CN216106954U - Contrast experimental apparatus for mycobacterium tuberculosis drug resistance experiments - Google Patents
Contrast experimental apparatus for mycobacterium tuberculosis drug resistance experiments Download PDFInfo
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- CN216106954U CN216106954U CN202122543868.4U CN202122543868U CN216106954U CN 216106954 U CN216106954 U CN 216106954U CN 202122543868 U CN202122543868 U CN 202122543868U CN 216106954 U CN216106954 U CN 216106954U
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- Prior art keywords
- mycobacterium tuberculosis
- drug resistance
- experimental apparatus
- test
- tank
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- 238000002474 experimental method Methods 0.000 title claims abstract description 30
- 241000187479 Mycobacterium tuberculosis Species 0.000 title claims abstract description 21
- 206010059866 Drug resistance Diseases 0.000 title claims abstract description 19
- 239000007788 liquid Substances 0.000 claims abstract description 47
- 238000002347 injection Methods 0.000 claims abstract description 20
- 239000007924 injection Substances 0.000 claims abstract description 20
- 239000012530 fluid Substances 0.000 claims abstract description 8
- 238000006073 displacement reaction Methods 0.000 claims description 15
- 238000007789 sealing Methods 0.000 claims description 9
- 230000000052 comparative effect Effects 0.000 claims 6
- 239000003814 drug Substances 0.000 description 7
- 201000008827 tuberculosis Diseases 0.000 description 7
- 241000282414 Homo sapiens Species 0.000 description 3
- 238000009434 installation Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 208000030507 AIDS Diseases 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 231100000676 disease causative agent Toxicity 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 208000008128 pulmonary tuberculosis Diseases 0.000 description 1
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- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The utility model provides a contrast experiment device for mycobacterium tuberculosis drug resistance experiments, which comprises a base, wherein a support frame is arranged at the upper end of the base, test tanks are respectively arranged in the support frame, experimental utensils are arranged in the test tanks, a flow guide disc is arranged at the center of the upper end in each test tank, an injection needle is arranged in each flow guide disc, a mounting frame is arranged at the upper end of the support frame, liquid measuring tanks are respectively arranged at two sides in each mounting frame, and the injection needle is connected with the liquid measuring tanks; the internal thread sleeve is connected to rotate between fluid measuring tank upper end and the inside roof of mounting bracket, and internal thread sleeve inside threaded connection has the threaded rod, and the threaded rod lower extreme is connected with the piston, and the piston slides inside fluid measuring tank, and the mounting bracket upper end is equipped with two step motor, and step motor is connected with threaded sleeve axle center respectively. The utility model can strictly control the dosage, ensure the accuracy of the dosage and avoid the failure of experiments due to the fact that the dosage of control experiments is different and cannot form effective contrast.
Description
Technical Field
The utility model mainly relates to the technical field of biological experiments, in particular to a contrast experiment device for drug resistance experiments of mycobacterium tuberculosis.
Background
Mycobacterium tuberculosis, commonly known as Mycobacterium tuberculosis, is the causative agent of tuberculosis. In 1882, the bacterium Guo Huo discovered and proved to be the pathogenic bacterium of tuberculosis of human beings in Germany, the bacterium can invade all organs of the whole body, but most of the tuberculosis can be caused, and the tuberculosis is an ancient disease, is widely distributed in the world and is the leading cause of death of bacterial infectious diseases.
Tuberculosis is a chronic infectious disease caused by infection with mycobacterium tuberculosis. Tubercle bacillus may invade various organs of the whole body of a human body, but mainly invades the lung, and is called pulmonary tuberculosis. By the late 80 s of the 20 th century, the morbidity and mortality of tuberculosis rapidly rise in the world due to factors such as poverty, AIDS, population mobility and drug resistance, and become infectious diseases with the most serious global harm in parallel with AIDS. The drug resistance of the mycobacterium tuberculosis is serious, the drug resistance rate is as high as 46%, and the drug resistance rate provides a serious challenge for preventing and treating tuberculosis.
