CN216457046U - Chromatography column frame - Google Patents
Chromatography column frame Download PDFInfo
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- CN216457046U CN216457046U CN202123436974.9U CN202123436974U CN216457046U CN 216457046 U CN216457046 U CN 216457046U CN 202123436974 U CN202123436974 U CN 202123436974U CN 216457046 U CN216457046 U CN 216457046U
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Abstract
The application discloses chromatography column frame. This chromatography column frame is including the box body that has the lateral wall, the box body includes upper portion and lower part, wherein upper portion include the equidistance distribute in horizontal separators and longitudinal baffle between the lateral wall, the lower part include the equidistance distribute in round hole between the lateral wall, wherein horizontal separators with longitudinal baffle forms square hole, the center pin in square hole with the center pin one-to-one of round hole aligns, and the length of side in square hole is not less than the diameter of round hole.
Description
Technical Field
The utility model relates to a chromatography separation technique, more specifically relate to a chromatography column frame.
Background
The small-sized chromatographic column is mainly used for manual operation, various solution reagents added into the small-sized chromatographic column must be added manually through a liquid transfer device, time consumption and error are prone to occurring, the conventional liquid workstation is designed according to the length and width dimensions of the pore plate (12.8cm by 8.5cm), the small-sized chromatographic column cannot be directly placed on the liquid workstation for use, and liquid addition is carried out through the liquid workstation. The small-sized chromatographic column is cylindrical, the pore plate is square, the frame is used for the pore plate, the appearance of the column is not changed, and in consideration of flux, 24 or more small-sized chromatographic columns are placed in one pore plate, and each column needs to meet the flux requirement of sample loading of 15ml sample amount. Meanwhile, the small chromatographic columns need to be adjusted according to the number of samples, and the small chromatographic columns do not affect each other after adjustment. Finally, small high throughput chromatography columns need to meet conventional well plate sizes for liquid workstation positioning, and for gripping and transfer using robotic arms.
There remains a need in the art to find a chromatography column holder that is suitable for holding a small chromatography column, while having high throughput, and for liquid station operation for gripping and transferring using robotic arms.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a chromatography column frame, it can realize being suitable for fixed small-size chromatography column, has high flux simultaneously to be suitable for liquid workstation operation to press from both sides in order to use the arm to get and shift.
Therefore, the utility model relates to a chromatography column frame, a serial communication port, chromatography column frame is including the box body that has the lateral wall, the box body includes upper portion and lower part, wherein upper portion include the equidistance distribute in horizontal separators and longitudinal baffle between the lateral wall, the lower part include the equidistance distribute in round hole between the lateral wall, wherein horizontal separators with longitudinal baffle forms square hole, the center pin in square hole with the center pin of round hole aligns one by one, and the length of side in square hole is not less than the diameter of round hole.
Drawings
The invention will be described in more detail below with reference to the accompanying drawings, in which:
fig. 1 is a schematic view of a chromatography column holder according to an embodiment of the invention.
FIG. 2 is a top view of the chromatography column storage rack shown in FIG. 1.
FIG. 3 is a sectional view of the chromatographic column storage rack shown in FIG. 1.
Detailed Description
The utility model relates to a chromatography column frame, chromatography column frame is including the box body that has the lateral wall. In one embodiment of the present invention, the box body comprises an upper portion and a lower portion, wherein the upper portion comprises a transverse partition and a longitudinal partition equidistantly distributed between the sidewalls, and the lower portion comprises a circular hole equidistantly distributed between the sidewalls. The utility model discloses an in the embodiment, horizontal baffle and longitudinal baffle form square hole, and the center pin in square hole aligns one by one with the center pin of round hole to the length of side in square hole is not less than the diameter of round hole. In the present invention, the two center axes "align" means that the two center axes are on the same straight line. The present invention is directed to a method for aligning a center axis of a square hole with a center axis of a round hole, which is characterized in that the center axis of a square hole is aligned with the center axis of a round hole. In the present invention, "equidistantly distributed" means that a plurality of objects are distributed at a central distance equal to each other in a certain dimension.
The side wall may have any height that does not affect the working height of the liquid workstation. In one embodiment of the invention, the height of the side wall is 1-10 cm. In a preferred embodiment of the invention, the height of the side wall is about 3.5 cm. In a preferred embodiment of the present invention, the height of the side wall is not less than the sum of the height of the upper portion and the height of the lower portion.
