CN220588288U - Subcutaneous body fluid extraction device - Google Patents
Subcutaneous body fluid extraction device Download PDFInfo
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- CN220588288U CN220588288U CN202320586172.6U CN202320586172U CN220588288U CN 220588288 U CN220588288 U CN 220588288U CN 202320586172 U CN202320586172 U CN 202320586172U CN 220588288 U CN220588288 U CN 220588288U
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Abstract
The utility model provides a subcutaneous body fluid extraction and storage device, which consists of an extraction end and a storage end, wherein the extraction end consists of a cavity and a microneedle arranged at the bottom of the cavity; a cavity structure is formed in the cavity; the micro needle is provided with a plurality of pore canals and is communicated with the cavity; and a supporting body for connecting the top and the bottom of the cavity is arranged in the cavity. The subcutaneous body fluid extraction and storage device adopts the design of the microneedles with multiple pore channels, so that the subcutaneous body fluid extraction speed is increased, and the occurrence of subcutaneous body fluid extraction failure caused by pore channel blockage is effectively reduced; meanwhile, the support body is arranged in the cavity structure, so that the mechanical property of the cavity is improved, the dead volume in the cavity is reduced, and more subcutaneous body fluid can be transferred into the negative pressure extraction device. The device has the advantages of simple operation, no need of large-scale equipment, high efficiency and low cost, can be widely applied to collection of subcutaneous body fluid, and has quite important significance for realizing health monitoring and early diagnosis of diseases through the subcutaneous body fluid.
Description
Technical Field
The utility model belongs to the technical field of medical appliances. And more particularly to a subcutaneous body fluid extraction device.
Background
With the increasing demands of people for health monitoring, disease prevention, timely diagnosis, accurate medical treatment and the like, in-vitro diagnosis technology plays an increasingly important role in the current clinical and medical research fields. The in vitro diagnosis mainly collects human body samples (subcutaneous body fluid, blood, tissues and the like), extracts and analyzes target detection substances in the human body samples, thereby monitoring physiological activities of the human body and providing clinical diagnosis information, and has wide application prospect in the fields of physical examination, chronic disease management, serious disease monitoring and the like. For analysis of blood sugar, lactic acid, hormone and other substance concentrations, at present, blood samples are mainly collected for analysis, and the more mature methods mainly comprise a venous blood sampling method and a fingertip blood sampling method. However, the collection of blood samples can bring wound surfaces and pain which are difficult to heal in a short period, and especially for people needing long-term monitoring, the problems of safety, cost, acceptance degree and the like of blood sample collection still limit the application of the blood sample collection in one-day multi-detection and real-time detection.
Subcutaneous body fluid (ISF) is used as a medium for exchanging plasma with cellular substances, has a composition similar to that of plasma, contains rich components such as glucose, lactic acid, protein, inorganic salt and the like, has physiological characteristics which are continuously changed along with the cell cycle, disease progress and the like, and is a good sample which can be extracted for disease detection. In addition, a large amount of subcutaneous body fluid is contained below the surface layer of the skin, the wound surface is small during extraction, the recovery is quick, the pain is low, the infection is not easy to happen, and the method has wider and wider application as a sample for real-time detection and long-term monitoring of in-vivo markers.
The existing subcutaneous body fluid extraction methods mainly use skin anti-reflection agents or chemical permeation promoters and the like to separate out the subcutaneous body fluid through the stratum corneum, sampling needles to extract, reverse iontophoresis and the like, but the methods often have the defects of low sampling amount, complex separation steps, difficult storage, damage to the skin and the like, and cannot realize the simple, direct and rapid mass collection of the subcutaneous body fluid, pollution avoidance and the like in the storage process. The prior art of subcutaneous body fluid detection device provides a scheme for detecting the blood sugar content by extracting the subcutaneous body fluid through negative pressure and a microneedle, but the subcutaneous body fluid detection device still has the problems of low extraction quantity and low extraction speed, and the extracted subcutaneous body fluid cannot be transported and stored and can only be detected by single components; therefore, there is a considerable need to provide a subcutaneous body fluid extraction device that is capable of rapid, large-scale extraction of subcutaneous body fluids, and convenient transport.
