CN216473230U - In vitro analysis diagnosis detection device and card box in-out bin structure - Google Patents

Abstract

The utility model relates to an in vitro analysis, diagnosis and detection device and a card box inlet and outlet structure. The support comprises a support plate and a guide plate. One side surface of the support plate is provided with a first concave part which is used for adapting to the reagent card box. When the reagent card box needs to be tested, the reagent card box enters the first concave part along the guide plate through the inlet and the outlet, namely the guide plate plays a role in guiding the reagent card box, and the position of the reagent card box is relatively stable under the action of the guide plate and the support plate after entering the first concave part; in addition, under the elastic force effect of first elastic component, limit baffle's the portion that blocks contradicts in reagent card box with certain pressure size for reagent card box can not break away from outwards from importing and exporting easily, and reagent card box can set up firmly in card box business turn over storehouse structure promptly, can guarantee reagent card box's testing result accuracy like this, and the overall structure of card box business turn over storehouse structure is simple reliable simultaneously.

Description

In vitro analysis diagnosis detection device and card box in-out bin structure

Technical Field

The utility model relates to the technical field of in-vitro analysis and diagnosis, in particular to an in-vitro analysis, diagnosis and detection device and a card box inlet and outlet bin structure.

Background

The quick detection pathogen POCT (Point-of-care testing) integrated instrument system based on PCR (polymerase chain reaction) technology is suitable for analyzing sample types such as nasopharyngeal swabs, sputum, urine, feces, cervical/vaginal swabs, blood, cerebrospinal fluid, skin, wound swabs and the like, adding a body fluid sample into a disposable reagent card box, putting the card box into the instrument system, and performing nucleic acid amplification, detection, calculation and result printing output. The instrument and the reagent are suitable for single or multiple detection of DNA or RNA of pathogens infecting human bodies.

In the field of biotechnology, nucleic acid extraction by a centrifugal column method or a magnetic bead method generally requires four steps of lysis, binding, washing, elution, and the like, followed by steps of nucleic acid molecule hybridization, polymerase chain reaction, molecule detection, and the like. The molecular detection technology is developed towards the direction of accuracy, convenience, sensitivity, automation and integration. However, due to the technical complexity of molecular detection, there are few fully automated instrument platforms from sample to result, the structure of the fully automated instrument platform is complex, and the reagent cartridge is loosened, which affects the detection result.

SUMMERY OF THE UTILITY MODEL

Based on this, it is necessary to overcome the defects of the prior art and to provide an in vitro analysis, diagnosis and detection device and a cassette in-out chamber structure, which can simplify the structure and make the reagent cassette stably installed.

The technical scheme is as follows: the utility model provides a card box business turn over storehouse structure, card box business turn over storehouse structure includes: the reagent cartridge holder comprises a holder body and a guide plate, wherein a first concave part is arranged on one side surface of the holder body and is used for adapting to a reagent cartridge, the guide plate is arranged on one side surface of the holder body, the guide plate is used for abutting against the reagent cartridge loaded into the first concave part, one side wall of the first concave part is provided with an inlet and an outlet, the other side wall of the first concave part is provided with a movable chamber, and the movable chamber is communicated with the first concave part; limit baffle and first elastic component, limit baffle set up movably in the activity room, limit baffle passes through first elastic component with the wall of activity room links to each other, limit baffle is equipped with the stop part, the stop part be used for with pack into in the first recess the reagent card box is inconsistent.

According to the cartridge in-out bin structure, when the reagent cartridge is required to be tested, the reagent cartridge enters the first concave part along the guide plate through the inlet and the outlet, namely the guide plate plays a role in guiding the reagent cartridge, the position of the reagent cartridge is relatively stable under the action of the guide plate and the support plate after entering the first concave part, the relative position of the reagent cartridge can be ensured to be relatively accurate, and the reagent cartridge can be aligned to components such as the first pressing piece, the second pressing piece, the first joint and the second joint; in addition, under the elastic force effect of first elastic component, limit baffle's the portion that blocks contradicts in reagent card box with certain pressure size for reagent card box can not break away from outwards from importing and exporting easily, and reagent card box can set up firmly in card box business turn over storehouse structure promptly, can guarantee reagent card box's testing result accuracy like this, and the overall structure of card box business turn over storehouse structure is simple reliable simultaneously.

In one embodiment, one end of the limit baffle is rotationally connected to the wall of the movable chamber through a rotating part; the other end of the limit baffle is connected with the wall of the movable chamber through the first elastic piece, and the other end of the limit baffle is also provided with the blocking part.

In one embodiment, the blocking part is provided with a guide edge which is obliquely arranged towards the access opening; the guide edge is inclined at an angle a of 30 to 60 degrees with respect to a direction in which the reagent cartridge enters and exits the first recess.

