CN216595167U

CN216595167U - Move liquid ware device and automatic sample processing system back

Info

Publication number: CN216595167U
Application number: CN202122674806.7U
Authority: CN
Inventors: 冀艳峰; 施建春; 叶锋
Original assignee: BEIJING SEARCH BIOTECH CO LTD
Current assignee: Beijing Genomeprecision Technology Co ltd
Priority date: 2021-11-03
Filing date: 2021-11-03
Publication date: 2022-05-24
Anticipated expiration: 2031-11-03

Abstract

The embodiment of the application provides a liquid withdrawing and transferring device which comprises a vacuumizing mechanism, a driving assembly, a first blocking piece and a motion limiting assembly; the vacuumizing mechanism is connected with the driving assembly, the vacuumizing mechanism and the motion limiting assembly are respectively connected with the first blocking piece and are uniformly distributed on one side of the first blocking piece, the pipettes are distributed on the other side of the first blocking piece, and the pipettes are detachably connected with one end of the vacuumizing mechanism; the movement limiting assembly is used for limiting the driving assembly to drive the first blocking piece to continue to move in the direction away from the pipettor. The vacuum pumping mechanism can effectively reduce the risk of damage to the vacuum pumping mechanism.

Description

Move liquid ware device and automatic sample processing system move back

Technical Field

The embodiments of the present application belong to the field of automatic sample processing systems, and more particularly, to a liquid withdrawing and transferring device and an automatic sample processing system.

Background

In the field of liquid biopsy in medical clinic, a full-automatic sample processing system with functions of capturing, dyeing and marking Circulating Tumor Cells (CTCs) and the like is realized, has functions of quasi-pipetting, precise sample adding, heating and incubation and the like, and mainly aims at simulating manual operation and surpassing manual operation.

The automatic sample processing system has a wide application range, and in the application occasions of biological experiments, clinical examinations and the like, reagents and samples need to be subjected to liquid transferring and separating treatment, the pipettors need to be inserted and withdrawn in both manual operation and full-automatic sample processing systems, and for a machine, the automatic liquid withdrawing and transferring device is not easy to realize.

The method for withdrawing the liquid transfer device is mainly characterized in that a first blocking piece in a semicircular opening shape is installed at a waste liquid transfer device collecting position of a working platform of a full-automatic sample processing system, when the liquid transfer device needs to be withdrawn, the liquid transfer device enters into the opening of the first blocking piece, and a liquid transfer device supporting piece is lifted upwards; since the pipette is blocked by the first blocking piece, the pipette support and the pipette are naturally separated.

The method for withdrawing the pipette has the following problems:

1. the first stop piece is arranged on the working platform, and when the device is debugged, the pipette support easily collides against the first stop piece, so that the pipette support or a liquid suction pump above the pipette support is damaged.

2. The first blocking piece is arranged on the working platform, and an opening structure is arranged on the first blocking piece. On the one hand, there is a risk of collision with other moving parts; on the other hand, the operator sometimes needs to insert his hand into the workbench to replace the accessories and accessories on the workbench, and the operator may accidentally bump into the first blocking member to cause personal injury.

3. When the first blocking piece is installed, threaded holes need to be punched in the workbench, and all the threaded holes almost need to be punched through the workbench due to the fact that the thickness of the table top of the workbench is generally insufficient; this can easily result in leakage of liquid from the top of the table, which can cause damage to the electronic components in the table.

4. The first blocking piece with the opening structure is arranged on the workbench, so that the workbench is extremely unattractive.

It can be seen that there is a need for an improved pipetting device for use in automated sample processing systems.

