CN216386870U

CN216386870U - Full-automatic high-precision capillary electrophoresis apparatus

Info

Publication number: CN216386870U
Application number: CN202122534128.4U
Authority: CN
Inventors: 周灵灵; 张元飞
Original assignee: Beijing Huaren Biotechnology Co ltd
Current assignee: Beijing Huaren Biotechnology Co ltd
Priority date: 2021-10-21
Filing date: 2021-10-21
Publication date: 2022-04-26
Anticipated expiration: 2031-10-21

Abstract

The utility model relates to the technical field of electrophoresis apparatuses, and discloses a full-automatic high-precision capillary electrophoresis apparatus which comprises a bottom plate, wherein a driving assembly with one end extending to the upper part of the bottom plate is arranged on the rear side of the bottom plate, and a sampling assembly with one end extending to the bottom of the driving assembly is arranged at the top of the driving assembly. This full-automatic high accuracy capillary electrophoresis apparatus, through holding two handles and pulling forward handheld piece, and then drive the movable plate through the connecting rod and move forward, the movable plate then can drive two slider compression positioning spring relative movements through the traction lever at the in-process that removes, and then drive two locating piece relative movements, shift out from the inside of constant head tank until the locating piece, thereby remove the position restriction to the mounting panel, can upwards mention the mounting panel together with the capillary through the handle this moment, thereby dismantle the mounting panel, change the capillary with this, finally realized being convenient for to the purpose that the capillary was changed.

Description

Full-automatic high-precision capillary electrophoresis apparatus

Technical Field

The utility model relates to the technical field of electrophoresis apparatuses, in particular to a full-automatic high-precision capillary electrophoresis apparatus.

Background

Capillary electrophoresis is a separation technology which is rapidly developed in recent ten years, and is a liquid phase separation technology which takes a high-voltage electric field as a driving force and a capillary as a separation channel and achieves the separation purpose according to the mobility and the distribution behavior difference among components of a sample.

But the mounting means of capillary is mostly fixed on the current capillary electrophoresis apparatus, because the frequent use of capillary, consequently need often clear up the capillary, lead to the capillary to have inconveniently in the change process, the practicality is relatively poor, so provide full-automatic high accuracy capillary electrophoresis apparatus.

SUMMERY OF THE UTILITY MODEL

Technical problem to be solved

Aiming at the defects of the prior art, the utility model provides a full-automatic high-precision capillary electrophoresis apparatus, which has the advantages of being convenient to replace capillaries and the like, and solves the problems that the capillary is inconvenient to replace and poor in practicability due to the fact that the capillary is required to be cleaned frequently because the capillary is frequently used and the mounting mode of the capillary on the existing capillary electrophoresis apparatus is mostly fixed.

(II) technical scheme

In order to achieve the purpose of conveniently replacing the capillary tube, the utility model provides the following technical scheme: the full-automatic high-precision capillary electrophoresis apparatus comprises a bottom plate, wherein a driving assembly with one end extending to the upper part is arranged at the rear side of the bottom plate, a sampling assembly with one end extending to the bottom is arranged at the top of the driving assembly, a storage box positioned at the right side of the sampling assembly is arranged at the top of the bottom plate, a sample box positioned at the left side of the sampling assembly is arranged at the top of the bottom plate, a buffer liquid box positioned at the left side of the sample box is arranged at the top of the bottom plate, a mounting plate is arranged between the sample box and the buffer liquid box, a capillary tube with one end extending to the inside of the sample box and the other end extending to the inside of the buffer liquid box is arranged at the top of the mounting plate, handles are arranged at the front side and the rear side of the mounting plate, a mounting cavity is arranged in the mounting plate, positioning grooves are arranged at the opposite sides of the sample box and the buffer liquid box, and positioning assemblies with the left side and the right side extending to the inside of the two positioning grooves are arranged at the rear side of the inner wall of the mounting cavity, one end of the traction component is movably connected with the front side of the positioning component, and the other end of the traction component extends into the front side handle.

