CN215694290U - Screening mechanism of milling and mixing device for valsartan intermediate production - Google Patents
Screening mechanism of milling and mixing device for valsartan intermediate production Download PDFInfo
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- CN215694290U CN215694290U CN202122081480.7U CN202122081480U CN215694290U CN 215694290 U CN215694290 U CN 215694290U CN 202122081480 U CN202122081480 U CN 202122081480U CN 215694290 U CN215694290 U CN 215694290U
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- valsartan
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- milling
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- 238000012216 screening Methods 0.000 title claims abstract description 51
- 239000004072 C09CA03 - Valsartan Substances 0.000 title claims abstract description 38
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 title claims abstract description 38
- 229960004699 valsartan Drugs 0.000 title claims abstract description 38
- 238000002156 mixing Methods 0.000 title claims abstract description 18
- 238000003801 milling Methods 0.000 title claims abstract description 16
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 5
- 239000000463 material Substances 0.000 claims abstract description 42
- 239000008187 granular material Substances 0.000 claims abstract description 38
- 239000000843 powder Substances 0.000 claims abstract description 33
- 238000004140 cleaning Methods 0.000 claims abstract description 23
- 229920000742 Cotton Polymers 0.000 claims description 14
- 235000004237 Crocus Nutrition 0.000 claims 1
- 241000596148 Crocus Species 0.000 claims 1
- 239000002245 particle Substances 0.000 abstract description 10
- 238000001125 extrusion Methods 0.000 abstract description 5
- 238000007873 sieving Methods 0.000 description 10
- 238000000227 grinding Methods 0.000 description 7
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 6
- 239000004744 fabric Substances 0.000 description 3
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 2
- USAWIVMZUYOXCF-UHFFFAOYSA-N Valsartan metabolite Chemical compound C1=CC(C(=O)O)=CC=C1C1=CC=CC=C1C1=NNN=N1 USAWIVMZUYOXCF-UHFFFAOYSA-N 0.000 description 2
- 238000005886 esterification reaction Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000007779 soft material Substances 0.000 description 2
- 239000002253 acid Substances 0.000 description 1
- 238000005917 acylation reaction Methods 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 description 1
- 229940126317 angiotensin II receptor antagonist Drugs 0.000 description 1
- 239000002220 antihypertensive agent Substances 0.000 description 1
- 229940127088 antihypertensive drug Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000006482 condensation reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000001603 reducing effect Effects 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229960004295 valine Drugs 0.000 description 1
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- Combined Means For Separation Of Solids (AREA)
Abstract
The utility model discloses a screening mechanism of a milling and mixing device for producing a valsartan intermediate, belonging to the technical field of valsartan production equipment. And this screening mechanism includes the circulating device that box and box one side set up, circulating device and box intercommunication, and the top of box is equipped with the feed inlet, is equipped with the squeeze roll under the feed inlet, and the below of squeeze roll is equipped with the screening net, and the below of screening net is equipped with and connects the flitch, and the screening net all is equipped with cleaning device with the surface that connects the flitch, and the inner wall butt of screening net and box connects the inner wall fixed connection of flitch and box, and the screening net with connect the equal slope of flitch to set up. In addition, the circulation device can repeatedly extrude and grind the granules by the extrusion roller until the granules are screened and fall on the material receiving plate, so that the desired particle size of the valsartan intermediate powder can be obtained through the arrangement of the meshes of the screening mesh, and the uniformity of the particle size of the milled valsartan intermediate powder is ensured.
Description
Technical Field
The utility model belongs to the technical field of valsartan production equipment, and particularly relates to a screening mechanism of a milling and mixing device for producing a valsartan intermediate.
Background
The valsartan is an angiotensin II receptor antagonist antihypertensive drug and has the characteristics of lasting and stable blood pressure reducing effect and small toxic and side effects. The valsartan acid is prepared by taking L-valine as an initial raw material, performing esterification condensation reaction and acylation reaction, cyclizing with sodium azide, adjusting acid to neutralize to obtain the valsartan acid, and finally recrystallizing to obtain a final product. In the preparation process, after the valsartan intermediate obtained through the esterification reaction is dried, ground and screened, the valsartan intermediate undergoes cyclization reaction with sodium azide, and if the ground and screened granularity is not uniform, the mixing uniformity of the valsartan intermediate and the sodium azide is affected, and further the efficiency and yield of the slow reaction are affected.
