CN216756256U

CN216756256U - Mixing arrangement is used in octreotide acetate production

Info

Publication number: CN216756256U
Application number: CN202220054804.XU
Authority: CN
Inventors: 孙杰
Original assignee: China National Pharmaceutical Group Chengdu Xinlibang Biopharmaceutical Co ltd
Current assignee: China National Pharmaceutical Group Chengdu Xinlibang Biopharmaceutical Co ltd
Priority date: 2022-01-11
Filing date: 2022-01-11
Publication date: 2022-06-17
Anticipated expiration: 2032-01-11

Abstract

The utility model provides a mixing device for octreotide acetate production, which comprises: the workbench is provided with a mixing box; the baffle plate is arranged in the mixing box and divides the mixing box into a primary mixing cavity and a secondary mixing cavity; the stirring device is arranged in the primary mixing cavity; the first valve is arranged on the partition plate; the linear driving mechanism is arranged on the workbench; one end of the connecting rod is connected with the linear driving mechanism, and the other end of the connecting rod penetrates into the mixing box and is connected with a pushing plate; the second valve is arranged at the inner bottom of the mixing box and is connected with the liquid outlet pipe; the hot water cavity surrounds the side wall of the mixing box; an electric heating pipe and an aqueous solution are arranged in the hot water device; one end of the water pump is connected with the hot water device, and the other end of the water pump is connected with the hot water cavity; the bottom of the pushing plate is close to the inner bottom of the mixing box. Agitating unit and slurcam carry out the secondary to the liquid medicine and stir the mixture, and the slurcam bottom is close to the interior bottom of mixing box moreover, can stir the mixture many times to the liquid medicine that deposits well for stir the misce bene.

Description

Mixing arrangement is used in octreotide acetate production

Technical Field

The utility model relates to the technical field of medicine mixing devices, in particular to a mixing device for octreotide acetate production.

Background

Octreotide acetate is a chemical, the main component of which is octreotide, can inhibit pathological hypersecretion of growth hormone, thyrotropin, gastrointestinal tract and pancreatic endocrine hormone, and is mainly suitable for acromegaly, some digestive tract carcinoid and neuroendocrine tumors which need to be administrated for a long time.

At present, when octreotide acetate is produced, mixing is needed, and during mixing, because a liquid outlet is often positioned at the bottom end, added powder medicine often sinks to the liquid outlet, liquid medicine at the liquid outlet is not uniformly mixed, and a pipeline is blocked when the medicine is excessively precipitated; therefore, it is necessary to provide a mixing device for octreotide acetate production.

SUMMERY OF THE UTILITY MODEL

The utility model provides a mixing device for octreotide acetate production, which aims to solve the technical problem that liquid medicine at a liquid outlet is not uniformly mixed at present and even a pipeline is blocked.

In order to achieve the purpose, the utility model adopts the following technical scheme:

a mixing arrangement is used in octreotide acetate production, includes: a workbench provided with a mixing box; the baffle plate is arranged in the mixing box and divides the interior of the mixing box into a primary mixing cavity and a secondary mixing cavity; the stirring device is arranged in the primary mixing cavity; the feeding pipe is arranged at the top of the mixing box and is communicated with the primary mixing cavity; the first valve is arranged on the partition plate to control the on-off of the primary mixing cavity and the secondary mixing cavity; the linear driving mechanism is arranged on the workbench; one end of the connecting rod is connected with the action end of the linear driving mechanism, and the other end of the connecting rod penetrates into the mixing box and is connected with a pushing plate; the second valve is arranged at the inner bottom of the mixing box and is connected with a vertically arranged liquid outlet pipe; a hot water chamber surrounding a sidewall of the mixing tank; the water heating device is internally provided with an electric heating pipe and aqueous solution; one end of the water pump is connected with the hot water device, and the other end of the water pump is connected with the hot water cavity; the pushing plate is vertically arranged, the bottom of the pushing plate is close to the inner bottom of the mixing box, and a plurality of through holes which transversely penetrate through the pushing plate are formed in the pushing plate.

