CN216724876U - Engineering gas pipe substitute with multi-material separation annular structure - Google Patents
Engineering gas pipe substitute with multi-material separation annular structure Download PDFInfo
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- CN216724876U CN216724876U CN202122164840.XU CN202122164840U CN216724876U CN 216724876 U CN216724876 U CN 216724876U CN 202122164840 U CN202122164840 U CN 202122164840U CN 216724876 U CN216724876 U CN 216724876U
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Abstract
The utility model provides an engineering gas pipe substitute with a multi-material separation annular structure, which comprises the following components: a micron-sized guide net and a support ring; the engineering gas pipe is integrally cylindrical and comprises a 3D printed non-degradable support ring and a near-field direct-writing degradable micron-sized guide net, the near-field direct-writing-3D printing technology is integrated to form, the micron-sized guide net can promote the climbing of tissues such as blood vessels and the like, the repair process is promoted, the in-vivo integration of autologous tissues to the engineering gas pipe is completed, the micron-sized guide net is easy to degrade after the tissues grow in, the overall biocompatibility of the engineering gas pipe substitute can be further improved, the engineering gas pipe substitute is made of common high polymer materials, and large-scale engineering production can be carried out.
Description
Technical Field
The utility model relates to the field of medical instruments, in particular to an engineering gas pipe substitute with a multi-material separation annular structure.
Background
Malignant tumor, benign disease and trauma can cause tracheal stenosis, endanger the life of a patient, surgical resection followed by end-to-end anastomosis is the most effective treatment scheme for tracheal stenosis, but when the lesion is large, long-section tracheal resection can cause overlarge tension of an anastomosis port, and further cause serious postoperative complications, so that long-section tracheal reconstruction is a historical problem in the field of surgery. In order to improve the survival of the patient after the operation, a substitute with good biocompatibility needs to be implanted to fill up the missing part of the trachea.
Currently clinically used tracheal substitutes include: artificial prosthesis trachea, allogenic trachea and autologous tissue reconstructed trachea. The reconstruction of blood circulation is difficult during the allogeneic tracheal transplantation, which easily causes the necrosis and infection of the graft; the mechanical strength of the autologous tissue reconstructed trachea-like tissue is low, and additional surgical trauma can be brought; the prior artificial prosthesis trachea is mostly prepared by metal and other materials, has poor tissue compatibility, and is easy to cause granulation hyperplasia to cause tracheal stenosis. Therefore, it is necessary to develop an engineering gas tube substitute which can maintain mechanical properties for a long time and is not suitable for inducing airway constriction.
SUMMERY OF THE UTILITY MODEL
The utility model aims to provide an engineering gas pipe substitute with a multi-material separation annular structure aiming at the defects in the prior art.
In order to achieve the purpose, the utility model adopts the technical scheme that:
an engineered tracheal substitute of multi-material separation ring structure comprising: a micron-sized guide net and a plurality of support rings;
the support rings are uniformly arranged on a circular ring surrounded by the micron-sized guide nets, and the inner diameter of each support ring is equal to the outer diameter of the circular ring surrounded by the micron-sized guide nets; the micron-sized guide net is made of a high-molecular degradable material, and the support ring is made of a high-molecular non-degradable material.
Preferably, the high molecular degradable material is selected from polycaprolactone, polylactic acid caprolactone and polylactic acid.
Preferably, the polymeric non-degradable material is selected from polyetheretherketone, polyethylene and polypropylene.
Preferably, the apertures on the micro-scale guide mesh are identical parallelograms.
More preferably, the distance between any two vertices on the aperture is no more than 400 microns.
Preferably, the micron-sized guiding net is made of a filamentous high-molecular degradable material with the diameter of 9-11 microns.
Preferably, the micron-sized guide net and the support ring are integrally constructed.
By adopting the technical scheme, compared with the prior art, the utility model has the following technical effects:
the engineering gas pipe substitute is provided with a micron-sized guide net and a support ring, the whole engineering gas pipe is cylindrical and comprises a 3D-printed non-degradable support ring and a near-field direct-writing degradable micron-sized guide net, the near-field direct-writing-3D printing technology is integrated to form the engineering gas pipe substitute, the micron-sized guide net can promote the climbing of tissues such as blood vessels and the like, the repair process is promoted, the in-vivo integration of autologous tissues on the engineering gas pipe is completed, the micron-sized guide net is easy to degrade after the tissues grow in, the biocompatibility of the whole engineering gas pipe substitute can be further improved, and the engineering gas pipe substitute is made of common high polymer materials and can be used for large-scale engineering production.
Drawings
FIG. 1 is a schematic diagram of the basic structure of an engineered gas tube replacement in one embodiment of the present invention;
the reference numerals in the figures include:
a micron-sized guide tube 1; a support ring 2.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It should be noted that the embodiments and features of the embodiments may be combined with each other without conflict.
