CN216628817U - Cell patch transplanting tool - Google Patents
Cell patch transplanting tool Download PDFInfo
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- CN216628817U CN216628817U CN202121626973.8U CN202121626973U CN216628817U CN 216628817 U CN216628817 U CN 216628817U CN 202121626973 U CN202121626973 U CN 202121626973U CN 216628817 U CN216628817 U CN 216628817U
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- 239000007769 metal material Substances 0.000 description 6
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- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 4
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- Materials For Medical Uses (AREA)
Abstract
The present disclosure provides a cell patch transplantation tool, which mainly comprises: the bearing part is of a porous flexible net-shaped structure; the bearing part is used for bearing the cell membrane and realizing the attachment between the cell membrane and the tissue to be repaired during transplantation. The cell membrane is supported by the supporting part which is provided with the flexible net-shaped structure with the holes and used as a cell membrane transplanting tool, so that the cell membrane can be flatly spread on the surface of the supporting part and can leak liquid in a liquid environment through the holes, and the damage of the liquid surface tension to the cell membrane can be reduced; meanwhile, when the cell membrane is transplanted to the surface of the tissue to be repaired, the transplanting tool and the cell membrane are attached to the surface of the tissue to be repaired together, and the cell membrane is convenient to be well attached to the surface of the tissue to be repaired based on the flexibility of the cell membrane, so that a better transplanting effect is achieved.
Description
Technical Field
The disclosure relates to the field of medical equipment, in particular to a cell patch transplanting tool.
Background
The cell patch is a novel tissue engineering technology which is researched and developed in recent years, and is a novel dosage form of cell preparation. When the cell membrane is prepared, cells are planted and cultured in a temperature sensitive culture dish with a temperature sensitive macromolecule surface, the cells are closely attached to the surface of the temperature sensitive culture dish for proliferation at a culture temperature of 37 ℃, and the cells are closely connected with each other by secreting extracellular matrix. After the cells are fully converged, the temperature-sensitive culture dish with the cultured cells is cooled and placed in a room temperature environment of 20-25 ℃, and the fully converged cells automatically separate from the bottom of the temperature-sensitive culture dish in a lamellar membrane shape due to chain end structure change of temperature-sensitive polymers on the surface of the culture dish, so that a single-layer cell membrane is formed.
The cell membrane has the advantages that the cell membrane is beneficial to being transplanted to a diseased part in a centralized way, the local loss of cells and the mistaken entry of the cells into other visceral organs are reduced, but the cell membrane is easy to damage when being operated by using sharp instruments such as tweezers and the like due to thin thickness and weak mechanical toughness; furthermore, in the process of taking out the cell membrane from the preservation solution or the balance cleaning solution, the cell membrane is also subjected to edge tearing due to the influence of the surface tension of the liquid, so that the cell membrane is damaged and is not favorable for transplantation.
SUMMERY OF THE UTILITY MODEL
An object of the disclosed embodiment is to provide a cell membrane transplantation tool, which is used for solving the problem that the mechanical toughness of a cell membrane is weak, and the cell membrane is easily damaged when being operated by using sharp instruments such as tweezers, so that the transplantation effect is poor in the prior art.
The embodiment of the disclosure adopts the following technical scheme: a cell patch transplantation tool comprising: the bearing part is a porous flexible net-shaped structure; the bearing part is used for bearing the cell membrane and realizing the attachment between the cell membrane and the tissue to be repaired during transplantation.
In some embodiments, the surface area of the carrier is greater than the surface area of the cell patch.
In some embodiments, the shape of the load bearing portion includes at least one of: circular, oval, polygonal.
In some embodiments, the shape of the carrier matches the shape of the cell patch.
In some embodiments, the shape of the hole on the bearing part comprises at least one of: circular, oval, polygonal.
In some embodiments, when the hole is circular, the hole is configured to have a pore size of between 18 microns and 550 microns; when the hole is non-circular, the maximum sphere diameter allowed to pass through the hole is configured to be between 18 microns and 550 microns.
In some embodiments, the material used for the load-bearing part comprises at least one of the following: polyethylene, polypropylene, polycarbonate, polystyrene, nylon, cotton, cellulose acetate, 304 stainless steel, 306 stainless steel, 316L stainless steel, 317L stainless steel, pure titanium, titanium-based alloys, silver, gold.