In the technical field of the existing grinding and screening equipment, the granularity of the ground powder is difficult to accurately control, the powder with uniform granularity can be obtained only by manually collecting the granular materials and repeatedly putting the granular materials into the grinding and screening equipment, and the defects of time consumption and labor consumption exist.
Therefore, the utility model provides a screening mechanism of a milling and mixing device for producing a valsartan intermediate.
SUMMERY OF THE UTILITY MODEL
In order to solve the technical problems mentioned in the background technology, the utility model provides a screening mechanism of a milling and mixing device for producing a valsartan intermediate.
The purpose of the utility model can be realized by the following technical scheme:
the screening mechanism of the milling and mixing device for producing the valsartan intermediate comprises a box body and a circulating device arranged on one side of the box body, wherein the circulating device is communicated with the box body, a feed inlet is formed in the top of the box body, a squeezing roller is arranged right below the feed inlet, a screening net is arranged below the squeezing roller, a material receiving plate is arranged below the screening net, cleaning devices are arranged on the surfaces of the screening net and the material receiving plate, the screening net is abutted against the inner wall of the box body, the material receiving plate is fixedly connected with the inner wall of the box body, the screening net and the material receiving plate are obliquely arranged, a granular material outlet is formed in the abutted position of the bottom end of the screening net and the side wall of the box body, a powder material outlet is formed in the joint of the bottom end of the material receiving plate and the side wall of the box body, electromagnetic valves are arranged on the granular material outlet and the powder material outlet, and supporting legs are fixedly arranged at the bottom of the box body;
the spring is oppositely arranged on two sides of the lower portion of the screening net, the mounting plate is fixedly arranged at the bottom end of the spring, the mounting plate is fixedly connected with the side wall of the box body, the vibrating motor is fixedly arranged on the lower surface of the screening net, and then vibration of the vibrating motor drives vibration of the screening net.
Further, circulating device includes the rotating electrical machines, output one side of rotating electrical machines is equipped with the circulation case, be equipped with the rotation axis in the circulation case, rotation axis and rotating electrical machines's output fixed connection, the periphery of rotation axis is equipped with the spiral leaf, the bottom of circulation case is equipped with the granule material inlet pipe, granule material inlet pipe and granule material export intercommunication, the top of circulation case is equipped with the circulating pipe, circulating pipe and feed inlet intercommunication, the fixed support frame that is equipped with on the outer wall of circulation case, compared with the prior art, circulating device can make the granule material repeated by the squeeze roll extrusion grinding, until being selected by the screening mesh screen and falling on the flange, then the setting of accessible screening mesh hole, obtain the valsartan midbody powder granularity of wanting, and guaranteed the homogeneity of the valsartan midbody powder granularity after the grinding.
Further, cleaning device includes the mount pad, the outer wall fixed connection of mount pad and box, be equipped with the cylinder on the mount pad, the output fixedly connected with head rod of cylinder, the outer wall of box is run through on the top of head rod, and be equipped with the cleaning board, be equipped with on the cleaning board and clean the cotton, it makes for soft material to clean the cotton, two clean the cotton respectively with the screen mesh, connect the flitch contact, compared with the prior art, through cleaning device, open the cylinder, clean the cotton and clean valsartan midbody granule on the screen mesh, prevent the jam of granule to the mesh of screen mesh, it is intraductal to promote granule to get into the granule material charge, clean the cotton and clean valsartan midbody powder on the flitch, be convenient for the collection of valsartan midbody powder.
