the high specificity of antigen-antibody reaction and the specific color and excitation spectrum of the colloidal gold or the fluorescent microspheres, then the substance to be detected is collected through a water absorption pad 14, a macroscopic red strip or spot is displayed through a detection window 6, or the fluorescence intensity of a specific wavelength is detected through an instrument, so that the qualitative or quantitative analysis of the substance to be detected is realized, the detection result is recorded through a two-dimensional code 3 at the top end of an upper clamping shell 2, and the problem that the device slips off is avoided through the arrangement of an anti-slip bump 4.

The above description is only a preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art of fluorescence immunochromatography detection card technology will be able to cover the scope of the present invention by equivalent substitutions or changes according to the technical solution of the present invention and the inventive concept.

Claims

1. A gastric function fluorescence immunochromatography detection card, comprising:

the top end of the lower clamping shell (1) is provided with an upper clamping shell (2);

the sampling hole (5) is formed in the top end of the upper clamping shell (2);

the detection window (6) is arranged at the top end of the upper clamping shell (2) and is positioned at one end of the sample adding hole (5);

the clamping shell mechanism is arranged at the bottom end of the upper clamping shell (2) and inside the lower clamping shell (1) and is used for fixing the lower clamping shell (1) and the upper clamping shell (2);

the test paper mechanism is arranged in the lower clamping shell (1), is positioned at the bottom end of the detection window (6) and is used for qualitatively or quantitatively analyzing the object to be detected.

2. The gastric function fluorescence immunochromatographic assay card according to claim 1, wherein the cartridge mechanism is composed of a pre-joint unit, a clamping unit and an auxiliary unit, the pre-joint unit comprises a plurality of rubber columns (9) arranged on the inner wall of the lower cartridge (1), the rubber columns (9) are uniformly distributed on both sides of the inner wall of the lower cartridge (1), and the horizontal height of the rubber columns (9) is slightly higher than the height of the test paper mechanism.

3. The gastric function fluorescence immunochromatographic assay card according to claim 2, wherein the clamping unit comprises an upper fixing foot (7) disposed at the bottom end of the upper clamping shell (2), a fixing protrusion (10) is disposed on one side of the upper fixing foot (7), a lower fixing hole (8) matched with the upper fixing foot (7) is disposed inside the lower clamping shell (1), and a plurality of upper fixing feet (7) and a plurality of lower fixing holes (8) are disposed and distributed correspondingly inside the bottom end of the upper clamping shell (2) and the lower clamping shell (1).

4. The gastric function fluorescence immunochromatographic detection card according to claim 2, wherein the auxiliary unit comprises a two-dimensional code (3) disposed on the top end of the upper card shell (2), the two-dimensional code (3) is located at one end of the sample adding hole (5) far away from the detection window (6), one end of the detection window (6) far away from the sample adding hole (5) is provided with an anti-skid block (4), and the anti-skid block (4) is located on the top end of the upper card shell (2).

5. The gastric functional fluorescence immunochromatographic assay card according to claim 3, wherein said test paper mechanism is composed of a sample unit, a test unit and a collection unit, said sample unit comprises a sample pad (12) disposed inside the lower card housing (1), a bottom plate (11) is disposed at the bottom end of said sample pad (12), and a plurality of said lower fixing holes (8) are located outside said bottom plate (11).

6. The gastric function fluorescence immunochromatography test card according to claim 5, wherein the test unit comprises a coating film (13) disposed on the top end of the lower cartridge shell (1) and located at one end of the sample pad (12), the top end of the coating film (13) is provided with a plurality of detection lines (15), the detection lines (15) are uniformly distributed on the top end of the coating film (13), the top end of the coating film (13) is provided with a quality control line (16) located at one end of the detection line (15).

7. The gastric functional fluorescence immunochromatographic detection card according to claim 5, wherein the collection unit comprises a water absorption pad (14) disposed on the top end of the bottom plate (11), the water absorption pad (14) is located at one end of the quality control line (16) far from the detection line (15), and the end of the water absorption pad (14) near the quality control line (16) is provided with a hydrophobic layer.