Preferably, drive assembly is including installing the piece, the rear side fixed mounting of bottom plate has quantity to be two and be the installation piece that bilateral symmetry distributes, the left side fixed mounting of installation piece has servo motor, servo motor's output shaft extends to the right side of left side installation piece and fixed mounting has one end and right side installation piece swing joint's threaded rod, the outside threaded connection of threaded rod has the L template that one end extends to the bottom plate top, the front side of L template and the rear side swing joint of bottom plate.

Preferably, the sampling component includes first pneumatic cylinder, the equal fixed mounting in both sides has the output to extend to the first pneumatic cylinder of its bottom around the top of L template, the front side the output fixed mounting of first pneumatic cylinder has the stock solution storehouse of the first pneumatic cylinder output fixed connection of one end and rear side, the inside movable mounting in stock solution storehouse has the piston, the top fixed mounting in stock solution storehouse has the second pneumatic cylinder that is located between two first pneumatic cylinders, the output of second pneumatic cylinder extend to the inside of stock solution storehouse and with the top fixed connection of piston, the interior diapire fixed mounting in stock solution storehouse has the transfer line that one end extends to its bottom, the storage box is located the right side in stock solution storehouse, the sample box is located the left side in stock solution storehouse.

Preferably, locating component includes the slider, the equal movable mounting in both ends has the slider about installation intracavity wall rear side, two the equal fixed mounting in dorsal part of slider has one end to run through the mounting panel and extend to the inside locating piece of two constant head tanks respectively, two fixed mounting has the location spring between the slider.

Preferably, the traction assembly includes the movable plate, movable mounting has the movable plate that is located the slider front side between the inner wall left and right sides of installation cavity, two the equal movable mounting in front side of slider has one end and movable plate rear side swing joint's traction lever, the front side fixed mounting of movable plate has one end to run through the mounting panel and extends to the inside connecting rod of front side handle, fixed mounting has the reset spring of cover in the connecting rod outside between the inner wall front side of installation cavity and the movable plate, the front side fixed mounting of connecting rod has handheld piece.

Preferably, the right side the left side fixed mounting of installation piece has the bearing, the threaded rod passes through the bearing and is connected with the rotation of right side installation piece, the screw hole with threaded rod looks adaptation is seted up to the inside of L template.

(III) advantageous effects

Compared with the prior art, the utility model provides a full-automatic high-precision capillary electrophoresis apparatus, which has the following beneficial effects:

this full-automatic high accuracy capillary electrophoresis apparatus, through holding two handles and pulling forward handheld piece, and then drive movable plate compression reset spring forward movement through the connecting rod, the movable plate then can drive two slider compression positioning spring relative movements through the traction lever at the in-process that removes, and then drive two locating piece relative movements, shift out from the inside of constant head tank until the locating piece, thereby remove the position restriction to the mounting panel, can upwards mention the mounting panel together with the capillary through the handle this moment, thereby dismantle the mounting panel, change the capillary with this, finally realized being convenient for to the purpose that the capillary was changed, and the practicability is improved.

Drawings

FIG. 1 is a top view of the present invention;

FIG. 2 is a left side cross-sectional view of the drive assembly of the present invention;

FIG. 3 is a top cross-sectional view of the mounting plate of the present invention.

