CN216208840U

CN216208840U - Closed medicine thin layer chromatography jar for experiments

Info

Publication number: CN216208840U
Application number: CN202122532739.5U
Authority: CN
Inventors: 李华; 张敏; 崔景霞
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-10-21
Filing date: 2021-10-21
Publication date: 2022-04-05
Anticipated expiration: 2031-10-21

Abstract

The utility model provides a closed medicine thin-layer chromatography cylinder for experiments, which comprises a cylinder body and a cylinder cover buckled on the cylinder body, wherein the cylinder cover is provided with a convex part, the convex part is inserted into an opening of the cylinder body and is abutted against the side wall of the cylinder body, the cylinder cover is provided with a plurality of slots, a fixer is inserted into each slot, a chromatography plate is inserted into the fixer, a liquid storage tank is arranged at the position, corresponding to the slots, of the bottom of the cylinder body, and the lower part of the chromatography plate is inserted into the liquid storage tank. The utility model discloses a cylinder cap can be inseparable with the cylinder body lock, and is difficult for removing, and the seal is good, practices thrift reagent, and is applicable to experiment in a plurality of congeneric or different kinds of medicine samples.

Description

Closed medicine thin layer chromatography jar for experiments

Technical Field

The utility model relates to the technical field of drug detection and analysis, in particular to a closed drug thin-layer chromatography cylinder for experiments.

Background

Thin-layer chromatography, also called thin-layer chromatography, is a very important experimental technique in qualitative analysis of drugs, wherein a drug sample solution is spotted on one end of a thin-layer plate by a capillary tube and placed in a closed groove, and a proper reagent is added as a mobile phase. Due to the capillary principle, the reagent is drawn up, moves along the plate and brings the components of the drug sample forward, a process called unfolding. Because the components have different properties and different moving distances, the component spots separated from each other are obtained after the components are spread for a certain distance.

In the prior art, when the area of a thin-layer plate is large, a thin-layer chromatography cylinder made of rectangular glass is adopted to unfold the thin-layer plate, one thin-layer plate is obliquely placed in the thin-layer chromatography cylinder, a reagent is injected into the bottom of the cylinder, and the upper part of the cylinder is covered with a glass cover plate, so that the thin-layer chromatography cylinder has the following defects:

(1) the glass cover plate and the cylinder body are not fixed, so the glass cover plate is easy to move and poor in tightness, the expansion result of the medicine sample is greatly influenced by the change of air temperature and humidity, and the operation is inconvenient when the chromatography plate is placed every time;

(2) only one chromatography plate can be obliquely arranged in the device, and only the drug sample on one chromatography plate can be subjected to experimental operation at one time, so that the operation efficiency is low;

(3) reagent distributes in whole cylinder body bottom, causes the waste of reagent.

SUMMERY OF THE UTILITY MODEL

In view of the above, the present invention provides a closed thin layer chromatography cylinder for experimental drugs to solve the above technical problems.

In order to achieve the purpose, the technical scheme of the utility model is realized as follows:

the utility model provides an experimental closed medicine thin layer chromatography jar, includes cylinder body and the cylinder cap of lock on the cylinder body, the cylinder cap is provided with the bellying, the bellying is inserted and is established the cylinder body opening part with cylinder body lateral wall butt, a plurality of slots have been seted up on the cylinder cap, every the slot interpolation is equipped with the fixer, it is equipped with the chromatography board to insert on the fixer, the position that cylinder body bottom and slot correspond is provided with the reservoir, the chromatography board lower part inserts in the reservoir.

This closed medicine thin layer chromatography jar for experiments has good seal, need not to open the cylinder cap, just can place or take out the chromatography board, and the fixer carries out the centre gripping to the chromatography board, puts into the reservoir with it, and a plurality of slots correspond the reservoir, are convenient for operate single chromatography board, do not influence other chromatography boards and experiment.

Preferably, a groove is circumferentially arranged on the outer side of the protruding portion, a sealing ring is arranged in the groove, and the sealing ring is made of rubber or silica gel.

The sealing ring has elasticity, can enable the bulge part to be tightly matched with the opening of the cylinder body, improves the sealing property, and is not easy to cause the cylinder cover to move or separate from the cylinder body.

Preferably, the periphery of the slot is provided with a sinking platform, the sinking platform is arranged on one side of the upper surface of the cylinder cover, the fixer comprises an inserting part and a supporting part which are fixedly connected, the inserting part is inserted into the slot, and the supporting part abuts against the sinking platform.

