CN215740873U

CN215740873U - Vaccine preparation equipment

Info

Publication number: CN215740873U
Application number: CN202121991520.5U
Authority: CN
Inventors: 刘忠英
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-08-23
Filing date: 2021-08-23
Publication date: 2022-02-08
Anticipated expiration: 2031-08-23

Abstract

The embodiment of the utility model discloses vaccine preparation equipment, which comprises: the blood collection device, the blood separation device, the treatment device, the irradiation device, the inactivated virus collection device and the feedback device; the blood sampling device is used for collecting and conveying blood; the blood separation device is used for separating blood into plasma and blood cells, and the output end of the blood separation device is respectively connected with a plasma catheter and a blood cell catheter; the treatment device is connected with the plasma catheter, plasma can be conveyed into the treatment device through the plasma catheter, the irradiation device is used for irradiating the plasma temporarily stored in the treatment device, and the output end of the treatment device outputs the plasma after virus inactivation; the input end of the inactivated virus collecting device is connected with the output end of the treatment device, and at least part of the virus inactivated blood plasma output by the treatment device enters the inactivated virus collecting device to be collected and used for forming vaccines; the input end of the feedback device is respectively connected with the output ends of the blood cell catheter and the therapeutic device.

Description

Vaccine preparation equipment

Technical Field

The utility model relates to the field of medical equipment, in particular to vaccine equipment preparation.

Background

Vaccines are drugs used to inhibit the reproduction of various pathogens. The vaccines used will vary according to the pathogen that it is desired to suppress. Inactivated vaccines belong to a large group of vaccines.

In the related art, inactivated vaccines are prepared by culturing viruses or bacteria and then inactivating them with heat or chemical agents. Inactivated vaccines may consist of whole viruses or bacteria, or they may consist of their split fragments as split vaccines. According to the existing production process of inactivated vaccines, viruses or bacteria need to be cultured in the existing production process of inactivated vaccines, and the process is troublesome.

SUMMERY OF THE UTILITY MODEL

One aim of the utility model is to provide a new technical scheme for vaccine equipment preparation.

According to one aspect of the present invention, there is provided a vaccine apparatus preparation comprising

The blood sampling device is used for collecting and conveying blood;

the blood separation device is used for separating the blood into plasma and blood cells, and the output end of the blood separation device is respectively connected with a plasma catheter and a blood cell catheter;

the treatment device is connected with the plasma conduit, the plasma can be conveyed into the treatment device through the plasma conduit, the irradiation device is used for irradiating the plasma temporarily stored in the treatment device, and the output end of the treatment device outputs the plasma after virus inactivation;

the input end of the inactivated virus collecting device is connected with the output end of the treatment device, and at least part of the virus inactivated blood plasma output by the treatment device enters the inactivated virus collecting device to be collected and used for forming vaccines;

and the input end of the feedback device is respectively connected with the blood cell catheter and the output end of the treatment device.

Optionally, the vaccine preparation apparatus further comprises a filter device connected between the treatment device, the inactivated virus collection device and the return device.

Optionally, the input end of the filtering device is connected with the output end of the treatment device;

and the output end of the filtering device is respectively connected with the input end of the inactivated virus collecting device and the input end of the feedback device.

Optionally, an inactivated plasma input device is connected to the treatment device, and is used for injecting virus-inactivated plasma into the treatment device;

and under the condition that the virus inactivated plasma is injected into the treatment device, the irradiation device is used for carrying out secondary virus inactivation on the virus inactivated plasma through illumination.

Optionally, the input end of the blood separation device is connected with the output end of the blood sampling device through a blood supply conduit, and the blood separation device is configured to separate the blood conveyed by the blood sampling device into plasma and blood cells under the action of centrifugal force;

the output end of the blood separation device is divided into two branches:

one of the branches is connected with the plasma conduit, the plasma conduit is used for conveying the centrifugally separated plasma, a plasma pump is arranged on the plasma conduit, and a medicine injection device is further connected with the plasma conduit;

the other branch is connected with the blood cell conduit, and the blood cell conduit is used for conveying the centrifuged blood cells to the back transfusion device.

Optionally, the vaccine preparation apparatus further comprises a control device;

the control device is electrically connected with the blood sampling device, the blood separation device, the irradiation device and the feedback device respectively;

the blood separation device is connected with a blood component detection device, and the blood component detection device is electrically connected with the control device;

the blood sampling device is respectively connected with an anticoagulant adding device and a pressure detection device, the feedback device is connected with a feedback catheter, and the feedback catheter is connected with a bubble detection device; the anticoagulant adding device, the pressure detection device and the bubble detection device are all electrically connected with the control device.

Optionally, the vaccine preparation apparatus further comprises a supplementary device, an output end of the supplementary device is connected with the return conduit, virus-inactivated plasma is collected in the supplementary device, and the virus-inactivated plasma can be input into the body of the patient through the return conduit according to a set amount.

Optionally, the blood separation device comprises a rotatable support structure and a centrifugal separation channel, the centrifugal separation channel being arranged on the support structure;

one end of the centrifugal separation channel is an input end of the blood separation device, a blood input port is formed in the end of the centrifugal separation channel, and the blood input port is connected with an output end of the blood sampling device through a blood supply catheter;

the other end of the centrifugal separation channel is the output end of the blood separation device, a plasma output port and a blood cell output port are respectively arranged on the other end of the centrifugal separation channel, the blood cell output port is connected with the input end of the feedback device through the blood cell catheter, and a blood cell pump is arranged on the blood cell catheter.

