CN216082704U

CN216082704U - Sampling tube adjusting mechanism of 15-bit dissolution instrument

Info

Publication number: CN216082704U
Application number: CN202120302871.4U
Authority: CN
Inventors: 李定中; 张鸿; 雷浩
Original assignee: Lufen Apparatus Zhenjiang Co ltd
Current assignee: Lufen Apparatus Zhenjiang Co ltd
Priority date: 2021-02-03
Filing date: 2021-02-03
Publication date: 2022-03-18
Anticipated expiration: 2031-02-03

Abstract

The utility model relates to a 15-bit stripping instrument sampling tube adjusting mechanism, which comprises a fixed seat, a sliding plate and a movable plate, the vertical section of the fixing seat is in an Contraband-shaped structure, the upper ends of two sides of the fixing seat are fixedly connected with the fixing frame, three groups of supporting plates are horizontally arranged on two sides of the fixing seat, a movable opening is arranged at one end of each supporting plate, a fixing block is fixedly arranged in the fixing seat, three movable grooves are transversely arranged on the fixing block, two movable plates are arranged in each movable groove, a pin shaft is arranged at the top of the adjacent end of each movable plate, two ends of each movable plate horizontally penetrate through two sides of the fixing seat respectively and are placed on the supporting plates, and one end that two activity boards kept away from is equipped with the locating piece, runs through on the locating piece and is provided with the sampling needle, and sampling needle one end all vertically passes the movable mouthful in the backup pad, and the slide sets up on the fixed block, and three guide way has been seted up to the slide bottom, and the pin shaft imbeds the both ends of guide way respectively on two activity boards. Can be switched at any time, and realizes the automatic sampling compatible with the small cup method.

Description

Sampling tube adjusting mechanism of 15-bit dissolution instrument

Technical Field

The utility model belongs to the technical field of drug dissolution instruments, and particularly relates to a 15-bit dissolution instrument sampling tube adjusting mechanism.

Background

The drug dissolution instrument is used for checking the dissolution speed and degree of a drug from a solid preparation such as a tablet or a capsule in a specified solvent, and also can be said to be a method for simulating disintegration and dissolution in intestines and stomach by the instrument, and is an effective means for checking the quality and the production process level of the preparation, and is also a standard for evaluating the bioavailability of active ingredients of the preparation and the uniformity of the preparation.

There are two solubility testers on the market today, containing 8 and 12 bits, respectively. The 8-position tester meets the criteria of Chp, and contains 6 sample cuvettes (Chp pharmacopoeia) in addition to 1 standard cuvette and 1 blank cuvette. If the user does not need to use standard solution or blank solution to perform the dissolution test, the 2 dissolution cups can be used as fluid replacement cups. The 12-position tester met the criteria of Chp, in which 12 samples, including 12 sample cups (Chp requires only 6 positions), were tested simultaneously in 2 sets, but the standard and 1 blank cups had to be placed outside the water bath, losing the "same test condition". In addition, in order to externally supplement the liquid, a user needs to use an additional water interlayer cup, and the design occupies too much space of a laboratory workbench. As more tests are generated, this 6X2 container layout becomes impractical in the laboratory.

Patent 201811305368.3 discloses a highly effective drug dissolution apparatus. The medicine dissolving-out instrument comprises a machine head and a machine base; the machine base is internally provided with a water bath box, the water bath box is internally provided with 12 dissolution cups in a matrix manner, and the dissolution cups are distributed in a 2 x 6 manner. The medicine dissolving instrument is a 12-bit tester, does not comprise a sampling system, and needs to be additionally provided with a sampling needle structure, because the capacity of the existing dissolving cup is 1000ml, when a medicine with relatively high cost is tested, a small cup method is generally adopted for testing, the position structure of the existing sampling needle is relatively fixed, and when a 250ml small cup is sampled, the situation that the sampling needle extends out of the cup is easy to occur, so that normal sampling is influenced.