When the drug resistance experiment of the mycobacterium tuberculosis is carried out, a control experiment is needed to obtain an effective conclusion, the control experiment needs to keep the same constant, however, in the existing experiment process, the dosage is usually distinguished by human eyes, and the dosage inevitably generates errors, so that the accuracy of the experiment is not high, and the final experiment conclusion is influenced.
SUMMERY OF THE UTILITY MODEL
The utility model mainly provides a contrast experiment device for a mycobacterium tuberculosis drug resistance experiment, which is used for solving the technical problems in the background technology.
The technical scheme adopted by the utility model for solving the technical problems is as follows: a contrast experiment device for drug resistance experiments of mycobacterium tuberculosis comprises a base, wherein a support frame is installed at the upper end of the base, test tanks are respectively arranged in the support frame, experimental utensils are placed in the test tanks, a flow guide disc is installed at the center of the upper end of the inner part of each test tank, an injection needle is arranged in the flow guide disc, a T-shaped mounting frame is installed at the upper end of the support frame, liquid measuring tanks are respectively arranged on two sides of the inner part of the mounting frame, and the injection needle is connected with the liquid measuring tanks; the device comprises a liquid measuring tank, a piston, an installation frame, an inner thread sleeve, a threaded rod, a piston, two stepping motors and a control device, wherein the inner thread sleeve is connected between the upper end of the liquid measuring tank and the inner top wall of the installation frame in a rotating mode, the inner thread sleeve is communicated with the liquid measuring tank, the inner thread sleeve is in threaded connection with the threaded rod, the lower end of the threaded rod is connected with the piston, the piston slides inside the liquid measuring tank, the upper end of the installation frame is provided with the two stepping motors, and each stepping motor is connected with the axis of the relative inner thread sleeve respectively.
Preferably, the test tank is transparent, and a switch door is arranged on one side of the test tank.
Preferably, the injection needle penetrates through the test tank and the support frame, and the injection needle and the liquid measuring tank are of an integrated structure.
Preferably, a sealing ring is arranged at the joint of the internal thread sleeve and the liquid measuring tank.
Preferably, a liquid inlet pipeline is installed at the upper end of the side wall of the liquid measuring tank, the other end of the liquid inlet pipeline is connected with a sealing cover, and a liquid discharge valve is installed at the lower end of the side wall of the liquid measuring tank.
Preferably, a displacement sensor is mounted on the piston.
Preferably, the mounting frame is provided with a controller.
Compared with the prior art, the utility model has the beneficial effects that:
starting step motor through controller control, make the internal thread sleeve pipe rotate, the drive threaded rod removes, thereby promote the piston and remove, carry out the liquid medicine injection through the syringe needle, can know the displacement distance of threaded rod through displacement sensor, guarantee that two sets of experiment threaded rod displacement distances are the same, can guarantee to add the dose the same, and because the volume of liquid jar bottom area and the dose all are known conditions, can calculate the distance that the threaded rod needs to remove easily, thereby carry out accurate control, be convenient for use in the contrast experiment, the practicality is high.
The present invention will be explained in detail below with reference to the drawings and specific embodiments.
Drawings
FIG. 1 is a perspective view of the present invention;
FIG. 2 is a schematic view of the internal structure of the test tank of the present invention;
FIG. 3 is a schematic view of the internal structure of the liquid measuring tank of the present invention;
FIG. 4 is an enlarged view of the present invention at A.
In the figure: 1. a base; 11. a support frame; 12. a mounting frame; 2. a test tank; 21. a laboratory vessel; 22. opening and closing the door; 23. a flow guide disc; 3. a liquid measuring tank; 31. an injection needle; 32. a piston; 33. a displacement sensor; 34. a liquid inlet pipeline; 35. a sealing cover; 36. a drain valve; 4. a stepping motor; 41. an internally threaded sleeve; 42. a threaded rod; 43. a seal ring; 5. and a controller.
Detailed Description
In order to facilitate an understanding of the utility model, the utility model will now be described more fully hereinafter with reference to the accompanying drawings, in which several embodiments of the utility model are shown, but which may be embodied in different forms and not limited to the embodiments described herein, but which are provided so as to provide a more thorough and complete disclosure of the utility model.