In the figure: the device comprises a base plate 1, a driving assembly 2, a mounting block 21, a servo motor 22, a threaded rod 23, a 24L-shaped plate, a sampling assembly 3, a first hydraulic cylinder 31, a liquid storage bin 32, a piston 33, a second hydraulic cylinder 34, a liquid conveying pipe 35, a material storage box 4, a sample box 5, a buffer box 6, a mounting plate 7, a capillary tube 8, a lifting handle 9, a mounting cavity 10, a positioning groove 11, a positioning assembly 12, a sliding block 121, a positioning block 122, a positioning spring 123, a traction assembly 13, a movable plate 131, a traction rod 132, a connecting rod 133, a return spring 134 and a handheld block 135.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Referring to fig. 1-3, the present invention provides a technical solution: full-automatic high accuracy capillary electrophoresis apparatus, comprising a base plate 1, the rear side fixed mounting of bottom plate 1 has drive assembly 2 that one end extends to its top, drive assembly 2 is including installation piece 21, the rear side fixed mounting of bottom plate 1 has quantity to be two and be bilateral symmetry distribution's installation piece 21, the left side fixed mounting of left side installation piece 21 has servo motor 22, servo motor 22's output shaft extends to the right side of left side installation piece 21 and fixed mounting has one end and right side installation piece 21 swing joint's threaded rod 23, the outside threaded connection of threaded rod 23 has the L template 24 that one end extends to bottom plate 1 top, the front side of L template 24 and the rear side swing joint of bottom plate 1, the left side fixed mounting of right side installation piece 21 has the bearing, threaded rod 23 passes through the bearing and is connected with right side installation piece 21 rotation, the screw hole with threaded rod 23 looks adaptation is seted up to the inside of L template 24.

The top of the driving component 2 is fixedly provided with a sampling component 3 with one end extending to the bottom thereof, the top of the bottom plate 1 is fixedly provided with a storage box 4 positioned on the right side of the sampling component 3, the top of the bottom plate 1 is fixedly provided with a sample box 5 positioned on the left side of the sampling component 3, the sampling component 3 comprises a first hydraulic cylinder 31, the front side and the rear side of the top of the L-shaped plate 24 are both fixedly provided with a first hydraulic cylinder 31 with an output end extending to the bottom thereof, the output end of the first hydraulic cylinder 31 on the front side is fixedly provided with a liquid storage bin 32 with one end fixedly connected with the output end of the first hydraulic cylinder 31 on the rear side, a piston 33 is movably arranged in the liquid storage bin 32, the top of the liquid storage bin 32 is fixedly provided with a second hydraulic cylinder 34 positioned between the two first hydraulic cylinders 31, the output end of the second hydraulic cylinder 34 extends to the inside of the liquid storage bin 32 and is fixedly connected with the top of the piston 33, the inner bottom wall of the liquid storage bin 32 is fixedly provided with a liquid conveying pipe 35 with one end extending to the bottom thereof, storage box 4 is located the right side of stock solution storehouse 32, and sample box 5 is located the left side of stock solution storehouse 32, and bottom plate 1's top fixed mounting has and is located 5 left buffer boxes 6 of sample box, and movable mounting has mounting panel 7 between sample box 5 and the buffer boxes 6, and mounting panel 7's top fixed mounting has one end to extend to 5 inside and the other end of sample box and extends to 6 inside capillary 8 of buffer boxes.

Equal fixed mounting in both sides has handle 9 around mounting panel 7, mounting chamber 10 has been seted up to mounting panel 7's inside, constant head tank 11 has all been seted up to the opposite side of sample box 5 and buffer box 6, the inner wall rear side movable mounting of mounting chamber 10 has left and right both sides to extend to the inside locating component 12 of two constant head tanks 11 respectively, locating component 12 includes slider 121, the equal movable mounting in both ends has slider 121 about the mounting chamber 10 inner wall rear side, the equal fixed mounting in dorsal part of two sliders 121 has one end to run through mounting panel 7 and extend to the inside locating piece 122 of two constant head tanks 11 respectively, fixed mounting has positioning spring 123 between two sliders 121.