Optionally, the plasma output port of the blood separation device is connected to the input port of the treatment device via the plasma conduit;

the output end of the treatment device is connected with the input end of the filtering device, the filtering device and the blood separating device are arranged in a separating mode, the filtering device is connected with the inactivated virus collecting device through a temporary storage device, the output end of the filtering device is connected with the input end of the feedback device through an output conduit, and a first circulating pump is arranged on the output conduit;

the filtering device is configured to filter the virus-inactivated plasma output by the treatment device to separate out inactivated viruses, the inactivated viruses enter the temporary storage device to be collected, and the rest of components obtained by filtering by the filtering device enter the feedback device.

the output end of the treatment device is connected with the input end of the filtering device, the filtering device is arranged on the supporting structure of the blood separation device and is positioned at the inner ring of the centrifugal separation channel, the filtering device is connected with the inactivated virus collecting device through a temporary storage device, and the output end of the filtering device is connected with the feedback device.

Optionally, the filtering device includes a first centrifugal channel and a second centrifugal channel disposed on an outer ring of the first centrifugal channel, and a filter screen is disposed between the first centrifugal channel and the second centrifugal channel and is capable of blocking passage of the inactivated viruses;

the inlet of the first centrifugal channel is connected with the output end of the treatment device through a first conduit, the outlet of the first centrifugal channel is connected with a second conduit, and a directional valve is arranged on the second conduit and is respectively connected with the temporary storage device and the feedback device through the directional valve; the outlet end of the second centrifugal channel is connected with the feedback device.

Optionally, the outlet end of the second centrifugal channel is connected to the back-infusion device by a third conduit.

Optionally, the outlet end of the second centrifugation channel is connected to the blood cell conduit by a communication conduit.

Optionally, the plasma output port of the blood separation device is connected to the filtration device;

the filtering device is arranged on the supporting structure of the blood separating device and is positioned at the inner ring of the centrifugal separation channel, the filtering device is respectively connected with the input end of the treatment device and the input end of the feedback device, the output end of the treatment device is connected with the input end of the feedback device, and the output end of the treatment device is also connected with a temporary storage device.

the inlet of the first centrifugal channel is connected with the plasma output port through a first communicating pipe, the outlet of the first centrifugal channel is connected with the input end of the treatment device through a second communicating pipe, and a third circulating pump is arranged on the second communicating pipe; the outlet end of the second centrifugal channel is connected with the input end of the feedback device through a third communicating pipe;

the output end of the treatment device is connected with a fourth communicating pipe, a direction valve is arranged on the fourth communicating pipe, and the fourth communicating pipe is respectively connected with the feedback device and the temporary storage device through the direction valve.

The utility model has the beneficial effects that:

the embodiment of the utility model provides a vaccine preparation scheme, which can form a vaccine by obtaining plasma after virus inactivation from blood of a patient, and the formed vaccine can be returned to the patient in a systemic circulation mode, namely, the vaccine can be used as an autologous vaccine; furthermore, the vaccine formed can also be collected and infused into the body of another person, i.e. used as a foreign vaccine. Compared with the existing scheme, the scheme of the utility model does not need to culture the virus or bacteria independently, and can simplify the vaccine preparation process.

Other features of the present invention and advantages thereof will become apparent from the following detailed description of exemplary embodiments thereof, which proceeds with reference to the accompanying drawings.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the utility model and together with the description, serve to explain the principles of the utility model.

Fig. 1 is a block diagram of a vaccine preparation apparatus according to an embodiment of the present invention.

Fig. 2 is a second block diagram of the vaccine preparation apparatus according to the embodiment of the present invention.

Fig. 3 is a second block diagram of the vaccine preparation apparatus according to the embodiment of the present invention.

Fig. 4 is a schematic structural diagram of a vaccine preparation apparatus provided in an embodiment of the present invention.

Fig. 5 is a second schematic structural diagram of a vaccine preparation apparatus provided in an embodiment of the present invention.

Fig. 6 is a third schematic structural diagram of a vaccine preparation apparatus according to an embodiment of the present invention.

FIG. 7 is a fourth schematic view of the vaccine preparation apparatus according to the embodiment of the present invention.

Description of reference numerals:

1-a blood collection device, 2-a blood separation device, 3-a plasma tube, 4-a blood cell tube, 5-a treatment device, 6-an irradiation device, 7-a filtration device, 8-an inactivated virus collection device, 9-a reinfusion device, 10-an output tube, 11-a blood supply tube, 12-a reinfusion tube, 13-a drug infusion device, 14-a supplement device, 15-a control device, 16-a blood component detection device, 17-an anticoagulant addition device, 18-a pressure detection device, 19-a bubble detection device, 20-a directional valve, 21-a blood cell pump, 22-an inactivated plasma input device, 23-a blood pump, 24-a first circulation pump, 25-a temporary storage device, 26-a first tube, 27-a second tube, 28-a third conduit, 29-a communicating conduit, 30-a first communicating pipe, 31-a second communicating pipe, 32-a third circulating pump, 33-a third communicating pipe, 34-a fourth communicating pipe;

201-support structure, 202-centrifugal separation channel, 2021-blood input port, 2022-plasma output port, 2023-blood cell output port;

701-first centrifugal channel, 7011-inlet, 7012-outlet, 702-second centrifugal channel, 7021-outlet, 703-filter screen.

