CN216654486U

CN216654486U - N-butyl lithium dropping device

Info

Publication number: CN216654486U
Application number: CN202122894482.8U
Authority: CN
Inventors: 朱献存; 王鑫; 郑轶群; 陈仁萍; 李福海; 吴后江
Original assignee: Shandong Qidu Pharmaceutical Co Ltd
Current assignee: Shandong Qidu Pharmaceutical Co Ltd
Priority date: 2021-11-19
Filing date: 2021-11-19
Publication date: 2022-06-03
Anticipated expiration: 2031-11-19

Abstract

The utility model relates to an n-butyl lithium dropping device which comprises an upper cavity and a lower cavity which are arranged in a shell, wherein a first dropping pipe is connected between the upper cavity and the lower cavity, a control valve is arranged on the first dropping pipe, observation ports are respectively arranged on the upper cavity and the lower cavity, a viewing mirror is arranged on the outer side of each observation port, the top of the upper cavity is connected with a first nitrogen adding pipe and a liquid inlet pipe, the bottom of the lower cavity is provided with a second dropping pipe which is divided into an inner pipe and an outer pipe, the inner pipe is connected with the lower cavity, the bottom of the outer pipe is connected with a connecting flange, and one side of the appearance is connected with a second nitrogen adding pipe. The utility model reduces the use of glass articles. More durable and less prone to damage. The device can be used as an independent dripping unit after connection is finished, so that excessive hose connection is reduced, and the operation is easier. And nitrogen is introduced for protection before dropwise addition, so that the method is safer and is convenient to manufacture.

Description

N-butyl lithium dropping device

Technical Field

The utility model relates to a n-butyl lithium dripping device, and belongs to the technical field of liquid medicine dripping.

Background

In the production of the bulk drug tropisetron hydrochloride, the dropwise adding operation of the hazardous chemical n-butyllithium is carried out in one step. The n-butyl lithium can be combusted in the air, and in order to observe the filling speed of the n-butyl lithium in the operation process, a simple device consisting of a simple glass product and a thick-wall rubber tube is used for carrying out dropwise adding operation.

The defects and shortcomings of the prior art are as follows:

1. glassware was extremely fragile. In the dropping process, the equipment cleaning and maintenance process, the glass breakage is easy to cause personnel injury and fire, explosion and other dangers.

2. Each part is complicated to splice before every use, wastes time and energy and easily causes device connection errors because of negligence.

3. The processing difficulty of the glass product special-shaped piece is large, and the processing difficulty of the standard piece with consistent size is large.

SUMMERY OF THE UTILITY MODEL

The utility model provides a n-butyllithium dropping device, which solves the problems in the background technology.

The utility model relates to an n-butyl lithium dropping device which comprises an upper cavity and a lower cavity which are arranged in a shell, wherein a first dropping pipe is connected between the upper cavity and the lower cavity, a control valve is arranged on the first dropping pipe, observation ports are respectively arranged on the upper cavity and the lower cavity, a viewing mirror is arranged on the outer side of each observation port, the top of the upper cavity is connected with a first nitrogen adding pipe and a liquid inlet pipe, the bottom of the lower cavity is provided with a second dropping pipe which is divided into an inner pipe and an outer pipe, the inner pipe is connected with the lower cavity, the bottom of the outer pipe is connected with a connecting flange, and one side of the appearance is connected with a second nitrogen adding pipe. Except that the sight glass is adopted, the other parts can be made of corrosion-resistant and easily-processed materials such as stainless steel, titanium materials and the like. The characteristics of metal determine its greater durability and less susceptibility to damage.

Preferably, the two observation ports are arranged on the upper cavity and the lower cavity, the two observation ports are symmetrically arranged about the central line of the upper cavity, a sealing gasket is arranged between the observation ports and the sight glass, and a fixing flange for pressing the sight glass through a fixing bolt is arranged on the outer side of the sight glass. The sight glass adopts the symmetry design, can add lighting apparatus such as eyehole lamp and assist the observation when light is not good. The sight glass is the thickening sight glass, and intensity is higher, and sealed pad prevents the weeping.

Preferably, the shell outside the upper cavity and the lower cavity is fixed through a connecting plate.

Preferably, the bottom of the liquid inlet pipe is provided with a downward inclined opening, the bottom of the first nitrogen adding pipe is provided with a flat opening, and the bottom of the liquid inlet pipe is positioned below the bottom of the first nitrogen adding pipe. The n-butyl lithium liquid inlet pipe adopts a lower inclined opening, and the nitrogen adding pipe I adopts a lower flat opening, so that the liquid residue is convenient to distinguish and reduce.

Preferably, the bottoms of the first dripping pipe and the first inner pipe are both provided with downward inclined openings. The liquid residue is reduced.

The utility model has the following beneficial effects:

the use of glass products is reduced. More durable and less prone to damage. The device can be used as an independent dripping unit after connection is finished, so that excessive hose connection is reduced, and the operation is easier. And nitrogen is introduced for protection before dropwise addition, so that the method is safer and is convenient to manufacture.

Drawings

FIG. 1 is a schematic front view of the present invention;

FIG. 2 is a left side view of the present invention;

in the figure: 1. the device comprises a liquid inlet pipe, 2, a nitrogen adding pipe I, 3, a fixing bolt, 4, a viewing mirror, 5, a fixing flange, 6, a sealing gasket, 7, a control valve, 8, a lower cavity, 9, a connecting flange, 10, an inner pipe, 11, an outer pipe, 12, a nitrogen adding pipe II, 13, a dropping pipe I, 14, an upper cavity, 15 and a connecting plate.

