CN216572604U

CN216572604U - High-flux polypeptide synthesizer

Info

Publication number: CN216572604U
Application number: CN202122638542.XU
Authority: CN
Inventors: 葛志闯
Original assignee: Shanghai Ambiopharm Inc
Current assignee: Shanghai Ambiopharm Inc
Priority date: 2021-11-01
Filing date: 2021-11-01
Publication date: 2022-05-24
Anticipated expiration: 2031-11-01

Abstract

The utility model relates to the technical field of polypeptide synthesis, in particular to a high-flux polypeptide synthesis device, which comprises a supporting bottom plate, wherein moving wheels are arranged at the bottom corner of the supporting bottom plate, a supporting column is arranged at the corner of the top surface of the supporting bottom plate, an installation sleeve plate is arranged at the upper side of the supporting column, a reaction tank is sleeved inside the installation sleeve plate, a stirring assembly is arranged inside the reaction tank, a motor installation frame is arranged at the center of the top of the reaction tank, a driving motor is arranged at the upper side of the motor installation frame and corresponds to the stirring assembly, a stirring auxiliary shaft can be driven to rotate when a stirring main shaft rotates through a driving bevel gear and a driven bevel gear, the stirring main shaft can drive a first stirring blade to stir below an inner tank, and the stirring auxiliary shaft can drive a second stirring blade to stir at the upper side of the inner tank, thereby, the solvent in the device can be stirred more fully, and the stirring time can be reduced.

Description

High-flux polypeptide synthesizer

Technical Field

The utility model relates to the technical field of polypeptide synthesis, in particular to a high-throughput polypeptide synthesis device.

Background

The polypeptide is a bioactive substance related to various cell functions in a living body, has a molecular structure between amino acids and proteins, is a compound formed by combining a plurality of amino acids through peptide bonds according to a certain arrangement sequence, is a general name of bioactive substances related to various cell functions in the living body, and is often applied to the fields of function analysis, antibody research, particularly drug research and development and the like.

The existing polypeptide synthesis device has insufficient stirring, the stirring time is too long, the integral proper quality is influenced, the strict temperature requirement is required during polypeptide synthesis, and the external temperature can influence the synthesis effect during synthesis.

There is therefore a need for a high throughput polypeptide synthesis apparatus that ameliorates the above problems.

SUMMERY OF THE UTILITY MODEL

The present invention is directed to a high-throughput polypeptide synthesis apparatus, which solves the above problems of the prior art.

In order to achieve the purpose, the utility model provides the following technical scheme:

the utility model provides a high flux polypeptide synthesizer, includes supporting baseplate, supporting baseplate's bottom corner is provided with the removal wheel, the corner of supporting baseplate top surface is provided with the support column, the upside of support column is provided with the installation lagging, the retort has been cup jointed to the inside of installation lagging, the inside of retort is provided with the stirring subassembly, right side corner is provided with the controller behind the installation lagging top surface, the top center department of retort is provided with motor mounting bracket, motor mounting bracket's upside is and be provided with driving motor with the stirring subassembly correspondence.

As a preferable scheme of the utility model, the reaction tank comprises an outer tank, an inner tank, a first feed inlet, a second feed inlet and a discharge pipe, the outer tank is sleeved inside the mounting sleeve plate, the inner tank is sleeved inside the outer tank, the first feed inlet is arranged on the left side of the top surface of the outer tank, the second feed inlet is arranged on the right side of the top surface of the outer tank, and the discharge pipe is arranged at the bottom of the inner tank and penetrates through the outer tank.

As a preferable scheme of the present invention, the stirring assembly includes a stirring main shaft, a connecting sleeve, auxiliary stirring shafts, a driving bevel gear, a driven bevel gear, first stirring blades, and second stirring blades, the stirring main shaft is disposed inside the inner tank, the connecting sleeve is symmetrically sleeved on the outer wall of the stirring main shaft in the up-down direction, the auxiliary stirring shafts are disposed on the left and right sides of the connecting sleeve, the driving bevel gear is sleeved on the outer wall of the stirring main shaft and located on the lower side of the connecting sleeve, the driven bevel gear is sleeved on the outer wall of the stirring auxiliary shaft, the first stirring blades are symmetrically disposed on the outer wall of the bottom of the stirring main shaft in the left-right direction, and the second stirring blades are symmetrically disposed on the outer wall of the stirring auxiliary shaft in the up-down direction.

In a preferred embodiment of the present invention, the space between the outer vessel and the inner vessel is in a vacuum state.

As a preferable scheme of the utility model, valves are respectively arranged on the first feeding port, the second feeding port and the discharging pipe.

As a preferable scheme of the present invention, the stirring main shaft penetrates through the top of the reaction tank and is connected to the driving motor, and the stirring main shaft and the reaction tank are connected in a rotating manner.

As a preferable scheme of the utility model, the connection mode of the stirring main shaft and the connecting sleeve is rotation.

As the preferable scheme of the utility model, the connection modes of the auxiliary stirring shaft, the connecting sleeve and the inner tank are all in rotating connection.