Detailed Description

Various exemplary embodiments of the present invention will now be described in detail with reference to the accompanying drawings. It should be noted that: the relative arrangement of the components and steps, the numerical expressions and numerical values set forth in these embodiments do not limit the scope of the present invention unless specifically stated otherwise.

The following description of at least one exemplary embodiment is merely illustrative in nature and is in no way intended to limit the utility model, its application, or uses.

Techniques, methods, and apparatus known to those of ordinary skill in the relevant art may not be discussed in detail but are intended to be part of the specification where appropriate.

In all examples shown and discussed herein, any particular value should be construed as merely illustrative, and not limiting. Thus, other examples of the exemplary embodiments may have different values.

It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, further discussion thereof is not required in subsequent figures.

The vaccine preparation equipment provided by the embodiment of the utility model can form a closed-loop system with the body of a patient when in use, the whole closed-loop environment is safe and reliable, and the condition of blood infection can be avoided.

It should be noted that the vaccine preparation device can be connected with the body of a patient to form a closed system, so as to prevent invasion of external bacteria, viruses and the like and avoid danger caused by infection.

In addition, the vaccine preparation apparatus provided by the embodiment of the present invention may be applied to a human body, an animal body, and the like, and the present invention is not limited thereto.

The vaccine preparation device provided by the embodiment of the utility model, referring to fig. 1, comprises a blood sampling device 1, wherein the blood sampling device 1 is used for collecting and delivering blood.

For example, the blood collection device 1 includes components well known to those skilled in the art, such as a blood collection needle, a blood collection pump, a filter, and a blood collection tube, which will not be described in detail herein.

The vaccine preparation device provided by the embodiment of the utility model, referring to fig. 1, comprises a blood separation device 2, wherein the blood separation device 2 is used for separating the blood into plasma and blood cells, and the output end of the blood separation device 2 is respectively connected with a plasma conduit 3 and a blood cell conduit 4.

In fact, for viruses or bacteria, the viruses or bacteria exist mainly in blood plasma but not in blood cells, therefore, the blood plasma in the blood is separated by the blood separation device 2 so as to inactivate the bacteria or the viruses in the blood in a targeted manner, and then the inactivated vaccine can be prepared.

The vaccine preparation device provided by the embodiment of the utility model, referring to fig. 1, comprises a treatment device 5 and an irradiation device 6. The input end of the treatment device 5 is connected to the plasma tube 3, and the plasma is delivered to the treatment device 5 through the plasma tube 3. The irradiation device 6 is used for irradiating the plasma temporarily stored in the treatment device 5, and the output end of the treatment device 5 outputs the plasma after virus inactivation.

The treatment device 5 may be a light-transmitting container, such as a transparent blood storage bag.

The treatment device 5 can be used to receive the plasma separated by the blood separation device 2.

The irradiation device 6 is capable of generating therapeutic light for irradiation of a set intensity and duration.

The irradiation treatment light can be used for irradiating the plasma (possibly containing viruses or bacteria) temporarily stored in the treatment device 5.

The irradiation therapeutic light emitted by the irradiation device 6 may be any one or all of UVA, UVB, UVC, and visible light, and may be flexibly selected according to specific situations, which is not limited in the present invention.

Because the treatment device 5 is transparent, the irradiation treatment light emitted by the irradiation device 6 can irradiate the plasma inside the treatment device 5 through the treatment device 5 to perform virus inactivation treatment on the plasma, so that the treatment device 5 can output the plasma after virus inactivation, which is the key for forming vaccine.

The vaccine preparation device provided by the embodiment of the utility model, referring to fig. 1, comprises an inactivated virus collecting device 8.

The input end of the inactivated virus collecting device 8 is connected with the output end of the treatment device 5, and at least part of the virus inactivated blood plasma output by the treatment device 5 enters the inactivated virus collecting device 8 for collection and vaccine formation.

The inactivated virus collecting device 8 can directly collect the virus-inactivated plasma output by the treatment device 5, which can be directly used as an inactivated vaccine.

Wherein, the inactivated virus collecting device 8 is set to collect in a single time. Alternatively, it may be arranged to periodically collect virus inactivated plasma a plurality of times, and to infuse the inactivated vaccine into the patient's body when a sufficient clinical usage amount is reached.

The inactivated plasma collected in the inactivated virus collecting device 8 can be self-transfused as an autovaccine, and can also be used for inputting to other people as a foreign vaccine.

The vaccine preparation device provided by the embodiment of the utility model, referring to fig. 1, comprises a back infusion device 9. The input end of the feedback device 9 is respectively connected with the output ends of the blood cell catheter 4 and the therapeutic device 5.

For example, the back-infusion device 9 may include components well known to those skilled in the art, such as blood delivery needles, blood delivery pumps, filters, and blood delivery conduits, which will not be described in detail herein.

The return device 9 can be used in conjunction with the lancing device 1 to carry out a closed loop cycle.

The reinfusion device 9 can reinfuse virus-free blood components (mainly water) and blood cells into the body of a patient. The plasma containing inactivated virus can be temporarily collected in the inactivated virus collecting device 8, although the plasma can be directly returned.

Referring to fig. 2, the vaccine preparation apparatus according to the embodiment of the present invention further includes a filtering device 7, wherein the filtering device 7 is connected between the treatment device 5, the inactivated virus collecting device 8 and the back-infusion device 9.

The plasma after being filtered by the filtering device 7 has higher inactivated virus load, namely higher virus concentration, namely, concentrated inactivated virus plasma can be formed.