In one embodiment of the utility model, a water inlet pipe is arranged at the bottom of one side of the hot water cavity, a water outlet pipe is arranged at the bottom of the other side of the hot water cavity, the hot water cavity is connected with the water pump through the water inlet pipe, and the hot water cavity is connected with the hot water device through the water outlet pipe.

In one embodiment of the utility model, a sealing ring is arranged at the penetrating position of the connecting rod and the mixing box.

In one embodiment disclosed by the utility model, the stirring device comprises a stirring motor, a stirring shaft and a plurality of stirring blades, wherein the stirring motor is arranged at the top of the mixing box, the stirring shaft is rotatably connected between the top in the mixing box and the partition plate, the stirring motor is connected with the stirring shaft, and the stirring blades are arranged on the stirring shaft.

In one embodiment of the utility model, the stirring blades are rectangular plates, and a plurality of stirring blades are uniformly distributed on the stirring shaft.

In one embodiment of the present disclosure, the stirring blade on one side of the stirring shaft is disposed obliquely downward, and the stirring blade on the other side of the stirring shaft is disposed obliquely upward.

In one embodiment of the disclosure, the stirring blades arranged obliquely downwards and the stirring blades arranged obliquely upwards are arranged in a staggered or symmetrical manner.

In one embodiment of the present disclosure, the linear driving mechanism is a pneumatic cylinder or a hydraulic cylinder.

In one embodiment of the present disclosure, the linear driving mechanism, the connecting rod and the pushing plate form a mixing mechanism, and the number of the mixing mechanisms is 2 and the mixing mechanisms are symmetrically arranged.

In one embodiment disclosed by the utility model, 2 first valves are symmetrically arranged on the partition plate, a mounting plate is arranged below the partition plate, a circulating pump is arranged on the mounting plate, the circulating pump is provided with a reversing valve, one outlet of the reversing valve is communicated with the secondary mixing cavity through a pipeline, the other outlet of the reversing valve is connected with one of the first valves through a pipeline, and the circulating pump is connected with the other first valve through a pipeline.

In conclusion, the utility model has the following beneficial effects: according to the utility model, the mixing box is divided into the primary mixing cavity and the secondary mixing cavity by the partition plate, the stirring device is used for stirring and mixing the liquid medicine for the first time in the primary mixing cavity, the stirred liquid medicine enters the secondary mixing cavity through the first valve, the push plate is used for stirring and mixing the liquid medicine for the second time through the driving of the linear driving mechanism, the bottom of the push plate is close to the inner bottom of the mixing box, the precipitated liquid medicine can be well stirred and mixed for multiple times, the stirring and mixing are uniform, and the uniformly mixed liquid medicine is discharged through the second valve and the liquid outlet pipe.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.

Fig. 1 is a schematic structural diagram of a mixing device for octreotide acetate production according to some embodiments of the present invention.

Fig. 2 is a schematic diagram of a circulation pump and reversing valve according to some embodiments of the present invention.

Reference numerals:

1. a work table; 11. a linear drive mechanism; 12. a connecting rod; 121. a seal ring; 13. a push plate; 131. a through hole;

2. a mixing box; 21. a partition plate; 22. a primary mixing chamber; 23. a secondary mixing chamber; 24. a feed pipe; 25. a first valve; 26. a second valve; 27. a liquid outlet pipe;

3. a stirring device; 31. a stirring motor; 32. a stirring shaft; 33. stirring blades;

4. a hot water device; 41. a hot water cavity; 42. an electric heating tube; 43. a water pump; 44. a water inlet pipe; 45. a water outlet pipe;

5. mounting a plate; 51. a circulation pump; 52. a reversing valve.

Detailed Description

In the following, only certain exemplary embodiments are briefly described. As those skilled in the art will recognize, the described embodiments may be modified in various different ways, all without departing from the spirit or scope of the embodiments of the utility model. Accordingly, the drawings and description are to be regarded as illustrative in nature, and not as restrictive.