It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may be present, and when an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present, as the terms "vertical", "horizontal", "left", "right" and the like are used herein for descriptive purposes only.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs, and the knowledge of the terms used herein in the specification of the present invention is for the purpose of describing particular embodiments and is not intended to limit the present invention, and the term "and/or" as used herein includes any and all combinations of one or more of the associated listed items.
Referring to fig. 1 and 2, the present invention provides a technical solution: the utility model provides a contrast experimental apparatus that mycobacterium tuberculosis drug resistance experiments were used, includes base 1, support frame 11 is installed to base 1 upper end, 11 inside experimental tank 2 that are equipped with respectively of support frame, experimental tank 2 is the transparence, just 2 one sides of experimental tank are equipped with switch door 22, experimental tank 2 embeds there is laboratory vessel 21, and transparent experimental tank 2 is convenient for carry out real-time observation, through opening or closing switch door 22, and getting of laboratory vessel 21 of being convenient for is put, and laboratory vessel 21 is used for placing mycobacterium tuberculosis, every the guiding disc 23 is all installed at 2 inside upper end centers of experimental tank, the inside injection syringe needle 31 that is equipped with of guiding disc 23, and guiding disc 23 can ensure that injection syringe needle 31 spun liquid medicine enters into laboratory vessel 21.
Please refer to fig. 1, 3 and 4, the upper end of the supporting frame 11 is provided with a T-shaped mounting frame 12, two sides inside the mounting frame 12 are respectively provided with a liquid measuring tank 3, the injection needle 31 is connected with the liquid measuring tank 3, the injection needle 31 penetrates through the test tank 2 and the supporting frame 11, the injection needle 31 and the liquid measuring tank 3 are of an integrated structure, a sealing ring 43 is arranged at the joint of the internal thread sleeve 41 and the liquid measuring tank 3, the sealing ring 43 ensures the sealing performance of the device and avoids the influence of the external environment on the experiment, the upper end of the side wall of the liquid measuring tank 3 is provided with a liquid inlet pipeline 34, the other end of the liquid inlet pipeline 34 is connected with a sealing cover 35, the sealing cover 35 is opened to add liquid medicine into the liquid measuring tank 3, the lower end of the side wall of the liquid measuring tank 3 is provided with a liquid discharge valve 36, and the liquid discharge valve 36 can discharge redundant liquid medicine inside.
Please refer to fig. 1, 3 and 4 again, an internal thread bushing 41 is rotatably connected between the upper end of the liquid measuring tank 3 and the inner top wall of the mounting frame 12, the internal thread bushing 41 is communicated with the liquid measuring tank 3, a threaded rod 42 is connected to the inner thread of the internal thread bushing 41, a piston 32 is connected to the lower end of the threaded rod 42, the piston 32 slides inside the liquid measuring tank 3, two stepping motors 4 are arranged at the upper end of the mounting frame 12, each stepping motor 4 is connected with the axis of the corresponding internal thread bushing 41, a displacement sensor 33 is arranged on the piston 32, the displacement sensor 33 can be a sensor with the model LT20, a controller 5 is arranged on the mounting frame 12, the controller 5 can be a controller with the model NUC120, and the signal output end of the controller 5 is electrically connected with the displacement sensor 33 and the stepping motors 4. Starting step motor 4 through controller 5 control for internal thread sleeve 41 rotates, and drive threaded rod 42 removes, thereby promotes piston 32 and removes, can know threaded rod 42's displacement distance through displacement sensor 33, guarantees that the displacement distance is the same, can guarantee to add the dose the same, and because the volume of liquid measuring tank 3 bottom and the dose all are known conditions, can calculate the distance that threaded rod 42 need remove easily, thereby carry out accurate control.
The specific operation mode of the utility model is as follows:
when the staff is using, at first arrange mycobacterium tuberculosis respectively in on the laboratory glassware 21, then arrange two laboratory glassware 21 respectively in two experimental tanks 2, open sealed lid 35, the inside liquid medicine that adds of vector fluid reservoir 3 (the amount of adding will be greater than the injection volume), start step motor 4 through controller 5 control, make internal thread sleeve 41 rotate, drive threaded rod 42 removes, thereby promote piston 32 and remove, carry out the liquid medicine injection through syringe needle 31, can know the displacement distance of threaded rod 42 through displacement sensor 33, guarantee that two sets of experimental threaded rod 42 displacement distances are the same, can guarantee to add the dose the same, after the injection, open flowing back valve 36, discharge inside unnecessary liquid medicine.
