CN216712074U - Quantitative biochip reaction instrument - Google Patents
Quantitative biochip reaction instrument Download PDFInfo
- Publication number
- CN216712074U CN216712074U CN202122991144.6U CN202122991144U CN216712074U CN 216712074 U CN216712074 U CN 216712074U CN 202122991144 U CN202122991144 U CN 202122991144U CN 216712074 U CN216712074 U CN 216712074U
- Authority
- CN
- China
- Prior art keywords
- machine body
- side wall
- piece
- reaction
- support frame
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000006243 chemical reaction Methods 0.000 title claims abstract description 50
- 238000000018 DNA microarray Methods 0.000 title claims abstract description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 238000003756 stirring Methods 0.000 claims abstract description 11
- 239000010453 quartz Substances 0.000 claims abstract description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000007788 liquid Substances 0.000 claims description 9
- 238000007789 sealing Methods 0.000 claims description 6
- 239000003381 stabilizer Substances 0.000 claims description 3
- 238000009434 installation Methods 0.000 claims description 2
- 230000005389 magnetism Effects 0.000 claims 1
- 238000004140 cleaning Methods 0.000 abstract description 11
- 239000007921 spray Substances 0.000 abstract description 7
- 230000001954 sterilising effect Effects 0.000 abstract description 7
- 238000012864 cross contamination Methods 0.000 abstract description 5
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 2
- 238000001514 detection method Methods 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000000249 desinfective effect Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 239000010865 sewage Substances 0.000 description 3
- 239000011324 bead Substances 0.000 description 2
- 238000012742 biochemical analysis Methods 0.000 description 2
- -1 genomicDNA Proteins 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000003760 hair shine Effects 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Images
Landscapes
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The utility model discloses a quantitative biochip reaction instrument, which belongs to the technical field of chip reaction instruments and comprises a machine body, wherein a spray head is arranged at the top of the inner side wall of the machine body, the spray head is connected with a water supply device through a water pipe and a valve, an ultraviolet lamp is arranged in the middle of the inner side wall of the machine body, a quartz sleeve is covered on the outer side wall of the ultraviolet lamp, a stirring shaft is arranged in the middle of the inner side wall of the machine body, a plurality of support frames are locked and connected on the outer side wall of the stirring shaft, each support frame comprises an inner ring, a support rod and an end piece, the outer side wall of the inner ring is fixedly connected with the support rod, the tail end of the support rod is fixedly connected with the end piece, a groove is formed in the top of the end piece, the quantitative biochip reaction instrument is convenient to quickly install a reaction disc on the support frame, the reaction disc can be quickly taken down from the support frame, and automatic cleaning and sterilizing equipment is arranged in the machine body, can replace artificial intelligent cleaning and disinfection and prevent cross contamination.
Description
Technical Field
The utility model relates to the field of chip reactors, in particular to a quantitative biochip reactor.
Background
The biochip (biochip or bioarray) integrates biochemical analysis process on the chip surface according to the principle of specific interaction between biomolecules to realize high-throughput rapid detection of DNA, RNA, polypeptide, protein and other biological components, the narrow biochip concept is a biomolecule lattice formed by fixing biomolecules (oligonucleotide, cDNA, genomicDNA, polypeptide, antibody, antigen, etc.) on solid phase transmitters such as silicon chip, glass chip (bead), plastic sheet (bead), gel, nylon membrane, etc. by different methods, the biochip concept is an integration concept, the biochip is the integration of biological materials, like laboratory detection, the detection of blood sugar, protein, enzyme activity, etc. on the biochip is based on the same biological reaction principle, so the biochip is a carrier platform, which is a carrier, which is a micro biochemical analysis system integrating discontinuous analysis process in the scientific life field on the substrate surface, the detection of cells, proteins, genes and other biological components is accurate, rapid and large in information quantity, the detection is faster, sensitive and accurate due to the technical advantages of the biological chip, equipment such as a nucleic acid amplification instrument, a chip hybridization instrument, a chip cleaning machine and the like is generally needed when a biological sample is reacted at present, and the whole set of relevant equipment on the market is expensive, large in size, heavy, not suitable for frequent movement and difficult to move.
The existing quantitative biochip reactor has the following disadvantages: 1. the reaction disc of the existing quantitative biochip reactor is difficult to be quickly mounted or dismounted, so that a large amount of time is needed, and the working efficiency is reduced; 2. the existing quantitative biochip reaction instrument cannot be intelligently cleaned and disinfected, and is very troublesome because workers need to manually clean and disinfect the existing quantitative biochip reaction instrument.
