CN216440588U - Crosslinking of production microballon, integrative device washs - Google Patents
Crosslinking of production microballon, integrative device washs Download PDFInfo
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- CN216440588U CN216440588U CN202123014261.3U CN202123014261U CN216440588U CN 216440588 U CN216440588 U CN 216440588U CN 202123014261 U CN202123014261 U CN 202123014261U CN 216440588 U CN216440588 U CN 216440588U
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Abstract
The utility model discloses a crosslinking and cleaning integrated device for producing microspheres, and belongs to the technical field of preparation of microspheres by a microfluidic method. The micro-fluidic chip cleaning device comprises a rotating mechanism, at least one cross-linking unit and at least one cleaning unit, wherein the cross-linking unit is arranged on the front side of a station of the micro-fluidic chip, and the cleaning unit is arranged on the front side of the station of the cross-linking unit; the rotating mechanism comprises a rotating seat, the cross-linking unit is connected with the rotating seat through a connecting rod I, and the cleaning unit is connected with the rotating seat through a connecting rod II; the cross-linking unit comprises a cross-linking groove and a cross-linking funnel, wherein a lifting mechanism I is arranged on one side of the cross-linking groove, the cross-linking funnel is sleeved on the lifting mechanism I, and the cross-linking funnel is arranged on the front side of the station of the microfluidic chip; the cleaning unit comprises a cleaning tank and a cleaning funnel, wherein a lifting mechanism II is arranged on one side of the cleaning tank, and the cleaning funnel is sleeved on the lifting mechanism II. The utility model ensures the continuity of the two procedures of crosslinking and cleaning, better links the liquid drop shearing in the former procedure and realizes the industrialization, the continuity and the large scale of the microsphere preparation process.
Description
Technical Field
The utility model relates to a device for producing microspheres, in particular to a crosslinking and cleaning integrated device for producing microspheres, and belongs to the technical field of microsphere preparation by a microfluidic method.
Background
The microfluidic droplet technology is a new technology for researching generation, control and application of micro-droplets in a scale range from several micrometers to hundreds of micrometers, which is developed on a microfluidic chip in recent years. In the process of generating droplets by a microfluidic method, two (or more than three) liquids which are not mutually soluble are respectively used as a continuous phase and a dispersed phase, and respectively enter different microchannels in a microfluidic chip under the drive of an injection pump with a fixed volume flow rate, when two (or more than three) flows meet at a cross point, the dispersed phase fluid continuously extends to form a plug-shaped or jet-shaped liquid column, then the plug-shaped or jet-shaped liquid column is broken due to the instability of a free interface under the shearing and extrusion action of the continuous phase fluid, the plug-shaped or jet-shaped liquid column is pinched off and dispersed in the continuous phase in the form of a micro volume unit to form droplets, and then the droplets are crosslinked and cleaned to obtain the microspheres. The micro-fluidic chip is used as a micro-reactor, can realize biochemical reaction, rapid reagent mixing, micro-particle synthesis and the like, and greatly strengthens the advantages of low consumption, automation, high flux and the like of the micro-fluidic chip.
At present, due to the limitation of the particularity of the microsphere preparation process, the existing equipment conditions and the like, the microsphere preparation process is difficult to realize continuity, batch and industrialization, and the microsphere preparation process has more manual operation procedures, so that the product performance is easily inconsistent, and the product pollution risk is increased. Such as: in the preparation process of the embolism microsphere, the internal phase liquid and the external phase liquid are respectively injected into the microfluidic chip through the injection pump, and are cut into liquid drops in the microfluidic chip, and then subsequent crosslinking and cleaning are carried out. At present, most of crosslinking and cleaning equipment is small equipment in a laboratory stage, and is difficult to put into a factory for industrial continuous production, so that the equipment becomes a bottleneck limiting the micro-fluidic microsphere preparation technology from moving to industrial production.