The utility model has the beneficial effects that:
according to the utility model, the circulating device can repeatedly extrude and grind the granules by the extrusion roller until the granules are screened and fall on the material receiving plate, and the desired particle size of the valsartan intermediate powder can be obtained through the arrangement of the meshes of the screening mesh, and the uniformity of the particle size of the milled valsartan intermediate powder is ensured;
the cleaning device promotes the particles to enter the particle material feeding pipe, so that the particles are prevented from blocking the meshes of the screening net; the cleaning cotton cleans the valsartan intermediate powder on the material plate, so that the valsartan intermediate powder is conveniently collected.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic structural diagram of a sieving mechanism of a milling and mixing device for producing a valsartan intermediate;
FIG. 2 is an enlarged schematic view of the structure at A in FIG. 1;
fig. 3 is a schematic top view of the screen of the present invention.
In the drawings, the components represented by the respective reference numerals are listed below:
10. a box body; 11. a feed inlet; 12. a squeeze roll; 13. screening a net; 131. a particulate material outlet; 132. a spring; 133. mounting a plate; 14. a material receiving plate; 141. a powder material outlet; 15. supporting legs; 20. a vibration motor; 30. a rotating electric machine; 31. a rotating shaft; 32. helical leaves; 33. a granular material feeding pipe; 34. a circulation pipe; 35. a support frame; 36. a circulation box; 40. a cylinder; 41. a mounting seat; 42. a first connecting rod; 43. and (4) cleaning the board.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-3, a sieving mechanism of a milling and mixing device for producing a valsartan intermediate comprises a box body 10 and a circulating device arranged on one side of the box body 10, the circulating device is communicated with the box body 10, a feed inlet 11 is arranged on the top of the box body 10, a squeezing roller 12 is arranged right below the feed inlet 11, a sieving net 13 is arranged below the squeezing roller 12, a material receiving plate 14 is arranged below the sieving net 13, cleaning devices are arranged on the surfaces of the sieving net 13 and the material receiving plate 14, the sieving net 13 is abutted against the inner wall of the box body 10, the material receiving plate 14 is fixedly connected with the inner wall of the box body 10, the sieving net 13 and the material receiving plate 14 are obliquely arranged, a granular material outlet 131 is arranged at the abutted position of the bottom end of the sieving net 13 and the side wall of the box body 10, a powder material outlet 141 is arranged at the connection position of the bottom end of the material receiving plate 14 and the side wall of the box body 10, electromagnetic valves are arranged at the granular material outlet 131 and the powder material outlet 141, the bottom of the box body 10 is fixedly provided with supporting legs 15;
the circulation device comprises a rotary motor 30, a circulation box 36 is arranged on one side of the output end of the rotary motor 30, a rotary shaft 31 is arranged in the circulation box 36, the rotary shaft 31 is fixedly connected with the output end of the rotary motor 30, spiral blades 32 are arranged on the periphery of the rotary shaft 31, a granular material feeding pipe 33 is arranged at the bottom of the circulation box 36, the granular material feeding pipe 33 is communicated with a granular material outlet 131, a circulation pipe 34 is arranged at the top of the circulation box 36, the circulation pipe 34 is communicated with a feeding hole 11, and a support frame 35 is fixedly arranged on the outer wall of the circulation box 36;
cleaning device includes mount pad 41, the outer wall fixed connection of mount pad 41 and box 10, be equipped with cylinder 40 on the mount pad 41, the output fixedly connected with head rod 42 of cylinder 40, the outer wall of box 10 is run through on head rod 42's top, and be equipped with cleaning plate 43, be equipped with on cleaning plate 43 and clean the cotton, it makes for soft material to clean the cotton, two clean the cotton respectively with the screen cloth 13, connect flitch 14 contact, compared with the prior art, through cleaning device, open cylinder 40, clean the cotton and clean the valsartan midbody granule on the screen cloth 13, prevent the jam of granule to the mesh of screen cloth 13, promote in the granule gets into granule material inlet pipe 33, clean the cotton and clean the valsartan midbody powder on the flitch 14, be convenient for the collection of valsartan midbody powder.