SUMMERY OF THE UTILITY MODEL

In order to solve the problems existing in the prior liquid withdrawing and transferring device, on one hand, the application provides a liquid withdrawing and transferring device, and the purpose of the application is realized by the following technical scheme:

the embodiment of the application provides a liquid withdrawing and transferring device which comprises a vacuumizing mechanism, a driving assembly, a first blocking piece and a motion limiting assembly; the vacuumizing mechanism is connected with the driving assembly, the vacuumizing mechanism and the motion limiting assembly are respectively connected with the first blocking piece and are uniformly distributed on one side of the first blocking piece, the pipettes are distributed on the other side of the first blocking piece, and the pipettes are detachably connected with one end of the vacuumizing mechanism; the movement limiting assembly is used for limiting the driving assembly to drive the first blocking piece to continue to move in the direction away from the pipettor.

As a further improvement of the embodiment of the present application, the liquid withdrawing and transferring device further includes a first mounting member and a second mounting member, the driving assembly and the motion limiting assembly are respectively connected to the first mounting member, and the vacuum pumping mechanism is connected to the second mounting member.

As a further improvement of this application embodiment, drive assembly includes motor, action wheel and follows the driving wheel, the motor is fixed on the first installed part, follow the driving wheel with first installed part is connected, the action wheel with the motor is connected, the action wheel with pass through the driving medium from the driving wheel and connect.

As a further improvement of the embodiment of the application, a sliding rail is arranged on the first installation part, a sliding block is arranged on the sliding rail, the sliding block is connected with the sliding rail in a sliding mode, and the transmission part is connected with the second installation part through the sliding block.

As the further improvement of this application embodiment, evacuation mechanism one end is equipped with pipettor support piece, be equipped with the through-hole on the first piece that stops, pipettor support piece is kept away from evacuation mechanism's one end passes the through-hole is connected with the pipettor, wherein, the through-hole diameter is less than the external diameter of pipettor.

As a further improvement of the embodiments of the present application, the motion-limiting assembly includes: the elastic piece, the second blocking piece, the guide post and the connecting piece; the connecting piece is connected with the second mounting piece, a guide hole is formed in the connecting piece, one end of the guide column penetrates through the guide hole to be connected with the first blocking piece, and the other end of the guide column is connected with the second blocking piece; the elastic piece is arranged between the connecting piece and the guide post, and two ends of the elastic piece are respectively abutted against the second blocking piece and the connecting piece.

As a further improvement of this application embodiment, be equipped with the stopper on the guide post, be equipped with spacing step in the guiding hole, the stopper with spacing step butt, spacing step is used for the restriction the motion stroke of stopper, elastic component one end with the stopper butt.

As a further improvement of the embodiment of the present application, the second blocking member includes a blocking piece and a fixing member; the stop block penetrates through the fixing piece and is connected with the guide post, the fixing piece is connected with the first mounting piece, and the other end of the elastic piece is abutted to the stop block.

As a further improvement of the embodiment of the application, the number of the motion limiting assemblies is two, and the two motion limiting assemblies are respectively arranged at the left end and the right end of the first blocking piece.

In another aspect, an automatic sample processing system is provided in an embodiment of the present application, and the automatic sample processing system includes the above-mentioned liquid withdrawing and transferring device.

The first blocking piece and the vacuumizing mechanism are installed in a limiting mode, and the first blocking piece can move synchronously along with the vacuumizing mechanism during normal work; when the pipettor needs to be withdrawn, the drive assembly drives the vacuumizing mechanism to move, the first blocking piece is limited by the limiting movement assembly to continue moving towards the direction far away from the pipettor, so that the vacuumizing mechanism and the first blocking piece are relatively displaced, the first blocking piece is connected with the pipettor, and the pipettor is detached from the vacuumizing mechanism.

Drawings

The accompanying drawings, which are included to provide a further understanding of the application and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the application and together with the description serve to explain the application and not to limit the application. Some specific embodiments of the present application will be described in detail hereinafter by way of illustration and not limitation with reference to the accompanying drawings. The same reference numbers will be used throughout the drawings to refer to the same or like parts or portions, and it will be understood by those skilled in the art that the drawings are not necessarily drawn to scale, in which:

FIG. 1 is a schematic diagram of the overall structure of an embodiment of the present application;

FIG. 2 is an enlarged view of portion A of FIG. 1;

fig. 3 is a schematic cross-sectional view of a connecting member and a guide post according to an embodiment of the present application.