The utility model is further described with reference to the following drawings and specific examples, which are not intended to be limiting.
Examples
The application of the engineering gas tube substitute with a multi-material separation annular structure in the defect of the long segment of the trachea of the dog is as follows:
as illustrated in fig. 1, the present embodiment provides an engineered gas tube replacement comprising: a micron-sized guide net 1 and a support ring 2;
the support rings 2 are uniformly arranged on a circular ring surrounded by the micron-sized guide net 1, the pores on the micron-sized guide net 1 are identical parallelograms, and the distance between any two vertexes on the pores is not more than 400 micrometers; the inner diameter of the support ring 2 is equal to the outer diameter of a circular ring surrounded by the micron-sized guide net 1, and the micron-sized guide net 1 and the support ring 2 are integrally constructed and formed; the micron-sized guide net 1 is made of filamentous high-molecular degradable materials with the diameter of 9-11 microns, the high-molecular degradable materials are selected from polycaprolactone, polylactic acid caprolactone and polylactic acid, the support ring 2 is made of high-molecular non-degradable materials, and the high-molecular non-degradable materials are selected from polyether ether ketone, polyethylene and polypropylene.
When the trachea substitute is used, medical personnel carry out CT scanning on a part needing to be replaced and carry out three-dimensional reconstruction, a model of a required trachea substitute is constructed, the constructed model is subjected to real object printing through a near-field direct writing-3D printing technology, polyether-ether-ketone is selected to print the support ring 2, and polycaprolactone is printed on the micron-sized guide net 1; transplanting the engineered trachea substitute into muscle tissue beside the trachea of the dog, and carrying out prevascularization for two weeks; after two weeks, blood vessels are attached to the micron-sized guide net 1 in a climbing mode, the micron-sized guide net 1 is degraded, and the tissue-wrapped organ substitute forms a complete lumen with blood supply and good mechanical strength; the engineered trachea substitute with complete prevascularization is peeled from muscles, pedicel is transplanted to a trachea defect part, and after in-situ repair, the bronchoscope shows that a trachea lumen is not narrow and collapsed, and a dog survives for a long time.
In conclusion, the engineered trachea substitute is provided with the micron-sized guide net and the support ring, the whole engineered trachea is cylindrical and comprises the nondegradable support ring printed in a 3D mode and the degradable micron-sized guide net written in a near field mode, the near field direct writing-3D printing technology is integrated to build and form, the micron-sized guide net can promote the climbing of tissues such as blood vessels and the like, the repair process is promoted, the in-vivo integration of autologous tissues to the engineered trachea is completed, the micron-sized guide net is extremely easy to degrade after the tissues grow in, the biocompatibility of the whole engineered trachea substitute can be further improved, the engineered trachea substitute is made of common high polymer materials, and large-scale engineering production can be carried out.
While the utility model has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the spirit and scope of the utility model.
Claims (5)
1. An engineered gas tube substitute of multi-material separation ring structure, comprising: a micron-sized guide net (1) and a plurality of support rings (2);
the support rings (2) are uniformly arranged on a circular ring formed by the micron-sized guide nets (1), and the inner diameter of each support ring (2) is equal to the outer diameter of the circular ring formed by the micron-sized guide nets (1); the micron-sized guide net (1) is made of a high-molecular degradable material, and the support ring (2) is made of a high-molecular non-degradable material.
2. Engineered airway substitute according to claim 1, characterized in that the apertures on the micrometric guiding mesh (1) are identical parallelograms.
3. The engineered gas tube replacement according to claim 2, wherein a distance between any two vertices on the pores does not exceed 400 microns.
4. The engineered airway substitute according to claim 1, characterized in that the micrometric guiding mesh (1) is made of a filiform polymeric degradable material with a diameter comprised between 9 and 11 microns.
5. The engineered airway substitute according to claim 1, characterized in that the micrometric guiding mesh (1) and the supporting ring (2) are of one piece construction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122164840.XU CN216724876U (en) | 2021-09-08 | 2021-09-08 | Engineering gas pipe substitute with multi-material separation annular structure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122164840.XU CN216724876U (en) | 2021-09-08 | 2021-09-08 | Engineering gas pipe substitute with multi-material separation annular structure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN216724876U true CN216724876U (en) | 2022-06-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202122164840.XU Active CN216724876U (en) | 2021-09-08 | 2021-09-08 | Engineering gas pipe substitute with multi-material separation annular structure |
Country Status (1)
| Country | Link |
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| CN (1) | CN216724876U (en) |
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2021
- 2021-09-08 CN CN202122164840.XU patent/CN216724876U/en active Active
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