The prior art CN105709696A discloses a 'chitosan microsphere micro-fluidic one-step synthesis method for heavy metal wastewater treatment', which comprises the following steps: preparing a chitosan aqueous solution as a dispersion phase; preparing an oil phase added with a cross-linking agent as a continuous phase; introducing the obtained continuous phase and the dispersed phase into a micro-fluidic chip for shearing to form chitosan droplets, and performing cross-linking and curing; cleaning the obtained cross-linked and solidified chitosan particles, and drying to obtain chitosan microspheres, wherein corresponding cross-linking and cleaning equipment is not involved or disclosed;
in addition, CN208732742U discloses an "automatic microorganism immobilization forming apparatus", in which a carrier is dropped into a reaction barrel, and reacts with a curing agent to form immobilized microorganism microspheres, which are discharged from a discharge port; and the automatic microorganism immobilization forming equipment also comprises a cleaning device, the cleaning device is arranged below the discharge port of the reaction barrel, and the formed immobilized microorganism microspheres are discharged into the cleaning device from the discharge port and then cleaned by deionized water. CN102211008A discloses a detachable T-shaped microchannel device and a method for preparing monodisperse polymer microspheres by using the same, which only relates to that under the action of a shaking table, an organic solvent is diffused from liquid drops, and the liquid drops are solidified to form polymer microspheres with uniform particle size; CN104829851A discloses a method for preparing monodisperse gelatin embolization microspheres with accurately controlled particle size, wherein a disperse phase I, a disperse phase II and a continuous phase are respectively loaded into an injector and are respectively connected with a microchannel reactor through a micro-injection pump, the structure of the microchannel reactor consists of a theta tube, a collecting tube and an outer tube, the formation process of gelatin droplets is completed in the microchannel reactor, and the flowing directions of the disperse phase and the continuous phase are the same or opposite; taking gelatin aqueous solution and cross-linking agent aqueous solution as two paths of dispersed phases, and simultaneously enabling the two paths of dispersed phases to parallelly enter a microchannel reactor; collecting the generated gelatin liquid drops, placing the gelatin liquid drops in a drying oven for heat preservation, carrying out crosslinking curing reaction on gelatin to obtain cured gelatin microspheres, and then carrying out microsphere separation and drying to obtain the gelatin microspheres.
Furthermore, in the process of preparing microspheres, the processing equipment involved is either small equipment in a laboratory stage or production equipment which is not complete and cannot be systematically arranged and cannot realize continuous production. Therefore, an apparatus for solving the problems that the industrial and continuous production cannot be realized in the microsphere preparation process is urgently needed.
Disclosure of Invention
The utility model aims to overcome the defects of the prior art and provides a crosslinking and cleaning integrated device for producing microspheres. In the technical scheme, the continuity of the cross-linking and cleaning processes is ensured by the arrangement of the cross-linking and cleaning integrated device, and the liquid drop shearing in the previous process can be better connected, so that the industrialization, the continuity and the large scale of the microsphere preparation process are realized.
In order to achieve the technical purpose, the following technical scheme is proposed:
a crosslinking and cleaning integrated device for producing microspheres comprises a rotating mechanism, at least one crosslinking unit and at least one cleaning unit, wherein the crosslinking unit is arranged on the front side of a station of a microfluidic chip, and the cleaning unit is arranged on the front side of the station of the crosslinking unit;
the rotating mechanism comprises a rotating seat, the cross-linking unit is connected with the rotating seat through a connecting rod I, the cleaning unit is connected with the rotating seat through a connecting rod II, and the rotation of the rotating mechanism can drive the cross-linking unit and the cleaning unit to rotate, so that on one hand, the cross-linking time and the cleaning time of liquid drops cut by the microfluidic chip can be well controlled, on the other hand, cross-linking efficiency and quality can be ensured by adjusting the liquid drops in different cross-linking units to contact cross-linking liquid with proper concentration, and on the other hand, cleaning efficiency and quality can be ensured by adjusting microspheres after cross-linking and curing to contact clean cleaning liquid in different cleaning units; in addition, the next batch of liquid drops can be better linked for crosslinking and/or the next microsphere is cleaned;
the cross-linking unit comprises a cross-linking groove and a cross-linking funnel, wherein a lifting mechanism I is arranged on one side of the cross-linking groove, the cross-linking funnel is sleeved on the lifting mechanism I, the cross-linking funnel is arranged on the front side of a station of the microfluidic chip, and after the liquid drops are cross-linked and cured in cross-linking liquid, the collection of microspheres can be carried out only by taking the cross-linking funnel out of the cross-linking groove (the cross-linking funnel is lifted) so as to facilitate subsequent cleaning, provide cross-linking space for the next batch of liquid drops to be cross-linked, and facilitate cleaning and replacement of the cross-linking groove;
the cleaning unit comprises a cleaning tank and a cleaning funnel, wherein an elevating mechanism II is arranged on one side of the cleaning tank, the cleaning funnel is sleeved on the elevating mechanism II, the microspheres are cleaned in the cleaning liquid, and the cleaning unit can collect the microspheres after cleaning only by taking out the cleaning funnel from the cleaning tank (the cleaning funnel rises) so as to facilitate subsequent treatment and the like, and meanwhile, the cleaning unit also provides a cleaning space for the next batch of microspheres to be cleaned, and also facilitates cleaning and replacement of the cleaning tank and the like.
