CN216417178U

CN216417178U - Implanted flexible bioelectrode sensor

Info

Publication number: CN216417178U
Application number: CN202122836959.7U
Authority: CN
Inventors: 高汉民; 李令帅; 王士凡; 韩益民
Original assignee: Suzhou Zhongxing Medical Technology Co ltd
Current assignee: Suzhou Zhongxing Medical Technology Co ltd
Priority date: 2021-11-18
Filing date: 2021-11-18
Publication date: 2022-05-03
Anticipated expiration: 2031-11-18

Abstract

The utility model discloses an implantable flexible bioelectrode sensor, including the flexible substrate, the flexible substrate includes substrate main part and flexible implantation portion, be equipped with first conducting layer and second conducting layer in the substrate main part, first conducting layer include first electrically conductive main part and with the first electrically conductive implantation portion of flexible implantation portion looks adaptation, be formed with first reference electrode and working electrode in the first electrically conductive main part, be equipped with silver chloride layer and biological enzyme layer in the first electrically conductive implantation portion; the second conductive layer comprises a second conductive main body and a second conductive implant part matched with the flexible implant part, and a counter electrode is formed on the second conductive main body. The bioelectrode sensor can be flexibly implanted under the skin to detect bioelectricity signals, so that the human body feels more comfortable, and the implanted skin has small wound and no pain.

Description

Implanted flexible bioelectrode sensor

Technical Field

The utility model relates to an implantation nature sensor technical field, more specifically says, it relates to implantation nature flexible bioelectrode sensor.

Background

Diabetes is a group of metabolic diseases characterized by hyperglycemia. Hyperglycemia is caused by a defect in insulin secretion or an impaired biological action, or both. The chronic hyperglycemia results in chronic damage and dysfunction of various tissues, particularly eyes, kidneys, heart, blood vessels and nerves. Blood glucose monitoring has become an increasingly indispensable clinical tool. Subcutaneously implantable blood glucose sensors are well-known in the medical diagnostic field and, when implanted subcutaneously, can monitor molecular activity, i.e., blood glucose, in living animals in real time. However, the existing bioelectrode sensor for detecting blood sugar has large and painful wounds after being implanted into the skin, and more importantly, has poor stability of collected signals.

SUMMERY OF THE UTILITY MODEL

The utility model discloses not enough to prior art exists, the utility model provides an implantation nature flexibility bioelectrode sensor, this bioelectrode sensor can detect the bioelectricity signal under the skin is implanted to the flexibility, makes the human body feel more comfortable, and implants skin wound little, painless.

In order to achieve the above purpose, the utility model provides a following technical scheme: the implantable flexible bioelectrode sensor comprises a flexible base material, wherein the flexible base material comprises a base material main body and a flexible implantation part, a first conducting layer and a second conducting layer are arranged on the base material main body, the first conducting layer comprises a first conducting main body and a first conducting implantation part matched with the flexible implantation part, a first reference electrode and a working electrode are formed on the first conducting main body, and a silver chloride layer and a biological enzyme layer are arranged on the first conducting implantation part; the second conductive layer comprises a second conductive main body and a second conductive implant part matched with the flexible implant part, and a counter electrode is formed on the second conductive main body.

On the bioelectrode sensor, a flexible substrate is used as a main carrier to provide load support; the first conducting layer and the second conducting layer are used for transmitting the collected biological signals; the silver chloride layer is used as a reference electrode and provides a constant reference signal; and the biological enzyme layer is used for reacting with corresponding substances in biological tissue fluid and generating biological signals. The bioelectrode sensor can be flexibly implanted under the skin to detect bioelectricity signals, so that the human body feels more comfortable, and the implanted skin has small wound and no pain.

Preferably, a first conductive layer is arranged on the upper side of the flexible substrate, and a second conductive layer is arranged on the lower side of the flexible substrate; a first insulating layer is arranged on the upper side of the first conducting layer; and a second insulating layer is arranged on the lower side of the second conducting layer.

Preferably, the first insulating layer comprises a first insulating layer main body and a first insulating layer implant part integrally molded with the first insulating layer main body, and the shape of the first insulating layer implant part is matched with that of the flexible implant part; the second insulating layer comprises a second insulating layer main body and a second insulating layer implantation part integrally formed with the second insulating layer main body, and the shape of the second insulating layer implantation part is matched with that of the flexible implantation part.

Preferably, the first insulating layer and the second insulating layer are both made of UV insulating paste and are both formed by printing.

Preferably, a biocompatible coating is further provided on the flexible implanted portion, and the biocompatible coating covers the first insulating layer implanted portion, the second insulating layer implanted portion, the silver chloride layer, the biological enzyme layer, and the flexible implanted portion.