In the description of the embodiments of the present invention, it should be understood that the terms "length", "vertical", "horizontal", "top", "bottom", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only used for convenience in describing the embodiments of the present invention and simplifying the description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the embodiments of the present invention.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the embodiments of the present invention, "a plurality" means two or more unless specifically limited otherwise.

In the embodiments of the present invention, unless otherwise explicitly specified or limited, the terms "mounted," "connected," "fixed," and the like are to be construed broadly, e.g., as being fixedly connected, detachably connected, or integrated; the connection can be mechanical connection, electrical connection or communication; either directly or indirectly through intervening media, either internally or in any other relationship. Specific meanings of the above terms in the embodiments of the present invention can be understood by those of ordinary skill in the art according to specific situations.

In embodiments of the utility model, unless expressly stated or limited otherwise, the first feature "on" or "under" the second feature may comprise the first and second features being in direct contact, or the first and second features being in contact, not directly, but via another feature therebetween. Also, the first feature being "on," "above" and "over" the second feature includes the first feature being directly on and obliquely above the second feature, or merely indicating that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly under and obliquely below the second feature, or simply meaning that the first feature is at a lesser elevation than the second feature.

The following disclosure provides many different embodiments or examples for implementing different configurations of embodiments of the utility model. To simplify the disclosure of embodiments of the utility model, the components and arrangements of specific examples are described below. Of course, they are merely examples and are not intended to limit embodiments of the utility model. Furthermore, embodiments of the present invention may repeat reference numerals and/or letters in the various examples, such repetition is for the purpose of simplicity and clarity and does not in itself dictate a relationship between the various embodiments and/or configurations discussed.

Embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

As shown in fig. 1, the present embodiment provides a mixing device for octreotide acetate production, including: a workbench 1 provided with a mixing box 2; a partition plate 21 disposed inside the mixing box 2 and dividing the inside of the mixing box 2 into a primary mixing chamber 22 and a secondary mixing chamber 23; a stirring device 3 disposed in the primary mixing chamber 22; a feeding pipe 24 arranged at the top of the mixing box 2 and communicated with the primary mixing cavity 22; a first valve 25 disposed on the partition 21 to control the connection and disconnection between the primary mixing chamber 22 and the secondary mixing chamber 23; a linear driving mechanism 11 provided on the table 1; one end of the connecting rod 12 is connected with the action end of the linear driving mechanism 11, and the other end penetrates into the mixing box 2 and is connected with a pushing plate 13; a second valve 26 disposed at the inner bottom of the mixing box 2 and connected with a vertically disposed liquid outlet pipe 27; a hot water chamber 41 surrounding a sidewall of the mixing box 2; a water heater 4 having an electric heating tube 42 and an aqueous solution therein; one end of the water pump 43 is connected with the hot water device 4, and the other end is connected with the hot water cavity 41; wherein, the pushing plate 13 is vertically arranged and the bottom thereof is close to the inner bottom of the mixing box 2, and the pushing plate 13 is provided with a plurality of through holes 131 which transversely penetrate.

It should be understood that, in use, the raw materials enter the primary mixing chamber 22 from the feeding pipe 24, the stirring device 3 stirs and mixes the raw materials, the stirred and mixed liquid medicine enters the secondary mixing chamber 23 from the first valve 25, the linear driving mechanism 11 drives the connecting rod 12, the connecting rod 12 drives the pushing plate 13 to transversely move back and forth, the pushing plate 13 mixes the liquid medicine, the liquid medicine can pass through the pushing plate 13 back and forth through the through hole 131, so that the mixing is more uniform, and the uniformly mixed liquid medicine is discharged through the second valve 26 and the liquid outlet pipe 27; wherein, in mixing process, electric heating pipe 42 heating aqueous solution, water pump 43 arrives hot water extraction side by side hot water cavity 41, hot water cavity 41 is right the heating of mixing box 2, stirs under the thermal environment and mixes, is favorable to the misce bene.