In one embodiment, the cartridge in-out structure further comprises a first hold-down assembly disposed on the support plate; the first pressing assembly comprises a first driving mechanism and at least one first pressing piece; the first driving mechanism is used for driving at least one first pressing member to move, and the first pressing member is used for pressing or loosening a first valve of the reagent cartridge.

In one embodiment, the first compression assembly further comprises a first mounting plate; at least one first pressing piece is arranged on the first mounting plate; the first driving mechanism is connected with the first mounting plate and used for driving the first mounting plate to be close to or far away from the supporting plate.

In one embodiment, the cartridge in-out structure further comprises a second hold-down assembly disposed on the support plate; the second pressing assembly comprises a second driving mechanism, a second mounting plate and at least one second pressing piece; at least one second pressing piece is arranged on the second mounting plate; the second driving mechanism is connected with the second mounting plate and used for driving the second mounting plate to be close to or far away from the supporting plate.

In one embodiment, the cartridge access structure further comprises a slide rail assembly; the sliding rail assembly comprises a fixed frame arranged on the supporting plate, a first sliding rail and a second sliding rail which are arranged on the fixed frame, a first sliding block which is arranged on the first sliding rail in a sliding manner, a second sliding block which is arranged on the second sliding rail in a sliding manner, a first connecting plate connected with the first sliding block, and a second connecting plate connected with the second sliding block; the first connecting plate is connected with the first mounting plate, and the second connecting plate is connected with the second mounting plate.

In one embodiment, the cartridge in-out structure further comprises a first sensor and a first trigger member in induction fit with the first sensor; the first sensor is arranged on the supporting plate, and the first trigger piece is arranged on the first mounting plate or the first connecting plate; the card box in-out bin structure further comprises a second sensor and a second trigger piece in induction fit with the second sensor; the second sensor is arranged on the supporting plate, and the second trigger piece is arranged on the second mounting plate or the second connecting plate.

In one embodiment, the first pressing assembly further includes at least one second elastic member mounted on the first mounting plate, at least one of the first pressing members and at least one of the second elastic members are disposed in one-to-one correspondence, and the first pressing member is connected to the first mounting plate through the second elastic member;

the second pressing component further comprises at least one third elastic piece arranged on the second mounting plate, the at least one second pressing piece and the at least one third elastic piece are arranged in a one-to-one correspondence mode, and the second pressing piece is connected with the second mounting plate through the third elastic piece.

In one embodiment, a first accommodating chamber and a first guide through hole communicated with the first accommodating chamber are arranged in the first mounting plate, the second elastic member is arranged in the first accommodating chamber, one end of the first pressing member is positioned in the first accommodating chamber and connected with the second elastic member, the first pressing member is movably arranged in the first guide through hole, and the other end of the first pressing member extends out of the first guide through hole and is used for pressing or loosening a first valve of the reagent card box;

the inside second that is equipped with of second mounting panel holds the room and with the second guide through hole that the room is linked together is held to the second, the third elastic component is located the second holds indoorly, the one end that the second compressed tightly is located the second holds the inside of room and with the third elastic component links to each other, the second compress tightly the piece set up movably in the second guide through hole, the other end that the second compressed tightly stretches out the outside of second guide through hole and is used for compressing tightly or unclamping the second valve of reagent card box.

In one embodiment, the cartridge access structure further comprises at least one air tube; the trachea install in on the first mounting panel, tracheal both ends are provided with first joint and second respectively and connect, first joint be used for with the gas pocket of reagent card box is linked together, the second connects and is used for being linked together with external equipment.

In one embodiment, the cartridge access structure further comprises at least one fourth elastic member; the at least one air pipe and the at least one fourth elastic piece are arranged in a one-to-one correspondence mode; the air pipe is connected with the first mounting plate through the corresponding fourth elastic piece.

The in-vitro analysis, diagnosis and detection device comprises the cartridge in-out structure.

When the in-vitro analysis diagnosis detection device needs to test the reagent card box, the reagent card box enters the first concave part along the guide plate through the inlet and the outlet, namely the guide plate plays a role in guiding the reagent card box, the position of the reagent card box is relatively stable under the action of the guide plate and the support plate after entering the first concave part, the relative position of the reagent card box can be ensured to be relatively accurate, and the reagent card box can be aligned to components such as the first pressing piece, the second pressing piece, the first joint, the second joint and the like; in addition, under the elastic force effect of first elastic component, limit baffle's the portion that blocks contradicts in reagent card box with certain pressure size for reagent card box can not break away from outwards from importing and exporting easily, and reagent card box can set up firmly in card box business turn over storehouse structure promptly, can guarantee reagent card box's testing result accuracy like this, and the overall structure of card box business turn over storehouse structure is simple reliable simultaneously.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this application, illustrate embodiments of the utility model and, together with the description, serve to explain the utility model and not to limit the utility model.