SUMMERY OF THE UTILITY MODEL

Aiming at the problems, the utility model discloses a 15-bit sampling tube adjusting mechanism of a dissolution instrument, which solves the problem that the sampling needle structure of the dissolution instrument in the prior art cannot be adjusted, so that the small cup method sampling cannot be considered.

The specific technical scheme is as follows:

a15-position sampling tube adjusting mechanism of a dissolution instrument is arranged at the bottom of a head of the dissolution instrument and comprises a fixed seat, a sliding plate and movable plates, wherein the vertical section of the fixed seat is in an Contraband-shaped structure, the upper ends of the two sides of the fixed seat are fixedly connected with a fixed frame, the two sides of the fixed seat are horizontally provided with three groups of supporting plates, one end of each supporting plate is provided with a movable opening, a fixed block is fixedly arranged in the fixed seat, the fixed block is transversely provided with three movable grooves corresponding to the three groups of supporting plates, two movable plates are respectively arranged in each movable groove, the tops of the adjacent ends of the two movable plates are respectively provided with a pin shaft, the two ends of the two movable plates respectively horizontally penetrate through the two sides of the fixed seat and are arranged on the supporting plates, the far ends of the two movable plates are respectively provided with a positioning block, a sampling needle penetrates through the positioning block, one end of the sampling needle longitudinally penetrates through the movable openings on the supporting plates, the sliding plate is arranged on the fixed block, three guide grooves corresponding to the three movable grooves are formed in the bottom of the sliding plate, and the pin shafts on the two movable plates are respectively embedded into two ends of the guide grooves.

Furthermore, the guide groove is of a V-shaped structure, and two ends of the guide groove extend to two sides of the sliding plate.

Further, still be equipped with positioning mechanism on the sampling needle adjustment mechanism, positioning mechanism includes the location handle, vertically runs through the positioning screw who sets up on the slide and sets up in the constant head tank of fixing base and fixed block bottom, two be connected with the sliding opening between the constant head tank, positioning screw and slide threaded connection, the positioning screw lower extreme passes the sliding opening is equipped with the stopper, and the pot head is equipped with the spring under the positioning screw, the location handle cover is established at the positioning screw lower extreme, and is equipped with the storage tank bottom the location handle, and the storage tank top supports to press in the top of spring, location handle upper end is embedded into in the constant head tank and is carried on spacingly.

Furthermore, the upper end of the positioning handle is of a conical surface structure and is matched with the positioning groove in shape.

Further, the size of the sliding opening is matched with the size of the movable length of the sliding plate.

Furthermore, the width dimension of the sliding plate is adapted to the distance between two sides of the fixed seat.

The working principle of the sampling needle adjusting mechanism is as follows:

through horizontal activity slide for the fly leaf slides to both sides or to the center in the activity groove under the guide of guide way through the round pin axle, thereby drives the sample needle and to both sides or to the center removal, thereby is applicable to the little cup method sample that the size is less. When fixing a position the slide, through the pulling location handle downwards for location handle upper end no longer carries on spacingly, slides the slide simultaneously, makes the locating lever slide in the sliding opening, and makes the location handle remove to another constant head tank below, loosens behind the location handle, makes the location handle imbed under the spring action and carry on spacingly in the constant head tank.

The utility model has the beneficial effects that:

(1) the sampling needle adjustment mechanism can slide to two sides or to the center in the movable groove under the guide of the guide groove through the pin shaft by the aid of the horizontal movable sliding plate, so that the sampling needle is driven to move to two sides or to the center, the sampling needle is suitable for sampling by a small cup method, switching can be performed at any time, and automatic sampling by a compatible small cup method is achieved.

(2) The positioning handle in the sliding plate accessible positioning mechanism is embedded into the positioning grooves at the bottoms of the fixed seat and the fixed block, so that positioning is realized, the sliding plate is effectively prevented from moving due to misoperation, and the sliding plate is safer and more reliable.

Drawings

FIG. 1 is a perspective view of a sampling needle adjustment mechanism of the present invention.

FIG. 2 is a front view of the sampling needle adjustment mechanism of the present invention.

FIG. 3 is a schematic diagram of a top view of a standard dissolution cup when a sampling needle adjusting mechanism of the present invention samples the sample.