It is to be understood that the stirring device 3 and the linear driving mechanism 11 may be constructed as described in the following embodiments, or may be constructed by using an existing apparatus having the same function.

In some embodiments, the bottom of one side of the hot water cavity 41 is provided with a water inlet pipe 44, the bottom of the other side is provided with a water outlet pipe 45, the hot water cavity 41 is connected with the water pump 43 through the water inlet pipe 44, and the hot water cavity 41 is connected with the hot water device 4 through the water outlet pipe 45. In this scheme, through inlet tube 44 with outlet pipe 45's setting forms hot water circulation, and the hydrothermal heat of make full use of avoids extravagant, but also can with hot water cavity 41 with mixing box 2 maintains in certain temperature range to guarantee the misce bene.

In some embodiments, a sealing ring 121 is disposed at the penetration of the connecting rod 12 and the mixing box 2. In this embodiment, the sealing ring 121 is provided to prevent the liquid medicine from leaking to the outside.

In some embodiments, the stirring device 3 includes a stirring motor 31, a stirring shaft 32 and stirring blades 33, the stirring motor 31 is disposed on the top of the mixing box 2, the stirring shaft 32 is rotatably connected between the top of the mixing box 2 and the partition plate 21, the stirring motor 31 is connected to the stirring shaft 32, and the stirring blades 33 are plural and disposed on the stirring shaft 32. In this scheme, agitator motor 31 drive (mixing) shaft 32 rotates, agitator shaft 32 drives stirring leaf 33 and rotates, and is a plurality of stirring leaf 33 stirs the mixture to the liquid medicine.

In some embodiments, the stirring blade 33 is a rectangular plate, and the stirring blades 33 are uniformly distributed on the stirring shaft 32. In this scheme, this setting does benefit to the misce bene.

In some embodiments, the stirring blades 33 on one side of the stirring shaft 32 are arranged obliquely downward, and the stirring blades 33 on the other side of the stirring shaft 32 are arranged obliquely upward. In this scheme, the inclination angle that inclines downwards and incline upwards is 45 degrees, and the downward and the upward setting of slope stirring leaf 33 is favorable to stirring the misce bene.

In some embodiments, the mixing blade 33 disposed obliquely downward and the mixing blade 33 disposed obliquely upward are disposed in a staggered or symmetrical manner. In this scheme, the stirring leaves 33 that incline downwards and incline upwards set up misplace or the symmetry sets up, is favorable to stirring misce bene.

In some embodiments, the linear drive mechanism 11 is a pneumatic or hydraulic cylinder. In this solution, the air cylinder or hydraulic cylinder is convenient for driving the pushing plate 13 to move back and forth transversely.

In some embodiments, the linear driving mechanism 11, the connecting rod 12 and the pushing plate 13 constitute a mixing mechanism, and the mixing mechanism is provided in 2 and is symmetrically arranged. In this scheme, 2 the mixing mechanism is favorable to the misce bene.

In some embodiments, as shown in fig. 2, there are 2 first valves 25 symmetrically disposed on the partition 21, a mounting plate 5 is disposed below the partition 21, a circulation pump 51 is disposed on the mounting plate 5, the circulation pump 51 is provided with a direction valve 52, one outlet of the direction valve 52 is communicated with the secondary mixing chamber 23 through a pipe, the other outlet of the direction valve 52 is connected with one of the first valves 25 through a pipe, and the circulation pump 51 is connected with the other first valve 25 through a pipe. In this embodiment, the circulating pump 51 draws the liquid medicine at the bottom of the primary mixing chamber 22 through the other first valve 25, and discharges the liquid medicine into the primary mixing chamber 22 again through the reversing valve 52 and one of the first valves 25, so that the liquid medicine at the bottom of the primary mixing chamber 22 continuously flows, and can be uniformly stirred and mixed, and the liquid medicine after being uniformly stirred and mixed enters the secondary mixing chamber 23 through the circulating pump 51 and the reversing valve 52.