In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.

FIG. 1 is a schematic view of a cassette access structure according to an embodiment of the present invention;

FIG. 2 is a schematic view of another perspective structure of the cartridge loading and unloading structure according to an embodiment of the present invention;

FIG. 3 is a perspective view of a frame of the cartridge in and out-of-bin structure of one embodiment of the present invention;

FIG. 4 is a view of another perspective of the frame of the cartridge access structure of one embodiment of the present invention;

FIG. 5 is an enlarged schematic view of the guide plate of FIG. 4 after it is hidden and at A;

FIG. 6 is a schematic diagram of a reagent cartridge according to an embodiment of the present invention;

FIG. 7 is a perspective view of a first mounting plate according to an embodiment of the present invention;

FIG. 8 is a view of the first mounting plate from another perspective in accordance with one embodiment of the present invention;

FIG. 9 is a further perspective view of the first mounting plate of one embodiment of the present invention;

FIG. 10 is a cross-sectional view at B-B of FIG. 9;

FIG. 11 is a perspective view of a second mounting plate according to an embodiment of the present invention;

FIG. 12 is a perspective view of the slide rail assembly according to an embodiment of the utility model;

fig. 13 is another perspective view of the slide rail assembly according to an embodiment of the utility model.

10. A support; 11. a support plate; 111. a first recess; 112. an inlet and an outlet; 113. an activity room; 12. a guide plate; 121. a first via hole; 122. a second via hole; 20. a limit baffle; 21. a blocking portion; 211. a guide edge; 22. a rotating member; 30. a first elastic member; 40. a reagent cartridge; 41. a projection; 42. a first valve; 43. a second valve; 44. a sample chamber; 45. a pre-processing chamber; 46. a mixing chamber; 47. a PCR chamber; 48. air holes; 50. a first hold-down assembly; 51. a first drive mechanism; 52. a first pressing member; 53. a first mounting plate; 531. a first accommodating chamber; 532. a first guide through hole; 533. a third guide through hole; 534. a first step; 54. a second elastic member; 60. a second hold-down assembly; 61. a second drive mechanism; 62. a second pressing member; 63. a second mounting plate; 70. a slide rail assembly; 71. a fixed mount; 72. a first slide rail; 73. a second slide rail; 74. a first slider; 75. a second slider; 76. a first connecting plate; 77. a second connecting plate; 81. a first sensor; 82. a first trigger; 83. a second sensor; 84. a second trigger; 91. an air tube; 911. a first joint; 912. a second joint; 913. a second step; 92. a fourth elastic member; 93. a thermal cracking assembly; 94. a magnetic hybrid assembly.

Detailed Description

In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.

Referring to fig. 1 to 6, fig. 1 and 2 respectively show two different perspective structural diagrams of a cartridge access structure in an embodiment of the present invention, fig. 3 and 4 respectively show two different perspective structural diagrams of a bracket 10 of the cartridge access structure in an embodiment of the present invention, fig. 5 shows an enlarged schematic structural diagram at a position a of the guide plate 12 of fig. 4 after being hidden, and fig. 6 shows a schematic structural diagram of a reagent cartridge 40 in an embodiment. According to the card box in-and-out structure provided by the embodiment of the utility model, the card box in-and-out structure comprises a support 10, a limiting baffle 20 and a first elastic member 30. The bracket 10 includes a support plate 11 and a guide plate 12. One of the side surfaces of the support plate 11 is provided with a first recess 111, the first recess 111 being adapted to accommodate the reagent cartridge 40. The guide plate 12 is provided on one side surface of the support plate 11, and the guide plate 12 is configured to abut against a side surface of the reagent cartridge 40 loaded into the first recess 111. One side wall of the first concave portion 111 is provided with an inlet/outlet 112, and the other side wall of the first concave portion 111 is provided with a movable chamber 113. The movable chamber 113 communicates with the first recess 111. The limit baffle 20 is movably arranged in the movable chamber 113, the limit baffle 20 is connected with the wall of the movable chamber 113 through the first elastic element 30, and the limit baffle 20 is provided with a blocking part 21. The blocking portion 21 is used to interfere with the reagent cartridge 40 loaded into the first recess 111.

