CN216727246U - Washing and purifying device for cross-linked sodium hyaluronate gel - Google Patents
Washing and purifying device for cross-linked sodium hyaluronate gel Download PDFInfo
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- CN216727246U CN216727246U CN202123432731.8U CN202123432731U CN216727246U CN 216727246 U CN216727246 U CN 216727246U CN 202123432731 U CN202123432731 U CN 202123432731U CN 216727246 U CN216727246 U CN 216727246U
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- sodium hyaluronate
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Abstract
The utility model belongs to the technical field of washing and purifying devices, and particularly relates to a washing and purifying device for cross-linked sodium hyaluronate gel. The washing and purifying device for the cross-linked sodium hyaluronate gel comprises: a tank body; the stirring mechanism is arranged on the tank body; the screen is arranged at the discharge port of the tank body and is in contact connection with the inner wall of the tank body; the lifting mechanism is arranged on the tank body and used for lifting the screen to enable the gel to move to the discharge port from a gap between the screen and the inner wall of the tank body. The utility model relates to a washing and purifying device for cross-linked sodium hyaluronate gel, which is characterized in that a stirring mechanism is used for stirring the gel and washing the gel after a washing liquid is added, a screen is used for separating the gel from the washing liquid, and a lifting mechanism is used for lifting the screen to enable the gel to slide out along the inner wall of a tank body. Compare other washing purification jars, do not need the manual transfer of gel on the jar body bottom with the screen cloth of artifical dismantlement, only need the lifting screen cloth, the gel can be followed jar internal wall and flowed, and the gel avoids contacting with external environment in purification process, reduces the pollution risk, improves the yield.
Description
Technical Field
The utility model belongs to the technical field of washing and purifying devices, and particularly relates to a washing and purifying device for cross-linked sodium hyaluronate gel.
Background
Sodium Hyaluronate (HA) is a linear polymeric polysaccharide that is crosslinked under alkaline conditions with a crosslinking agent such as 1, 4-butanediol diglycidyl ether or divinyl sulfone to form a crosslinked sodium hyaluronate gel. The gel prepared by crosslinking not only retains the good biocompatibility of HA, but also greatly prolongs the retention time in vivo, and is the most common tissue filler in clinic at present. Because the residual cross-linking agent has certain toxicity to human bodies, the unreacted free cross-linking agent needs to be removed after the cross-linking of the sodium hyaluronate is completed. The current common method is to put the gel into a rinsing tank with a screen with a fixed mesh number, add the rinsing liquid to wash for a period of time, then discharge the rinsing liquid, and then add the rinsing liquid and repeat the process so as to achieve the purpose of purification. However, in the purification method, after purification is finished, all the gel is retained on the screen at the lower end of the washing tank, an operator needs to disassemble the screen, and manually take out all the gel on the screen and transfer the gel to a next container for subsequent use, so that the operation exposes the gel to the external environment for a long time, which undoubtedly increases the risk of product pollution and affects the product quality.
SUMMERY OF THE UTILITY MODEL
The utility model aims to provide a washing and purifying device for cross-linked sodium hyaluronate gel, which solves the technical problem that gel on a screen is manually cleaned in the product transfer process after the cross-linked sodium hyaluronate gel is produced and purified by the conventional washing and purifying device, so that the gel is exposed in the external environment for a long time to cause pollution.
In order to solve the above technical problems, the present invention provides a washing and purifying device for cross-linked sodium hyaluronate gel, comprising:
a tank for containing a gel and a washing solution;
the stirring mechanism is arranged on the tank body and used for rotating and stirring the gel and the washing liquid in the tank body;
the screen is arranged at the discharge port of the inner cavity of the tank body, is in contact connection with the inner wall of the tank body and is used for separating gel from the washing liquid;
and the lifting mechanism is arranged on the tank body and used for lifting the screen to enable the gel to move to the discharge port from a gap between the screen and the inner wall of the tank body.
Further, the stirring mechanism comprises a rotating motor, a rotating shaft and a stirring paddle; wherein
The rotating motor is fixedly arranged at the top of the tank body;
the axis of rotation rotates and sets up on the jar body, and the upper end of axis of rotation is connected with the rotating electrical machines, and the lower extreme of axis of rotation stretches out the inner chamber of the jar body and is connected with the stirring rake.
Further, the rotating motor is arranged on one side of the rotating shaft and is connected with the rotating shaft through a bevel gear set;
the lifting mechanism comprises an upper jacking cylinder and an upper push rod;
the upper jacking cylinder is fixedly arranged at the bottom of the tank body;
the upper push rod is connected with a piston rod of the upper ejection cylinder, and the upper end of the upper push rod penetrates into the inner cavity of the tank body to be connected with the screen.