As a preferable aspect of the present invention, the drive bevel gear and the driven bevel gear are connected in a meshing manner.

Compared with the prior art, the utility model has the beneficial effects that:

1. according to the utility model, the driving bevel gear and the driven bevel gear which are arranged can drive the stirring auxiliary shaft to rotate when the stirring main shaft rotates, at the moment, the stirring main shaft can drive the first stirring blade to stir below the inner tank, and the stirring auxiliary shaft can also drive the second stirring blade to stir at the middle upper side of the inner tank, so that the solvent in the inner tank is stirred more fully, and the stirring time can be reduced.

2. According to the utility model, the outer tank can play a role in protection from outside, so that the synthesis of the polypeptide is prevented from being influenced by external collision during reaction, and the space between the outer tank and the inner tank is in a vacuum state, so that the function of insulating temperature can be achieved, the synthesis of the polypeptide is prevented from being influenced by external temperature, and the synthesis effect of the polypeptide is better.

Drawings

FIG. 1 is a schematic view of the overall structure of the present invention;

FIG. 2 is a schematic view of the internal structure of the reaction tank of the present invention;

FIG. 3 is a schematic view of a portion of the stirring assembly of the present invention.

In the figure: 1. a support base plate; 2. a moving wheel; 3. a support pillar; 4. installing a sleeve plate; 5. a reaction tank; 6. a stirring assembly; 7. a controller; 8. a motor mounting bracket; 9. a drive motor; 501. an outer tank; 502. an inner tank; 503. a first feed inlet; 504. a second feed inlet; 505. discharging the material pipe; 601. a stirring main shaft; 602. connecting sleeves; 603. stirring the auxiliary shaft; 604. a drive bevel gear; 605. a driven bevel gear; 606. a first stirring blade; 607. and a second stirring blade.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, rather than all embodiments, and all other embodiments obtained by a person of ordinary skill in the art without any creative work based on the embodiments of the present invention belong to the protection scope of the present invention.

While several embodiments of the present invention will be described more fully hereinafter with reference to the accompanying drawings, in order to facilitate an understanding of the utility model, the utility model may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein, but rather should be construed to provide a more complete disclosure of the utility model.

It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present, that when an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present, and that the terms "vertical", "horizontal", "left", "right" and the like are used herein for descriptive purposes only.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs, and the terms used herein in the specification of the present invention are for the purpose of describing particular embodiments only and are not intended to limit the present invention, and the term "and/or" as used herein includes any and all combinations of one or more of the associated listed items.

Referring to fig. 1-3, the present invention provides a technical solution:

a high-flux polypeptide synthesis device comprises a supporting base plate 1, wherein moving wheels 2 are arranged at the bottom corners of the supporting base plate 1, supporting columns 3 are arranged at the corners of the top surface of the supporting base plate 1, an installation sleeve plate 4 is arranged on the upper side of each supporting column 3, a reaction tank 5 is sleeved inside the installation sleeve plate 4, a stirring assembly 6 is arranged inside the reaction tank 5, a controller 7 is arranged at the right corner behind the top surface of the installation sleeve plate 4, a motor installation frame 8 is arranged at the center of the top of the reaction tank 5, a driving motor 9 is arranged on the upper side of the motor installation frame 8 and corresponds to the stirring assembly 6, the reaction tank 5 comprises an outer tank 501, an inner tank 502, a first feeding port 503, a second feeding port 504 and a discharging pipe 505, the outer tank 501 is sleeved inside the installation sleeve plate 4, the inner tank 502 is sleeved inside the outer tank 501, the left side of the top surface of the outer tank 501 is provided with a first feed inlet 503, the right side of the top surface of the outer tank 501 is provided with a second feed inlet 504, the bottom of the inner tank 502 is provided with a discharge pipe 505 penetrating through the outer tank 501, the stirring component 6 comprises a stirring main shaft 601, a connecting sleeve 602, a stirring auxiliary shaft 603, a driving bevel gear 604, a driven bevel gear 605, a first stirring blade 606 and a second stirring blade 607, the stirring main shaft 601 is arranged inside the inner tank 502, the connecting sleeve 602 is sleeved on the outer wall of the stirring main shaft 601 in an up-and-down symmetrical manner, the stirring auxiliary shafts 603 are arranged on the left and right sides of the connecting sleeve 602, the driving bevel gear 604 is sleeved on the outer wall of the stirring main shaft 601 and located on the lower side of the connecting sleeve 602, the driven bevel gear 605 is sleeved on the outer wall of the stirring auxiliary shaft 603, the first stirring blades 606 are arranged on the outer wall of the bottom of the stirring main shaft 601 in a left-and right symmetrical manner, the outer wall of the stirring auxiliary shaft 603 is provided with the second stirring blade 607, the space between outer jar 501 and the inner tank 502 is vacuum state, all install the valve on first charge door 503, second charge door 504 and the blowing pipe 505, stirring main shaft 601 runs through the top of retort 5 and is connected with driving motor 9, the connected mode of stirring main shaft 601 and retort 5 is for rotating the connection, the connected mode of stirring main shaft 601 and adapter sleeve 602 is for rotating, the connected mode of stirring auxiliary shaft 603 and adapter sleeve 602, inner tank 502 is rotation connection, the connected mode of initiative bevel gear 604 and driven bevel gear 605 is for the meshing connection.