Although the foregoing embodiments have described a number of specific embodiments of the present invention, it will be appreciated by those skilled in the art that various changes or modifications may be made to these embodiments without departing from the principles and spirit of the utility model, and such changes and modifications are intended to fall within the scope of the utility model.

Claims

1. The utility model provides a mixing arrangement is used in octreotide acetate production which characterized in that includes:

a workbench provided with a mixing box;

the baffle plate is arranged in the mixing box and divides the interior of the mixing box into a primary mixing cavity and a secondary mixing cavity;

the stirring device is arranged in the primary mixing cavity;

the feeding pipe is arranged at the top of the mixing box and is communicated with the primary mixing cavity;

the first valve is arranged on the partition plate to control the on-off of the primary mixing cavity and the secondary mixing cavity;

the linear driving mechanism is arranged on the workbench;

one end of the connecting rod is connected with the action end of the linear driving mechanism, and the other end of the connecting rod penetrates into the mixing box and is connected with a pushing plate;

the second valve is arranged at the inner bottom of the mixing box and is connected with a vertically arranged liquid outlet pipe;

a hot water chamber surrounding a sidewall of the mixing tank;

the water heating device is internally provided with an electric heating pipe and aqueous solution;

one end of the water pump is connected with the hot water device, and the other end of the water pump is connected with the hot water cavity;

the pushing plate is vertically arranged, the bottom of the pushing plate is close to the inner bottom of the mixing box, and a plurality of through holes which transversely penetrate through the pushing plate are formed in the pushing plate.

2. The mixing device for octreotide acetate production according to claim 1, wherein a water inlet pipe is arranged at the bottom of one side of the hot water cavity, a water outlet pipe is arranged at the bottom of the other side of the hot water cavity, the hot water cavity is connected with the water pump through the water inlet pipe, and the hot water cavity is connected with the hot water device through the water outlet pipe.

3. The mixing device for octreotide acetate production according to claim 1, wherein a seal ring is provided at a penetration of the connecting rod and the mixing tank.

4. The mixing device for octreotide acetate production according to claim 1, wherein the stirring device comprises a stirring motor, a stirring shaft and stirring blades, the stirring motor is arranged at the top of the mixing box, the stirring shaft is rotatably connected between the top of the mixing box and the partition plate, the stirring motor is connected with the stirring shaft, and a plurality of stirring blades are arranged on the stirring shaft.

5. The mixing device for octreotide acetate production according to claim 4, wherein the stirring blade is a rectangular plate, and a plurality of stirring blades are uniformly distributed on the stirring shaft.

6. The mixing device for octreotide acetate production according to claim 4, wherein the stirring blade on one side of the stirring shaft is disposed obliquely downward, and the stirring blade on the other side of the stirring shaft is disposed obliquely upward.

7. The mixing device for octreotide acetate production according to claim 6, wherein the stirring blade provided obliquely downward and the stirring blade provided obliquely upward are disposed in a staggered or symmetrical manner.

8. The mixing device for octreotide acetate production according to claim 1, wherein the linear driving mechanism is a pneumatic cylinder or a hydraulic cylinder.

9. The mixing device for octreotide acetate production according to claim 1, wherein the linear driving mechanism, the connecting rod and the pushing plate constitute a mixing mechanism, and the number of the mixing mechanisms is 2 and the mixing mechanisms are symmetrically arranged.

10. The mixing device for octreotide acetate production according to claim 1, wherein 2 first valves are symmetrically arranged on the partition plate, a mounting plate is arranged below the partition plate, a circulating pump is arranged on the mounting plate, the circulating pump is provided with a reversing valve, one outlet of the reversing valve is communicated with the secondary mixing chamber through a pipeline, the other outlet of the reversing valve is connected with one of the first valves through a pipeline, and the circulating pump is connected with the other first valve through a pipeline.