According to the cartridge in-and-out bin structure, when the reagent cartridge 40 needs to be tested, the reagent cartridge 40 enters the first concave part 111 along the guide plate 12 through the inlet and outlet 112, namely the guide plate 12 guides the reagent cartridge 40, and the position of the reagent cartridge 40 is relatively stable under the action of the guide plate 12 and the support plate 11 after entering the first concave part 111, so that the relative position of the reagent cartridge 40 can be ensured to be relatively accurate, and the reagent cartridge 40 can be aligned to the first pressing part 52, the second pressing part 62, the first connector 911, the second connector 912 and other parts; in addition, under the elastic force of the first elastic member 30, the blocking portion 21 of the limiting baffle 20 is pressed against the reagent cartridge 40 with a certain pressure, so that the reagent cartridge 40 cannot easily separate from the inlet/outlet 112, i.e. the reagent cartridge 40 can be stably disposed in the cartridge in-out structure, thereby ensuring the accuracy of the detection result of the reagent cartridge 40, and the overall structure of the cartridge in-out structure is simple and reliable.

After the analysis and detection operation of the reagent cartridge 40 is completed, the stopper 20 is driven to move so that the blocking portion 21 is separated from the reagent cartridge 40, and the reagent cartridge 40 is taken out through the inlet/outlet 112.

It should be noted that the "blocking portion 21" may be a part of the "limit baffle 20", that is, the "blocking portion 21" and the "other part of the limit baffle 20" are integrally formed; or a separate component which can be separated from the other parts of the limit stop 20, namely the stop part 21 can be manufactured separately and then combined with the other parts of the limit stop 20 into a whole. In one embodiment, as shown in fig. 5, the "stop portion 21" is a part of the "limit stop 20" that is integrally formed.

Referring to fig. 4 and 5, further, one end of the limit stop 20 is rotatably connected to the wall of the movable chamber 113 through the rotating member 22. The other end of the limit baffle 20 is connected with the wall of the movable chamber 113 through the first elastic element 30, and the other end of the limit baffle 20 is further provided with a blocking part 21.

Referring to fig. 4 to 6, in one embodiment, the blocking portion 21 is provided with a guiding edge 211, and the guiding edge 211 is disposed to be inclined toward the access opening 112. The angle of inclination of the guide edge 211 with respect to the direction in which the reagent cartridge 40 enters and exits the first recess 111 is a, and a is 30 ° to 60 °, but a may be any angle from 0 ° to 90 °, and is not limited herein and may be set according to actual needs. When the reagent cartridge 40 is inserted into the first recess 111 through the inlet/outlet 112, the protrusion 41 of the reagent cartridge 40 contacts the guide edge 211, gradually enters the first recess 111 under the guide of the guide edge 211, and simultaneously pushes and compresses the first elastic member 30 through the guide edge 211; when the reagent cartridge 40 is moved to the proper position, the blocking portion 21 is moved back under the action of the first elastic member 30 and then is in limit contact with the protruding portion 41 of the reagent cartridge 40, so that the effect of clamping the protruding portion 41 of the reagent cartridge 40 can be achieved, and the reagent cartridge 40 is prevented from being separated from the outlet 112.

The direction in which the reagent cartridge 40 moves into and out of the first recess 111 is indicated by a double-headed arrow S in fig. 5.

Referring to fig. 1, fig. 2, fig. 7 and fig. 8 respectively show structural schematic diagrams of the first mounting plate 53 at two different viewing angles according to an embodiment. In one embodiment, the cartridge access structure further comprises a first hold-down assembly 50 disposed on the support plate 11. The first pressing assembly 50 includes a first driving mechanism 51 and at least one first pressing member 52. The first driving mechanism 51 is used for driving at least one first pressing member 52 to move, and the first pressing member 52 is used for pressing or releasing the first valve 42 of the reagent cartridge 40. Specifically, the first pressing member 52 is, for example, a thimble, a push rod, or the like, as long as the first valve 42 can be pushed to close the first valve 42, or the first valve 42 can be opened when the first valve 42 is released. The size of the abutting end face of the first pressing member 52 is set to correspond to the size of the first valve 42.

Referring to fig. 1, 2, 7 and 8, further, the first pressing assembly 50 further includes a first mounting plate 53. At least one first pressing member 52 is mounted on the first mounting plate 53. The first driving mechanism 51 is connected to the first mounting plate 53 for driving the first mounting plate 53 closer to or farther from the support plate 11.

Referring to fig. 1, 2 and 11, in one embodiment, the cartridge access structure further includes a second pressing member 60 disposed on the supporting plate 11. The second compression assembly 60 includes a second drive mechanism 61, a second mounting plate 63, and at least one second compression member 62. At least one second compression member 62 is mounted on the second mounting plate 63. The second driving mechanism 61 is connected to the second mounting plate 63 for driving the second mounting plate 63 closer to or farther from the support plate 11. Thus, the second driving mechanism 61 drives the second mounting plate 63 to move, the second mounting plate 63 drives the second pressing member 62 to move, and the second pressing member 62 can press or release the second valve 43 of the reagent cartridge 40. When the second pressing member 62 presses the second valve 43, the second valve 43 is closed; when the second pressing member 62 releases the second valve 43, the second valve 43 is opened.