Preferably, a second reference electrode is further formed on the first conductive body.

Preferably, the bending included angle between the substrate main body and the flexible implantation part is 125-145 degrees.

Preferably, the flexible substrate is made of PET, PVC, PP or PE.

To sum up, the utility model discloses following beneficial effect has:

1. the bioelectrode sensor can be flexibly implanted under the skin to detect bioelectricity signals, so that the human body feels more comfortable, and the implanted skin has small wound and no pain;

2. the bioelectrode sensor is also provided with an insulating layer which has waterproof and insulating functions, so that the acquired signals are more stable;

3. the bioelectrode sensor is also provided with a biocompatible coating film, so that the biocompatibility of the bioelectrode sensor is better, the acquired signal is more accurate, and the allergy and rejection to organisms are smaller.

Drawings

FIG. 1 is a schematic structural diagram of an implantable flexible bioelectrode sensor;

fig. 2 is an exploded view of an implantable flexible bioelectrode sensor.

Reference numerals: 1. a flexible substrate; 2. a substrate body; 3. a flexible implant portion; 4. a first conductive layer; 6. A first conductive implant; 7. a working electrode; 8. a first reference electrode; 9. a second reference electrode; 10. a silver chloride layer; 11. a biological enzyme layer; 12. a first insulating layer; 13. a second insulating layer; 14. covering a film with biocompatibility; 15. a second conductive layer; 17. a second conductive implant; 18. a counter electrode.

Detailed Description

The present invention will be further explained with reference to the accompanying drawings.

The embodiment discloses an implantable flexible bioelectrode sensor, as shown in fig. 1-2, which includes a flexible substrate 1, the flexible substrate 1 is made of PET, PVC, PP or PE, the flexible substrate 1 includes a substrate main body 2 and a flexible implantation portion 3, the substrate main body 2 is provided with a first conductive layer 4 and a second conductive layer 15, the first conductive layer 4 includes a first conductive main body and a first conductive implantation portion 6 adapted to the flexible implantation portion 3, the first conductive main body is formed with a first reference electrode 8 and a working electrode 7, and the first conductive implantation portion 6 is provided with a silver chloride layer 10 and a bio-enzyme layer 11; the second conductive layer 15 comprises a second conductive body on which a counter electrode 18 is formed, and a second conductive implant 17 fitted to the flexible implant 3. On the bioelectrode sensor, a flexible substrate 1, which is used as a main carrier, provides load support; a first conductive layer 4 and a second conductive layer 15 for transmitting the collected bio-signals; a silver chloride layer 10, formed by printing, as a reference electrode, providing a constant reference signal; and the biological enzyme layer 11 comprises biological enzyme liquid, and the biological enzyme comprises one of glucose oxidase or glucose dehydrogenase, which is formed by spraying and is used for reacting with corresponding substances in the biological tissue liquid and generating biological signals. The bioelectrode sensor can be flexibly implanted under the skin to detect bioelectricity signals, so that the human body feels more comfortable, and the implanted skin has small wound and no pain.

In some embodiments, the upper side of the flexible substrate 1 is provided with the first conductive layer 4, and the lower side of the flexible substrate 1 is provided with the second conductive layer 15; a first insulating layer 12 is arranged on the upper side of the first conducting layer 4; a second insulating layer 13 is provided on the underside of the second conductive layer 15. Therefore, the insulating layer plays a role in water resistance and insulation, and the acquired signals are more stable. The first insulating layer 12 comprises a first insulating layer main body and a first insulating layer implanted part integrally formed with the first insulating layer main body, and the shape of the first insulating layer implanted part is matched with that of the flexible implanted part 3; the second insulating layer 13 comprises a second insulating layer main body and a second insulating layer implant part integrally formed with the second insulating layer main body, and the shape of the second insulating layer implant part is matched with that of the flexible implant part 3; and the length of the first and second insulating layer implants is less than the length of the flexible implant 3. The first insulating layer 12 and the second insulating layer 13 are made of UV insulating glue and are formed by printing. In addition, the first insulating layer 12 is provided with first through holes corresponding to the first reference electrode 8, the working electrode 7 and the counter electrode 18; meanwhile, a second through hole communicated with the first through hole is formed in the flexible substrate 1 corresponding to the counter electrode 18. The second insulating layer 13 is provided with a third through hole corresponding to the counter electrode 18.

In some embodiments, a biocompatible coating 14 is further disposed on the flexible implant portion 3, and is formed by dip-coating, wherein the biocompatible coating 14 covers the implant portion of the first insulating layer 12, the implant portion of the second insulating layer 13, the silver chloride layer 10, the bio-enzyme layer 11, and the flexible implant portion 3. Therefore, the biocompatibility of the biological sensor is better, the signal acquisition is more accurate, and the allergy and rejection to organisms are less.