In one embodiment of the invention, the height of the upper part is 1-7 cm. In a preferred embodiment of the invention, the height of the upper part is about 2.5 cm.
In one embodiment of the invention, the height of the lower part is 1-3 cm. In a preferred embodiment of the invention, the height of the lower part is about 1.0 cm.
In one embodiment of the present invention, the thickness of the spacer is 0.05-0.3 cm. In one embodiment of the present invention, the thickness of the spacer is about 0.1 cm.
In the present invention, the number of transverse and longitudinal partitions may be any suitable number, depending on the desired flux of the chromatography column. In a preferred embodiment of the invention, the number of transverse partitions is 1-15 and the number of longitudinal partitions is 1-10. In one embodiment of the present invention, the number of square holes is the same as the number of round holes. In a preferred embodiment of the present invention, the number of transverse partitions is 3, the number of longitudinal partitions is 5, and the number of square holes and circular holes is 24.
The utility model discloses in, the length of side in square hole can be suitable for inserting the chromatography column wherein and make the chromatography column can not take place obvious displacement's arbitrary length because of the epitaxial prominent structure of chromatography column and the contact of square hole after inserting. In one embodiment of the invention, at least part of the cross-section of the chromatography column is circular. In one embodiment of the present invention, the epitaxial projection structure of the chromatography column is on the upper part of the chromatography column. In one embodiment of the present invention, the side length of the square hole may be slightly larger than the outer diameter of the chromatography column. In one embodiment of the present invention, the sides of the square holes are 1-5 cm. In a preferred embodiment of the invention, the sides of the square holes are about 1.7 cm.
The utility model discloses in, the diameter of round hole can be suitable for blocking the chromatography post after the chromatography post inserts the round hole and make the chromatography post can not take place the arbitrary length of obvious displacement in the vertical direction. In one embodiment of the invention, at least part of the cross-section of the chromatography column is circular. In one embodiment of the present invention, the diameter of the circular hole may be slightly larger than the outer diameter of the chromatography column. In one embodiment of the invention, the diameter of the circular hole is 1-5 cm. In a preferred embodiment of the invention, the diameter of the circular hole is about 1.5 cm.
In one embodiment of the invention, the cross-section of the box is rectangular, comprising 2 long side walls and 2 short side walls. The utility model discloses in, the length of long lateral wall is greater than the length of short lateral wall, and long lateral wall is parallel with transverse partition to short lateral wall is parallel with longitudinal baffle. In one embodiment of the invention, the length of the long side wall is 5-100 cm. In a preferred embodiment of the invention, the length of the long side wall is about 12.3 cm. In one embodiment of the invention the length of the short side walls is 3-50 cm. In a preferred embodiment of the invention, the length of the short side walls is about 8.0 cm. In one embodiment of the invention, the thickness of the long side wall is 0.1-2 cm. In a preferred embodiment of the invention, the thickness of the long side wall is about 0.5 cm. In one embodiment of the invention, the thickness of the short side walls is 0.1-2 cm. In a preferred embodiment of the invention, the thickness of the short side walls is about 0.8 cm.
Optionally, the chromatography column rack of the present invention may further comprise a base located at the bottom of the box body, the base comprising a protruding structure connected to the side wall. The utility model discloses in, base length is not less than the length of long lateral wall to the base width is not less than the length of short lateral wall. In one embodiment of the present invention, the cross section of the base is the same as the cross section of the box body. In one embodiment of the invention, the cross-section of the base is rectangular. In one embodiment of the present invention, the base has a length of 5-100 cm. In a preferred embodiment of the invention, the base is about 12.8cm in length. In one embodiment of the present invention, the base has a width of 3-50 cm. In a preferred embodiment of the invention, the base width is about 8.5 cm. In one embodiment of the present invention, the base has a height of 0.1-0.5 cm. In a preferred embodiment of the invention, the base height is about 0.2 cm.
The chromatography column rack of the present invention can be made of any suitable material. In one embodiment of the present invention, the chromatography column rack of the present invention is made of polypropylene.
The present invention will be described in further detail with reference to the accompanying drawings.
