CN216093737U - Micro-fluidic skin tissue fluid collection device - Google Patents
Micro-fluidic skin tissue fluid collection device Download PDFInfo
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- CN216093737U CN216093737U CN202122777602.6U CN202122777602U CN216093737U CN 216093737 U CN216093737 U CN 216093737U CN 202122777602 U CN202122777602 U CN 202122777602U CN 216093737 U CN216093737 U CN 216093737U
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Abstract
The utility model relates to the technical field of collecting devices, in particular to a microfluidic skin tissue fluid collecting device which comprises a glass slide, a top cover and an inlet, wherein the top cover is arranged on the glass slide, a storage cavity for storing tissue fluid is formed between the top cover and the glass slide, the inlet is arranged at the end parts of the glass slide and the top cover and is communicated with the storage cavity, the inlet is a capillary pipeline, and the top cover is made of a flexible material. The microfluidic skin tissue fluid collecting device comprises a glass slide, a top cover and an inlet; in the concrete use, the terminal air that will store in the chamber of pressing the top cap is discharged, forms a vacuum state, and tissue fluid can be because capillary effect is inhaled in the entry of collection device, and the pressing of release top cap next utilizes vacuum effect to further inhale the tissue fluid in the storage chamber, accomplishes the collection of tissue fluid, can directly carry out the collection and the transfer of tissue fluid, need not pass through other transfer equipment, avoids tissue fluid to be contaminated.
Description
Technical Field
The utility model relates to the technical field of collecting devices, in particular to a microfluidic skin tissue fluid collecting device.
Background
Interstitial fluid is a body fluid that exists between cells and is distributed throughout the body. Because the skin is the most easily detected organ of human body, it has good clinical significance to extract skin tissue fluid and analyze the molecular information in the tissue fluid. The most common method of skin interstitial fluid extraction is currently through microneedle arrays. These microneedles, which tend to be between 200 and 1500 microns in length, do not puncture blood vessels when they penetrate the skin and do not cause pain. Current methods can generally be divided into two methods in terms of collecting skin tissue fluid. The first method is to directly aspirate skin tissue fluid into the microneedles and then extract the desired biomarkers from the microneedles for analysis or to analyze them directly in the microneedles. The second method is to collect the skin tissue fluid in a storage container, such as a glass capillary, paper, centrifuge tube, etc. In this method the microneedles function only to penetrate the skin to release interstitial fluid and provide a conduit for delivery of the interstitial fluid to the reservoir.
With the first collection method, i.e., collecting skin interstitial fluid in the microneedles, the method has a disadvantage in that some treatment, such as centrifugation or dissolution, is required to remove the interstitial fluid. These processing steps not only require the provision of corresponding equipment and consumables, but also may contaminate the sample, affecting the accuracy of the results of the downstream subsystem. While the second method has the disadvantage of low capacity. Since the storage containers are connected to the microneedle array, the containers typically have a capacity of only a few microliters to a dozen or so microliters. This low volume of skin interstitial fluid can prevent the throughput of downstream analysis and the possibility of multiplexed analysis. In addition to this, a common disadvantage of both methods is the high cost.
SUMMERY OF THE UTILITY MODEL
The utility model aims to solve at least one technical problem in the prior art and provides a microfluidic skin tissue fluid collecting device.
In order to achieve the purpose, the technical scheme adopted by the utility model is as follows: the utility model provides a micro-fluidic skin tissue fluid collection device, includes slide, top cap, entry, the top cap sets up on the slide, be formed with the storage chamber that is used for saving tissue fluid between top cap and the slide, the entry sets up the tip at slide and top cap, entry and storage chamber intercommunication, the entry is capillary tube, the top cap is flexible material.
Further, the top cover is made of polydimethylsiloxane.
Further, the slide is rectangular.
Further, the outer side of the slide is provided with a frosted surface.
Further, the storage chamber has a volume of at least 30 microliters.
Further, the height of the storage cavity is 0.05 mm.
Furthermore, a plurality of supporting columns are arranged in the storage cavity, one ends of the supporting columns are connected with the top cover, and the other ends of the supporting columns are connected with the glass slide.
Furthermore, the strut and the top cover are made of the same material.
Furthermore, the pillars are distributed in the storage cavity transversely and longitudinally uniformly.
Further, at least 27 support posts are arranged.