Furthermore, the tank body is provided with an air injection port suitable for injecting compressed air into the tank body.
Furthermore, the tank body is provided with an injection port suitable for injecting gel into the tank body;
the tank body is provided with a liquid injection port suitable for injecting washing liquid into the tank body.
Furthermore, a pipeline suitable for glue discharging is arranged at the discharge port.
Further, the outer side of the tank body is sleeved with a jacket for heating the tank body.
In another aspect, the present invention further provides a washing and purifying device for cross-linked sodium hyaluronate gel, which is different from the above utility model in that:
the rotating shafts are arranged in a hollow manner;
the lifting mechanism comprises a pressing cylinder and a lower push rod;
the pressing cylinder is fixedly arranged at the top of the tank body;
the lower push rod is connected with a piston rod of the lower pressing cylinder, and the lower end of the lower push rod penetrates through the rotating shaft to be connected with the screen.
The washing and purifying device for the cross-linked sodium hyaluronate gel has the beneficial effects that the stirring mechanism is used for stirring the gel and washing the gel after the washing liquid is added, the solid-liquid separation of the gel and the washing liquid is realized through the screen, and the screen is lifted by the lifting mechanism so that the gel slides out of the discharge hole along the inner wall of the tank body. Compare other washing purification jars, the back is accomplished in the purification of cross-linking sodium hyaluronate gel, does not need operating personnel to dismantle jar body bottom and manually shifts the gel on the screen cloth, only needs the lifting screen cloth, and the gel can follow jar internal wall outflow and get into next process, and the gel can avoid completely in the purification process and external environment contact, reduces the pollution risk, improves the yield.
Additional features and advantages of the utility model will be set forth in the description which follows, and in part will be obvious from the description, or may be learned by practice of the utility model.
In order to make the aforementioned and other objects, features and advantages of the present invention comprehensible, preferred embodiments accompanied with figures are described in detail below.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
Fig. 1 is a schematic structural view of a preferred embodiment 1 of the washing and purifying device for crosslinked sodium hyaluronate gel (lifting mechanism is in top state) of the present invention;
fig. 2 is a schematic structural view of a preferred embodiment 1 of the washing and purifying device for cross-linked sodium hyaluronate gel (lifting mechanism in retracted state) of the present invention;
FIG. 3 is a schematic structural view of a preferred embodiment 2 of the washing and purifying device for cross-linked sodium hyaluronate gel (lifting mechanism in retracted state) of the present invention;
fig. 4 is a schematic structural diagram of a preferred embodiment 2 of the washing and purifying device for cross-linked sodium hyaluronate gel (the lifting mechanism is in a pressed state) of the present invention.
In the figure:
a tank body 1;
the stirring mechanism 2, a rotating motor 21, a rotating shaft 22, a stirring paddle 23 and a bevel gear group 24;
a screen 3, a discharge port 4 and a gap 5;
the lifting mechanism 6, a lower pressing cylinder 61, a lower push rod 62, an upper jacking cylinder 63 and an upper push rod 64;
Detailed Description
To make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings, and it is apparent that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
As shown in fig. 1, the washing and purifying device for cross-linked sodium hyaluronate gel of the present embodiment comprises: the device comprises a tank body 1, a stirring mechanism 2, a screen 3 and a lifting mechanism 6; wherein, the tank body 1 is used for containing gel and washing liquid; the stirring mechanism 2 is arranged on the tank body 1 and is used for rotationally stirring the gel and the washing liquid in the tank body 1; the screen 3 is arranged at a discharge port 4 of the inner cavity of the tank body 1, is in contact connection with the inner wall of the tank body 1 and is used for separating gel from washing liquid; a lifting mechanism 6 is provided on the tank 1 to lift the screen 3 to move the gel from the gap 5 between the screen 3 and the inner wall of the tank 1 to the discharge port 4. The inner wall of the bottom of the tank body 1 is of an inclined non-arc structure, and the included angle between the inner wall and the screen is within the range of 120-145 degrees, so that the gel is prevented from remaining on the inner wall of the tank body 1. The gel is stirred by the stirring mechanism 2 and is washed after the washing liquid is added, the solid-liquid separation of the gel and the washing liquid is realized by the screen 3, and the screen 3 is lifted by the lifting mechanism 6 so that the gel slides out of the discharge port 4 along the inner wall of the tank body 1. Compare other washing purification jars, the purification of cross-linking sodium hyaluronate gel is accomplished the back, does not need operating personnel to dismantle jar body 1 bottom and shifts the manual gel on the screen cloth 3, only needs lifting screen cloth 3, and the gel can follow 1 inner walls of jar body and flow out and get into next process, and the gel can avoid completely in the purification process and external environment contact, reduces the pollution risk, improves the yield.