The utility model is described above with reference to the accompanying drawings, it is obvious that the utility model is not limited to the above-described embodiments, and it is within the scope of the utility model to adopt such insubstantial modifications of the inventive method concept and solution, or to apply the inventive concept and solution directly to other applications without modification.
Claims (7)
1. The utility model provides a contrast experimental apparatus that mycobacterium tuberculosis drug resistance experiment was used, includes base (1), its characterized in that: the test device is characterized in that a support frame (11) is installed at the upper end of the base (1), test tanks (2) are respectively arranged in the support frame (11), a test vessel (21) is arranged in each test tank (2), a flow guide disc (23) is installed at the center of the upper end in each test tank (2), an injection needle (31) is arranged in each flow guide disc (23), a T-shaped mounting frame (12) is installed at the upper end of the support frame (11), liquid measuring tanks (3) are respectively arranged on two sides in each mounting frame (12), and the injection needle (31) is connected with the liquid measuring tanks (3);
volume fluid reservoir (3) upper end and mounting bracket (12) inside roof rotate between be connected with interior thread sleeve pipe (41), interior thread sleeve pipe (41) and volume fluid reservoir (3) intercommunication, interior thread sleeve pipe (41) internal thread is connected with threaded rod (42), threaded rod (42) lower extreme is connected with piston (32), piston (32) slide inside volume fluid reservoir (3), mounting bracket (12) upper end is equipped with two step motor (4), and every step motor (4) are connected with relative interior thread sleeve pipe (41) axle center respectively.
2. The comparative experimental apparatus for drug resistance experiment of mycobacterium tuberculosis as claimed in claim 1, wherein: the test tank (2) is transparent, and one side of the test tank (2) is provided with an opening and closing door (22).
3. The comparative experimental apparatus for drug resistance experiment of mycobacterium tuberculosis as claimed in claim 1, wherein: the injection needle (31) penetrates through the test tank (2) and the support frame (11), and the injection needle (31) and the liquid measuring tank (3) are of an integrated structure.
4. The comparative experimental apparatus for drug resistance experiment of mycobacterium tuberculosis as claimed in claim 1, wherein: and a sealing ring (43) is arranged at the joint of the internal thread sleeve (41) and the liquid measuring tank (3).
5. The comparative experimental apparatus for drug resistance experiment of mycobacterium tuberculosis as claimed in claim 1, wherein: liquid inlet pipeline (34) are installed to volume fluid reservoir (3) lateral wall upper end, the liquid inlet pipeline (34) other end is connected with sealed lid (35), flowing back valve (36) are installed to volume fluid reservoir (3) lateral wall lower extreme.
6. The comparative experimental apparatus for drug resistance experiment of mycobacterium tuberculosis as claimed in claim 1, wherein: and a displacement sensor (33) is arranged on the piston (32).
7. The comparative experimental apparatus for drug resistance experiment of mycobacterium tuberculosis as claimed in claim 1, wherein: the mounting frame (12) is provided with a controller (5).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122543868.4U CN216106954U (en) | 2021-10-21 | 2021-10-21 | Contrast experimental apparatus for mycobacterium tuberculosis drug resistance experiments |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122543868.4U CN216106954U (en) | 2021-10-21 | 2021-10-21 | Contrast experimental apparatus for mycobacterium tuberculosis drug resistance experiments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN216106954U true CN216106954U (en) | 2022-03-22 |
Family
ID=80694466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202122543868.4U Expired - Fee Related CN216106954U (en) | 2021-10-21 | 2021-10-21 | Contrast experimental apparatus for mycobacterium tuberculosis drug resistance experiments |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN216106954U (en) |
-
2021
- 2021-10-21 CN CN202122543868.4U patent/CN216106954U/en not_active Expired - Fee Related
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| Date | Code | Title | Description |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20220322 |