Referring to FIGS. 6 to 10, in one embodiment, the first mounting plate 53 is provided with the first clamping members 52 in an amount not less than the number of the first valves 42 of the reagent cartridge 40, and the second mounting plate 63 is provided with the second clamping members 62 in an amount not less than the number of the second valves 43 of the reagent cartridge 40. In this way, when the first driving mechanism 51 drives the first mounting plate 53 to move, all the first valves 42 of the reagent cartridge 40 can be opened or closed; similarly, when the second driving mechanism 61 drives the second mounting plate 63 to move, all the second valves 43 of the reagent cartridge 40 can be opened or closed. For example, the number of the first pressing members 52 in this embodiment is four, wherein three first pressing members 52 are disposed corresponding to three first valves 42 of the reagent cartridge 40, and another first pressing member 52 is also used for pressing or releasing the reagent cartridge 40, but is not pressed at the position where the first valve 42 is disposed, so as to ensure a better pressing effect on the side surface of the reagent cartridge 40. In addition, the number of the second pressing members 62 in this embodiment is, for example, four, and four second pressing members 62 are provided in one-to-one correspondence with the four second valves 43 of the reagent cartridge 40.

As an alternative, for example, the first pressing member 52 of the first pressing assembly 50 and the second pressing member 62 of the second pressing assembly 60 are collectively disposed on the same mounting plate, that is, two mounting plates are not required, and the mounting plate on which the first pressing member 52 and the second pressing member 62 are disposed is driven to move by a driving mechanism. In addition, for example, a third pressing assembly or a fourth pressing assembly, etc. are also provided, and are not limited herein.

The first driving mechanism 51 is, for example, a motor screw driving structure, a cylinder driving structure, a hydraulic cylinder driving structure, an electric cylinder driving structure, a cam driving structure, etc., and is not limited herein, and may be provided according to actual requirements. The second drive mechanism 61 is similar to the first drive mechanism 51 and will not be described in detail herein.

Referring to fig. 1, fig. 2, fig. 12 and fig. 13 respectively show two different perspective structural schematic views of the slide rail assembly 70. In one embodiment, the cartridge access structure further comprises a slide assembly 70. The slide rail assembly 70 includes a fixing frame 71 installed on the supporting plate 11, a first slide rail 72 and a second slide rail 73 installed on the fixing frame 71, a first slider 74 slidably installed on the first slide rail 72, a second slider 75 slidably installed on the second slide rail 73, a first connecting plate 76 connected to the first slider 74, and a second connecting plate 77 connected to the second slider 75. The first connecting plate 76 is connected to the first mounting plate 53, and the second connecting plate 77 is connected to the second mounting plate 63. Like this, when first actuating mechanism 51 drive first mounting panel 53 removed, first connecting plate 76 drives first slider 74 and removes along first slide rail 72, and the operating stability of first mounting panel 53 is better like this, and then can control the motion stroke of first mounting panel 53 comparatively accurately, and the motion stroke precision of first pressure piece 52 reaches 0.05mm promptly. In addition, due to the high precision of the movement stroke of the first compressing member 52, when the first valve 42 is opened, the first compressing member 52 moves away from the first valve 42 by a distance of, for example, 0.1mm or 0.2mm under the power of the first driving mechanism 51 to release the first valve 42 of the reagent cartridge 40, and at this time, the first compressing member 52 still interferes with the side surface of the reagent cartridge 40 to play a positioning role, so that the reagent cartridge 40 is stably disposed on the rack 10.

Similarly, when the second driving mechanism 61 drives the second mounting plate 63 to move, the second connecting plate 77 drives the second slider 75 to move along the second slide rail 73, so that the operation stability of the second mounting plate 63 is good, and the movement stroke of the second mounting plate 63 can be controlled accurately, that is, the movement stroke precision of the second pressing member 62 reaches 0.05 mm.

Specifically, the first mounting plate 53, the second mounting plate 63, the first slider 74, the second slider 75, the first connecting plate 76, and the second connecting plate 77 are specifically made of, for example, aluminum, copper, iron, stainless steel, wood, plastic, etc., and are not limited herein, and may be set according to actual requirements.

It should be noted that the "first connecting plate 76" may be a part of the "first slider 74", that is, the "first connecting plate 76" and the "other part of the first slider 74" are integrally formed; or a separate member that is separable from the "other portion of the first slider 74", i.e., the "first connecting plate 76" may be separately manufactured and then integrated with the "other portion of the first slider 74".