In some examples of the utility model, referring to fig. 2, the input of the filtering means 7 is connected to the output of the treatment means 5; the output end of the filtering device 7 is respectively connected with the input end of the inactivated virus collecting device 8 and the input end of the feedback device 9.

The treatment device 5 is capable of delivering plasma after inactivation of the virus. The inactivated virus collecting device 8 can directly collect the plasma after the inactivation of the virus, or the plasma after the inactivation of the virus is firstly filtered by the filtering device 7 and then collected by the inactivated virus collecting device 8. The plasma after being filtered by the filtering device 7 has higher inactivated virus load, namely higher virus concentration, namely, concentrated inactivated virus plasma can be formed.

If it is not necessary to purify and concentrate the plasma (filter out water to collect inactivated virus), the plasma after virus inactivation may be directly taken out without filtration, i.e., without the above-mentioned filter 7.

In some examples of the utility model, referring to fig. 3, the treatment device 5 is further connected to an inactivated plasma input device 22, the inactivated plasma input device 22 being used for directly injecting virus-inactivated plasma, for example, from the outside, into the treatment device 5; when the virus-inactivated plasma is injected into the treatment device 5, the irradiation device 6 performs secondary virus inactivation on the virus-inactivated plasma by light irradiation.

When an autologous vaccine is injected, no biological problems generally arise.

When a biological problem or incomplete inactivation problem may occur when injecting a foreign vaccine, the inactivated plasma input device 22 may be connected to the treatment device 5 for injecting virus-inactivated plasma extracted from the patient's body into the treatment device 5.

In some embodiments of the present invention, referring to fig. 1 to 3, the input end of the blood separation device 2 is connected to the output end of the blood collection device 1 through a blood supply conduit 11, and the blood separation device 2 is configured to separate the blood delivered by the blood collection device 1 into plasma and blood cells under the action of centrifugal force;

the output of the blood separation device 2 is divided into two branches:

one of the branches is connected with the plasma tube 3, the plasma tube 3 is used for conveying the centrifugally separated plasma, a plasma pump 23 is arranged on the plasma tube 3, and a medicine injection device 13 is also connected with the plasma tube 3;

the other branch is connected with the blood cell conduit 4, and the blood cell conduit 4 is used for conveying the centrifuged blood cells to the back transfusion device 9.

The lancing device 1 can be connected to the blood separation device 2 via a donor line 11, in which case the blood withdrawn from the patient can be fed via the donor line 11 into the blood separation device 2 for separation into plasma and blood cells.

The plasma pump 23 may be used to effect the flow of plasma within the plasma conduit 3.

The drug delivery device 13 may deliver a photosensitizer or related drug into the treatment device 5.

The plasma separated by the blood separation device 2 can be first conveyed into the treatment device 5 for collection, after the accumulation reaches a certain volume, the photosensitizer (or drug) is injected into the treatment device 5 by the drug injection device 13, and after the photosensitizer (or drug) and the separated plasma are fully mixed, the irradiation device 6 irradiates light to inactivate viruses, so that the inactivation efficiency and effect are improved.

In some embodiments of the present invention, referring to fig. 1 to 3, the vaccine preparation apparatus further comprises a control device 15; the control device 15 is electrically connected to the blood sampling device 1, the blood separation device 2, the irradiation device 6, and the feedback device 9, respectively.

The control device 15 can provide corresponding automated control of the lancing device 1, the blood separation device 2, the irradiation device 6 and the return device 9.

Further, the control device 15 may have a display device, and a user may control and observe the operation state and the like of each component by operating the display device. The display device may be a display device known to those skilled in the art, such as a touch display screen, for example, and the present invention is not limited thereto.

Wherein the blood separation device 2 is connected to a blood component detection device 16, and the blood component detection device 16 is electrically connected to the control device 15.

The blood component detection means 16 is connected to the blood separation means 2 by a detection line or a communication control line. The blood component detecting means 16 is connected to the control means 15 through a detection line or a communication control line. The blood component detection device 16 is used to detect the components, purity, and the like of each part separated by the blood separation device 2, and can control the blood separation process so that different components can form a good layered state, which is beneficial to separate extraction of different components. That is, when the blood separation apparatus 2 separates blood into different components, the blood component detection apparatus 16 can detect the state of stratification, the type and the purity of each component.

The blood component detection device 16 may be selectively provided or not provided as needed.

The blood sampling device 1 is connected with an anticoagulant adding device 17 and a pressure detection device 18 respectively, and the anticoagulant adding device 17 and the pressure detection device 18 are electrically connected with the control device 15.

The anticoagulant adding device 17 is used for adding anticoagulant into the blood sampling device 1.

When the blood sampling device 1 draws blood, feeds the blood into the blood supply catheter 11 and starts to circulate, the coagulation of the blood being processed can be effectively prevented by adding anticoagulant, so that the smooth proceeding of the whole blood circulation process can be ensured.

The amount of the anticoagulant added may be flexibly controlled as needed, but the present invention is not limited thereto.

The anticoagulant adding device 17 may be integrated directly with the blood collection device 1. Of course, the anticoagulant adding device 17 may be connected to the blood collection device 1 through a tube. Both of these approaches can achieve the addition of an anticoagulant.

The anticoagulant adding device 17 can also be connected with the control device 15 through a communication control line. The design can realize the automatic control of the anticoagulant addition through the control device 15, and the mode is convenient to operate and easy to control the addition amount.