FIG. 4 is a schematic diagram of a side view of a standard dissolution cup sampling by the sampling needle adjustment mechanism of the present invention.

FIG. 5 is a schematic top view showing the structure of the sampling needle adjusting mechanism of the present invention when sampling the small-sized dissolution cup.

FIG. 6 is a schematic diagram showing the side view of the sampling needle adjusting mechanism of the present invention for sampling the small dissolution cup.

Reference numerals

The sampling probe comprises a sampling needle 1, a fixed seat 2, a fixed block 21, a movable groove 211, a supporting plate 22, a movable opening 221, a positioning groove 23, a sliding opening 24, a sliding plate 3, a guide groove 31, a positioning screw 32, a limiting block 33, a spring 34, a positioning handle 35, a containing groove 36, a movable plate 4, a pin shaft 41 and a positioning block 42.

Detailed Description

In order to make the technical scheme of the utility model clearer and clearer, the utility model is further described with reference to the accompanying drawings, and any scheme obtained by carrying out equivalent replacement and conventional reasoning on the technical characteristics of the technical scheme of the utility model falls into the protection scope of the utility model. The fixing and the arrangement of the fixing and the connection are all general connection modes in the mechanical field, and the fixing and the connection can be performed by welding, bolt and nut connection and screw connection.

In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of describing the present invention and simplifying the description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention.

As shown in fig. 1-6, a 15-position sampling tube adjusting mechanism for a dissolution apparatus is installed at the bottom of a head of the dissolution apparatus, and comprises a fixed seat 2, a sliding plate 3 and movable plates 4, wherein the vertical section of the fixed seat 2 is in an Contraband-shaped structure, the upper ends of two sides of the fixed seat 2 are fixedly connected with a fixed frame, three groups of supporting plates 22 are horizontally arranged at two sides of the fixed seat 2, one end of each supporting plate 22 is provided with a movable opening 221, a fixed block 21 is fixedly arranged in the fixed seat 2, three movable grooves 211 corresponding to the three groups of supporting plates 22 are transversely arranged on the fixed block 21, two movable plates 4 are respectively arranged in each movable groove 211, the top of the adjacent end of each movable plate 4 is provided with a pin shaft 41, the two ends of each movable plate 4 respectively horizontally penetrate through two sides of the fixed seat 2 and are placed on the supporting plates 22, and the end far away from the two movable plates 4 is provided with a positioning block 42, the positioning block 42 is provided with a sampling needle 1 in a penetrating manner, one end of the sampling needle 1 longitudinally penetrates through the movable port 221 in the supporting plate 22, the sliding plate 3 is arranged on the fixing block 21, the bottom of the sliding plate 3 is provided with three guide grooves 31 corresponding to the positions of the three movable grooves 211, and the two movable plates 4 are respectively embedded into two ends of the guide grooves 31 through the pin shafts 41.

Further, the guide groove 31 is of a V-shaped structure, and two ends of the guide groove 31 extend to two sides of the sliding plate 3.

Further, still be equipped with positioning mechanism on the 1 adjustment mechanism of sampling needle, positioning mechanism includes location handle 35, vertically runs through the setting at slide 3 on positioning screw 32 and set up in the constant head tank 23 of fixing base 2 and fixed block 21 bottom, two be connected with smooth mouthful 24 between the constant head tank 23, positioning screw 32 and slide 3 threaded connection, positioning screw 32 lower extreme pass smooth mouthful 24 and be equipped with stopper 33, and the pot head is equipped with spring 34 under the positioning screw 32, the cover is established at positioning screw 32 lower extreme to location handle 35 cover, and is equipped with storage tank 36 bottom location handle 35, and the top of storage tank 36 is supported and is pressed spring 34's top, and it is spacing to imbed in the constant head tank 23 in location handle 35 upper end.

Furthermore, the upper end of the positioning handle 35 is of a conical structure and is matched with the positioning groove 23 in shape.

Further, the size of the sliding opening 24 is adapted to the size of the movable length of the sliding plate 3.