Should set up that the fixer can be fine and the slot cooperation, heavy platform plays the supporting role to the fixer, prevents that its depth of insertion is too big.

Preferably, the fixer further comprises a fixing part, the fixing part is inserted into the insertion part, the fixing part is fixedly connected with the insertion part, and an insertion opening for inserting the chromatographic plate is formed in the middle of the fixing part.

Should set up the fixed part and be used for connecting the chromatography board, fixed part and grafting portion are split type, can be convenient for change the fixed part, and the fixed part of being convenient for adopts the material that is suitable for centre gripping chromatography board.

Preferably, the fixer further comprises a handle, and the handle is fixedly arranged on one side of the supporting part far away from the inserting part.

This setting is convenient for hold the fixer with the hand, gets to put of chromatography board and operates.

Preferably, a liquid outlet hole is formed in the bottom of the liquid storage tank, the liquid outlet hole penetrates through the cylinder body bottom plate, and a liquid outlet plug is detachably arranged on the liquid outlet hole.

This setting is avoided opening the cylinder cap and is discharged the reagent in the reservoir, and the simple operation has increased the seal of chromatography jar.

Preferably, the lateral part of the liquid storage tank is provided with a liquid inlet hole, the liquid inlet hole penetrates through the side wall of the cylinder body, and the liquid inlet hole is detachably provided with a liquid inlet plug.

This setting is avoided opening the cylinder cap and is injected reagent into the reservoir, and the simple operation has increased the seal of chromatography jar.

Preferably, the liquid outlet plug, the liquid inlet plug and the fixing part are made of rubber or silica gel.

The liquid outlet plug, the liquid inlet plug and the fixing part are elastic due to the arrangement, the liquid outlet plug and the liquid inlet plug are good in plugging effect, and the fixing part has a good clamping effect on the chromatography plate.

Preferably, the liquid inlet hole is obliquely arranged on the side wall of the cylinder body, and the liquid inlet hole is arranged on the upper part of the hole of the inner side wall of the cylinder body at the hole of the outer side wall of the cylinder body. The reagent is convenient to be injected into the liquid storage tank from top to bottom and is not easy to spill out of the liquid storage tank.

Preferably, the number of the liquid storage tanks corresponds to the number of the slots. Facilitating the adsorption of the corresponding chromatography plate.

The closed medicine thin-layer chromatography cylinder for experiments has the following advantages:

(1) according to the sealed medicine thin-layer chromatography cylinder for experiments, the cylinder cover can be tightly buckled with the cylinder body and is not easy to move, the placement and extraction of the chromatography plate can be completed without opening the cylinder cover, the tightness of the thin-layer chromatography cylinder is ensured, the operation is easy, and the experiment process is simple and easy to implement;

(2) according to the closed medicine thin-layer chromatography cylinder for experiments, the liquid storage tank can greatly save the use of reagents, the input and the discharge of the reagents can be completed without opening the cylinder cover, and the good tightness of the thin-layer chromatography cylinder is further guaranteed.

(3) The sealed medicine thin-layer chromatography cylinder for experiments can be used for detecting a plurality of same medicine samples or different medicine samples, a plurality of chromatography plates can be taken and placed at the same time, and can also be taken and placed at intervals according to needs, and the sealed medicine thin-layer chromatography cylinder for experiments is convenient and quick.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate an embodiment of the utility model and, together with the description, serve to explain the utility model and not to limit the utility model. In the drawings:

FIG. 1 is a schematic diagram of an external structure of a closed type drug thin-layer chromatography cylinder for experiments according to an embodiment of the present invention;

FIG. 2 is a schematic structural diagram of a cylinder body according to an embodiment of the present invention;

FIG. 3 is a schematic structural diagram of a cylinder head according to an embodiment of the present invention;

FIG. 4 is a schematic view of a fastener according to an embodiment of the present invention;

FIG. 5 is a sectional view of the interior of the closed type medicine thin layer chromatography cylinder for experiments according to the embodiment of the present invention;

FIG. 6 is an enlarged view taken at A of FIG. 5 in accordance with the present invention;

FIG. 7 is an enlarged view taken at B of FIG. 5 in accordance with the present invention;

fig. 8 is a partial sectional view of a lower portion of the cylinder head at the inlet port according to the present invention.