One end and the locating component 12 front side swing joint and the other end extend to the inside subassembly 13 that pulls of front side handle 9 are movably mounted between the inner wall left and right sides of installation cavity 10, pull the subassembly 13 and include movable plate 131, movable plate 131 that is located the slider 121 front side is movably mounted between the inner wall left and right sides of installation cavity 10, the equal movable mounting of front side of two sliders 121 has one end and the pull rod 132 of movable plate 131 rear side swing joint, the front side fixed mounting of movable plate 131 has one end to run through mounting panel 7 and extend to the inside connecting rod 133 of front side handle 9, fixed mounting has the reset spring 134 of cover in the connecting rod 133 outside between the inner wall front side of installation cavity 10 and the movable plate 131, the front side fixed mounting of connecting rod 133 has handheld piece 135.

The two handles 9 are held, the handheld block 135 is pulled forwards, the connecting rod 133 drives the moving plate 131 to compress the return spring 134 to move forwards, the moving plate 131 drives the two sliding blocks 121 to compress the positioning springs 123 to move relatively through the traction rod 132 in the moving process, the two positioning blocks 122 are further driven to move relatively until the positioning blocks 122 are moved out of the positioning grooves 11, the position limitation on the mounting plate 7 is removed, the mounting plate 7 and the capillary tube 8 can be integrally lifted upwards through the handles 9, the mounting plate 7 is detached, and therefore the capillary tube 8 is replaced.

When the sample solution feeding device is used, a sample solution is poured into the storage box 4, then the servo motor 22 is started to drive the threaded rod 23 to rotate, further the L-shaped plate 24 is driven to move to the upper part of the storage box 4, then the first hydraulic cylinder 31 is started to drive the liquid storage bin 32 to move downwards integrally, the second hydraulic cylinder 34 is started to extract an equal amount of sample solution from the storage box 4, then the liquid storage bin 32 is driven to move upwards integrally, the servo motor 22 rotates reversely to drive the liquid storage bin 32 to move to the upper part of the sample box 5, at the moment, the second hydraulic cylinder 34 is started to input the sample solution into the sample box 5, so that the adding work of the sample solution is automatically completed, the amount of the sample solution is accurately controlled, the waste of the sample solution is avoided, then the anode of an external high-voltage power supply is connected into the sample box 5 through a lead, and the cathode of the external high-voltage power supply is connected into the buffer liquid box 6 through a lead, under the driving of the high-voltage electric field, the sample solution in the sample box 5 enters the capillary 8 to perform separation between the components of the sample.

To sum up, the full-automatic high-precision capillary electrophoresis apparatus, by holding two handles 9 and pulling the hand-held block 135 forward, further drives the moving plate 131 to compress the return spring 134 to move forward through the connecting rod 133, the moving plate 131 drives the two sliders 121 to compress the positioning spring 123 to move relatively through the traction rod 132 in the moving process, further drives the two positioning blocks 122 to move relatively until the positioning blocks 122 are moved out from the inside of the positioning grooves 11, thereby removing the position limitation on the mounting plate 7, at this time, the mounting plate 7 and the capillary tube 8 can be lifted up integrally through the handles 9, thereby detaching the mounting plate 7, and replacing the capillary tube 8, finally achieving the purpose of conveniently replacing the capillary tube 8, improving the practicability, solving the problems that the mounting mode of the capillary tube on the existing capillary electrophoresis apparatus is mostly fixed, and due to the frequent use of the capillary tube, therefore, the capillary tube needs to be cleaned frequently, which causes the problems that the capillary tube is inconvenient in the replacement process and the practicability is poor.

It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.