The utility model has the beneficial effects that: as can be seen from the above description of the present invention, compared with the prior art, the microfluidic skin tissue fluid collection device of the present invention comprises a slide, a top cover and an inlet, wherein the top cover is arranged on the slide, a storage chamber is formed between the top cover and the slide, the inlet is communicated with the storage chamber, the inlet is a capillary channel, and the top cover is made of a flexible material; in specific use, after the skin tissue fluid is released to the skin surface by some technologies, firstly, the tail end of the top cover is pressed to exhaust the air in the storage cavity to form a vacuum state, then the inlet of the collecting device is touched with the skin tissue fluid, the tissue fluid is sucked into the inlet of the collecting device due to capillary action, then the pressing of the top cover is released, the tissue fluid is further sucked into the storage cavity by utilizing the vacuum effect, the step is repeated until the storage cavity is filled with the skin tissue fluid, the collection of the tissue fluid is completed, the tissue fluid releasing is also completed by pressing the tail end of the top cover, the tissue fluid flows out from the inlet to be transferred after the pressing, the collecting device can directly collect and transfer the tissue fluid, other transfer equipment is not needed, the tissue fluid is prevented from being polluted, in addition, the capacity of the collecting device is larger, the manufacturing cost is lower, the practicability is higher.
Drawings
FIG. 1 is a schematic top view of a microfluidic skin interstitial fluid collection device according to a preferred embodiment of the present invention;
FIG. 2 is a schematic front view of a microfluidic skin interstitial fluid collection device according to a preferred embodiment of the present invention;
reference numerals: 1. glass slide; 2. a top cover; 3. an inlet; 4. a storage chamber; 5. and a support pillar.
Detailed Description
The technical solutions in the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments.
In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "connected" and "connected" are to be interpreted broadly, e.g., as being fixed or detachable or integrally connected; can be mechanically or electrically connected; may be directly connected or indirectly connected through an intermediate. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Referring to fig. 1-2, in a preferred embodiment of the present invention, a microfluidic skin tissue fluid collecting device includes a slide 1, a top cover 2, and an inlet 3, wherein the top cover 2 is disposed on the slide 1, a storage chamber 4 for storing tissue fluid is formed between the top cover 2 and the slide 1, the inlet 3 is disposed at an end of the slide 1 and the top cover 2, the inlet 3 is communicated with the storage chamber 4, the inlet 3 is a capillary channel, and the top cover 2 is made of a flexible material.
The utility model has the beneficial effects that: as can be seen from the above description of the present invention, compared with the prior art, the microfluidic skin tissue fluid collecting device of the present invention comprises a slide 1, a top cover 2 and an inlet 3, wherein the top cover 2 is arranged on the slide 1, a storage chamber 4 is formed between the top cover 2 and the slide 1, the inlet 3 is communicated with the storage chamber 4, the inlet 3 is a capillary channel, and the top cover 2 is made of a flexible material; in specific use, after the skin tissue fluid is released to the skin surface by some technologies, firstly, the tail end of the top cover 2 is pressed to exhaust the air in the storage cavity 4 to form a vacuum state, then the inlet 3 of the collecting device is touched with the skin tissue fluid, the tissue fluid can be sucked into the inlet 3 of the collecting device due to capillary action, then, the pressing of the top cover 2 is released, the tissue fluid is further sucked into the storage cavity 4 by utilizing the vacuum effect, the step is repeated until the storage cavity 4 is filled with the skin tissue fluid, the collection of the tissue fluid can be completed quickly, the efficiency is high, the tissue fluid release is also completed by pressing the tail end of the top cover 2, the tissue fluid can flow out from the inlet 3 for transfer after the pressing, the collecting device can directly collect and transfer the tissue fluid without passing through other transfer equipment, and the tissue fluid is prevented from being polluted, in addition, the utility model has the advantages of larger capacity, lower manufacturing cost and higher practicability.
As a preferred embodiment of the present invention, it may also have the following additional technical features:
in this embodiment, the top cover 2 is made of polydimethylsiloxane. The use of a top cap 2 made of polydimethylsiloxane facilitates the user's depression to create a vacuum in the storage chamber 4, improving the efficiency of tissue fluid aspiration.
In this embodiment, the slide glass 1 has a rectangular shape, and a frosted surface is provided on the outer side of the slide glass 1. The glass sheet 1 is arranged into a regular rectangle, so that the manufacturing is convenient, and the outer side part of the glass sheet 1 is provided with a frosted surface, so that characters are left on the frosted surface, and the sample information is convenient to record.