Preferably, the rotary base is connected with a rotary pump, and the rotary pump provides power for the rotation of the rotary base and then respectively transmits the power to the cross-linking unit and the cleaning unit.
Preferably, the connecting rod I and the connecting rod II are both hydraulic connecting rods.
Preferably, be provided with crosslinked liquid import and crosslinked waste liquid export on the crosslinked groove, the crosslinked liquid import is connected with the crosslinked liquid storage tank through the crosslinked liquid pipe, and the crosslinked waste liquid export is connected with crosslinked waste liquid recovery jar through the recovery tube, realizes that the crosslinked liquid is orderly, effectual entering into to the crosslinked groove in, simultaneously, carries out recycle with the crosslinked waste liquid, guarantees the cross-linking process's that this device relates economy, effectively practices thrift the cost.
Preferably, be provided with washing liquid import and washing waste liquid export on the washing tank, the washing liquid import is connected with the washing liquid storage tank through washing liquid pipe, and washing waste liquid export is connected with washing waste liquid recovery jar through waste liquid pipe, realizes that the washing liquid is orderly, effectual entering to the washing tank in, simultaneously, will wash the waste liquid and collect, guarantees the stability, controllability and the feature of environmental protection of the cleaning technology that this device relates to.
Preferably, the number of the cross-linking units is at least two, the number of the cleaning units is at least two, and the cross-linking units and the cleaning units are respectively arranged on the circumference with the rotating seat as the center of a circle, so that cross-linking of droplets and cleaning of microspheres in each batch are facilitated, and the orderliness of cross-linking and cleaning operations is ensured.
Preferably, the lifting mechanism I and the lifting mechanism II are both sliding type lifting mechanisms and comprise mounting columns and lead screws arranged on the mounting columns, and the cross-linking funnel and/or the cleaning funnel are/is sleeved on the lead screws; be provided with the guide rail on the erection column, be provided with on cross-linking funnel and/or the washing funnel with guide rail matched with slider, this setting can realize the semi-automatization of this device, and then guarantee the continuity of cross-linking, washing process.
Preferably, a liquid drop discharge pipe is arranged between the microfluidic chip and the cross-linking funnel, one end of the liquid drop discharge pipe is connected with the microfluidic chip, the other end of the liquid drop discharge pipe extends to the position of the cross-linking funnel, and liquid drops cut by the microfluidic chip are orderly and controllably discharged into the cross-linking funnel for cross-linking.
In this technical scheme, according to the actual demand, set up corresponding liquid pump, solenoid valve, conductivity detector, motor and control system etc. for example: controlling the crosslinking liquid to enter a crosslinking tank, and discharging and recycling the crosslinking waste liquid; controlling the cleaning solution to enter a cleaning tank and discharging cleaning waste liquid; the rotating speed of the rotating mechanism is controlled to control the crosslinking of liquid drops, the cleaning batch and time and the like. Wherein, the related liquid pump, electromagnetic valve, conductivity detector, motor and control system are all the existing mature technologies.
In the technical scheme, the positional relationships such as "inside", "front side of station", "up", "one end", "the other end", "between", "center", "on circumference", "one side", and the like are defined according to the actual use state, and are conventional terms in the technical field and conventional terms in the actual use process of the person skilled in the art.