SUMMERY OF THE UTILITY MODEL
The utility model aims to provide a quantitative biochip reactor, which is convenient for quickly mounting and dismounting a reaction disc on and from a support frame, and automatic cleaning and sterilizing equipment is arranged in a machine body, so that artificial intelligent cleaning and sterilizing can be replaced, cross contamination is prevented, and the problems in the background art are solved.
In order to achieve the purpose, the utility model provides the following technical scheme:
a quantitative biochip reaction instrument comprises a machine body, a spray head is arranged at the top of the inner side wall of the machine body, the spray head is connected with a water supply device through a water pipe and a valve, the middle part of the inner side wall of the machine body is provided with an ultraviolet lamp, the outer side wall of the ultraviolet lamp is covered with a quartz sleeve, the middle part of the inner side wall of the machine body is provided with a stirring shaft, the outer side wall of the stirring shaft is connected with a plurality of support frames in a locking way, each support frame comprises an inner ring, a support rod and an end piece, the outer side wall of the inner ring is fixedly connected with a supporting rod, the tail end of the supporting rod is fixedly connected with an end piece, the top of the end piece is provided with a groove, a second magnetic attraction piece is arranged at the bottom of the inner side wall of the groove, a first magnetic attraction piece is magnetically attracted at the top of the second magnetic attraction piece, the reaction disc is installed at the top of the first magnetic attraction piece, and the magnetic pole of the first magnetic attraction piece is opposite to that of the second magnetic attraction piece.
As a further scheme of the utility model: the supporting leg is installed to the organism bottom, the stabilizer blade is installed to the supporting leg bottom.
As a still further scheme of the utility model: the liquid outlet has been seted up to the organism bottom, liquid outlet lateral wall can be dismantled and is connected with sealed lid.
As a still further scheme of the utility model: the machine body opening is rotatably connected with a cabinet door through a hinge, and a handle is arranged on the surface of the cabinet door.
As a still further scheme of the utility model: the cabinet door edge bonds and has the gasket, the gasket is made for the rubber material.
As a still further scheme of the utility model: the power input end of the stirring shaft is connected with the power output end of a motor, and the motor is installed at the bottom of the machine body.
Compared with the prior art, the utility model has the beneficial effects that:
1. the quantitative biochip reaction apparatus is convenient for quickly mounting the reaction disc on the support frame and quickly taking down the reaction disc from the support frame, when the reaction disc needs to be mounted on the end piece, the first magnetic suction piece at the bottom of the reaction disc is aligned to the upper part of the groove, because the bottom of the inner side wall of the groove is provided with the second magnetic suction piece with the magnetic pole opposite to that of the first magnetic suction piece, the magnet has the characteristic of opposite attraction, when the first magnetic suction piece at the bottom of the reaction disc is inserted into the groove, the second magnetic suction piece can firmly adsorb the second magnetic suction piece, so that the reaction disc is firmly placed at the top of the end piece, when the reaction disc needs to be taken down, the reaction disc can be directly taken down, and the problem that the reaction disc of the conventional quantitative biochip reaction apparatus is difficult to be quickly mounted or dismounted is solved.
2. The automatic cleaning and disinfecting equipment is arranged in the body of the quantitative biochip reaction instrument, manual intelligent cleaning and disinfecting can be replaced, cross contamination is prevented, after work is completed, the cabinet door is closed, the valve and the ultraviolet lamp are opened, water in the water supply device flows to the spray head through the water pipe and is sprayed in the body, the inner side wall of the body is cleaned, meanwhile, the ultraviolet lamp emits ultraviolet rays, the ultraviolet rays irradiate in the body through the quartz sleeve to sterilize and disinfect the body, the sealing cover is opened at the same time, sewage in the body is discharged from the liquid outlet, and the problem that the existing quantitative biochip reaction instrument cannot be intelligently cleaned and disinfected is solved.
Drawings
FIG. 1 is a first schematic structural diagram of a quantitative biochip reaction apparatus according to an embodiment of the present invention;
FIG. 2 is a schematic structural diagram of a quantitative biochip reaction apparatus according to an embodiment of the present invention;
FIG. 3 is a schematic cross-sectional view of a quantitative biochip reaction apparatus according to an embodiment of the present invention;
fig. 4 is a schematic structural diagram at a in fig. 3.