Reference numerals: 1. a first mounting member; 2. a vacuum pumping mechanism; 21. a pipettor support; 22. a connecting member; 23. a guide hole; 24. a limiting step; 3. a pipettor; 4. a first blocking member; 41. a through hole; 5. a motor; 6. a driving wheel; 7. a driven wheel; 8. a transmission member; 9. a slide rail; 10. a slider; 11. a fixing member; 12. a blocking block; 13. a nut; 14. a guide post; 15. a limiting block; 16. a second mount; 17. an elastic member.

Detailed Description

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs; the terminology used in the description of the application herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application; the terms "including" and "having," and any variations thereof, in the description and claims of this application and the description of the above figures are intended to cover non-exclusive inclusions. The terms "first," "second," and the like in the description and claims of this application or in the above-described drawings are used for distinguishing between different objects and not for describing a particular order.

In order to make the technical solutions better understood by those skilled in the art, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. It is to be understood that the described embodiments are merely exemplary of some, and not all, of the present application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

As shown in fig. 1 to 3, the present application provides a liquid ejector device, which includes a first mounting member 1, a vacuum pumping mechanism 2, a liquid shifter 3, a driving assembly, a first blocking member 4, and a movement limiting assembly, where the driving assembly and the movement limiting assembly are mounted on the first mounting member 1, and the first mounting member 1 is a mounting substrate of the driving assembly. The driving assembly is connected with the vacuumizing mechanism 2 and used for driving the vacuumizing mechanism 2 to move. In the embodiment of the application, the vacuum pumping mechanism 2 is a liquid transfer pump, the liquid transfer device 3 is a hollow cylindrical structure with an open end, in other embodiments, the vacuum pumping mechanism 2 may also be other mechanical or electronic devices with a vacuum pumping function, the liquid transfer device 3 is installed at one end of the vacuum pumping mechanism 2 and detachably connected to the vacuum pumping mechanism 2, the vacuum pumping mechanism 2 and the motion limiting component are respectively connected to the first blocking member 4 and are uniformly distributed on one side of the first blocking member 4, the liquid transfer device 3 is distributed on the other side of the first blocking member 4, when the driving component drives the vacuum pumping mechanism to move upwards, the motion limiting component is used for limiting the driving component to drive the first blocking member 4 to continue moving in a direction away from the liquid transfer device 3, in the embodiment of the application, the situation that the first blocking member 4 hits the vacuum pumping mechanism when the vacuum pumping mechanism and the first blocking member 4 are installed together can be completely avoided debugging equipment, reduced the impaired risk of evacuation mechanism, can reduce simultaneously that first blockking 4 causes the possibility of injury to operating personnel, guarantee operating personnel's personal safety, and need not punch on full-automatic sample processing system's work platform, the electronic components of not only the good workstation below of protection that not only can be better also make whole workstation seem more pleasing to the eye clean and tidy.

When the driving assembly drives the vacuumizing mechanism 2 to move, the first blocking piece 4 can move synchronously with the vacuumizing mechanism 2; in the moving process, the limit driving component drives the first blocking piece 4 to continue to move in the direction away from the pipette 3, so that the first blocking piece 4 and the vacuumizing mechanism 2 are relatively displaced, and the first blocking piece 4 is connected with the pipette 3; as the vacuum mechanism 2 continues to move, the pipette 3 is separated from the vacuum mechanism 2 by the first blocking member 4, and the operation of withdrawing the pipette 3 is completed.