Claims

1. Full-automatic high-precision capillary electrophoresis apparatus, comprising a bottom plate (1), wherein a driving component (2) with one end extending to the upper part of the bottom plate is arranged at the rear side of the bottom plate (1), a sampling component (3) with one end extending to the bottom of the driving component (2) is arranged at the top of the driving component (2), a storage box (4) positioned at the right side of the sampling component (3) is arranged at the top of the bottom plate (1), a sample box (5) positioned at the left side of the sampling component (3) is arranged at the top of the bottom plate (1), a buffer liquid box (6) positioned at the left side of the sample box (5) is arranged at the top of the bottom plate (1), a mounting plate (7) is arranged between the sample box (5) and the buffer liquid box (6), a capillary tube (8) with one end extending to the inside of the sample box (5) and the other end extending to the inside of the buffer liquid box (6) is arranged at the top of the mounting plate (7), the method is characterized in that: both sides all are provided with handle (9) around mounting panel (7), the inside of mounting panel (7) is provided with installation cavity (10), the opposite side of sample box (5) and buffer box (6) all is provided with constant head tank (11), the inner wall rear side of installation cavity (10) is provided with about both sides and extends to two constant head tank (11) inside locating component (12) respectively, be provided with between the inner wall left and right sides of installation cavity (10) one end and locating component (12) front side swing joint and the other end extend to front side handle (9) inside subassembly (13) that pulls.

2. The full-automatic high-precision capillary electrophoresis apparatus according to claim 1, wherein: drive assembly (2) are including installation piece (21), the rear side fixed mounting of bottom plate (1) has quantity to be two and be bilateral symmetry distribution's installation piece (21), the left side fixed mounting of installation piece (21) has servo motor (22), the output shaft of servo motor (22) extends to the right side of left side installation piece (21) and fixed mounting has one end and right side installation piece (21) swing joint's threaded rod (23), the outside threaded connection of threaded rod (23) has L template (24) that one end extends to bottom plate (1) top, the front side of L template (24) and the rear side swing joint of bottom plate (1).

3. The full-automatic high-precision capillary electrophoresis apparatus according to claim 2, wherein: the sampling assembly (3) comprises a first hydraulic cylinder (31), the output end of the first hydraulic cylinder (31) is fixedly mounted with a liquid storage bin (32) fixedly connected with the output end of the first hydraulic cylinder (31) at one end and the rear end around the top of the L-shaped plate (24), a piston (33) is movably mounted inside the liquid storage bin (32), a second hydraulic cylinder (34) between the two first hydraulic cylinders (31) is fixedly mounted at the top of the liquid storage bin (32), the output end of the second hydraulic cylinder (34) is fixedly connected with the inside of the liquid storage bin (32) and the top of the piston (33), an infusion tube (35) with one end extending to the bottom is fixedly mounted at the inner bottom wall of the liquid storage bin (32), and the storage box (4) is located at the right side of the liquid storage bin (32), the sample box (5) is positioned at the left side of the liquid storage bin (32).

4. The full-automatic high-precision capillary electrophoresis apparatus according to claim 1, wherein: locating component (12) include slider (121), the equal movable mounting in both ends has slider (121), two about installation cavity (10) inner wall rear side the equal fixed mounting in opposite sides of slider (121) has one end to run through mounting panel (7) and extend to locating piece (122) inside two constant head tanks (11) respectively, two fixed mounting has positioning spring (123) between slider (121).

5. The full-automatic high-precision capillary electrophoresis apparatus according to claim 4, wherein: traction assembly (13) is including movable plate (131), movable mounting has movable plate (131) that are located slider (121) front side between the inner wall left and right sides of installation cavity (10), two the equal movable mounting of front side of slider (121) has traction lever (132) of one end and movable plate (131) rear side swing joint, the front side fixed mounting of movable plate (131) has one end to run through mounting panel (7) and extend to connecting rod (133) of front side handle (9) inside, fixed mounting has reset spring (134) of cover in connecting rod (133) outside between the inner wall front side of installation cavity (10) and movable plate (131), the front side fixed mounting of connecting rod (133) has handheld piece (135).

6. The full-automatic high-precision capillary electrophoresis apparatus according to claim 2, wherein: the right side the left side fixed mounting of installation piece (21) has the bearing, threaded rod (23) are connected with right side installation piece (21) rotation through the bearing, the screw hole with threaded rod (23) looks adaptation is seted up to the inside of L template (24).