In the figure: 1. a body; 2. sealing the sheet; 3. a spray head; 4. a water pipe; 5. a stirring shaft; 6. a support frame; 601. an inner ring; 602. a strut; 603. an end piece; 7. a reaction disc; 8. supporting legs; 9. a support leg; 10. an electric motor; 11. a liquid outlet; 12. a sealing cover; 13. a valve; 14. a hinge; 15. a cabinet door; 16. a first magnetic attraction sheet; 17. a second magnetic attraction sheet; 18. a groove; 19. an ultraviolet lamp; 20. a quartz sleeve; 21. a handle.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1 to 4, in the embodiment of the present invention, a quantitative biochip reaction apparatus includes a body 1, a nozzle 3 is installed on a top portion of an inner side wall of the body 1, the nozzle 3 is connected to a water supply device through a water pipe 4 and a valve 13, an ultraviolet lamp 19 is installed in a middle portion of the inner side wall of the body 1, a quartz sleeve 20 is covered on an outer side wall of the ultraviolet lamp 19, a stirring shaft 5 is installed in the middle portion of the inner side wall of the body 1, a support frame 6 is connected to an outer side wall of the stirring shaft 5 in a locking manner, the support frame 6 includes a plurality of support frames 6, the support frame 6 includes an inner ring 601, a support rod 602 and an end piece 603, a support rod 602 is fixedly connected to an outer side wall of the inner ring 601, an end piece 603 is fixedly connected to a tail end of the support rod 602, a groove 18 is formed in a top portion of the end piece 603, a second magnetic absorption piece 17 is installed at a bottom portion of the inner side wall of the groove 18, a first magnetic absorption piece 16 is magnetically absorbed at a top portion of the second magnetic absorption piece 17, the reaction disc 7 is arranged at the top of the first magnetic attraction piece 16, the magnetic pole of the first magnetic attraction piece 16 is opposite to that of the second magnetic attraction piece 17, the quantitative biochip reaction instrument is convenient to quickly arrange the reaction disc 7 on the support frame 6, the reaction disc 7 can be quickly taken down from the support frame 6, and automatic cleaning and sterilizing equipment is arranged in the machine body 1 and can replace artificial intelligent cleaning and sterilizing to prevent cross contamination.
Wherein, supporting leg 8 is installed to 1 bottom of organism, stabilizer blade 9 is installed to supporting leg 8 bottom, and the support is firm.
Wherein, liquid outlet 11 has been seted up to organism 1 bottom, sealed lid 12 can be dismantled and be connected with to the 11 lateral walls of liquid outlet, conveniently emit the inside sewage of washing organism 1.
The machine body 1 is provided with a cabinet door 15 at an opening through a hinge 14, and a handle 21 is arranged on the surface of the cabinet door 15, so that the material can be conveniently discharged or taken.
Wherein, 15 edges of cabinet door bonds and has gasket 2, gasket 2 is made for the rubber material, and the rubber matter is soft elasticity, and pressurized ability kick-backs rapidly under normal atmospheric temperature, and is sealed effectual.
The power input end of the stirring shaft 5 is connected with the power output end of a motor 10, and the motor 10 is installed at the bottom of the machine body 1, so that the stirring shaft 5, the support frame 6 and the reaction disc 7 can be conveniently driven to rotate.
The working principle of the utility model is as follows: the quantitative biochip reaction apparatus of the utility model facilitates the reaction disk 7 to be quickly installed on the supporting frame 6, and also can quickly take off the reaction disk 7 from the supporting frame 6, when the reaction disk 7 is needed to be installed on the end piece 603, the first magnetic attraction piece 16 at the bottom of the reaction disk 7 is aligned to the upper part of the groove 18, because the bottom of the inner side wall of the groove 18 is provided with the second magnetic attraction piece 17 with the magnetic pole opposite to that of the first magnetic attraction piece 16, the magnet has the characteristic of opposite attraction, when the first magnetic attraction piece 16 at the bottom of the reaction disk 7 is inserted into the groove 18, the second magnetic attraction piece 17 can firmly attract the second magnetic attraction piece 17, so that the reaction disk 7 is firmly placed at the top of the end piece 603, when the reaction disk 7 is needed to be taken off, the reaction disk can be directly taken off, the automatic cleaning and sterilizing equipment is arranged inside the body 1 of the quantitative biochip reaction apparatus of the utility model, which can replace artificial intelligent cleaning and sterilizing, prevent cross contamination, after the work is accomplished, close cabinet door 15, open valve 13 and ultraviolet lamp 19, make the water in the water supply installation through 4 flows to shower nozzle 3, sprays in organism 1, washs 1 inside wall of organism, and ultraviolet lamp 19 sends the ultraviolet ray simultaneously, shines in organism 1 through quartz sleeve 20, for the disinfection of disinfecting in the organism 1, opens sealed lid 12 simultaneously, emits the sewage in the organism 1 from liquid outlet 11.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and equivalent alternatives or modifications according to the technical solution of the present invention and the inventive concept thereof should be covered by the scope of the present invention.