Disclosure of Invention
Aiming at the problems of low extraction quantity, low extraction speed and incapability of transferring by adopting a microneedle in the prior art, the utility model aims to provide a subcutaneous body fluid extraction device, so as to improve the extraction efficiency of the subcutaneous body fluid and realize the transferring of the subcutaneous body fluid.
The utility model aims to provide a subcutaneous body fluid extraction and storage device.
The above object of the present utility model is achieved by the following technical scheme:
the utility model provides a subcutaneous body fluid extraction device, which consists of an extraction end and a storage end, wherein the extraction end consists of a cavity and a microneedle arranged at the bottom of the cavity; the storage end is composed of a connecting pipe and a negative pressure extraction device; a cavity structure is formed in the cavity; the number of the micro-needles is a plurality, and the micro-needles are provided with a plurality of pore canals penetrating through the bottom of the cavity and communicated with the cavity; the side surface of the cavity is provided with a through connecting part, one end of the connecting pipe is connected with the connecting part, and the other end of the connecting pipe is connected with the negative pressure extraction device; the inside support body that is provided with connection cavity top and bottom of cavity.
The subcutaneous body fluid extraction device provided by the utility model is characterized in that an extraction end is formed by a cavity and a microneedle, and the subcutaneous body fluid in skin tissues is extracted for storage and transportation under the action of negative pressure provided by a negative pressure extraction device after the hollow microneedle is penetrated into the skin; the arranged support body can improve the mechanical property of the cavity, can reduce the dead volume in the cavity, and can transfer more subcutaneous body fluid into the storage device; the microneedle is provided with a plurality of pore channels, so that the speed of extracting subcutaneous body fluid can be improved, and the problem that the subcutaneous body fluid cannot be extracted due to the blockage of the pore channels can be avoided.
Preferably, the support body, when disposed, avoids the opening of the microneedle through-channel within the cavity. The main purpose of avoiding the opening is to avoid the support body from blocking the pore canal of the microneedle and interfering with the extraction of subcutaneous body fluid.
More preferably, the supports are disposed parallel to each other or around the center of the cavity.
More preferably, the support bodies are not connected to each other. More preferably, the support body and the cavity side wall are not connected to each other.
Preferably, the support body is provided with a through hole. The through holes on the support body are used for the subcutaneous body fluid in the cavity to flow.
Preferably, the tip circumference of the microneedle is smaller than the bottom circumference of the microneedle.
More preferably, the microneedle morphology includes, but is not limited to, conical, square conical, pyramidal, multiple conical, multiple square conical, multiple pyramidal, or a combination thereof.
Preferably, the top surface of the cavity is square, or elliptical, or circular, or a combination of square, elliptical, and circular.
Preferably, the top surface of the cavity has a structural form of either a plane, a protrusion or a depression. The top surface of the cavity may be planar, or convex, or concave in configuration when viewed from the side.
Preferably, the bottom surface of the cavity is of a planar structure.
More preferably, the cavity floor has a flexible or deformable structure.
More preferably, the bottom surface of the cavity is of a curved surface structure.
When the cavity is pressed to make the microneedle array penetrate into the skin and in the process of extracting subcutaneous body fluid, the bottom surface of the cavity can be closely attached to the skin.
Preferably, the connecting portion is a cylindrical structure. The connecting pipe is connected with the connecting part in a nested way, is a hose and is nested at the outer side of the connecting part.
Preferably, the connecting pipe is a through pipe with two open ends, and a hollow connecting pipe cavity is arranged between the two open ends.
Preferably, the negative pressure extraction device has two forms, one of which is a negative pressure generation and storage integrated device; and the second is a negative pressure generation and storage separation type device.
More preferably, the integrated device for generating and storing negative pressure includes, but is not limited to, an integrated device that is previously evacuated to different vacuum degrees, and that is used for collecting and simultaneously storing samples.
More preferably, the integrated negative pressure generating and storing device includes, but is not limited to, a vacuum sampling tube, or a reduced pressure sampling tube. When in use, the extraction end is pressed firstly, so that the microneedle array pierces the skin; then one end of the connecting tube with the needle head is inserted into a vacuum sampling tube, or a decompression sampling tube, and subcutaneous body fluid is rapidly extracted and transferred from the lower part of the skin to the connecting tube, the vacuum sampling tube, or the decompression sampling tube by utilizing the negative pressure provided by the vacuum sampling tube.