In the description of the present technical solution, it should be noted that, unless explicitly stated or limited otherwise, the terms "disposed" and "connected" should be understood broadly, for example, they may be fixedly connected, conveniently connected, or integrally connected; can be mechanically or electrically connected; either directly or indirectly through intervening media, or may be interconnected between two elements unless otherwise specifically limited or defined herein. The specific meanings of the above terms in the present invention can be understood in a specific case to those of ordinary skill in the art.
By adopting the technical scheme, the beneficial technical effects brought are as follows:
the utility model has simple structure and reasonable design, and can better connect the micro-fluidic chip and the subsequent application processing of the microspheres. The problems of industrialization, continuity and the like of cross-linking and cleaning processes in the preparation of microspheres in the prior art are effectively solved through the arrangement of a rotating mechanism, at least one cross-linking unit, at least one cleaning unit and the like;
the rotation of the rotating mechanism can drive the cross-linking unit and the cleaning unit to rotate, so that on one hand, the cross-linking time and the cleaning time of liquid drops cut by the microfluidic chip can be well controlled, on the other hand, the liquid drops can be contacted with cross-linking liquid with proper concentration in different cross-linking units by adjusting, so that the cross-linking efficiency and quality are ensured, and on the other hand, the microspheres subjected to cross-linking and curing can be contacted with clean cleaning liquid in different cleaning units by adjusting, so that the cleaning efficiency and quality are ensured; in addition, the next batch of liquid drops can be better linked for crosslinking and/or the next microsphere is cleaned;
the cross-linking unit comprises a cross-linking groove and a cross-linking funnel, one side of the cross-linking groove is provided with a lifting mechanism I, the cross-linking funnel is sleeved on the lifting mechanism I, the cross-linking funnel is arranged on the front side of a station of the microfluidic chip, after the liquid drops are cross-linked and cured in cross-linking liquid, the microspheres can be collected only by taking the cross-linking funnel out of the cross-linking groove (the cross-linking funnel is lifted), so that the subsequent cleaning is facilitated, meanwhile, cross-linking space and the like are provided for the next batch of liquid drops to be cross-linked, and the cleaning, the replacement and the like of the cross-linking groove and the like are facilitated; in addition, the cross-linking groove and the cross-linking funnel are matched, so that the droplets are cross-linked into microspheres, and the microspheres are convenient to collect after cross-linking;
the cleaning unit comprises a cleaning tank and a cleaning funnel, wherein a lifting mechanism II is arranged on one side of the cleaning tank, the cleaning funnel is sleeved on the lifting mechanism II, after the microspheres are cleaned in cleaning liquid, the cleaned microspheres can be collected only by taking out the cleaning funnel from the cleaning tank (the cleaning funnel rises), so that the subsequent treatment and the like are facilitated, meanwhile, a cleaning space and the like are provided for the next batch of microspheres to be cleaned, and the cleaning and the replacement of the cleaning tank and the like are facilitated; in addition, the cleaning tank and the cleaning funnel are matched, so that the microspheres are cleaned, and the microspheres are convenient to collect after being cleaned;
therefore, the utility model better ensures the continuity, controllability, semi-automation and economy of the crosslinking and cleaning process for preparing the microspheres by the microfluidic technology.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic diagram of the operation of the present invention;
FIG. 3 is a schematic structural view of a crosslinking unit in the present invention;
FIG. 4 is a schematic view of the structure of a crosslinking bath in the present invention;
FIG. 5 is a schematic view of the structure of a cleaning unit according to the present invention;
FIG. 6 is a schematic view of the cleaning tank of the present invention;
FIG. 7 is a schematic structural diagram of a cross-linking funnel or a washing funnel in a lifted state according to the present invention;
FIG. 8 is a schematic diagram of the lifting state of the cross-linking funnel or the cleaning funnel according to the present invention;
wherein: 1. the device comprises a rotary base, 2, a cross-linking unit, 201, a cross-linking groove, 202, a cross-linking funnel, 3, a cleaning unit, 301, a cleaning groove, 302, a cleaning funnel, 4, a connecting rod I, 5, a connecting rod II, 6, a lifting mechanism I, 7, a lifting mechanism II, 8, a cross-linking liquid inlet, 9, a cross-linking waste liquid outlet, 10, a cross-linking liquid pipe, 11, a cross-linking liquid storage tank, 12, a recovery pipe, 13, a cross-linking waste liquid recovery tank, 14, a cleaning liquid inlet, 15, a cleaning liquid pipe, 16, a cleaning liquid storage tank, 17, a cleaning waste liquid outlet, 18, a waste liquid pipe, 19, a cleaning waste liquid recovery tank, 20, an installation column, 21, a lead screw, 22, a guide rail, 23, a sliding block, 24, a liquid drop discharge pipe, 25 and a micro-fluidic chip.