Of course, the anticoagulant addition device 17 may not be connected to the control device 15, and in this case, the addition and addition amount of the anticoagulant may be manually controlled.

A pressure detection device 18 is provided outside the blood collection device 1. The pressure detection device 18 is used to detect the pressure in the lancing device 1, for example in a lancing line, and in a donor line 11 connected to the lancing device 1. Whether the needle (such as a blood taking needle) and the corresponding pipeline are blocked or not can be judged through pressure detection. Once the blockage occurs, the pressure in the pipe is easy to be abnormal, and the danger is caused.

The pressure detection device 18 is connected with the control device 15 through a communication control line. The design can realize the control of the conductive control device 15 on the pressure detection device 18, that is, the pressure detection device 18 can be controlled to start pressure detection at a proper time, and certainly, the pressure detection device 18 can also be controlled not to perform pressure detection.

The feedback device 9 is connected with a feedback conduit 12, the feedback conduit 12 is connected with a bubble detection device 19, and the bubble detection device 19 is electrically connected with the control device 15.

The bubble detecting means 19 detects whether the returned blood contains bubbles, for example, by using ultrasound, and immediately stops the blood returning to the body and gives an alarm once bubbles are detected in the blood, otherwise the blood entering the body may be dangerous.

The bubble detecting means 19 is also connected to the control means 15 via a communication control line. This design enables the control device 15 to control the bubble detection device 19, i.e., the bubble detection device 19 may be controlled to start detection at an appropriate timing, or the bubble detection device 19 may be controlled not to perform detection.

The reinfusion catheter 12 may also be provided with a pressure detection device, which can determine whether the needle (e.g., blood transfusion needle) and the corresponding tubing are clogged. Once the blockage occurs, the pressure in the pipe is easy to be abnormal, and the danger is caused.

In some embodiments of the utility model, referring to fig. 1-3, the vaccine preparation apparatus further comprises a supplemental device 14. The output of the supplementary device 14 is connected to the return line 12. The supplemental device 14 contains virus-inactivated plasma, which can be delivered to the patient in a set amount via the return line 12.

It should be noted that the embodiment of the present invention separately designs a supplemental device 14 that can be used to store the previously inactivated plasma, rather than the inactivated plasma produced in the present cycle.

In some embodiments of the present invention, referring to fig. 4-7, the blood separation device 2 comprises a rotatable support structure 201 and a centrifugation channel 202, the centrifugation channel 202 being arranged on the support structure 201; one end of the centrifugal separation channel 202 is an input end of the blood separation device and is provided with a blood input port 2021, and the blood input port 2021 is connected with an output end of the blood collection device 1 through a blood supply catheter 11; the other end of the centrifugal separation channel 202 is an output end of the blood separation device, and a plasma output port 2022 and a blood cell output port 2023 are respectively arranged on the other end.

Wherein the blood cell output port 2023 is connected to the back-infusion device 9 through the blood cell tube 4. The blood cell tube 4 is provided with a blood cell pump 21, and the blood cell pump 21 is configured to promote the flow of the blood cells in the blood cell tube 4.

The blood separation apparatus 2 is capable of separating blood into two major components, plasma and blood cells, by centrifugal force. Blood is derived, for example, from blood taken from the body of a patient by the lancing device 1.

The support structure 201 is, for example, a disk. The support structure 201 is capable of high speed rotation.

The centrifugal separation channel 202 is, for example, C-shaped or circular.

The blood to be separated enters from the blood input port 2021 of the centrifugal separation channel 202 and flows to the output end of the centrifugal separation channel 202, and is separated into a plasma layer and a blood cell layer at the output end of the centrifugal separation channel 202 under the action of centrifugal force, wherein the outlet inside the output end of the centrifugal separation channel 202, i.e. near the center of the disk, is the plasma output port 2022, plasma can be output from the plasma output port 2022, and blood cells are output from the blood cell output port 2023 and directly introduced into the reinfusion device 9 through the blood cell conduit 4.

Since the plasma output from the plasma output port 2022 contains viruses to be inactivated, the output plasma needs to be treated separately and cannot be directly returned through the return device 9, which is different from the flow direction of blood cells.

In some embodiments of the present invention, referring to fig. 4, the blood separation device 2 comprises a rotatable support structure 201 and a centrifugal separation channel 202, the centrifugal separation channel 202 being arranged on the support structure 201; the blood inlet 2021 of the centrifugal separation channel 202 is connected to the output of the lancing device 1 via the donor line 11 for introducing blood into the centrifugal separation channel 202; the output end of the centrifugal separation channel 202 is respectively provided with a plasma output port 2022 and a blood cell output port 2023; the blood cell output port 2023 is connected to the back infusion device 9 through the blood cell catheter 4; the plasma outlet 2022 is connected to the input of the treatment device 5 via the plasma tube 3; the output end of the treatment device 5 is connected with the input end of the filtering device 7, the filtering device 7 and the blood separating device 2 are arranged in a separating mode, the filtering device 7 is connected with the inactivated virus collecting device 8 through a temporary storage device 25, the output end of the filtering device 7 is connected with the input end of the feedback device 9 through an output conduit 10, and a first circulating pump 24 is arranged on the output conduit 10.

The filtering device 7 is configured to filter the virus-inactivated plasma output by the treatment device 5 to separate inactivated viruses, the inactivated viruses enter the temporary storage device 25 to be collected, and the rest of the components obtained by filtering by the filtering device 7 enter the feedback device 9.