Preferably, the means for separating the generation and storage of negative pressure includes, but is not limited to, means for adding a reservoir before the means for generating negative pressure. The negative pressure generating and storing separation device refers to a device which drives a sample to flow and extract the sample through a negative pressure space, and stores the sample on a channel of which the negative pressure drives the sample to flow, wherein the storage space is separated from the space of the negative pressure generator and is not the same space.
More preferably, the reservoir is a negative pressure generating and storing integrated device. At this time, multi-stage negative pressure supply is formed, so that one extraction end can be provided with a multi-stage negative pressure supply device, and the subcutaneous body fluid extraction and storage capacity of the device is improved.
Preferably, the height of the cavity is 0.5-2.5mm.
Preferably, the number of the microneedles is 5×5 to 20×20. The hollow microneedle array at this scale takes into account the extraction capacity of the microneedles and the size of the patch, which meets the extraction requirements of the detection.
Preferably, the length of the microneedle is 300 to 1500 μm. The length of the microneedle is set to avoid the contact of the microneedle with the dermis layer, the contact with nerve endings can be avoided, and the pain and the skin trauma of a patient are reduced.
Preferably, the center-to-center distance between the microneedle and the adjacent microneedle is 300-3000 μm. The center distance can meet the requirements of the device size in different scenes.
Preferably, the number of the pore channels is one, two, three or four.
Preferably, the diameter of the pore canal is 10-1000 μm.
Preferably, the number of the supporting bodies is a plurality.
Preferably, the number of the connecting parts is a plurality. More preferably, the number of the connection parts is 1 to 4.
Preferably, the materials of the extraction end include, but are not limited to, organic high molecular polymers and inorganic materials.
More preferably, the inorganic material comprises a metallic, inorganic nonmetallic material.
More preferably, the organic high molecular polymer includes but is not limited to methacryloylated gelatin, methacryloylated hyaluronic acid, methacryloylated polyethylene glycol and other methacrylic end polymers, polydimethylsiloxane, polyvinyl alcohol, polyurethane, polyethylene glycol, photo-curable resin.
More preferably, the photocurable resin is a biocompatible photocurable resin.
More preferably, the biocompatible photocurable resin is prepared by reacting a methacrylate oligomer, a methacrylate monomer, an acrylic monomer and a photoinitiator.
Preferably, the extraction end is an integrally formed structure.
Preferably, the preparation method of the extraction end comprises, but is not limited to, 3D printing, micro-casting, template method, laser etching method.
The utility model has the following beneficial effects:
the subcutaneous body fluid extraction and storage device provided by the utility model adopts the design of the microneedles with multiple pore channels, so that the subcutaneous body fluid extraction speed is increased, and meanwhile, the occurrence of subcutaneous body fluid extraction failure caused by pore channel blockage is effectively reduced; meanwhile, the support body is arranged in the cavity structure, so that the mechanical property of the cavity structure is improved, the dead volume in the cavity is reduced, and more subcutaneous body fluid can be transferred into the negative pressure extraction device. The device has the advantages of simple operation, no need of large-scale equipment, high efficiency and low cost, can be widely applied to collection of subcutaneous body fluid, and has quite important significance for realizing health monitoring and early diagnosis of diseases through the subcutaneous body fluid.
Drawings
Fig. 1 is a schematic view showing the structure of a subcutaneous body fluid extraction device according to example 1.
Fig. 2 is a schematic view of the structure of the extraction end of the subcutaneous body fluid extraction device shown in fig. 1.
Fig. 3 is a schematic view of the cavity structure of the subcutaneous body fluid extraction device shown in fig. 1.
Fig. 4 is a schematic structural view of the subcutaneous body fluid extraction device according to example 2.
Fig. 5 is a schematic view of the structure of the cavity of the subcutaneous body fluid extraction device shown in fig. 4.
Fig. 6 is a schematic structural view of a subcutaneous body fluid extraction device according to example 3.
Fig. 7 is a schematic view of the cavity structure of the subcutaneous body fluid extraction device shown in fig. 6.
Drawing and annotating: 1-a cavity; 2-microneedles; 3-connecting pipes; 4-a negative pressure extraction device; 5-cavity; a 6-connection; 7-connecting the tube lumen; 8-a support; 9-a reservoir; 10-a negative pressure generating device.