As shown in fig. 2, in the present embodiment, specifically, the stirring mechanism 2 includes a rotating motor 21, a rotating shaft 22, and a stirring paddle 23; wherein, the rotating motor 21 is fixedly arranged at the top of the tank body 1; the rotating shaft 22 is rotatably arranged on the tank body 1, the upper end of the rotating shaft 22 is connected with the rotating motor 21, and the lower end of the rotating shaft 22 extends out of the inner cavity of the tank body 1 and is connected with the stirring paddle 23. Drive axis of rotation 22 through rotating electrical machines 21 rotatory for axis of rotation 22 drives stirring rake 23 and rotates with gel and the washing liquid in the agitator tank body 1, thereby realizes washing purification gel, and it is convenient to wash, and degree of automation is high.
As shown in fig. 2, in the present embodiment, specifically, the lifting mechanism 6 includes an upper ejection cylinder 63 and an upper push rod 64; wherein, the upper top cylinder 63 is fixedly arranged at the bottom of the tank body 1; the upper push rod 64 is connected with the piston rod of the upper top cylinder 63, and the upper end of the upper push rod 64 penetrates into the inner cavity of the tank body 1 to be connected with the screen 3. When the screen 3 is pushed by the upper jacking cylinder 63 and the upper pushing rod 64, the screen 3 moves away from the discharge port 4, and the screen 3 and the inner wall of the tank body 1 form the gap 5, so that the gel can conveniently pass through the gap 5. The upper pushing cylinder 63 drives the upper pushing rod 64 to do telescopic motion, so that the upper pushing rod 64 drives the screen 3 to lift or descend, the screen 3 blocks the discharge port 4 or moves away from the discharge port 4, and the washed and purified gel is controlled to slide from the gap 5 and is discharged out of the tank body 1 from the discharge port 4. The screen cloth 3 at the bottom of the tank body 1 does not need to be repeatedly disassembled, the discharging and the cleaning are convenient, the automation degree is high, and the life cycle of the equipment is prolonged. Completely avoids unnecessary pollution caused by artificial contact with gel, improves the working efficiency and improves the product quality.
In the present embodiment, as shown in fig. 1 and 2, it is preferable that a gas injection port 7 is formed on the tank 1 and adapted to inject compressed air into the tank 1 to accelerate the separation efficiency of the gel and the washing liquid.
As shown in fig. 1 and fig. 2, in the present embodiment, a filling port 8 is formed on the tank 1 and is adapted to fill gel into the tank 1; the tank body 1 is provided with a liquid injection port 9 suitable for injecting a cleaning liquid into the tank body 1.
As shown in fig. 1 and 2, in the present embodiment, a pipe 10 suitable for discharging gel is preferably provided at the discharge port 4, so that the gel flows into a subsequent collecting device along a set pipeline for the next process.
As shown in fig. 1 and 2, in the present embodiment, it is preferable that a jacket 11 for heating the can body 1 is provided on the outer side of the can body 1. The temperature of the tank body 1 is controlled within the range of 35-45 ℃ by heating the jacket 11, which is beneficial to the elution of the residual cross-linking agent in the gel and improves the washing and purifying effects.
Example 2
As shown in fig. 3 and 4, the present invention provides another alternative embodiment of a washing and purifying device for cross-linked sodium hyaluronate gel.
The difference from example 1 is that:
the rotating motor 21 is arranged on one side of the rotating shaft 22, and the rotating motor 21 is connected with the rotating shaft 22 through a bevel gear set 24; the rotating shaft 22 is arranged in a hollow manner; the lifting mechanism 6 includes a push-down cylinder 61 and a push-down lever 62; the downward-pressing cylinder 61 is fixedly arranged at the top of the tank body 1; the lower push rod 62 is connected to a piston rod of the lower air cylinder 61, and the lower end of the lower push rod 62 is connected to the screen 3 through the rotary shaft 22. The lower push rod 62 is driven by the lower pressing cylinder 61 to do telescopic motion, so that the lower push rod 62 drives the screen 3 to lift or descend, the screen 3 is blocked by the discharge hole 4 or is moved away from the discharge hole 4, and the gel after washing and purification is controlled to slide from the gap 5 and is discharged out of the tank body 1 from the discharge hole 4. The screen cloth 3 at the bottom of the tank body 1 does not need to be repeatedly disassembled, the discharging and the cleaning are convenient, the automation degree is high, and the life cycle of the equipment is prolonged. Completely avoids unnecessary pollution caused by artificial contact with gel, improves the working efficiency and improves the product quality.