Description of reference numerals:

1. a cylinder cover; 11. a holder; 12. a plug-in part; 13. a support portion; 14. a handle; 15. a fixed part; 16. a boss portion; 17. a slot; 18. sinking a platform; 19. a seal ring; 2. a cylinder body; 21. a liquid inlet plug; 22. a support leg; 23. a liquid storage tank; 24. a liquid outlet hole; 25. a liquid outlet plug; 26. and a liquid inlet hole.

Detailed Description

It should be noted that the embodiments and features of the embodiments may be combined with each other without conflict.

The description in this invention relating to "first", "second", "inner", "outer", "upper", "lower", etc. is for descriptive purposes only and is not to be understood as indicating or implying a relative importance or implying a number of technical features indicated, the "inner" being the side pointing towards the cylinder volume, the "outer" being the side of the cylinder remote from the volume, the "upper", "lower" being indicated in the drawings. In addition, the technical solutions in the embodiments may be combined with each other, but it is necessary that a person skilled in the art can realize the combination, and the technical solutions in the embodiments are within the protection scope of the present invention.

The present invention will be described in detail below with reference to the embodiments with reference to the attached drawings.

The specific embodiment provides a sealed medicine thin layer chromatography cylinder for experiments, as shown in figures 1 to 8,

the thin-layer chromatography cylinder comprises a cylinder body 2 and a cylinder cover 1 buckled on the cylinder body 2, wherein the cylinder body 2 is cuboid, the cylinder cover 1 is rectangular plate-shaped, after the cylinder cover 1 is buckled on the cylinder body 2, the peripheral edge of the cylinder cover 1 extends out of the cylinder body 2, the edge of the cylinder cover 1 is conveniently held by two hands when the cylinder cover 1 is taken and placed, a protruding part 16 is arranged at the lower part of the cylinder cover 1, the protruding part 16 is inserted into an opening of the cylinder body 2 and is abutted against the side wall of the cylinder body 2, a groove is circumferentially arranged at the outer side of the protruding part 16, a sealing ring 19 is arranged in the groove, the sealing ring 19 is made of rubber or silica gel, preferably, the cross section of the groove is square, triangular or semicircular to accommodate the square, triangular or circular sealing ring 19, the sealing ring 19 has elasticity, the protruding part 16 is in transition fit when abutted against the opening of the cylinder body 2, the cylinder cover 1 is not easy to fall off, and the tightness of the thin-layer chromatography cylinder is ensured;

the cylinder cover 1 is provided with a plurality of slots 17, the slots 17 are through slots and are uniformly distributed along the width direction or the length direction, a fixer 11 is inserted into each slot 17, and a chromatography plate 3 is inserted into each fixer 11; the arrangement can finish the taking and placing of the chromatographic plate 3 without opening the cylinder cover 1, can ensure that the thin-layer chromatography cylinder has good tightness and is convenient to operate;

specifically, the periphery of the slot 17 is provided with a sinking platform 18, the sinking platform 18 is arranged on one side of the upper surface of the cylinder cover 1, the fixer 11 comprises an insertion part 12 and a supporting part 13 which are fixedly connected, the fixer further comprises a fixing part 15 and a handle 14, the insertion part 12 is inserted into the slot 17 of the cylinder cover 1, the supporting part 13 is abutted on the sinking platform 18, the lower surface of the supporting part 13 is abutted with the upper surface of the sinking platform 18, the sinking platform 18 plays a supporting role for the supporting part 13, the lower part of the insertion part 12 is provided with an insertion hole, the insertion hole is inserted with the fixing part 15, the fixing part 15 is fixedly connected with the insertion hole of the insertion part 12 in a screwing or bonding mode, the insertion hole extends to the lower surface of the supporting part 13, the end part of the fixing part 15 is contacted with the lower surface of the supporting part 13, the middle of the bottom of the fixing part 15 is provided with an insertion hole, the insertion hole extends to the lower surface of the supporting part 13, the upper part of the chromatography plate 3 is inserted in the insertion hole, so that the insertion range of the chromatography plate 3 can be enlarged, the insertion length can be adjusted, the fixing part 15 is made of rubber or silica gel, has elasticity, can be in transition fit with the chromatographic plate 3 to clamp the chromatographic plate, and can be used for conveniently taking down the chromatographic plate 3 under the action of external force of hands; the handle 14 is fixedly arranged on one side of the supporting part 13 far away from the inserting part 12, so that the taking and placing fixer 11 can be conveniently held by hands;