In one embodiment, the cartridge access structure further comprises a first sensor 81 and a first trigger 82 in inductive engagement with the first sensor 81. The first sensor 81 is mounted on the supporting plate 11, and the first triggering member 82 is mounted on the first mounting plate 53 or the first connecting plate 76. In this way, the first sensor 81 can sense the moving position of the first trigger 82, and the moving position information of the first mounting plate 53 can be obtained according to the sensing signal of the first trigger 82, so that the moving stroke of the first pressing member 52 can be correspondingly controlled within the preset range.

In addition, the cartridge access structure further comprises a second sensor 83 and a second trigger 84 in inductive engagement with the second sensor 83. The second sensor 83 is mounted on the support plate 11, and the second triggering member 84 is mounted on the second mounting plate 63 or the second connecting plate 77.

Specifically, the first sensor 81 is a photoelectric switch, a proximity switch, a correlation sensor or other type of sensor, as long as it can sense the moving position of the first trigger 82 and timely feed back the moving position signal of the first trigger 82. The second sensor 83 is similar to the first sensor 81 and will not be described in detail herein.

In one embodiment, the first compression assembly 50 further includes at least one second resilient member 54 mounted to the first mounting plate 53. The at least one first pressing member 52 is disposed in one-to-one correspondence with the at least one second elastic member 54, and the first pressing member 52 is connected to the first mounting plate 53 through the second elastic member 54. In this way, the first pressing member 52 can avoid damage to the reagent cartridge 40 during contact with the first valve 42 under the buffering action of the second elastic member 54.

Similarly, the second pressing assembly 60 further includes at least one third elastic member mounted on the second mounting plate 63, and the at least one second pressing member 62 is disposed in one-to-one correspondence with the at least one third elastic member. The second pressing member 62 is connected to the second mounting plate 63 through a third elastic member. Likewise, the second presser member 62 can avoid damage to the reagent cartridge 40 during contact with the second valve 43 under the cushioning action of the third resilient member.

Referring to fig. 9 and 10, in one embodiment, the first mounting plate 53 is provided therein with a first accommodating chamber 531 and a first guiding through hole 532 communicated with the first accommodating chamber 531. The second elastic member 54 is disposed in the first accommodating chamber 531, one end of the first pressing member 52 is disposed inside the first accommodating chamber 531 and connected to the second elastic member 54, the first pressing member 52 is movably disposed in the first guide through hole 532, and the other end of the first pressing member 52 protrudes outside the first guide through hole 532 and is used to press or release the first valve 42 of the reagent cartridge 40.

Similarly, the second mounting plate 63 is provided therein with a second accommodating chamber (not shown in the drawings) and a second guide through-hole (not shown in the drawings) communicating with the second accommodating chamber. The third elastic piece is arranged in the second accommodating chamber. One end of the second pressing member 62 is located inside the second receiving chamber and connected to the third elastic member, the second pressing member 62 is movably disposed in the second guide through-hole, and the other end of the second pressing member 62 protrudes outside the second guide through-hole and serves to press or release the second valve 43 of the reagent cartridge 40.

Specifically, the second elastic member 54 and the third elastic member are, for example, a spring, an elastic block, and the like, and are not limited herein, and may be set according to actual requirements.

Referring to fig. 6-10, in one embodiment, the cartridge access structure further comprises at least one air tube 91. The air pipe 91 is installed on the first installation plate 53, and a first connector 911 and a second connector 912 are respectively arranged at two ends of the air pipe 91. The first connector 911 is adapted to communicate with the air holes 48 of the reagent cartridge 40, and the second connector 912 is adapted to communicate with an external device, such as an air blowing device or a suction device. In this way, after the reagent cartridge 40 is loaded into the cartridge loading and unloading structure, the first driving mechanism 51 drives the first mounting plate 53 to move close to the supporting plate 11, so that not only the first pressing member 52 can press and close the first valve 42 of the reagent cartridge 40, but also the first connector 911 can be driven to communicate with the air hole 48 of the reagent cartridge 40. The external device delivers gas to the inside of the reagent cartridge 40 through the gas tube 91, and the gas entering the inside of the reagent cartridge 40 functions to push the liquid flow inside the reagent cartridge 40, or sucks the gas inside the reagent cartridge 40 outward through the gas tube 91, i.e., provides a suction force to make the liquid flow inside the reagent cartridge 40, so that the liquid flow inside the reagent cartridge 40 can be realized, for example, from the sample chamber 44 to the pre-processing chamber 45, or from the pre-processing chamber 45 to the mixing chamber 46, or from the mixing chamber 46 to the PCR chamber 47.