A pipette support 21 is arranged at one end of the vacuumizing mechanism 2, a through hole 41 is formed in the first blocking part 4, and one end, far away from the vacuumizing mechanism 2, of the pipette support 21 penetrates through the through hole 41 and then is connected with the pipette 3; the diameter of the through hole 41 is smaller than the outer diameter of the connecting end of the pipette 3 and the pipette support 41. When the liquid transferring device 3 needs to be withdrawn, the driving assembly drives the vacuumizing mechanism 2 to move, and the liquid transferring device support 41 and the vacuumizing mechanism 2 synchronously move; the movement limiting assembly limits the driving assembly to drive the first blocking piece 4 to continue to move in the direction away from the pipette 3, so that the first blocking piece 4 and the vacuumizing mechanism 2 are relatively displaced, the first blocking piece 4 is connected with the pipette 3 until the first blocking piece 4 extrudes the pipette 3 out of the pipette support 41, and the operation of withdrawing the pipette 3 is completed.

The driving assembly comprises a motor 5, a driving wheel 6 and a driven wheel 7, the motor 5 is fixedly mounted on the first mounting part 1 through screws, the driving wheel 6 is fixedly connected with a rotating shaft of the motor 5, the driven wheel 7 is connected with the first mounting part 1 through screws in an adjustable limiting manner, the driving wheel 6 is connected with the driven wheel 7 through a transmission part 8, and the vacuumizing mechanism 2 is connected with the transmission part 8; in the embodiment of the present application, the transmission member 8 is a transmission belt, and in other embodiments, the transmission member 8 may also be a transmission chain or other mechanical structure with transmission function. The tightness of the transmission member 8 can be adjusted by adjusting the position of the driven wheel 7 on the first mounting member 1. When the synchronous rotation device works, the motor 5 drives the driving wheel 6 to rotate, the driving wheel 6 can drive the transmission piece 8 to move and is dragged by the transmission piece 8, and the driven wheel 7 can synchronously rotate along with the driving wheel 6; the transmission piece 8 carries the vacuum-pumping mechanism 2 to move in the process of moving, so that the operation of withdrawing and moving the liquid device 3 is completed.

A sliding rail 9 is fixedly mounted on the first mounting part 1, a sliding block 10 is arranged on the sliding rail 9 in a sliding mode, one side of the sliding block 10 is fixedly connected with the transmission part 8 through a screw, the other side of the sliding block 10 is connected with a second mounting part 16, and the second mounting part 16 is fixedly connected with the vacuumizing mechanism 2. When the motor 5 works, the driving wheel 6 rotates to drive the transmission member 8 to move, the transmission member 8 drives the sliding block 10 to slide on the sliding rail 9, and the sliding block 10 drives the second installation member 16 and the vacuum-pumping mechanism 2 to move synchronously while moving. By arranging the slide rail 9 and the slider 10, the driving force loss of the driving assembly can be reduced, and the transmission efficiency of the device is improved.

The motion limiting assembly comprises: the elastic member 17, the second blocking member, the guide post 14 and the connecting member 22; the connecting piece 22 is connected with the second mounting piece 16, a guide hole 23 is arranged in the connecting piece 22, one end of the guide column 14 penetrates through the guide hole 23 to be connected with the first blocking piece 4, and the other end of the guide column is connected with the second blocking piece; the elastic member 17 is disposed between the connecting member 22 and the guide post 14, and both ends of the elastic member 17 are respectively abutted against the second blocking member and the connecting member 22.

In order to prevent the guide post 14 from falling out of the guide hole 23, the guide post 14 is provided with a limiting block 15, a limiting step 24 is arranged in the guide hole 23, the limiting block 15 is abutted against the limiting step 24, and the limiting step 24 is used for limiting the movement stroke of the limiting block 15, so that the guide post 14 is prevented from falling out of the guide hole 23. The guide post 14 is sleeved with an elastic part 17, one end of the elastic part 17 is abutted with the stop block 12, and the other end of the elastic part 16 is abutted with one end of the limit block 15 far away from the limit step 24.