In some embodiments, the first conductive body also has a second reference electrode 9 formed thereon; meanwhile, the first insulating layer 12 is provided with fourth through holes corresponding to the second reference electrode 9. If the first reference electrode 8 does not make good contact, the electrode will burn away; the provision of two reference electrodes prevents one from making poor contact and the other from making contact. As an embodiment, the first conductive layer and the second conductive layer are each formed by printing conductive carbon paste; the first conducting layer consists of two parts, including a first conducting layer A and a first conducting layer B, wherein the first conducting layer A is provided with a first reference electrode, a second reference electrode and a silver chloride layer; the first conductive layer B is provided with a working electrode and a biological enzyme layer 11.

In some embodiments, the bending angle between the substrate body 2 and the flexible implant 3 is 125-145 °. So, form the design of buckling between substrate main part 2 and the flexible portion 3 of implanting, make implant human subcutaneous distance longer, gather the bioelectricity signal more stable to the life of extension bioelectrode sensor.

The implantable flexible bioelectrode sensor sequentially comprises a first insulating layer 12, a first conducting layer 4, a flexible substrate 1, a second conducting layer 15 and a second insulating layer 13 from top to bottom; the first conducting layer 4 is provided with a silver chloride layer 10 and a biological enzyme layer 11, and meanwhile, a biocompatible coating 14 wraps the insulating layer implantation part, the silver chloride layer 10, the biological enzyme layer 11 and the flexible implantation part 3.

In the present invention, it should be understood that the terms "upper" and "lower" indicate the orientation or the position relationship based on the orientation or the position relationship shown in the drawings, which is only for the convenience of describing the present invention and simplifying the description, and therefore, the present invention is not limited thereto.

The directions given in the present embodiment are merely for convenience of describing positional relationships between the respective members and the relationship of fitting with each other. It is above only the utility model discloses a preferred embodiment, the utility model discloses a scope of protection does not only confine above-mentioned embodiment, the all belongs to the utility model discloses a technical scheme under the thinking all belongs to the utility model discloses a scope of protection. It should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims

1. The implanted flexible bioelectrode sensor is characterized in that: the flexible substrate comprises a flexible substrate (1), wherein the flexible substrate (1) comprises a substrate main body (2) and a flexible implantation part (3), a first conducting layer (4) and a second conducting layer (15) are arranged on the substrate main body (2), the first conducting layer (4) comprises a first conducting main body and a first conducting implantation part (6) matched with the flexible implantation part (3), a first reference electrode (8) and a working electrode (7) are formed on the first conducting main body, and a silver chloride layer (10) and a biological enzyme layer (11) are arranged on the first conducting implantation part (6); the second conductive layer (15) comprises a second conductive body and a second conductive implant (17) matched with the flexible implant (3), and a counter electrode (18) is formed on the second conductive body.

2. The implantable flexible bio-electrode sensor according to claim 1, wherein: a first conductive layer (4) is arranged on the upper side of the flexible base material (1), and a second conductive layer (15) is arranged on the lower side of the flexible base material (1); a first insulating layer (12) is arranged on the upper side of the first conducting layer (4); and a second insulating layer (13) is arranged on the lower side of the second conducting layer (15).

3. The implantable flexible bio-electrode sensor according to claim 2, wherein: the first insulating layer (12) comprises a first insulating layer main body and a first insulating layer implanted part which is integrally formed with the first insulating layer main body, and the shape of the first insulating layer implanted part is matched with that of the flexible implanted part (3); the second insulating layer (13) comprises a second insulating layer main body and a second insulating layer implanted part which is integrally formed with the second insulating layer main body, and the shape of the second insulating layer implanted part is matched with that of the flexible implanted part (3).

4. The implantable flexible bioelectrode sensor according to claim 3, wherein: the first insulating layer (12) and the second insulating layer (13) are made of UV insulating glue and are formed by printing.

5. The implantable flexible bio-electrode sensor according to claim 4, wherein: the flexible implanting part (3) is further provided with a biocompatible coating (14), and the biocompatible coating (14) wraps the first insulating layer (12) implanting part, the second insulating layer (13) implanting part, the silver chloride layer (10), the biological enzyme layer (11) and the flexible implanting part (3).

6. The implantable flexible bio-electrode sensor according to claim 1, wherein: a second reference electrode (9) is also formed on the first conductive body.

7. The implantable flexible bio-electrode sensor according to claim 1, wherein: the bending included angle between the substrate main body (2) and the flexible implantation part (3) is 125-145 degrees.

8. The implantable flexible bio-electrode sensor according to claim 1, wherein: the flexible base material (1) is made of PET, PVC, PP or PE.