the periphery of the outer side of the bottom of the cylinder body 2 is uniformly provided with support legs 22, the support legs 22 support the whole cylinder body 2, the inner side of the bottom of the cylinder body 2 is provided with liquid storage tanks 23 at positions corresponding to the slots 17, the number of the liquid storage tanks 23 corresponds to the slots 17 one by one, two sides of each liquid storage tank 23 are vertical liquid blocking walls, the middle part of each liquid storage tank is a groove part for containing a reagent, two ends of each liquid storage tank 23 extend and are respectively connected with two opposite side walls of the cylinder body 2, the reagent is contained in each groove, the lower part of the chromatography plate 3 is inserted into the liquid storage tanks 23 to adsorb the reagent, the liquid storage tanks 23 are provided with reagent saving parts, and the liquid storage tanks 23 can contain the same reagent or different reagents so as to meet the requirements of the chromatography plate 3;

preferably, the bottom of the liquid storage tank 23 is provided with a liquid outlet 24, the liquid outlet 24 is arranged on the bottom plate of the cylinder body 2 in a penetrating manner, a liquid outlet plug 25 is detachably arranged on the liquid outlet 24, the liquid outlet plug 25 is inserted from the end of the liquid outlet 24 on the outer side of the bottom plate of the cylinder body 2, when the reagent in the liquid storage tank 23 needs to be discharged, the liquid outlet plug 25 is taken down, and the liquid outlet 24 needs to be plugged at ordinary times, so that liquid leakage is avoided;

preferably, the end of the liquid storage tank 23 is provided with a liquid inlet hole 26, the liquid inlet hole 26 is arranged on the side wall of the cylinder body 2 in a penetrating manner, the liquid inlet hole 26 is detachably provided with a liquid inlet plug 21, the liquid inlet hole 26 is obliquely arranged on the side wall of the cylinder body 2, the opening of the liquid inlet hole 26 on the outer side wall of the cylinder body 2 is positioned at the upper part of the opening of the inner side wall of the cylinder body 2, so that a reagent flows into the liquid storage tank 23 when the reagent is input, the reagent is not easy to scatter out of the liquid storage tank 23, the liquid inlet plug 21 is plugged at one end of the outer side of the liquid inlet hole 26, when the reagent is required to be input, the liquid inlet plug 21 is taken down, and the liquid inlet hole 26 is required to be plugged at ordinary times, so as to avoid liquid leakage;

preferably, the liquid outlet plug 25 and the liquid inlet plug 21 are made of rubber or silica gel, have elasticity, are in transition fit with the hole walls, and have good tightness; the liquid outlet holes 24 and the liquid inlet holes 26 are consistent in number with the liquid storage tanks 23, the liquid outlet plugs 25 are consistent in number with the liquid outlet holes 24, the liquid inlet plugs 21 are consistent in number with the liquid inlet holes 26, the arrangement of the liquid outlet holes 24 and the liquid inlet holes 26 can avoid opening the cylinder cover 1, and reagents in the liquid storage tanks 23 can be directly discharged or injected into the liquid storage tanks 23, so that the sealing effect of the thin-layer chromatography cylinder is guaranteed, and meanwhile, the reagents are more convenient to use;

in this embodiment, the cylinder cover 1 is provided with three slots 17 into which three holders 11 can be inserted to perform an expansion experiment on three chromatography plates 3, three liquid reservoirs 23 are correspondingly disposed at the bottom of the cylinder body 2, a liquid inlet 26 is disposed at the end of each liquid reservoir 23, and a liquid outlet 24 is disposed at the bottom of each liquid reservoir 23. In other embodiments, the number of slots 17 may be set according to the use requirements.