In some embodiments, the wire diameter of the material used for the carrier is configured to be between 0.001 mm and 3 mm.
In some embodiments, the cell patch transplantation tool further comprises: the fixed end of each holding part is connected with the edge of the bearing part, and the free end, opposite to the fixed end, of each holding part is used for being held by a user.
In some embodiments, the material used for the gripping portion is the same as the material used for the carrier portion.
The beneficial effects of this disclosed embodiment lie in: the flexible net structure with the holes is used as a bearing part of the cell membrane transplanting tool to bear the cell membrane, so that the cell membrane can be flatly spread on the surface of the bearing part and can leak liquid in a liquid environment through the holes, and the damage of the liquid surface tension to the cell membrane can be reduced; meanwhile, when the cell membrane is transplanted to the surface of the tissue to be repaired, the transplanting tool and the cell membrane are attached to the surface of the tissue to be repaired together, and the cell membrane is convenient to be well attached to the surface of the tissue to be repaired based on the flexibility of the cell membrane, so that a better transplanting effect is achieved.
Drawings
In order to more clearly illustrate the embodiments of the present disclosure or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly introduced below, it is obvious that the drawings in the following description are only some embodiments described in the present disclosure, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic structural diagram of a cell patch transplantation tool according to an embodiment of the present disclosure;
FIG. 2 is a schematic view of a carrier with rectangular holes according to an embodiment of the present disclosure;
FIG. 3 is a schematic view of a carrier with holes in the shape of irregular polygons according to an embodiment of the present disclosure;
FIG. 4 is another schematic structural diagram of a cell patch transplantation tool according to an embodiment of the present disclosure.
Reference numerals
1-support part 2-cell membrane 3-holding part
Detailed Description
Various aspects and features of the disclosure are described herein with reference to the drawings.
It will be understood that various modifications may be made to the embodiments of the present application. Accordingly, the foregoing description should not be construed as limiting, but merely as exemplifications of embodiments. Other modifications will occur to those skilled in the art within the scope and spirit of the disclosure.
The accompanying drawings, which are incorporated in and constitute a part of the specification, illustrate embodiments of the disclosure and, together with a general description of the disclosure given above, and the detailed description of the embodiments given below, serve to explain the principles of the disclosure.
These and other characteristics of the present disclosure will become apparent from the following description of preferred forms of embodiment, given as non-limiting examples, with reference to the attached drawings.
It should also be understood that, although the present disclosure has been described with reference to some specific examples, a person of skill in the art shall certainly be able to achieve many other equivalent forms of the disclosure, having the characteristics as set forth in the claims and hence all coming within the field of protection defined thereby.
The above and other aspects, features and advantages of the present disclosure will become more apparent in view of the following detailed description when taken in conjunction with the accompanying drawings.
Specific embodiments of the present disclosure are described hereinafter with reference to the accompanying drawings; however, it is to be understood that the disclosed embodiments are merely exemplary of the disclosure that may be embodied in various forms. Well-known and/or repeated functions and structures have not been described in detail so as not to obscure the present disclosure with unnecessary or unnecessary detail. Therefore, specific structural and functional details disclosed herein are not to be interpreted as limiting, but merely as a basis for the claims and as a representative basis for teaching one skilled in the art to variously employ the present disclosure in virtually any appropriately detailed structure.
The description may use the phrases "in one embodiment," "in another embodiment," "in yet another embodiment," or "in other embodiments," which may each refer to one or more of the same or different embodiments in accordance with the disclosure.
In order to solve the problem that the mechanical toughness of a cell membrane is weak, and the cell membrane is easily damaged when being operated by using sharp instruments such as tweezers and the like, so that the transplanting effect is not good in the prior art, the embodiment of the disclosure provides a cell membrane transplanting tool, the structural schematic of which is shown in fig. 1, and the transplanting tool at least comprises a bearing part 1. Specifically, the bearing part 1 is a porous flexible net structure, and the shape of the net structure can be changed based on the shape of the surface of the object covered by the net structure or the external force applied condition to which the net structure is subjected. The bearing part 1 is mainly used for bearing the cell membrane 2, and in the process of transplanting the cell membrane, the transplanting tool and the cell membrane 2 are attached to the surface of the tissue to be repaired together, so that a better transplanting effect is achieved.