Fig. 1 is a schematic view of a chromatography column holder according to an embodiment of the present invention, and fig. 2 and 3 are a top view and a cross-sectional view of the chromatography column holder shown in fig. 1, respectively. As shown in fig. 1 to 3, a chromatography column holder according to an embodiment of the present invention includes: the rectangular box body is provided with 2 long side walls with the length of 12.3cm, the thickness of 0.5cm and the height of 3.5cm and 2 short side walls with the length of 8.0cm, the thickness of 0.8cm and the height of 3.5cm, the rectangular box body comprises an upper part and a lower part, wherein the height of the upper part is 2.5cm, the upper part comprises 3 transverse partition plates with the thickness of 0.1cm and 5 longitudinal partition plates which are equidistantly distributed between the side walls, the height of the lower part is 1.0cm, the lower part comprises 24 round holes which are equidistantly distributed between the side walls, the transverse partition plates and the longitudinal partition plates form 24 square holes, the central shafts of the square holes are aligned with the central shafts of the round holes one by one, the side length of each square hole is 1.7cm, and the diameter of each round hole is 1.5 cm; and a rectangular base 12.8cm in length, 8.5cm in width and 0.2cm in height.
Compared with the prior art, the beneficial effects of the utility model are that:
(1) the working efficiency is as follows: through the chromatographic column frame of the utility model, the liquid workstation can be used for adding various solution reagents, the traditional manual liquid adding is replaced, and 40% of the time of a single sample is saved;
(2) the accuracy is high: by the chromatography column frame, the small chromatography column purification method can be transferred to the liquid workstation, automation is realized, operation errors are avoided, and the chromatography column frame has good traceability, repeatability and accuracy;
(3) benefit cost: the small-sized chromatographic column purification method is transferred to a liquid workstation, automation is realized, the number of personnel is reduced from 2 or more to 1, manual intervention is not needed in the process, labor force is released, and labor cost is greatly reduced;
(4) platform prospect: compared with the conventional small-sized chromatographic column purification method, the magnetic bead packing has higher cost and limited volume; the volume of the 96-hole plate is small, other special purification equipment is expensive, a liquid workstation is used as common equipment in a laboratory, the operation can be completed within 1-2 hours, and the automation of a laboratory platform can be expanded;
(5) the fixing effect is as follows: through the utility model discloses a chromatography column frame, small-size chromatography column can be firmly fixed in wherein and can not change the chromatography column appearance, has avoided the meaningless displacement of chromatography column in transportation or operation process.
Finally, it should be noted that the above description is only a preferred embodiment of the present invention, but the protection scope of the present invention is not limited thereto, and for those skilled in the art, the technical solution and concept of the present invention can be modified or replaced equally, and all modifications, substitutions, improvements and the like made within the spirit of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. The utility model provides a chromatography column frame, its characterized in that, chromatography column frame is including the box body that has the lateral wall, the box body includes upper portion and lower part, wherein upper portion include the equidistance distribute in horizontal separators and longitudinal baffle between the lateral wall, the lower part include the equidistance distribute in round hole between the lateral wall, wherein horizontal separators with longitudinal baffle forms square hole, the center pin in square hole with the center pin one-to-one of round hole aligns, and the length of side in square hole is not less than the diameter of round hole.
2. The chromatography column rack of claim 1, wherein the height of the sidewall is 1-10 cm.
3. The chromatography column rack of claim 1, wherein the height of the upper portion is 1-7 cm.
4. A chromatography column rack according to claim 1, wherein the lower portion has a height of 1-3 cm.
5. The chromatography column rack of claim 1, wherein the separator has a thickness of 0.05-0.3 cm.
6. The chromatography column rack of claim 1, wherein the number of transverse partitions is 1-15 and the number of longitudinal partitions is 1-10.
7. A chromatography column frame according to claim 1, wherein the square holes have a side length of 1-5 cm.
8. The chromatography column rack of claim 1, wherein the circular hole has a diameter of 1-5 cm.
9. The chromatography column rack of claim 1, wherein said box body is rectangular in cross-section comprising 2 long side walls and 2 short side walls, wherein the length of said long side walls is 5-100cm and the length of said short side walls is 3-50 cm.
10. The chromatography column rack of claim 1, further comprising a base at the bottom of the cassette, the base comprising a protruding structure connected to the side walls.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202123436974.9U CN216457046U (en) | 2021-12-30 | 2021-12-30 | Chromatography column frame |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202123436974.9U CN216457046U (en) | 2021-12-30 | 2021-12-30 | Chromatography column frame |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN216457046U true CN216457046U (en) | 2022-05-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202123436974.9U Active CN216457046U (en) | 2021-12-30 | 2021-12-30 | Chromatography column frame |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN216457046U (en) |
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2021
- 2021-12-30 CN CN202123436974.9U patent/CN216457046U/en active Active
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