When the closed medicine thin-layer chromatography cylinder for experiments is used, the liquid inlet plugs 21 on the cylinder body 2 are taken down firstly, reagents are injected into the liquid inlet holes 26, three different reagents are injected in the embodiment, the liquid inlet plugs 21 are plugged, the holders 11 are taken down one by one from the slots 17 by holding the handles 14, the prepared three chromatography plates 3 are inserted into the fixing part 15, the inserting positions of the chromatography plates 3 are adjusted, different medicine samples are coated on the chromatography plates 3, the holders 11 are inserted into the slots 17 one by holding the handles, so that the bottoms of the chromatography plates 3 extend into the liquid storage tanks 23 to be contacted with the reagents until the experiments are developed, the holders 11 are taken out from the slots 17 by holding the handles, the chromatography plates 3 are taken down for observation, because of different samples, because of different reagent adsorption time of the chromatography plates 3, the chromatography plates 3 can be taken out according to requirements, and then the holders 11 are put into the slots 17, the development process of other chromatographic plates 3 is not influenced, in other embodiments, the same reagent can be placed in the three liquid storage tanks 23, and the development operation is carried out on a plurality of chromatographic plates 3 coated with the same medicine sample, the chromatographic cylinder meets various use requirements, has good tightness, and prevents the influence of the external environment during the operation.

Although the utility model has been described in detail hereinabove with reference to specific embodiments thereof, it will be apparent to one skilled in the art that modifications and improvements can be made thereto without departing from the scope of the utility model. Accordingly, such modifications and improvements are intended to be within the scope of the utility model as claimed.

Claims

1. The utility model provides an experimental closed medicine thin layer chromatography jar, includes cylinder body (2) and cylinder cap (1) of lock on cylinder body (2), its characterized in that, cylinder cap (1) lower part is provided with bellying (16), bellying (16) are inserted and are established cylinder body (2) opening part and with cylinder body (2) lateral wall butt, a plurality of slots (17), every have been seted up on cylinder cap (1) slot (17) interpolation is equipped with fixer (11), it is equipped with chromatography board (3) to insert on fixer (11), the position that cylinder body (2) bottom and slot (17) correspond is provided with reservoir (23), the insertion of chromatography board (3) lower part is in reservoir (23).

2. The hermetic medicine thin layer chromatography cylinder for experiments as claimed in claim 1, wherein a groove is circumferentially arranged on the outer side of the protrusion (16), a sealing ring (19) is arranged in the groove, and the sealing ring (19) is made of rubber or silica gel.

3. The sealed medicine thin-layer chromatography cylinder for experiments as claimed in claim 2, wherein a sinking platform (18) is arranged around the slot (17), the sinking platform (18) is arranged on one side of the upper surface of the cylinder cover (1), the fixer (11) comprises a plug-in part (12) and a supporting part (13) which are fixedly connected, the plug-in part (12) is inserted into the slot (17), and the supporting part (13) abuts against the sinking platform (18).

4. The closed medicine thin-layer chromatography cylinder for experiments as claimed in claim 3, wherein the holder (11) further comprises a fixing portion (15), the fixing portion (15) is inserted into the insertion portion (12), the fixing portion (15) is fixedly connected with the insertion portion (12), and an insertion opening for inserting the chromatography plate (3) is provided in the middle of the fixing portion (15).

5. The closed medicine thin layer chromatography cylinder for experiments as claimed in claim 4, wherein the holder (11) further comprises a handle (14), and the handle (14) is fixedly arranged at one side of the supporting portion (13) far away from the plug portion (12).

6. The closed medicine thin-layer chromatography cylinder for experiments as claimed in claim 4, wherein a liquid outlet hole (24) is formed at the bottom of the liquid storage tank (23), the liquid outlet hole (24) is arranged on the bottom plate of the cylinder body (2) in a penetrating manner, and a liquid outlet plug (25) is detachably arranged on the liquid outlet hole (24).

7. The closed medicine thin-layer chromatography cylinder for experiments as claimed in claim 6, wherein the end of the liquid storage tank (23) is provided with a liquid inlet hole (26), the liquid inlet hole (26) is penetratingly arranged on the side wall of the cylinder body (2), and the liquid inlet hole (26) is detachably provided with a liquid inlet plug (21).

8. The closed type medicine thin-layer chromatography cylinder for experiments as claimed in claim 7, wherein the liquid outlet plug (25), the liquid inlet plug (21) and the fixing portion (15) are made of rubber or silica gel.

9. The closed medicine thin-layer chromatography cylinder for experiments as claimed in claim 7, wherein the liquid inlet hole (26) is obliquely arranged on the side wall of the cylinder body (2), and the liquid inlet hole (26) is arranged on the upper part of the opening of the inner side wall of the cylinder body (2) at the opening of the outer side wall of the cylinder body (2).

10. The closed medicine thin layer chromatography cylinder for experiments as claimed in claim 9, wherein the number of the liquid storage tanks (23) corresponds to the number of the slots (17).