Referring to the example shown in fig. 4, the separated plasma (containing virus) can be pumped out to the treatment device 5 through the output conduit 10 by the first circulation pump 24, after the plasma temporarily stored in the treatment device 5 is irradiated by the irradiation device 6, the treatment device 5 outputs virus-inactivated plasma, the temporary storage device 25 is matched with the filtering device 7, the filtering device 7 can be used for blocking inactivated virus, the inactivated virus blocked by the filtering device 7 is left in the temporary storage device 25, and after a certain amount of the inactivated virus is collected, the inactivated virus is input to the inactivated virus collecting device 8, and components (filtered water and other liquid) which are not blocked by the filtering device 7 are transmitted to the feedback device 9.

The filter means 7 allows passage of substances smaller than the size of the virus, while passage of viruses and substances larger than the size of the virus is prevented. Different viruses have different sizes and the parameters of the filter can be selected according to the size of virus to be protected. Typically the virus size is greater than 100 nm.

In some embodiments of the present invention, referring to fig. 5, the blood separation device 2 comprises a rotatable support structure 201 and a centrifugal separation channel 202, the centrifugal separation channel 202 being arranged on the support structure 201; the blood inlet 2021 of the centrifugal separation channel 202 is connected to the output of the lancing device 1 via the donor line 11 for introducing blood into the centrifugal separation channel 202; the output end of the centrifugal separation channel 202 is respectively provided with a plasma output port 2022 and a blood cell output port 2023; the blood cell output port 2023 is connected to the back infusion device 9 through the blood cell catheter 4; the plasma outlet 2022 is connected to the input of the treatment device 5 via the plasma tube 3; the output end of the treatment device 5 is connected with the input end of the filtering device 7, the filtering device 7 is arranged on the supporting structure 201 of the blood separation device 2 and is positioned at the inner ring of the centrifugal separation channel 202, the filtering device 7 is connected with the inactivated virus collecting device 8 through the temporary storage device 25, and the output end of the filtering device 7 is connected with the feedback device 9.

Referring to fig. 5, the filter device 7 has the structure: the device comprises a first centrifugal channel 701 and a second centrifugal channel 702 arranged on the outer ring of the first centrifugal channel 701, wherein a filter screen 703 is arranged between the first centrifugal channel 701 and the second centrifugal channel 702, and the filter screen 703 can block the inactivated viruses from passing through; the inlet 7011 of the first centrifugal passage 701 is connected with the output end of the treatment device 5 through a first conduit 26, the outlet 7012 of the first centrifugal passage 701 is connected with a second conduit 27, and the second conduit 27 is provided with a directional valve 20 and is respectively connected with the feedback device 9 and the temporary storage device 25 through the directional valve 20; the outlet end 7021 of the second centrifugal channel 702 is connected to the back-infusion device 9.

With continued reference to fig. 5, the support structure 201 is provided with the filter means 7 in addition to the centrifugal separation channel 202. Wherein the centrifugal separation channel 202 for separating blood is located at the outer ring and the filter device 7 is located at the inner ring. The outer ring of the centrifugal separation channel 202 is used to separate blood into plasma and blood cells by centrifugal force to separate plasma. The filter means 7 located in the inner circle is used for concentrating the separated plasma.

Specifically, the method comprises the following steps: the separated plasma enters the first centrifugal channel 701, and under the action of centrifugal force, the plasma is pushed into the second centrifugal channel 702 by the filter screen 703, in the process, inactivated viruses are blocked, and liquid such as water enters the second centrifugal channel 702 through the filter screen 703 and is sent into the back-flow device 9 through the outlet end 7021.

The filter mesh 703 allows passage of substances smaller than the size of the virus, while passage of viruses and substances larger than the size of the virus is prevented. Different viruses have different sizes, and the parameters of the filter screen can be selected according to the size of the virus to be resisted, and the size of the virus is usually larger than 100 nm.

The directional valve 20 is used to control the flow direction of the inactivated virus separated by the filtering device 7, which may enter the temporary storage device 25 or be transported to the feedback device 9, and may be flexibly controlled according to specific situations.

Wherein, referring to fig. 5, the outlet end 7021 of the second centrifugal channel 702 is connected to the back-infusion device 9, for example, by a third catheter 28.

Referring to fig. 6, the difference from the embodiment shown in fig. 5 is that the outlet end 7021 of the second centrifugal channel 702 is connected to the blood cell conduit 4 via a communication conduit 29. In this embodiment, after the liquid such as water not blocked by the filter screen 703 is output through the outlet end 7021 of the second centrifugal channel 702, the liquid is introduced into the blood cell conduit 4 through the communication conduit 29, and then the liquid is transported to the reinfusion device 9 through the blood cell conduit 4 together with blood cells for reinfusion.

Alternatively, the plasma output from the blood separation device 2 may be filtered by the filter device 7 and then fed to the treatment device 5 for virus inactivation.

In some embodiments of the present invention, referring to fig. 7, the blood separation device 2 comprises a rotatable support structure 201 and a centrifugal separation channel 202, the centrifugal separation channel 202 being arranged on the support structure 201; the blood inlet 2021 of the centrifugal separation channel 202 is connected to the output of the lancing device 1 via the donor line 11 for introducing blood into the centrifugal separation channel 202; the output end of the centrifugal separation channel 202 is respectively provided with a plasma output port 2022 and a blood cell output port 2023; the blood cell output port 2023 is connected to the back infusion device 9 through the blood cell catheter 4; the plasma outlet 2022 is connected to the filter device 7; the filtering device 7 is arranged on the supporting structure 201 of the blood separating device 2 and is positioned at the inner ring of the centrifugal separation channel 202, the filtering device 7 is respectively connected with the input end of the treatment device 5 and the input end of the feedback device 9, the output end of the treatment device 5 is connected with the input end of the feedback device 9, and the output end of the treatment device 5 is also connected with a temporary storage device 25.