Detailed Description
Embodiments of the present utility model are described in detail below, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to like or similar elements or elements having like or similar functions throughout. The embodiments described below by referring to the drawings are illustrative and intended to explain the present utility model and should not be construed as limiting the utility model.
In the description of the present utility model, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. indicate orientations or positional relationships based on the drawings, are merely for convenience in describing the present utility model and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present utility model.
Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature. In the description of the present utility model, the meaning of "a plurality" is two or more, unless explicitly defined otherwise.
In the present utility model, unless explicitly specified and limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communicated with the inside of two elements or the interaction relationship of the two elements. The specific meaning of the above terms in the present utility model can be understood by those of ordinary skill in the art according to the specific circumstances.
In the present utility model, unless expressly stated or limited otherwise, a first feature "above" or "below" a second feature may include both the first and second features being in direct contact, as well as the first and second features not being in direct contact but being in contact with each other through additional features therebetween. Moreover, a first feature being "above," "over" and "on" a second feature includes the first feature being directly above and obliquely above the second feature, or simply indicating that the first feature is higher in level than the second feature. The first feature being "under", "below" and "beneath" the second feature includes the first feature being directly under and obliquely below the second feature, or simply means that the first feature is less level than the second feature.
Example 1A subcutaneous body fluid extraction and storage device
As shown in fig. 1, a subcutaneous body fluid extraction device is composed of an extraction end (fig. 2) and a storage end, wherein the extraction end is composed of a cavity 1 and a microneedle 2 arranged at the bottom of the cavity; the storage end consists of a connecting pipe 3 and a negative pressure extraction device 4; a cavity 5 structure is formed in the cavity 1; the number of the micro-needles 2 is 5 multiplied by 5, and the micro-needles 2 are provided with two pore channels penetrating through the bottom of the cavity and are communicated with the cavity 1; the side surface of the cavity 1 is provided with a through connecting part 6; the connecting pipe 3 is a through pipe with two open ends, and a hollow connecting pipe cavity 7 is arranged between the two open ends; one end of the connecting pipe 3 is connected with the connecting part 6, and the other end is connected with the negative pressure extraction device 4; a supporting body 8 for connecting the top and the bottom of the cavity is arranged in the cavity 5; the number of the supporting bodies 8 is 4, the 4 supporting bodies 8 are uniformly arranged around the center of the cavity 1, and two adjacent supporting bodies 8 are not connected with each other (figure 3); the negative pressure extraction device 4 is a vacuum sampling tube; the height of the cavity 5 in the cavity 1 is 1mm; the diameter of the pore canal is 300 mu m; the length of the microneedle 2 is 800 μm; the center distance of the microneedle 2 was 2000 μm; the microneedles 2 form a microneedle array with an area of 1.21cm 2 The method comprises the steps of carrying out a first treatment on the surface of the The connecting part 6 is in a round table structure; the material of the extraction end is biocompatible photo-curing resin; the extraction end is an integrally formed structure prepared by a 3D printing technology.
When the vacuum sampling tube is used, an operator pierces the skin, then the connecting tube is communicated with the vacuum sampling tube, and subcutaneous body fluid is rapidly extracted and transferred from the skin to the vacuum sampling tube by utilizing the negative pressure provided by the vacuum sampling tube; after the micro needle is inserted into the skin, the micro needle needs to be kept in a pressed state, and can be loosened after the extraction of the subcutaneous body fluid is completed; after the extraction of the subcutaneous body fluid is completed, the microneedle is removed from the skin surface and then the sampling tube is separated from the vacuum sampling tube.