Detailed Description
In the following, the technical solutions in the embodiments of the present invention are clearly and completely described, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
As shown in fig. 1-2: a crosslinking and cleaning integrated device for producing microspheres comprises a rotating mechanism, at least one crosslinking unit 2 and at least one cleaning unit 3, wherein the crosslinking unit 2 is arranged on the front side of a station 25 of a microfluidic chip, and the cleaning unit 3 is arranged on the front side of the station 2 of the crosslinking unit;
the rotating mechanism comprises a rotating seat 1, a cross-linking unit 2 is connected with the rotating seat 1 through a connecting rod I4 (such as a hydraulic connecting rod), a cleaning unit 3 is connected with the rotating seat 1 through a connecting rod II 5 (such as a hydraulic connecting rod), the cross-linking unit 2 and the cleaning unit 3 can be driven to rotate through the rotation of the rotating mechanism, on one hand, the cross-linking time and the cleaning time of liquid drops cut by the microfluidic chip 25 can be well controlled, on the other hand, cross-linking efficiency and quality can be guaranteed by adjusting the liquid drops in different cross-linking units to contact cross-linking liquid with proper concentration, and on the other hand, clean cleaning liquid can be contacted by adjusting microspheres after cross-linking and solidification in different cleaning units, so that the cleaning efficiency and quality are guaranteed; in addition, the next batch of liquid drops can be better linked for crosslinking and/or the next microsphere is cleaned; wherein, roating seat 1 is connected with the rotary pump, and the rotary pump provides power for roating seat 1's rotation, and then transmits respectively for crosslinking unit 2 and cleaning unit 3 through the hydraulic link again.
As shown in fig. 3-4: the cross-linking unit 2 comprises a cross-linking groove 201 and a cross-linking funnel 202, one side of the cross-linking groove 201 is provided with a lifting mechanism I6, the cross-linking funnel 202 is sleeved on the lifting mechanism I6, the cross-linking funnel 202 is arranged on the front side of a station 25 of the microfluidic chip, after the liquid drops are cross-linked and solidified in the cross-linking liquid, the microspheres can be collected only by taking the cross-linking funnel 202 out of the cross-linking groove 201 (the cross-linking funnel 202 is lifted), so that the subsequent cleaning is facilitated, meanwhile, a cross-linking space and the like are provided for the next batch of liquid drops to be cross-linked, and the cleaning, the replacement and the like of the cross-linking groove 201 are facilitated;
as shown in fig. 5-6: cleaning unit 3 includes washing tank 301 and washing funnel 302, washing tank 301 one side is provided with elevating system II 7, washing funnel 302 cover is established on elevating system II 7, treat that the microballon washs in the washing liquid and accomplish the back, only through taking out (washing funnel 302 rises) washing funnel 302 from washing tank 301 in, can wash the collection of back microballon, so that subsequent processing etc. simultaneously, also for next batch to treat that the microballon that washs provides cleaning space etc. simultaneously, also make things convenient for cleanness such as washing tank 301 and change etc..
In the present embodiment, the cross-linking unit 2 and the washing unit 3 are set to be identical, such as: the unit is a cross-linking unit when a cross-linking liquid medium is put in the unit, so that cross-linking solidification of liquid drops is realized; when a cleaning liquid medium is put into the unit, the cleaning unit is used for cleaning the microspheres. And then convenient assembly, change and washing, also be convenient for processing etc. one kind of mechanism both can be cross-linking unit 2, can be for the cleaning unit, carries out concrete settlement and step according to actual demand and existing production space finally.