Specifically, the cell patch 2 is placed in a culture dish containing a culture solution such as a preservation solution or an equilibrium washing solution before transplantation, and usually, the cell patch 2 floats on the liquid surface with a certain distance from the bottom surface of the culture dish. When needs transplant, put into liquid environment with load-bearing part 1 along the culture dish lateral wall, until load-bearing part 1 removes to cell membrane 2 below, accessible clamping means such as tweezers at this moment centre gripping load-bearing part 1 makes cell membrane 2 smooth spreading on load-bearing part 1 surface to drag for from the culture dish. In the fishing process, the culture solution leaks out through a plurality of holes on the bearing part 1, so that the damage of the liquid surface tension to the cell membrane 2 is reduced. When the cell membrane 2 is transferred, due to the hole structure on the bearing part 1, part of culture solution is remained between the holes, so that the shape and the humidity of the cell membrane 2 can be maintained for a short time, and the smooth spreading effect of the cell membrane 2 can be ensured.
When the cell membrane 2 is transplanted to the tissue surface to be repaired, the transplantation tool provided in the embodiment can be attached to the tissue surface to be repaired together with the cell membrane 2 loaded on the transplantation tool, and based on the flexible characteristics of the transplantation tool loading part 1, the transplantation tool can deform according to the actual shape of the tissue surface to be repaired, and meanwhile, the cell membrane 2 also deforms according to the shape of the tissue surface to be repaired, so that the cell membrane 2 is better attached to the tissue surface to be repaired, and the situation that the cell membrane 2 is folded or damaged in the attaching process is avoided. After the attachment is finished, the bearing part 1 and the cell membrane 2 are peeled off, and the cell membrane 2 is kept on the surface of the tissue to be repaired; specifically, when the bearing part 1 and the cell membrane 2 are separated, the flexible bearing part 1 can be slowly peeled off from the current attached position, at this time, due to the hole structure of the bearing part 1, the bonding force between the cell membrane 2 and the surface of the tissue to be repaired is greater than the bonding force between the cell membrane 2 and the bearing part 1, so that the cell membrane 2 is tightly attached to the surface of the tissue to be repaired in the peeling process of the bearing part 1, and the transplantation is completed. In addition, it should be noted that in the stripping process, the carrier part 1 can be washed by liquid such as physiological saline which does not affect the characteristics of the cell membrane 2, so as to realize the rapid separation between the cell membrane 2 and the carrier part 1.
In the embodiment, the flexible net-shaped structure with the holes is used as the bearing part of the cell membrane transplanting tool to bear the cell membrane, so that the cell membrane can be flatly spread on the surface of the bearing part and can leak liquid in a liquid environment through the holes, and the damage of the liquid surface tension to the cell membrane can be reduced; meanwhile, when the cell membrane is transplanted to the surface of the tissue to be repaired, the transplanting tool and the cell membrane are attached to the surface of the tissue to be repaired together, and the cell membrane is convenient to be well attached to the surface of the tissue to be repaired based on the flexibility of the cell membrane, so that a better transplanting effect is achieved.
In some embodiments, the surface area of the supporting part 1 needs to be larger than that of the cell membrane 2, so as to ensure that the cell membrane 2 can be completely and flatly spread on the supporting part 1 when being transplanted, and meanwhile, a certain position is reserved to facilitate the clamping of a clamping tool, so that the clamping tool can not contact the cell membrane 2 in the clamping process. The shape of the support part 2 may be circular, oval or any polygon, and the shape of the support part is optimally matched with the shape of the cell membrane 2 to be supported. In general, the cell membrane 2 is mainly circular, and the support member 1 may have a circular mesh structure.
In some embodiments, the holes on the carrier 1 may be arranged in a regular shape or an irregular shape, for example, they may be arranged in any one or more of a circle, an ellipse, and a polygon, which may be selected according to the type or size of the cell membrane 2 to be actually carried. Fig. 2 shows a schematic view of a carrier part with rectangular holes, and fig. 3 shows a schematic view of a carrier part with irregular polygonal holes. It should be noted that each of the plurality of holes may be configured to have the same shape and size, or may be configured to have different shapes and sizes as shown in fig. 2 or 3. The specific method can be adjusted according to different manufacturing materials and manufacturing processes, and the embodiment is not limited.