Example 2A subcutaneous body fluid extraction and storage device
Referring to fig. 4, a subcutaneous body fluid extraction device is composed of an extraction end and a storage end, wherein the extraction end is composed of a cavity 1 and a microneedle 2 arranged at the bottom of the cavity; the storage end consists of a connecting pipe 3 and a negative pressure extraction device 4; a cavity 5 structure is formed in the cavity 1; the number of the micro-needles 2 is 10 multiplied by 10, and the micro-needles 2 are provided with three pore channels and are communicated with the cavity 1; the number of the connecting parts 6 is two, and the connecting parts are respectively arranged at two sides of the cavity (as shown in figure 5); the connecting pipe 3 is a through pipe with two open ends, and a hollow connecting pipe cavity 7 is arranged between the two open ends; one end of the connecting pipe 3 is connected with the connecting part 6, and the other end is connected with the negative pressure extraction device 4; a supporting body 8 for connecting the top and the bottom of the cavity is arranged in the cavity 5; the number of the supporting bodies is 4, the 4 supporting bodies 8 are uniformly arranged around the center of the cavity, and two adjacent supporting bodies 8 are not connected with each other; the negative pressure extraction device 4 is a vacuum sampling tube; the height of the cavity 5 in the cavity 1 is 0.5mm; the diameter of the pore canal is 1000 mu m; the length of the microneedle 2 was 300 μm; the center distance of the microneedle 2 was 3000 μm; the microneedles 2 form a microneedle array with an area of 9.36cm 2 The method comprises the steps of carrying out a first treatment on the surface of the The connecting part 6 is in a round table structure; the material of the extraction end is methacryloylated gelatin; the cavity and the microneedle are integrally formed structures prepared by a micro-casting technology.
When the vacuum sampling tube is used, an operator pierces the skin, then the connecting tube is communicated with the vacuum sampling tube, and subcutaneous body fluid is rapidly extracted and transferred from the skin to the vacuum sampling tube by utilizing the negative pressure provided by the vacuum sampling tube; after the micro needle is inserted into the skin, the micro needle needs to be kept in a pressed state, and can be loosened after the extraction of the subcutaneous body fluid is completed; after the extraction of the subcutaneous body fluid is completed, the microneedle is removed from the skin surface and then the sampling tube is separated from the vacuum sampling tube.
Example 3A subcutaneous body fluid extraction and storage device
Referring to fig. 6, a subcutaneous body fluid extraction device is composed of an extraction end and a storage end, wherein the extraction end is composed of a cavity 1 and a microneedle 2 arranged at the bottom of the cavity; the storage end is connected with the pipe3. A negative pressure extraction device 4; a cavity 5 structure is formed in the cavity 1; the number of the micro-needles 2 is 20×20, and the micro-needles 2 are provided with four pore channels and are communicated with the cavity 1; the connecting pipe 3 is a through pipe with two open ends, and a hollow connecting pipe cavity 7 is arranged between the two open ends; one end of the connecting pipe 3 is connected with the connecting part 6, and the other end is connected with the negative pressure extraction device 4; a supporting body 8 for connecting the top and the bottom of the cavity is arranged in the cavity 5; the number of the supporting bodies 8 is 4, and the supporting bodies are arranged in parallel at the bottom surface of the cavity 1 and avoid the openings of the micro-needle through pore channels in the cavity 1 (as shown in figure 7); the negative pressure extraction device 4 is a vacuum sampling tube; the height of the cavity 5 in the cavity 1 is 2.5mm; the diameter of the pore canal is 10 mu m; the length of the microneedle 2 was 1500 μm; the center distance of the microneedle 2 was 300 μm; the microneedles 2 form a microneedle array with an area of 0.37cm 2 The method comprises the steps of carrying out a first treatment on the surface of the The connecting part 6 is in a round table structure; the material of the extraction end is metal; the extraction end is an integrally formed structure prepared by a template method.
When the vacuum sampling tube is used, an operator pierces the skin, then the connecting tube is communicated with the vacuum sampling tube, and subcutaneous body fluid is rapidly extracted and transferred from the skin to the vacuum sampling tube by utilizing the negative pressure provided by the vacuum sampling tube; after the micro needle is inserted into the skin, the micro needle needs to be kept in a pressed state, and can be loosened after the extraction of the subcutaneous body fluid is completed; after the extraction of the subcutaneous body fluid is completed, the microneedle is removed from the skin surface and then the sampling tube is separated from the vacuum sampling tube.