Example 2
Based on the embodiment 1, the present embodiment is further,
as shown in fig. 3: be provided with crosslinked liquid import 8 and crosslinked waste liquid export 9 on crosslinked groove 201, crosslinked liquid import 8 is connected with crosslinked liquid storage tank 11 through crosslinked liquid pipe 10, and crosslinked waste liquid export 9 is connected with crosslinked waste liquid recovery jar 13 through recovery tube 12, realizes that the crosslinked liquid is orderly, effectual entering into to crosslinked groove 201, simultaneously, carries out recycle with the crosslinked waste liquid, guarantees the cross-linking process's that this device relates economy, effectively practices thrift the cost. The specific positions (upper and lower, left and right) and the number of the crosslinking liquid inlet 8 and the crosslinking waste liquid outlet 9 on the crosslinking tank 201 can be adjusted according to actual requirements.
As shown in fig. 5: be provided with washing liquid inlet 14 and washing waste liquid export 17 on the washing tank 301, washing liquid inlet 14 is connected with washing liquid storage tank 16 through washing liquid pipe 15, and washing waste liquid export 17 is connected with washing waste liquid recovery jar 19 through waste liquid pipe 18, realizes that the washing liquid is orderly, effectual entering to the washing tank 301 in, simultaneously, will wash the waste liquid and collect, guarantees the stability, controllability and the feature of environmental protection of the cleaning technology that this device relates to. The specific positions (upper and lower, left and right) and number limits of the cleaning liquid inlet 14 and the cleaning waste liquid outlet 17 on the cleaning tank 301 can be adjusted according to actual requirements.
Example 3
Based on examples 1-2, this example was further,
the number of the cross-linking units 2 is at least two, the number of the cleaning units 3 is at least two, and the cross-linking units 2 and the cleaning units 3 are respectively arranged on the circumference which takes the rotating seat 1 as the center of a circle, so that the cross-linking of liquid drops and the cleaning of microspheres in each batch are convenient to carry out, and the orderliness of the cross-linking and cleaning operations is ensured.
When the number of the cross-linking units 2 is at least three or/and the number of the cleaning units 3 is at least three, the cross-linking units 2 and the cleaning units 3 may be alternately arranged, such as: the cross-linking unit, the cleaning unit, the cross-linking unit, the cleaning unit and the like are arranged in sequence; such as: the cross-linking unit, the cleaning unit, the cross-linking unit, the cleaning unit and the like are arranged in sequence; such as: the cross-linking unit, the cleaning unit and the like are regularly and sequentially arranged (as shown in figure 1); can be set according to actual requirements.
Example 4
Based on examples 1-3, this example was further,
as shown in fig. 6-7: the lifting mechanism I6 and the lifting mechanism II 7 are sliding type lifting mechanisms and comprise mounting columns 20 and lead screws 21 arranged on the mounting columns 20, and the cross-linking funnel 202 and/or the cleaning funnel 302 are/is sleeved on the lead screws 21; the installation column 20 is provided with a guide rail 22, and the cross-linking funnel 202 and/or the cleaning funnel 302 are/is provided with a slide block 23 matched with the guide rail 22, so that the semi-automation of the device can be realized, and the continuity of cross-linking and cleaning processes can be further ensured.
Example 5
Based on examples 1-4, this example was further,
a liquid drop discharge pipe 24 is arranged between the microfluidic chip 25 and the cross-linking funnel 202, one end of the liquid drop discharge pipe 24 is connected with the microfluidic chip 25, the other end of the liquid drop discharge pipe extends to the position of the cross-linking funnel 202, and liquid drops cut by the microfluidic chip 25 are orderly and controllably discharged into the cross-linking funnel 202 for cross-linking.