Wherein the second blocking member comprises a blocking block 12 and a fixing member 11; be equipped with on the mounting 11 and block piece 12, block piece 12 one end pass behind the mounting 11 with guide post 14 fixed connection, block piece 12 the other end pass through

limit nut

13 and 11 spacing connections of mounting, mounting 11 with first installed part 1 is connected, the elastic component 17 the other end with block piece 12 butt. Because the connection lengths of various pipettors 3 and the pipettor support member 21 are different, the length of the stop block 12 extending out of the fixing member 11 can be adjusted by adjusting the limit nut 13, so that the pipette support is suitable for pipettors 3 of different types. The embodiment of the present application has two motion-limiting mechanisms, which are respectively disposed on the left and right sides of the vacuum-pumping mechanism 2, in the embodiment of the present application, one end of the guide post 14 passes through the guide hole 23 to be connected with the first blocking member 4, and the other end is respectively connected with the corresponding blocking block 12. When the vacuumizing mechanism 2 is driven by the motor 5 to move upwards, the first blocking piece 4, the guide post 14 and the blocking piece 12 move synchronously along with the vacuumizing mechanism 2 at the beginning until the blocking piece 12 abuts against the fixing piece 11, the blocking piece 12 cannot move continuously under the limitation of the fixing piece 11, the elastic piece 17 starts to be compressed at the moment, the first blocking piece 4 and the vacuumizing mechanism 2 are displaced relatively, the first blocking piece 4 is connected with the pipettor 3 until the first blocking piece 4 extrudes the pipettor 3 out of the pipettor supporting piece 41, and therefore the operation of withdrawing and moving the liquid container 3 is completed.

The connecting pieces 22 are respectively arranged on the left side and the right side of the vacuumizing mechanism 2 so as to ensure the movement direction of the guide column 14, the connecting pieces 22 are respectively connected with the left side and the right side of the second mounting piece 16 and can synchronously move along with the vacuumizing mechanism 2, each connecting piece 22 is provided with a guide hole 23 penetrating through the connecting piece 22, one end of the guide column 14 can penetrate through the guide hole 23, and when the liquid withdrawing device is assembled, the guide column 14 penetrates through the guide hole 23 and then is fixedly connected with the first blocking piece 4; when the motor 5 works, the guide hole 23 limits the motion proceeding direction of the guide post 14, so that the motion direction of the guide post 14 is ensured to be consistent all the time, and the service life of the device is prolonged.

When the liquid withdrawing device of the present application is operated, when the motor 5 drives the vacuum mechanism 2 to move upwards, because the stopper 12 meets the block of the fixing member 11, the stopper 12 cannot move upwards any more, at this time, the elastic member 17 starts to compress, but the vacuum mechanism 2 continues to move upwards under the driving of the second mounting member 16, at this time, if the elastic member 17 is not provided, because the first stopper 4 is fixedly connected with the vacuum mechanism 2 through the second mounting member 16, the fixing member 11 stops the movement of the first stopper 4 and the vacuum mechanism 2, because the first stopper 4 of the present embodiment is connected with the second mounting member 16 through the two elastic members 17, the two guide posts 14, and the vacuum mechanism 2 can continue to move upwards for some distance, which is the compression space of the elastic member 17, the vacuum mechanism 2 continues to move upwards, pulling the pipette 3 into contact with the first stop 4 effects the withdrawal of the pipette 3.

In the embodiment of the present application, the elastic member 17 is a spring, and in other embodiments, other mechanical members having the same function may be adopted, for example: spring plate, elastic rubber ring, etc. In another embodiment, the guide post 14 does not need to be provided with the stop 15, nor does it need to be provided with the stop step 24 in the guide hole 23. When the liquid withdrawing and transferring device is assembled, one end of the elastic member 17 is abutted against the blocking block 12, and the other end is abutted against the upper end face of the connecting member 22, so that the guide post 14 can be limited, and the first blocking member 4 can be ensured to be automatically reset after the liquid withdrawing and transferring device 3 is completed.