Referring to fig. 7, the filtering device 7 includes a first centrifugal channel 701 and a second centrifugal channel 702 disposed at an outer ring of the first centrifugal channel 701, a filter screen 703 is disposed between the first centrifugal channel 701 and the second centrifugal channel 702, and the filter screen 703 can block passage of the inactivated virus; an inlet 7011 of the first centrifugal channel 701 is connected with the plasma output port 2022 through a first communicating pipe 30, an outlet 7012 of the first centrifugal channel 701 is connected with an input end of the treatment device 5 through a second communicating pipe 31, and a third circulating pump 32 is arranged on the second communicating pipe 31; the outlet end 7021 of the second centrifugal passage 702 is connected to the input end of the feedback device 9 through a third communicating pipe 33;

the output end of the treatment device 5 is connected with a fourth communicating pipe 34, the fourth communicating pipe 34 is provided with a direction valve 20, and the direction valve 20 is respectively connected with the feedback device 9 and the temporary storage device 25.

Referring to fig. 7, the plasma output from the blood separation device 2 is first sent to the filtering device 7 for filtering to obtain concentrated plasma; the concentrated plasma is then delivered to the treatment device 5 for virus inactivation. The blood cells and other components output from the blood separation device 2 are sent out to the fourth communication pipe 34 through the output end 7021 of the second centrifugal path 702, and are sent to the feedback device 9 through the fourth communication pipe 34.

The treatment device 5 can output the plasma after virus inactivation after being irradiated by the irradiation device 6, the flow direction of the plasma after virus inactivation can be controlled by the directional valve 20, the plasma can be input into the feedback device 9 as an autologous vaccine and can be feedback by the feedback device 9, or the plasma can be input into the temporary storage device 25 for temporary storage in a changed flow direction and then can be output into the inactivated virus collection device 8 for collection.

Although some specific embodiments of the present invention have been described in detail by way of examples, it should be understood by those skilled in the art that the above examples are for illustrative purposes only and are not intended to limit the scope of the present invention. It will be appreciated by those skilled in the art that modifications may be made to the above embodiments without departing from the scope and spirit of the utility model. The scope of the utility model is defined by the appended claims.

Claims

1. A vaccine preparation device is characterized by comprising

A blood collection device (1) for collecting and delivering blood;

the blood separation device (2) is used for separating the blood into plasma and blood cells, and the output end of the blood separation device (2) is respectively connected with a plasma catheter (3) and a blood cell catheter (4);

the treatment device (5) is connected with the plasma conduit (3), the plasma can be conveyed into the treatment device (5) through the plasma conduit (3), the irradiation device (6) is used for irradiating the plasma temporarily stored in the treatment device (5), and the output end of the treatment device (5) outputs the plasma after virus inactivation;

the input end of the inactivated virus collecting device (8) is connected with the output end of the treatment device (5), and at least part of the virus inactivated blood plasma output by the treatment device (5) enters the inactivated virus collecting device (8) for collection and vaccine formation;

and the input end of the feedback device (9) is respectively connected with the output ends of the blood cell catheter (4) and the treatment device (5).

2. The vaccine preparation apparatus according to claim 1, further comprising a filtration device (7), the filtration device (7) being connected between the treatment device (5), the inactivated virus collection device (8) and the return device (9).

3. The vaccine preparation apparatus according to claim 2, wherein the input of the filter device (7) is connected to the output of the treatment device (5);

the output end of the filtering device (7) is respectively connected with the input end of the inactivated virus collecting device (8) and the input end of the feedback device (9).

4. The vaccine preparation apparatus according to any one of claims 1 to 3, wherein the treatment device (5) is connected to an inactivated plasma input device (22), the inactivated plasma input device (22) being adapted to inject virus inactivated plasma into the treatment device (5);

in the case where the virus-inactivated plasma is injected into the treatment device (5), the irradiation device (6) is configured to perform secondary virus inactivation on the virus-inactivated plasma by illumination.

5. Vaccine preparation apparatus according to any of claims 1-3, wherein the input of the blood separation device (2) is connected to the output of the lancing device (1) via a feeding blood conduit (11), the blood separation device (2) being configured to separate the blood delivered by the lancing device (1) into plasma and blood cells under the influence of centrifugal force;

the output end of the blood separation device (2) is divided into two branches:

one of the branches is connected with the plasma conduit (3), the plasma conduit (3) is used for conveying the centrifugally separated plasma, a plasma pump (23) is arranged on the plasma conduit (3), and a medicine injection device (13) is also connected with the plasma conduit (3);

the other branch is connected with the blood cell catheter (4), and the blood cell catheter (4) is used for conveying the centrifuged blood cells to the back transfusion device (9).

6. The vaccine preparation apparatus according to any one of claims 1-3, further comprising a control device (15);

the control device (15) is electrically connected with the blood sampling device (1), the blood separation device (2), the irradiation device (6) and the feedback device (9) respectively;

the blood separation device (2) is connected with a blood component detection device (16), and the blood component detection device (16) is electrically connected with the control device (15);

the blood sampling device (1) is respectively connected with an anticoagulant adding device (17) and a pressure detection device (18), the feedback device (9) is connected with a feedback catheter (12), and the feedback catheter (12) is connected with a bubble detection device (19); the anticoagulant adding device (17), the pressure detection device (18) and the air bubble detection device (19) are all electrically connected with the control device (15).