In this embodiment, the storage chamber 4 has a capacity of at least 30 microliters and the height of the storage chamber 4 is 0.05 mm. The storage chamber 4 has a volume of at least 30 microliters, a relatively large volume to ensure that the testing requirements are met, and a height of the storage chamber 4 of 0.05mm to facilitate squeezing to a vacuum by a user.
In this embodiment, a plurality of pillars 5 are provided in the storage chamber 4, and one end of each pillar 5 is connected to the top cover 2 and the other end is connected to the slide 1. The storage chamber 4 is provided with a plurality of pillars 5, and the storage chamber 4 is prevented from crushing and deforming by being supported between the top cover 2 and the slide 1 by the pillars 5.
In the present embodiment, the pillar 5 and the top cover 2 are made of the same material. The support 5 is made of the same material as the top cover 2 so as to match the extrusion deformation of the top cover 2.
In the present embodiment, the pillars 5 are uniformly distributed in the storage chamber 4 in the longitudinal and transverse directions, and at least 27 pillars 5 are provided. The pillars 5 are distributed in the storage chamber 4 transversely and longitudinally, and at least 27 pillars 5 are arranged to ensure that the pillars 5 can cover and support the storage chamber 4 comprehensively.
The above additional technical features can be freely combined and used in superposition by those skilled in the art without conflict.
It is to be understood that the present invention has been described with reference to certain embodiments, and that various changes in the features and embodiments, or equivalent substitutions may be made therein by those skilled in the art without departing from the spirit and scope of the utility model. In addition, many modifications may be made to adapt a particular situation or material to the teachings of the utility model without departing from the essential scope thereof. Therefore, it is intended that the utility model not be limited to the particular embodiment disclosed, but that the utility model will include all embodiments falling within the scope of the appended claims.
Claims (10)
1. A microfluidic skin interstitial fluid collection device is characterized in that: including slide (1), top cap (2), entry (3), top cap (2) set up on slide (1), be formed with between top cap (2) and slide (1) and be used for saving storage chamber (4) of organizing liquid, entry (3) set up the tip at slide (1) and top cap (2), entry (3) and storage chamber (4) intercommunication, entry (3) are capillary pipeline, top cap (2) are flexible material.
2. The microfluidic skin interstitial fluid collection device according to claim 1, wherein: the top cover (2) is made of polydimethylsiloxane.
3. The microfluidic skin interstitial fluid collection device according to claim 1, wherein: the slide (1) is rectangular.
4. The microfluidic skin interstitial fluid collection device according to claim 1, wherein: the outer side of the glass sheet (1) is provided with a frosted surface.
5. The microfluidic skin interstitial fluid collection device according to claim 1, wherein: the volume of the storage chamber (4) is at least 30 microliters.
6. The microfluidic skin interstitial fluid collection device according to claim 1, wherein: the height of the storage chamber (4) is 0.05 mm.
7. The microfluidic skin interstitial fluid collection device according to claim 1, wherein: a plurality of supporting columns (5) are arranged in the storage cavity (4), one ends of the supporting columns (5) are connected with the top cover (2), and the other ends of the supporting columns (5) are connected with the glass slide (1).
8. The microfluidic skin interstitial fluid collection device according to claim 7, wherein: the strut (5) and the top cover (2) are made of the same material.
9. The microfluidic skin interstitial fluid collection device according to claim 7, wherein: the struts (5) are distributed in the storage cavity (4) transversely and longitudinally uniformly.
10. The microfluidic skin interstitial fluid collection device according to claim 7, wherein: at least 27 struts (5) are provided.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122777602.6U CN216093737U (en) | 2021-11-12 | 2021-11-12 | Micro-fluidic skin tissue fluid collection device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122777602.6U CN216093737U (en) | 2021-11-12 | 2021-11-12 | Micro-fluidic skin tissue fluid collection device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN216093737U true CN216093737U (en) | 2022-03-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202122777602.6U Active CN216093737U (en) | 2021-11-12 | 2021-11-12 | Micro-fluidic skin tissue fluid collection device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN216093737U (en) |
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2021
- 2021-11-12 CN CN202122777602.6U patent/CN216093737U/en active Active
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Effective date of registration: 20230308 Address after: 330000 no.1688 Meiling Avenue, Wanli District, Nanchang City, Jiangxi Province Patentee after: JIANGXI University OF TRADITIONAL CHINESE MEDICINE Address before: C20, 7th floor, CITIC Fuji pharmaceutical Valley, No. 898, Nanjing East Road, Qingshanhu District, Nanchang City, Jiangxi Province, 330000 Patentee before: Jiangxi weirun Xinjing Technology Co.,Ltd. |