Referring to FIG. 10, in one embodiment, the cartridge access structure further comprises at least one fourth resilient member 92. The at least one air tube 91 is disposed in one-to-one correspondence with the at least one fourth elastic member 92. The air pipe 91 is connected to the first mounting plate 53 by a corresponding fourth elastic member 92. Thus, when the first connector 911 of the air tube 91 is in butt joint communication with the air hole 48 of the reagent cartridge 40, the fourth elastic member 92 plays a role in buffering, and the first connector 911 is prevented from damaging the reagent cartridge 40. Specifically, the first mounting plate 53 is provided with a third guide through hole 533, the air pipe 91 is movably disposed in the third guide through hole 533, a first step 534 is disposed on a hole wall of the third guide through hole 533, a second step 913 is disposed on the air pipe 91, the fourth elastic member 92 is a spring sleeved on an outer wall of the air pipe 91, and two ends of the fourth elastic member 92 respectively abut against the first step 534 and the second step 913.

Referring to fig. 3, in one embodiment, the cartridge inlet/outlet structure further comprises a thermal cracking assembly 93, wherein the thermal cracking assembly 93 is disposed on the supporting plate 11 for performing a thermal cracking process on the liquid in the pretreatment chamber 45 of the reagent cartridge 40. In addition, the cartridge in-out structure further includes a magnetic mixing component 94, the magnetic mixing component 94 is disposed on the supporting plate 11 and is used for moving the magnetic beads in the mixing chamber 46 of the reagent cartridge 40 up and down, so that the liquid in the mixing chamber 46 is fully mixed to obtain the required mixed liquid.

Referring to fig. 4, in an embodiment, in order to avoid interference with the guide plate 12 in the process that the first pressing member 52 or the air tube 91 presses the side surface of the reagent cartridge 40, at least one first through hole 121 and at least one second through hole 122 are formed in the guide plate 12, and the at least one first through hole 121 and the at least one first pressing member 52 are arranged in a one-to-one correspondence manner, so that the first pressing member 52 can pass through; the at least one second through hole 122 is disposed corresponding to the first connector 911 of the at least one air pipe 91, and the first connector 911 can pass through the second through hole.

Referring to fig. 1 and fig. 2, in one embodiment, an in vitro analysis, diagnosis and detection device includes the cartridge in-and-out structure of any of the above embodiments.

When the in vitro analysis, diagnosis and detection device needs to test the reagent cartridge 40, the reagent cartridge 40 enters the first concave portion 111 through the inlet/outlet 112 along the guiding plate 12, that is, the guiding plate 12 guides the reagent cartridge 40, and the position of the reagent cartridge 40 after entering the first concave portion 111 is relatively stable under the action of the guiding plate 12 and the supporting plate 11, so that the relative position of the reagent cartridge 40 can be ensured to be relatively accurate, and the reagent cartridge 40 can be aligned to the first pressing member 52, the second pressing member 62, the first connector 911, the second connector 912 and other components; in addition, under the elastic force of the first elastic member 30, the blocking portion 21 of the limiting baffle 20 is pressed against the reagent cartridge 40 with a certain pressure, so that the reagent cartridge 40 cannot easily separate from the inlet/outlet 112, i.e. the reagent cartridge 40 can be stably disposed in the cartridge in-out structure, thereby ensuring the accuracy of the detection result of the reagent cartridge 40, and the overall structure of the cartridge in-out structure is simple and reliable.

The technical features of the above embodiments can be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the above embodiments are not described, but should be considered as the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above examples only show some embodiments of the present invention, and the description thereof is more specific and detailed, but not to be construed as limiting the scope of the utility model. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are used in the orientations and positional relationships indicated in the drawings for convenience in describing the utility model and to simplify the description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are not to be considered limiting of the utility model.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.

In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can, for example, be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be connected internally or in any other suitable relationship, unless expressly stated otherwise. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

In the present invention, unless otherwise expressly stated or limited, the first feature "on" or "under" the second feature may be directly contacting the first and second features or indirectly contacting the first and second features through an intermediate. Also, a first feature "on," "over," and "above" a second feature may be directly or diagonally above the second feature, or may simply indicate that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.

It will be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and the like as used herein are for illustrative purposes only and do not denote a unique embodiment.

Claims (13)

1. The utility model provides a card box business turn over storehouse structure which characterized in that, card box business turn over storehouse structure includes:

the reagent cartridge holder comprises a holder body and a guide plate, wherein a first concave part is arranged on one side surface of the holder body and is used for adapting to a reagent cartridge, the guide plate is arranged on one side surface of the holder body, the guide plate is used for abutting against the reagent cartridge loaded into the first concave part, one side wall of the first concave part is provided with an inlet and an outlet, the other side wall of the first concave part is provided with a movable chamber, and the movable chamber is communicated with the first concave part;

limit baffle and first elastic component, limit baffle set up movably in the activity room, limit baffle passes through first elastic component with the wall of activity room links to each other, limit baffle is equipped with the stop part, the stop part be used for with pack into in the first recess the reagent card box is inconsistent.