When the liquid withdrawing and transferring device of the embodiment of the application normally works, the vacuum pumping mechanism 2 can drive the liquid transfer device 3 and the first blocking piece 4 to synchronously move, when the liquid withdrawing and transferring device 3 is needed, the motor 5 drives the driving wheel 6 to rotate, the driving wheel 6 drives the transmission piece 8 to move, the transmission piece 8 drives the sliding block 10 and the second mounting piece 16 to upwards slide on the sliding rail 9, and further drives the vacuum pumping mechanism 2 to upwards slide on the sliding rail 9, in the upwards movement process of the vacuum pumping mechanism 2, the first blocking piece 4 can upwards move along with the vacuum pumping mechanism 2 at the beginning, and the connecting piece 22, the guide post 14 and the blocking piece 12 also synchronously upwards move until the blocking piece 12 abuts against the end face of the fixing piece 11, the blocking piece 12 cannot continuously move under the limitation of the fixing piece 11, at this time, the elastic piece 17 starts to compress, the first blocking piece 4 and the vacuum pumping mechanism 2 generate relative displacement, and the first blocking piece 4 is connected with the liquid transfer device 3, until the first stopper 4 pushes the pipette 3 out of the pipette support 41, thereby completing the operation of ejecting the pipette 3.

Finally, it should be noted that: the above embodiments are only used for illustrating the technical solutions of the present application, and not for limiting the same; although the present application has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art will understand that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present application.

Claims

1. A device for retracting a pipette, comprising: the device comprises a vacuumizing mechanism, a driving assembly, a first blocking piece and a motion limiting assembly;

the vacuumizing mechanism is connected with the driving assembly, the vacuumizing mechanism and the motion limiting assembly are respectively connected with the first blocking piece and are uniformly distributed on one side of the first blocking piece, the pipettes are distributed on the other side of the first blocking piece, and the pipettes are detachably connected with one end of the vacuumizing mechanism;

the movement limiting assembly is used for limiting the driving assembly to drive the first blocking piece to continue to move in the direction away from the pipettor.

2. The expulsor device according to claim 1, further comprising a first mounting member and a second mounting member, wherein said drive assembly and said motion limiting assembly are coupled to said first mounting member, respectively, and wherein said vacuum mechanism is coupled to said second mounting member.

3. The pipettor device of claim 2, wherein the drive assembly comprises a motor, a drive wheel, and a driven wheel, the motor being secured to the first mounting member, the driven wheel being connected to the first mounting member, the drive wheel being connected to the motor, the drive wheel and the driven wheel being connected by a transmission member.

4. The device according to claim 3, wherein the first mounting member has a slide rail, the slide rail has a slide block, the slide block is slidably connected to the slide rail, and the driving member is connected to the second mounting member through the slide block.

5. The pipette device according to any one of claims 2 to 4, wherein a pipette support is provided at one end of the evacuation mechanism, a through hole is provided on the first blocking member, and an end of the pipette support, which is far away from the evacuation mechanism, passes through the through hole to be connected with a pipette, wherein the diameter of the through hole is smaller than the outer diameter of the pipette.

6. The explanter device of claim 5, wherein the motion limiting assembly comprises: the elastic piece, the second blocking piece, the guide post and the connecting piece;

the connecting piece is connected with the second mounting piece, a guide hole is formed in the connecting piece, one end of the guide column penetrates through the guide hole to be connected with the first blocking piece, and the other end of the guide column is connected with the second blocking piece;

the elastic part is arranged between the connecting part and the guide post, and two ends of the elastic part are respectively abutted against the second blocking part and the connecting part.

7. The device of claim 6, wherein the guide post is provided with a stop block, the guide hole is internally provided with a stop step, the stop block abuts against the stop step, the stop step is used for limiting the movement stroke of the stop block, and one end of the elastic member abuts against the stop block.

8. The explanter device of claim 7, wherein the second barrier member comprises a barrier tab and a securing member;

the stop block penetrates through the fixing piece and is connected with the guide post, the fixing piece is connected with the first mounting piece, and the other end of the elastic piece is abutted to the stop block.

9. The pipette device of any of claims 6 to 8 wherein there are two of the motion limiting assemblies and the two motion limiting assemblies are disposed at the left and right ends of the first barrier member.

10. An automated sample processing system comprising the expletor device of any of claims 1-9.