Furthermore, the width dimension of the sliding plate 3 is adapted to the distance between the two sides of the fixed seat 2.

The working principle of the sampling needle adjusting mechanism is as follows:

through the horizontal movable sliding plate 3, the movable plate 4 slides to both sides or to the center in the movable groove 211 under the guidance of the guide groove 31 through the pin shaft 41, so as to drive the sampling needle 1 to move to both sides or to the center, thereby being suitable for small-cup sampling with small size. When fixing a position slide 3, through pulling location handle 35 downwards for location handle 35 upper end no longer carries on spacingly, slide 3 simultaneously, make the locating lever slide in sliding opening 24, and make location handle 35 remove to another constant head tank 23 below, loosen the location handle 35 after, make location handle 35 imbed under the spring 34 effect and carry on spacingly in the constant head tank 23.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are also included in the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims

1. A15-position sampling tube adjusting mechanism of a dissolution apparatus is arranged at the bottom of a head of the dissolution apparatus and is characterized by comprising a fixed seat (2), a sliding plate (3) and movable plates (4), wherein the vertical section of the fixed seat (2) is in an Contraband-shaped structure, the upper ends of two sides of the fixed seat (2) are fixedly connected with a fixed frame, three groups of supporting plates (22) are horizontally arranged at two sides of the fixed seat (2), a movable opening (221) is formed at one end of each supporting plate (22), a fixed block (21) is fixedly arranged in the fixed seat (2), three movable grooves (211) corresponding to the three groups of supporting plates (22) in position are transversely arranged on the fixed block (21), two movable plates (4) are arranged in each movable groove (211), a pin shaft (41) is arranged at the top of the adjacent end of each movable plate (4), two ends of each movable plate (4) horizontally penetrate through two sides of the fixed seat (2) respectively and are placed on the supporting plates (22), and one of keeping away from mutually of two fly leaf (4) is served and is equipped with locating piece (42), runs through on locating piece (42) and be provided with sampling needle (1), activity mouth (221) on backup pad (22) are all vertically passed to sampling needle (1) one end, slide (3) set up on fixed block (21), and slide (3) bottom is seted up with three guide way (31) that the position of three activity groove (211) is corresponding, and two fly leaf (4) go up round pin axle (41) and imbed the both ends of guide way (31) respectively.

2. The adjusting mechanism for the 15 th sampling tube of the dissolution instrument as claimed in claim 1, wherein the guiding groove (31) is of a "V" shape, and both ends of the guiding groove (31) extend to both sides of the sliding plate (3).

3. The 15-bit stripping instrument sampling tube adjusting mechanism according to claim 1, wherein a positioning mechanism is further disposed on the adjusting mechanism of the sampling needle (1), the positioning mechanism comprises a positioning handle (35), a positioning screw (32) longitudinally penetrating the sliding plate (3), and positioning grooves (23) disposed at the bottoms of the fixing base (2) and the fixing block (21), a sliding opening (24) is connected between the two positioning grooves (23), the positioning screw (32) is in threaded connection with the sliding plate (3), the lower end of the positioning screw (32) passes through the sliding opening (24) and is provided with a limiting block (33), a spring (34) is sleeved at the lower end of the positioning screw (32), an accommodating groove (36) is disposed at the bottom of the positioning handle (35), and the top end of the accommodating groove (36) abuts against the top end of the spring (34), the upper end of the positioning handle (35) is embedded into the positioning groove (23) for limiting.

4. The adjusting mechanism for the 15 th sampling tube of the dissolution instrument as set forth in claim 3, wherein the upper end of the positioning handle (35) is of a conical structure and is adapted to the shape of the positioning groove (23).

5. The 15-position dissolution apparatus sampling tube adjusting mechanism according to claim 3, wherein the size of the sliding port (24) is adapted to the size of the movable length of the sliding plate (3).

6. The adjusting mechanism for the 15 th sampling tube of the dissolution instrument as claimed in claim 1, wherein the width dimension of the sliding plate (3) is adapted to the space between the two sides of the fixed seat (2).