Example 4A subcutaneous body fluid extraction and storage device
A subcutaneous body fluid extraction device, which consists of an extraction end and a storage end, wherein the extraction end consists of a cavity 1 and a microneedle 2 arranged at the bottom of the cavity; the storage end consists of a connecting pipe 3 and a negative pressure extraction device 4; a cavity 5 structure is formed in the cavity 1; the number of the micro-needles 2 is 10 multiplied by 10, and the micro-needles 2 are provided with four pore channels and are communicated with the cavity 1; the connecting pipe 3 is a through pipe with two open ends, and a hollow connecting pipe cavity 7 is arranged between the two open ends; one end of the connecting pipe 3 is connected with the connecting part 6, and the other end is connected with the negative pressure extraction device 4; a connection is arranged in the cavity 5A support body 8 at the top and bottom of the cavity; the number of the supporting bodies 8 is 4, and the bottom surface of the cavity 1 is parallel to avoid the openings of the micro-needle through pore channels in the cavity; the negative pressure extraction device 4 is a vacuum sampling tube; the height of the cavity 5 in the cavity 1 is 0.5mm; the diameter of the pore canal is 1000 mu m; the length of the microneedle 2 was 300 μm; the center distance of the microneedle 2 was 3000 μm; the microneedles 2 form a microneedle array with an area of 36.72cm 2 The method comprises the steps of carrying out a first treatment on the surface of the The connecting part is in a round table structure; the material of the extraction end is metal; the extraction end is an integrally formed structure prepared by a template method.
When the vacuum sampling tube is used, an operator pierces the skin, then the connecting tube is communicated with the vacuum sampling tube, and subcutaneous body fluid is rapidly extracted and transferred from the skin to the vacuum sampling tube by utilizing the negative pressure provided by the vacuum sampling tube; after the micro needle is inserted into the skin, the micro needle needs to be kept in a pressed state, and can be loosened after the extraction of the subcutaneous body fluid is completed; after the extraction of the subcutaneous body fluid is completed, the microneedle is removed from the skin surface and then the sampling tube is separated from the vacuum sampling tube.
In the description of the present specification, a description referring to terms "one embodiment," "some embodiments," "examples," "specific examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present utility model. In this specification, schematic representations of the above terms are not necessarily directed to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Further, one skilled in the art can engage and combine the different embodiments or examples described in this specification.
While embodiments of the present utility model have been shown and described above, it will be understood that the above embodiments are illustrative and not to be construed as limiting the utility model, and that variations, modifications, alternatives and variations may be made to the above embodiments by one of ordinary skill in the art within the scope of the utility model.
Claims (10)
1. The subcutaneous body fluid extraction device is characterized by comprising an extraction end and a storage end, wherein the extraction end comprises a cavity (1) and a microneedle (2) arranged at the bottom of the cavity; the storage end consists of a connecting pipe (3) and a negative pressure extraction device (4); a cavity (5) structure is formed in the cavity (1); the number of the micro-needles (2) is a plurality, and the micro-needles (2) are provided with a plurality of pore canals penetrating through the bottom of the cavity and are communicated with the cavity (1); the side surface of the cavity (1) is provided with a through connecting part (6), one end of the connecting pipe (3) is connected with the connecting part (6), and the other end is connected with the negative pressure extraction device; a supporting body (8) which is used for connecting the top and the bottom of the cavity is arranged in the cavity (5).
2. Subcutaneous body fluid extraction device according to claim 1, characterized in that the support body (8) when arranged avoids the opening of the microneedle through-channels in the cavity (1).
3. Subcutaneous body fluid extraction device according to claim 1, characterized in that said negative pressure extraction device (4) has two forms, one of which is an integrated negative pressure generating and storing device; and the second is a negative pressure generation and storage separation type device.
4. Subcutaneous body fluid extraction device according to claim 1, characterized in that the number of microneedles (2) is 5 x 5-20 x 20.
5. Subcutaneous body fluid extraction device according to claim 1, characterized in that the height of the cavity in the cavity (1) is 0.5-2.5mm.
6. The subcutaneous body fluid extraction device according to claim 1, wherein the diameter of the tunnel is 10-1000 μm.
7. Subcutaneous body fluid extraction device according to claim 1, characterized in that the length of the microneedles (2) is 300-1500 μm.
8. Subcutaneous body fluid extraction device according to claim 1, characterized in that the central distance of the microneedles (2) is 300-3000 μm.
9. Subcutaneous body fluid extraction device according to claim 1, characterized in that the number of said connection portions (6) is several.
10. The subcutaneous body fluid extraction device according to claim 1, wherein said extraction tip is an integrally formed structure.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202320586172.6U CN220588288U (en) | 2023-03-13 | 2023-03-13 | Subcutaneous body fluid extraction device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202320586172.6U CN220588288U (en) | 2023-03-13 | 2023-03-13 | Subcutaneous body fluid extraction device |
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