Detailed Description

The present invention will be further described with reference to the following examples.

As shown in fig. 1 to 2, the utility model relates to an n-butyl lithium dropping device, which comprises an upper cavity 14 and a lower cavity 8 which are arranged in a shell, wherein a first dropping pipe 13 is connected between the upper cavity 14 and the lower cavity 8, a control valve 7 is arranged on the first dropping pipe 13, observation ports are arranged on the upper cavity 14 and the lower cavity 8, a viewing mirror 4 is arranged outside the observation ports, the top of the upper cavity 14 is connected with a first nitrogen adding pipe 2 and a liquid inlet pipe 1, the bottom of the lower cavity 8 is provided with a second dropping pipe which is divided into an inner pipe 10 and an outer pipe 11, the inner pipe 10 is connected with the lower cavity 8, the bottom of the outer pipe 11 is connected with a connecting flange 9, and one side of the appearance is connected with a second nitrogen adding pipe 12.

The observation ports of the upper cavity 14 and the lower cavity 8 are respectively provided with two observation ports, the two observation ports are symmetrically arranged about the central line of the upper cavity 14, a sealing gasket 6 is arranged between the observation ports and the sight glass 4, and the outer side of the sight glass 4 is provided with a fixing flange 5 tightly pressed through a fixing bolt 3.

The upper cavity 14 and the shell outside the lower cavity 8 are fixed through a connecting plate 15.

The bottom of the liquid inlet pipe 1 is arranged in a downward inclined opening mode, the bottom of the nitrogen adding pipe I2 is arranged in a flat opening mode, and the bottom of the liquid inlet pipe 1 is located below the bottom of the nitrogen adding pipe I2.

The bottoms of the first dripping pipe 13 and the first inner pipe 10 are both arranged by adopting downward inclined openings. Meanwhile, the sight glass adopts a thickening design, so that the damage frequency of the sight glass is further reduced.

During installation, flange 9 is installed on the feed inlet of retort, and at this moment, in 11 lower extremes of outer tube intercommunication retort, the bottom of inner tube 10 stretched into the feed inlet of retort in, before the dropwise add, earlier through nitrogen gas addition pipe 2 and nitrogen gas addition pipe two 12, pour into nitrogen gas into in cavity 14, lower cavity 8 and the retort, the exhaust air protects, then n-butyl lithium solution gets into cavity 14 from feed inlet pipe 1, goes up cavity 14 and can keep in n-butyl lithium material and use control valve 7 control dropwise add speed. Can observe the reserves of material through top sight glass 5, can observe liquid dropwise add speed through below sight glass 5 and be convenient for control, can add lighting apparatus auxiliary observation such as sight glass lamp in a side sight glass 5 when light is not good.

In summary, the present invention reduces the use of glass articles. More durable and less prone to damage. The device can be used as an independent dripping unit after connection is finished, so that excessive hose connection is reduced, and the operation is easier. And nitrogen is introduced for protection before dropwise addition, so that the method is safer and is convenient to manufacture.

Furthermore, it should be understood that although the present specification describes embodiments, not every embodiment includes only a single embodiment, and such description is for clarity purposes only, and it is to be understood that all embodiments may be combined as appropriate by one of ordinary skill in the art to form other embodiments as will be apparent to those of skill in the art from the description herein.

In the description of the present invention, the terms "inside", "outside", "longitudinal", "lateral", "up", "down", "top", "bottom", and the like indicate orientations or positional relationships based on those shown in the drawings, and are for convenience only to describe the present invention without requiring the present invention to be necessarily constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.

Claims

1. A n-butyl lithium dropwise adding device is characterized in that: including last cavity (14) and lower cavity (8) that set up in the casing, go up cavity (14) and be connected with between cavity (8) dropwise add pipe (13) down, be equipped with control flap (7) on dropwise add pipe (13), upward all be equipped with the viewing aperture on cavity (14) and lower cavity (8), the outside of viewing aperture is equipped with sight glass (4), the top of going up cavity (14) is connected with nitrogen gas and adds pipe (2) and feed liquor pipe (1), the bottom of cavity (8) is equipped with dropwise add pipe two down, the dropwise add pipe is divided into inner tube (10) and outer tube (11), cavity (8) under inner tube (10) connection, the bottom of outer tube (11) is connected with flange (9), outer tube one side is connected with nitrogen gas and adds pipe two (12).

2. The n-butyllithium dropping apparatus according to claim 1, characterized in that: the observation ports of the upper cavity (14) and the lower cavity (8) are respectively provided with two observation ports, the two observation ports are symmetrically arranged about the central line of the upper cavity (14), a sealing gasket (6) is arranged between the observation ports and the sight glass (4), and the outer side of the sight glass (4) is provided with a fixing flange (5) which is tightly pressed through a fixing bolt (3).

3. The n-butyllithium dropping apparatus according to claim 2, characterized in that: the upper cavity (14) and the shell outside the lower cavity (8) are fixed through a connecting plate (15).

4. The n-butyllithium dropping apparatus according to claim 3, characterized in that: the bottom of the liquid inlet pipe (1) is arranged by adopting a lower inclined opening, the bottom of the nitrogen adding pipe I (2) is arranged by adopting a flat opening, and the bottom of the liquid inlet pipe (1) is positioned below the bottom of the nitrogen adding pipe I (2).

5. The n-butyllithium dropping apparatus according to claim 4, characterized in that: the bottoms of the first dripping pipe (13) and the inner pipe (10) are both arranged by adopting downward inclined openings.