Referring to fig. 1-3, the driving bevel gear 604 and the driven bevel gear 605 are arranged to drive the auxiliary stirring shaft 603 to rotate when the main stirring shaft 601 rotates, at this time, the main stirring shaft 601 drives the first stirring blade 606 to stir below the inner tank 502, and the auxiliary stirring shaft 603 also drives the second stirring blade 607 to stir at the upper middle side of the inner tank 502, so that the solvent inside is stirred more sufficiently, and the stirring time can be reduced.

Referring to fig. 1-3, the outer tank 501 can protect the outside to prevent the synthesis of polypeptide from being affected by external collision during reaction, and the space between the outer tank 501 and the inner tank 502 is in a vacuum state, so that the function of thermal insulation can be achieved, the synthesis of polypeptide is prevented from being affected by external temperature, and the synthesis effect of polypeptide is better.

The working process of the utility model is as follows: during the use, add the material into inner tank 502 through first charge door 503, second charge door 504, then starter motor 9 drives stirring main shaft 601 and rotates, then first stirring leaf 606 can stir in inner tank 502's below, drive bevel gear 604 can drive driven bevel gear 605 and rotate this moment, stirring auxiliary shaft 603 can drive second stirring leaf 607 and stir including inner tank 502's well upper side, wait to stir the back, open the valve of discharging pipe 505, it can to discharge synthetic polypeptide.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.

Claims

1. A high throughput polypeptide synthesis apparatus comprising a support base plate (1), characterized in that: the utility model discloses a reactor, including supporting baseplate (1), mounting baseplate (5), retort (5), the bottom corner of supporting baseplate (1) is provided with removal wheel (2), the corner of supporting baseplate (1) top surface is provided with support column (3), the upside of support column (3) is provided with installation lagging (4), the inside of installation lagging (4) is cup jointed retort (5), the inside of retort (5) is provided with stirring subassembly (6), right side corner is provided with controller (7) behind installation lagging (4) top surface, the top center department of retort (5) is provided with motor mounting bracket (8), the upside of motor mounting bracket (8) is and be provided with driving motor (9) with stirring subassembly (6) correspondence.

2. The device for high-throughput polypeptide synthesis according to claim 1, wherein: retort (5) are including outer jar (501), inner tank (502), first charge door (503), second charge door (504) and blowing pipe (505), outer jar (501) have been cup jointed to the inside of installation lagging (4), inner tank (502) have been cup jointed to the inside of outer jar (501), the left side of outer jar (501) top surface is provided with first charge door (503), the right side of outer jar (501) top surface is provided with second charge door (504), the bottom of inner tank (502) is and run through outer jar (501) and be provided with blowing pipe (505).

3. The device for high-throughput polypeptide synthesis according to claim 2, wherein: the stirring component (6) comprises a stirring main shaft (601), a connecting sleeve (602), a stirring auxiliary shaft (603), a driving bevel gear (604), a driven bevel gear (605), a first stirring blade (606) and a second stirring blade (607), a stirring main shaft (601) is arranged in the inner tank (502), connecting sleeves (602) are symmetrically sleeved on the outer wall of the stirring main shaft (601) up and down, the left side and the right side of the connecting sleeve (602) are provided with auxiliary stirring shafts (603), the outer wall of the stirring main shaft (601) is sleeved with a driving bevel gear (604) at the lower side of the connecting sleeve (602), the outer wall of the stirring auxiliary shaft (603) is sleeved with a driven bevel gear (605), the outer wall of the bottom of the stirring main shaft (601) is bilaterally symmetrically provided with first stirring blades (606), and second stirring blades (607) are symmetrically arranged on the upper part and the lower part of the outer wall of the auxiliary stirring shaft (603).

4. The device for high-throughput polypeptide synthesis according to claim 2, wherein: the space between the outer tank (501) and the inner tank (502) is in a vacuum state.

5. The device for high-throughput polypeptide synthesis according to claim 2, wherein: valves are arranged on the first feed inlet (503), the second feed inlet (504) and the discharging pipe (505).

6. The device for high-throughput polypeptide synthesis according to claim 3, wherein: stirring main shaft (601) run through the top of retort (5) and be connected with driving motor (9), the connected mode of stirring main shaft (601) and retort (5) is for rotating the connection.

7. The device for high-throughput polypeptide synthesis according to claim 3, wherein: the stirring main shaft (601) and the connecting sleeve (602) are connected in a rotating mode.

8. The device for high-throughput polypeptide synthesis according to claim 3, wherein: the auxiliary stirring shaft (603) is rotatably connected with the connecting sleeve (602) and the inner tank (502).

9. The device for high-throughput polypeptide synthesis according to claim 3, wherein: the driving bevel gear (604) and the driven bevel gear (605) are connected in a meshing manner.