2. The cartridge access structure of claim 1, wherein one end of said retainer is rotatably connected to a wall of said movable chamber by a rotatable member; the other end of the limit baffle is connected with the wall of the movable chamber through the first elastic piece, and the other end of the limit baffle is further provided with the blocking part.

3. A cartridge loading/unloading structure according to claim 1, wherein said blocking portion is provided with a guide edge, said guide edge being disposed obliquely toward said inlet/outlet; the guide edge is inclined at an angle a of 30 to 60 degrees with respect to a direction in which the reagent cartridge enters and exits the first recess.

4. The cartridge access structure of claim 1, further comprising a first hold-down assembly disposed on the support plate; the first pressing assembly comprises a first driving mechanism and at least one first pressing piece; the first driving mechanism is used for driving at least one first pressing member to move, and the first pressing member is used for pressing or loosening a first valve of the reagent cartridge.

5. The cartridge access structure of claim 4, wherein said first hold-down assembly further comprises a first mounting plate; at least one first pressing piece is arranged on the first mounting plate; the first driving mechanism is connected with the first mounting plate and used for driving the first mounting plate to be close to or far away from the supporting plate.

6. The cartridge access structure of claim 5, further comprising a second hold-down assembly disposed on the support plate; the second pressing assembly comprises a second driving mechanism, a second mounting plate and at least one second pressing piece; at least one second pressing piece is arranged on the second mounting plate; the second driving mechanism is connected with the second mounting plate and used for driving the second mounting plate to be close to or far away from the supporting plate.

7. The cartridge access structure of claim 6, further comprising a slide assembly; the sliding rail assembly comprises a fixed frame arranged on the supporting plate, a first sliding rail and a second sliding rail which are arranged on the fixed frame, a first sliding block which is arranged on the first sliding rail in a sliding manner, a second sliding block which is arranged on the second sliding rail in a sliding manner, a first connecting plate connected with the first sliding block, and a second connecting plate connected with the second sliding block; the first connecting plate is connected with the first mounting plate, and the second connecting plate is connected with the second mounting plate.

8. The cartridge access structure of claim 7, further comprising a first sensor and a first trigger in inductive engagement with the first sensor; the first sensor is arranged on the supporting plate, and the first trigger piece is arranged on the first mounting plate or the first connecting plate; the card box in-out bin structure further comprises a second sensor and a second trigger piece in induction fit with the second sensor; the second sensor is arranged on the supporting plate, and the second trigger piece is arranged on the second mounting plate or the second connecting plate.

9. The cartridge access structure of claim 6, wherein the first pressing member further comprises at least one second elastic member mounted on the first mounting plate, at least one of the first pressing members and at least one of the second elastic members are disposed in one-to-one correspondence, and the first pressing member is connected to the first mounting plate through the second elastic member;

the second pressing component further comprises at least one third elastic piece arranged on the second mounting plate, the at least one second pressing piece and the at least one third elastic piece are arranged in a one-to-one correspondence mode, and the second pressing piece is connected with the second mounting plate through the third elastic piece.

10. A cartridge loading/unloading structure according to claim 9, wherein the first mounting plate is provided therein with a first accommodating chamber and a first guide through hole communicating with the first accommodating chamber, the second elastic member is provided in the first accommodating chamber, one end of the first pressing member is located inside the first accommodating chamber and connected to the second elastic member, the first pressing member is movably provided in the first guide through hole, and the other end of the first pressing member extends to the outside of the first guide through hole and is used for pressing or releasing the first valve of the reagent cartridge;

the inside second that is equipped with of second mounting panel holds the room and with the second guide through hole that the room is linked together is held to the second, the third elastic component is located the second holds indoorly, the one end that the second compressed tightly is located the second holds the inside of room and with the third elastic component links to each other, the second compress tightly the piece set up movably in the second guide through hole, the other end that the second compressed tightly stretches out the outside of second guide through hole and is used for compressing tightly or unclamping the second valve of reagent card box.

11. The cartridge access structure of claim 5, further comprising at least one air tube; the trachea install in on the first mounting panel, tracheal both ends are provided with first joint and second respectively and connect, first joint be used for with the gas pocket of reagent card box is linked together, the second connects and is used for being linked together with external equipment.

12. The cartridge access structure of claim 11, further comprising at least one fourth resilient member; the at least one air pipe and the at least one fourth elastic piece are arranged in a one-to-one correspondence mode; the air pipe is connected with the first mounting plate through the corresponding fourth elastic piece.

13. An in vitro assay diagnostic test device comprising the cartridge access structure of any one of claims 1 to 12.

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