Claims (6)
1. The utility model provides a quantitative biochip reaction appearance, includes organism (1), its characterized in that: shower nozzle (3) is installed at organism (1) inside wall top, shower nozzle (3) lead to pipe (4) and valve (13) and are connected with water supply installation, organism (1) inside wall mid-mounting has ultraviolet lamp (19), ultraviolet lamp (19) lateral wall cover has quartz sleeve pipe (20), organism (1) inside wall mid-mounting has (mixing) shaft (5), (mixing) shaft (5) lateral wall locking is connected with support frame (6), support frame (6) have a plurality of, support frame (6) include inner ring (601), branch (602) and end piece (603), inner ring (601) lateral wall fixedly connected with branch (602), branch (602) terminal fixedly connected with end piece (603), end piece (603) top is seted up flutedly (18), recess (18) inside wall bottom is installed the second magnetism and is inhaled piece (17), the reaction device is characterized in that a first magnetic attraction piece (16) is magnetically attracted to the top of the second magnetic attraction piece (17), a reaction disc (7) is mounted on the top of the first magnetic attraction piece (16), and the magnetic pole of the first magnetic attraction piece (16) is opposite to that of the second magnetic attraction piece (17).
2. The quantitative biochip reactor according to claim 1, wherein: supporting legs (8) are installed to organism (1) bottom, stabilizer blade (9) are installed to supporting leg (8) bottom.
3. The quantitative biochip reactor according to claim 1, wherein: a liquid outlet (11) is formed in the bottom of the machine body (1), and a sealing cover (12) is detachably connected to the outer side wall of the liquid outlet (11).
4. The quantitative biochip reactor according to claim 1, wherein: the opening of the machine body (1) is rotatably connected with a cabinet door (15) through a hinge (14), and a handle (21) is arranged on the surface of the cabinet door (15).
5. The quantitative biochip reactor according to claim 4, wherein: the edge of the cabinet door (15) is bonded with a sealing sheet (2), and the sealing sheet (2) is made of rubber.
6. The quantitative biochip reactor according to claim 1, wherein: the power input end of the stirring shaft (5) is connected with the power output end of a motor (10), and the motor (10) is installed at the bottom of the machine body (1).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202122991144.6U CN216712074U (en) | 2021-12-01 | 2021-12-01 | Quantitative biochip reaction instrument |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202122991144.6U CN216712074U (en) | 2021-12-01 | 2021-12-01 | Quantitative biochip reaction instrument |
Publications (1)
Publication Number | Publication Date |
---|---|
CN216712074U true CN216712074U (en) | 2022-06-10 |
Family
ID=81880174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202122991144.6U Expired - Fee Related CN216712074U (en) | 2021-12-01 | 2021-12-01 | Quantitative biochip reaction instrument |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN216712074U (en) |
-
2021
- 2021-12-01 CN CN202122991144.6U patent/CN216712074U/en not_active Expired - Fee Related
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0009320B1 (en) | Apparatus and method for harvesting material from micro-culture plates | |
JP4486964B2 (en) | Method and apparatus for detecting substances or analytes from analysis of one or more samples | |
CN1154847C (en) | Method for detection of contaminants | |
CN1648671B (en) | Detecting method for multiple reactor analytic chip and analytic chip and detector | |
CN1854719A (en) | Monitoring of a cleaning process | |
CN1912601A (en) | Monitoring of cleaning process | |
JP2004229657A (en) | Kit for separating and purifying nucleic acid or various biological materials, and system for automated operation of the same | |
US20060024710A1 (en) | Method and device for identifying germs | |
JP5570913B2 (en) | Biological cell culture container and culture apparatus | |
CN105861310B (en) | Integral type T cell culture apparatus and its application method | |
JP2011512148A (en) | Method and apparatus for culturing cells in open continuous mode | |
WO2020046878A1 (en) | System and method of metastable state mixing | |
CN110241008A (en) | A kind of device for extracting and detecting for large biological molecule | |
CN103207169A (en) | Microfluidic time-resolved fluorescence immunoassay device and application thereof | |
CN216712074U (en) | Quantitative biochip reaction instrument | |
CN210154899U (en) | Pesticide residue detection device convenient to sample | |
CN108579829B (en) | Pump-free micro-fluidic chip, preparation method thereof and portable biochemical analysis device | |
JP3587052B2 (en) | Biological sample pretreatment method and apparatus therefor | |
CN109929762A (en) | A kind of cell culture apparatus | |
CN105723202B (en) | Improved apparatus and method for reaction between solid and liquid phases | |
JPH05176752A (en) | Sampling device | |
CN203164120U (en) | Microfluidic time-resolved fluoroimmune assay device | |
CN117903937A (en) | Microfluidic cartridge for automatic perfusion culture of cells | |
CN217757457U (en) | Novel surface contact ware | |
CN214374844U (en) | Biotoxin detection device |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20220610 |
|
CF01 | Termination of patent right due to non-payment of annual fee |