Claims (8)
1. A crosslinking and cleaning integrated device for producing microspheres is characterized by comprising a rotating mechanism, at least one crosslinking unit (2) and at least one cleaning unit (3), wherein the crosslinking unit (2) is arranged on the front side of a station of a microfluidic chip (25), and the cleaning unit (3) is arranged on the front side of the station of the crosslinking unit (2);
the rotating mechanism comprises a rotating seat (1), the cross-linking unit (2) is connected with the rotating seat (1) through a connecting rod I (4), and the cleaning unit (3) is connected with the rotating seat (1) through a connecting rod II (5);
the cross-linking unit (2) comprises a cross-linking groove (201) and a cross-linking funnel (202), a lifting mechanism I (6) is arranged on one side of the cross-linking groove (201), the cross-linking funnel (202) is sleeved on the lifting mechanism I (6), and the cross-linking funnel (202) is arranged on the front side of a station of the microfluidic chip (25);
the cleaning unit (3) comprises a cleaning tank (301) and a cleaning funnel (302), wherein a lifting mechanism II (7) is arranged on one side of the cleaning tank (301), and the cleaning funnel (302) is sleeved on the lifting mechanism II (7).
2. The integrated apparatus for crosslinking and washing microspheres according to claim 1, wherein the rotary base (1) is connected with a rotary pump.
3. The integrated crosslinking and cleaning device for producing microspheres of claim 1, wherein the connecting rod I (4) and the connecting rod II (5) are hydraulic connecting rods.
4. The crosslinking-cleaning integrated device for producing microspheres according to claim 1, wherein the crosslinking tank (201) is provided with a crosslinking liquid inlet (8) and a crosslinking waste liquid outlet (9), the crosslinking liquid inlet (8) is connected with a crosslinking liquid storage tank (11) through a crosslinking liquid pipe (10), and the crosslinking waste liquid outlet (9) is connected with a crosslinking waste liquid recovery tank (13) through a recovery pipe (12).
5. The crosslinking and cleaning integrated device for producing microspheres according to claim 1 or 4, wherein the cleaning tank (301) is provided with a cleaning solution inlet (14) and a cleaning waste solution outlet (17), the cleaning solution inlet (14) is connected with a cleaning solution storage tank (16) through a cleaning solution pipe (15), and the cleaning waste solution outlet (17) is connected with a cleaning waste solution recovery tank (19) through a waste solution pipe (18).
6. The crosslinking-cleaning integrated apparatus for producing microspheres according to claim 1, wherein the crosslinking units (2) are at least two, the cleaning units (3) are at least two, and the crosslinking units (2) and the cleaning units (3) are respectively arranged on a circumference with the rotating base (1) as a center.
7. The crosslinking and cleaning integrated device for producing microspheres according to claim 1, wherein the lifting mechanism I (6) and the lifting mechanism II (7) are both sliding type lifting mechanisms, and comprise mounting columns (20) and lead screws (21) arranged on the mounting columns (20), and the crosslinking funnel (202) and/or the cleaning funnel (302) are/is sleeved on the lead screws (21); the mounting column (20) is provided with a guide rail (22), and the cross-linking funnel (202) and/or the cleaning funnel (302) is/are provided with a slide block (23) matched with the guide rail (22).
8. The crosslinking-cleaning integrated device for producing microspheres according to claim 1, wherein a droplet discharge pipe (24) is arranged between the microfluidic chip (25) and the crosslinking funnel (202), one end of the droplet discharge pipe (24) is connected with the microfluidic chip (25), and the other end extends to a station of the crosslinking funnel (202).
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| Application Number | Priority Date | Filing Date | Title |
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| CN202123014261.3U CN216440588U (en) | 2021-12-03 | 2021-12-03 | Crosslinking of production microballon, integrative device washs |
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| CN202123014261.3U CN216440588U (en) | 2021-12-03 | 2021-12-03 | Crosslinking of production microballon, integrative device washs |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114130318A (en) * | 2021-12-03 | 2022-03-04 | 四川大川合颐生物科技有限公司 | Large-scale production equipment for microspheres |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114130318A (en) * | 2021-12-03 | 2022-03-04 | 四川大川合颐生物科技有限公司 | Large-scale production equipment for microspheres |
| CN114130318B (en) * | 2021-12-03 | 2024-05-28 | 四川大川合颐生物科技有限公司 | Large-scale production equipment for microspheres |
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