Further, the specific size of the holes may also affect the transplantation effect, if the holes are too small, the tension between the bearing part 1 and the cell membrane 2 is large, which is not favorable for the separation operation of the bearing part and the cell membrane 2, and if the holes are too large, the cell membrane 2 is easily collapsed at the holes, which causes damage to the cell membrane 2. In addition, the specific size of the holes can be set according to the specific shape, when the holes are circular, the hole diameter is configured to be between 18 micrometers and 550 micrometers, preferably between 48 micrometers and 550 micrometers, and usually, the hole diameter can achieve the best bearing effect when the hole diameter is set to be between 80 micrometers and 550 micrometers, for example, holes with a hole diameter of 150 micrometers (100 meshes), 125 micrometers (120 meshes) or 106 micrometers (140 meshes) are selected; when the hole is non-circular, the diameter of the largest sphere that the hole allows to pass through is preferably set to be 18 to 550 μm.
In addition, when the size of the holes is actually selected, the size of the holes can be selected according to the bonding force between the surface of the tissue to be repaired and the cell membrane 2, so that the bonding force between the bearing part 1 and the cell membrane 2 is smaller than the bonding force between the surface of the tissue to be repaired and the cell membrane 2, and the problem of difficult peeling caused by the fact that the bonding force between the bearing part 1 and the cell membrane 2 is larger than the bonding force between the cell membrane 2 and the surface of the tissue to be repaired due to the over-small holes is solved.
In this embodiment, the carrier 1 should be made of a material that is not cytotoxic and does not react with a simulated body fluid such as physiological saline, a buffer solution, or a cell membrane preservation solution, and may be made of a metal material or a non-metal material, and the material should have good stability and be less likely to be oxidized, deformed, or aged in the air.
Specifically, the non-metallic materials include, but are not limited to, polyethylene, polypropylene, polycarbonate, polystyrene, nylon, cotton, cellulose acetate, and the like; the metal material includes, but is not limited to, 304 stainless steel, 306 stainless steel, 316L stainless steel, 317L stainless steel, pure titanium, titanium-based alloy, silver, gold, etc., and can be made of a combination of the above metal materials. In practice, it is preferable to use nylon, cellulose acetate, etc. to improve the flexibility of the carrier 1 and reduce the damage of the carrier 1 to the cell membrane 2.
Based on different materials of the bearing part 1, the bearing part 1 can be manufactured in different modes when the bearing part 1 is actually manufactured, and the bearing part 1 can be specifically manufactured by a weaving process for materials such as nylon, cotton, cellulose acetate and the like; for various metal materials, the bearing part 1 can be prepared by casting, punch forming, additive manufacturing and the like; for materials such as polyethylene, polypropylene, polycarbonate, polystyrene, etc., the carrier part 1 may be prepared by additive manufacturing, etc. Of course, in the actual preparation process, a combination of multiple preparation methods may be performed according to the actual material selection condition and the precision requirement, and other preparation methods that can achieve the same preparation effect may also be selected, which is not limited in this embodiment.
In some embodiments, the diameter of the filament selected for the preparation of the carrier part 1 is configured to be between 0.001 mm and 3 mm, preferably between 0.1 mm and 1 mm, and particularly for the preparation by a knitting process, nylon threads or the like in the above range can be directly selected; for the carrier part 1 prepared by casting or stamping, the wire diameter can be defined by analogy of the distance of the material between the holes to the wire diameter.
FIG. 4 is another schematic diagram of the cell patch transplantation tool. As shown in fig. 4, taking the circular carrying part 1 as an example, three holding parts 3 are arranged at the edge of the carrying part 1, and can be uniformly distributed on the circumference of the circular carrying part 1, the fixed end of each holding part 3 is connected with the edge of the carrying part 1, and the free end opposite to the fixed end is used for being held by a user, so that the carrying part 1 can be controlled more conveniently in the processes of fishing, transferring, attaching, separating and the like of the cell membrane 2. In actual use, the number of the grip portions 3 may be adjusted according to the shape of the carrier portion 1, and for example, when the carrier portion 1 is square, one grip portion may be provided at each of four corners of the square. It should be noted that the number of the holding portions should be three or more to ensure the balance of the carrying portion 1 when the user holds the holding portions 3. In addition, the material used for the grip portion 3 is guaranteed to be the same as the carrier portion 1 as much as possible, and can be prepared simultaneously with the carrier portion 1 at the time of preparation.