In conclusion, the device for washing and purifying the crosslinked sodium hyaluronate gel has the advantages that the stirring mechanism is used for stirring the gel and washing the gel after the washing liquid is added, the solid-liquid separation of the gel and the washing liquid is realized through the screen, and the screen is lifted by the lifting mechanism so that the gel slides out of the discharge hole along the inner wall of the tank body. Compare other washing purification jars, the back is accomplished in the purification of cross-linking sodium hyaluronate gel, does not need operating personnel to dismantle jar body bottom and manually shifts the gel on the screen cloth, only needs the lifting screen cloth, and the gel can follow jar internal wall outflow and get into next process, and the gel can avoid completely in the purification process and external environment contact, reduces the pollution risk, improves the yield. The washing and purifying device can completely avoid unnecessary pollution caused by artificial contact with gel, improve the working efficiency and improve the product quality.
The components selected for use in the present application (components not illustrated for specific structures) are all common standard components or components known to those skilled in the art, and the structure and principle thereof can be known to those skilled in the art through technical manuals or through routine experimentation.
In the description of the embodiments of the present invention, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; the two components can be directly connected or indirectly connected through an intermediate medium, and the two components can be communicated with each other. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or component being referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In light of the foregoing description of the preferred embodiment of the present invention, many modifications and variations can be made by the worker in the light of the above teachings without departing from the spirit of the utility model. The technical scope of the present invention is not limited to the content of the specification, and must be determined according to the scope of the claims.
Claims (8)
1. A washing and purifying device for cross-linked sodium hyaluronate gel, comprising:
a tank for containing a gel and a washing solution;
the stirring mechanism is arranged on the tank body and used for rotating and stirring the gel and the washing liquid in the tank body;
the screen is arranged at the discharge port of the inner cavity of the tank body, is in contact connection with the inner wall of the tank body and is used for separating gel from the washing liquid;
and the lifting mechanism is arranged on the tank body and used for lifting the screen to enable the gel to move to the discharge port from a gap between the screen and the inner wall of the tank body.
2. The washing and purifying device for crosslinked sodium hyaluronate gel according to claim 1,
the stirring mechanism comprises a rotating motor, a rotating shaft and a stirring paddle; wherein
The rotating motor is fixedly arranged at the top of the tank body;
the axis of rotation rotates and sets up on the jar body, and the upper end and the rotating electrical machines of axis of rotation are connected, and the lower extreme of axis of rotation stretches out the inner chamber of the jar body and is connected with the stirring rake.
3. The washing and purifying device for crosslinked sodium hyaluronate gel according to claim 1,
the lifting mechanism comprises an upper jacking cylinder and an upper push rod;
the upper jacking cylinder is fixedly arranged at the bottom of the tank body;
the upper push rod is connected with a piston rod of the upper ejection cylinder, and the upper end of the upper push rod penetrates into the inner cavity of the tank body to be connected with the screen.
4. The washing and purifying device for crosslinked sodium hyaluronate gel according to claim 2,
the rotating motor is arranged on one side of the rotating shaft and is connected with the rotating shaft through a bevel gear set;
the rotating shafts are arranged in a hollow manner;
the lifting mechanism comprises a pressing cylinder and a lower push rod;
the pressing cylinder is fixedly arranged at the top of the tank body;
the lower push rod is connected with a piston rod of the lower pressing cylinder, and the lower end of the lower push rod penetrates through the rotating shaft to be connected with the screen.
5. The washing and purifying device for crosslinked sodium hyaluronate gel according to claim 1,
the tank body is provided with an air injection port suitable for injecting compressed air into the tank body.
6. The washing and purifying device for crosslinked sodium hyaluronate gel according to claim 1,
the tank body is provided with a filling port suitable for filling gel into the tank body;
the tank body is provided with a liquid injection port suitable for injecting washing liquid into the tank body.
7. The washing and purifying device for crosslinked sodium hyaluronate gel according to claim 1,
and a pipeline suitable for discharging glue is arranged at the discharge port.
8. The washing and purifying device for crosslinked sodium hyaluronate gel according to claim 1,
the outer side of the tank body is sleeved with a jacket for heating the tank body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202123432731.8U CN216727246U (en) | 2021-12-30 | 2021-12-30 | Washing and purifying device for cross-linked sodium hyaluronate gel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202123432731.8U CN216727246U (en) | 2021-12-30 | 2021-12-30 | Washing and purifying device for cross-linked sodium hyaluronate gel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN216727246U true CN216727246U (en) | 2022-06-14 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202123432731.8U Active CN216727246U (en) | 2021-12-30 | 2021-12-30 | Washing and purifying device for cross-linked sodium hyaluronate gel |
Country Status (1)
| Country | Link |
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| CN (1) | CN216727246U (en) |
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2021
- 2021-12-30 CN CN202123432731.8U patent/CN216727246U/en active Active
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