7. The vaccine preparation apparatus according to claim 6, further comprising a supplementary device (14), wherein an output end of the supplementary device (14) is connected to the return conduit (12), wherein virus inactivated plasma is collected in the supplementary device (14), and wherein the virus inactivated plasma can be delivered into the patient through the return conduit (12) in a set amount.

8. The vaccine preparation apparatus according to claim 2, wherein the blood separation device (2) comprises a rotatable support structure (201) and a centrifugation channel (202), the centrifugation channel (202) being arranged on the support structure (201);

one end of the centrifugal separation channel (202) is an input end of the blood separation device, a blood input port (2021) is formed in the end, and the blood input port (2021) is connected with an output end of the blood collection device (1) through a blood supply catheter (11);

the other end of the centrifugal separation channel (202) is the output end of the blood separation device, and is provided with a plasma output port (2022) and a blood cell output port (2023) respectively, wherein the blood cell output port (2023) is connected with the input end of the feedback device (9) through the blood cell catheter (4), and the blood cell catheter (4) is provided with a blood cell pump (21).

9. The vaccine preparation apparatus according to claim 8, wherein the plasma outlet (2022) of the blood separation device (2) is connected to the input of the treatment device (5) via the plasma conduit (3);

the output end of the treatment device (5) is connected with the input end of the filtering device (7), the filtering device (7) and the blood separation device (2) are arranged in a separated mode, the filtering device (7) is connected with the inactivated virus collecting device (8) through a temporary storage device (25), the output end of the filtering device (7) is connected with the input end of the feedback device (9) through an output conduit (10), and a first circulating pump (24) is arranged on the output conduit (10);

the filtering device (7) is configured to filter the virus-inactivated plasma output by the treatment device (5) to separate inactivated virus, the inactivated virus enters the temporary storage device (25) to be collected, and the rest of the components obtained by filtering by the filtering device (7) enter the return device (9).

10. The vaccine preparation apparatus according to claim 8, wherein the plasma outlet (2022) of the blood separation device (2) is connected to the input of the treatment device (5) via the plasma conduit (3);

the output of treatment device (5) with the input of filter equipment (7) is connected, filter equipment (7) set up in on the bearing structure (201) of blood separator (2), and be located the inner circle of centrifugal separation passageway (202), filter equipment (7) through temporary storage device (25) with inactivation virus collection device (8) link to each other, the output of filter equipment (7) with reinfusion device (9) link to each other.

11. The vaccine preparation apparatus according to claim 10, wherein the filtering device (7) comprises a first centrifugal channel (701) and a second centrifugal channel (702) arranged outside the first centrifugal channel (701), a filter screen (703) is arranged between the first centrifugal channel (701) and the second centrifugal channel (702), and the filter screen (703) can block the inactivated virus from passing through;

an inlet (7011) of the first centrifugal channel (701) is connected with an output end of the treatment device (5) through a first conduit (26), an outlet (7012) of the first centrifugal channel (701) is connected with a second conduit (27), a directional valve (20) is arranged on the second conduit (27), and the second conduit is respectively connected with the temporary storage device (25) and the feedback device (9) through the directional valve (20); the outlet end (7021) of the second centrifugal channel (702) is connected to the back-feeding device (9).

12. The vaccine preparation apparatus according to claim 11, wherein the outlet end (7021) of the second centrifugation channel (702) is connected to the reinfusion device (9) by a third conduit (28).

13. The vaccine preparation apparatus according to claim 11, wherein the outlet end (7021) of the second centrifugal channel (702) is connected to the blood cell conduit (4) by a communication conduit (29).

14. The vaccine preparation apparatus according to claim 8, wherein the plasma outlet (2022) of the blood separation device (2) is connected to the filtration device (7);

the filtering device (7) is arranged on a supporting structure (201) of the blood separating device (2) and is positioned at the inner ring of the centrifugal separation channel (202), the filtering device (7) is respectively connected with the input end of the treatment device (5) and the input end of the feedback device (9), the output end of the treatment device (5) is connected with the input end of the feedback device (9), and the output end of the treatment device (5) is further connected with a temporary storage device (25).

15. The vaccine preparation apparatus according to claim 14, wherein the filtering device (7) comprises a first centrifugal channel (701) and a second centrifugal channel (702) arranged outside the first centrifugal channel (701), a filter screen (703) is arranged between the first centrifugal channel (701) and the second centrifugal channel (702), and the filter screen (703) can block the inactivated virus from passing through;

an inlet (7011) of the first centrifugal channel (701) is connected with the plasma output port (2022) through a first communicating pipe (30), an outlet (7012) of the first centrifugal channel (701) is connected with an input end of the treatment device (5) through a second communicating pipe (31), and a third circulating pump (32) is arranged on the second communicating pipe (31); the outlet end (7021) of the second centrifugal channel (702) is connected with the input end of the feedback device (9) through a third communicating pipe (33);

the output end of the treatment device (5) is connected with a fourth communicating pipe (34), a direction valve (20) is arranged on the fourth communicating pipe (34), and the fourth communicating pipe is connected with the feedback device (9) and the temporary storage device (25) through the direction valve (20).