In the actual transplantation of the cell patch 2, it is necessary to perform a sterilization operation on the cell patch transplantation tool in order to avoid contamination of the cell patch 2. The sterilization scheme of the cell patch transplanting tool comprises but is not limited to ethylene oxide sterilization, hydrogen peroxide plasma sterilization, high-temperature moist heat sterilization and high-temperature dry heat sterilization, and when the sterilization scheme is realized, the selected sterilization method is matched with the material.
Moreover, although exemplary embodiments have been described herein, the scope thereof includes any and all embodiments based on the disclosure with equivalent elements, modifications, omissions, combinations (e.g., of various embodiments across), adaptations or alterations. The elements of the claims are to be interpreted broadly based on the language employed in the claims and not limited to examples described in the present specification or during the prosecution of the application, which examples are to be construed as non-exclusive. It is intended, therefore, that the specification and examples be considered as exemplary only, with a true scope and spirit being indicated by the following claims and their full scope of equivalents.
The above description is intended to be illustrative and not restrictive. For example, the above-described examples (or one or more versions thereof) may be used in combination with each other. For example, other embodiments may be used by those of ordinary skill in the art upon reading the above description. In addition, in the foregoing detailed description, various features may be grouped together to streamline the disclosure. This should not be interpreted as an intention that a non-claimed disclosed feature is essential to any claim. Rather, the subject matter of the present disclosure may lie in less than all features of a particular disclosed embodiment. Thus, the following claims are hereby incorporated into the detailed description as examples or embodiments, with each claim standing on its own as a separate embodiment, and it is contemplated that these embodiments may be combined with each other in various combinations or permutations. The scope of the disclosure should be determined with reference to the appended claims, along with the full scope of equivalents to which such claims are entitled.
Although the present disclosure has been described in detail with reference to the specific embodiments, it should be understood that the present disclosure is not limited to those precise embodiments, and that various changes and modifications may be effected therein by one skilled in the art based on the teachings herein.
Claims (9)
1. A cell patch transplantation tool, comprising:
the bearing part is a porous flexible net-shaped structure; wherein,
the bearing part is used for bearing the cell membrane and realizing the attachment between the cell membrane and the tissue to be repaired during transplantation.
2. The cell patch transplantation tool according to claim 1,
the surface area of the bearing part is larger than that of the cell membrane.
3. The cell patch transplantation tool according to claim 1,
the shape of the bearing part at least comprises one of the following shapes: circular, oval, polygonal.
4. The cell patch transplantation tool according to claim 3,
the shape of the bearing part is matched with that of the cell membrane.
5. The cell patch transplantation tool according to claim 1,
the shape of the hole on the bearing part at least comprises one of the following shapes: circular, oval, polygonal.
6. The cell patch transplantation tool according to claim 5,
when the holes are circular, the hole diameters of the holes are configured to be 18-550 micrometers;
when the hole is non-circular, the maximum sphere diameter allowed to pass through the hole is configured to be between 18 microns and 550 microns.
7. The cell patch transplantation tool according to claim 1,
the diameter of the wire material of the bearing part is configured to be 0.001 mm to 3 mm.
8. The cell patch transplantation tool of any one of claims 1-7, further comprising:
the fixed end of each holding part is connected with the edge of the bearing part, and the free end, opposite to the fixed end, of each holding part is used for being held by a user.
9. The cell patch transplantation tool according to claim 8,
the holding part is made of the same material as the bearing part.
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|---|---|---|---|
| CN202121626973.8U CN216628817U (en) | 2021-07-16 | 2021-07-16 | Cell patch transplanting tool |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202121626973.8U CN216628817U (en) | 2021-07-16 | 2021-07-16 | Cell patch transplanting tool |
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| CN216628817U true CN216628817U (en) | 2022-05-31 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024114114A1 (en) * | 2022-11-30 | 2024-06-06 | 京东方科技集团股份有限公司 | Cell sheet cryopreservation device and cell sheet cooling device |
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- 2021-07-16 CN CN202121626973.8U patent/CN216628817U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024114114A1 (en) * | 2022-11-30 | 2024-06-06 | 京东方科技集团股份有限公司 | Cell sheet cryopreservation device and cell sheet cooling device |
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