The working principle is as follows:
grinding and sieving operations: the valsartan intermediate enters the interior of the box body 10 through the feeding hole 11, is ground and extruded by the extrusion roller 12 to form a mixture of particles and powder, the vibration motor 20 is started, the mixture is divided into particles and powder under the action of the screening mesh 13, the powder falls on the material receiving plate 14, and the particles are left on the surface of the screening mesh 13;
repeated grinding of the granules: closing the vibration motor 20, opening electromagnetic valves in the air cylinder 40 and the granular material outlet 131, allowing the granules to enter the granular material feeding pipe 33 under the action of the cleaning cotton and then enter the circulating box 36, grinding and extruding the granules again through the extrusion roller 12 through the circulating pipe 34 and the feeding hole 11 under the action of the spiral blade 32 to obtain smaller granular materials and powder, and repeating the sieving operation;
collecting powder materials: and opening electromagnetic valves in the cylinder 40 and the powder outlet 141, cleaning the powder on the material plate 14 by the cleaning cotton, so that the powder enters the powder outlet 141 and is discharged out of the box body 10, and collecting the powder.
In the description herein, references to the description of "one embodiment," "an example," "a specific example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the utility model. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The foregoing is merely exemplary and illustrative of the present invention, and various modifications, additions and substitutions may be made by those skilled in the art to the specific embodiments described without departing from the scope of the utility model as defined in the accompanying claims.
Claims (8)
1. Screening mechanism of crocus blending device for valsartan intermediate production, including box (10), the top of box (10) is equipped with feed inlet (11), is equipped with squeeze roll (12) under feed inlet (11), and the below of squeeze roll (12) is equipped with screening net (13), its characterized in that:
a circulating device is arranged on one side of the box body (10), the circulating device is communicated with the box body (10), a cleaning device is arranged on the surface of the screening net (13), the screening net (13) is abutted against the inner wall of the box body (10), the screening net (13) is obliquely arranged, a granular material outlet (131) is arranged at the abutted position of the bottom end of the screening net (13) and the side wall of the box body (10), a powder material outlet (141) is arranged on the side wall of the box body (10), the powder material outlet (141) is positioned below the granular material outlet (131), and electromagnetic valves are arranged in the granular material outlet (131) and the powder material outlet (141);
the spring (132) is oppositely arranged on two sides of the lower portion of the screening net (13), the mounting plate (133) is fixedly arranged at the bottom end of the spring (132), the mounting plate (133) is fixedly connected with the side wall of the box body (10), and the vibrating motor (20) is fixedly arranged on the lower surface of the screening net (13).
2. The screening mechanism of the milling and uniformly mixing device for producing the valsartan intermediate as claimed in claim 1, which is characterized in that: a material receiving plate (14) is arranged below the screening net (13), the material receiving plate (14) is fixedly connected with the inner wall of the box body (10), the material receiving plate (14) is obliquely arranged, and the bottom end of the material receiving plate (14) is close to the powder outlet (141).
3. The screening mechanism of the milling and uniformly mixing device for producing the valsartan intermediate as claimed in claim 2, which is characterized in that: the surface of the material receiving plate (14) is provided with a cleaning device.
4. The screening mechanism of the milling and uniformly mixing device for producing the valsartan intermediate as claimed in claim 1, which is characterized in that: circulating device includes rotating electrical machines (30), output one side of rotating electrical machines (30) is equipped with circulation case (36), be equipped with rotation axis (31) in circulation case (36), the output fixed connection of rotation axis (31) and rotating electrical machines (30), the periphery of rotation axis (31) is equipped with spiral leaf (32), the bottom of circulation case (36) is equipped with granule material inlet pipe (33), granule material inlet pipe (33) and granule material export (131) intercommunication, the top of circulation case (36) is equipped with circulating pipe (34), circulating pipe (34) and feed inlet (11) intercommunication.
5. The screening mechanism of the milling and uniformly mixing device for producing the valsartan intermediate as claimed in claim 4, which is characterized in that: a supporting frame (35) is fixedly arranged on the outer wall of the circulating box (36).
6. The screening mechanism of the milling and uniformly mixing device for producing the valsartan intermediate as claimed in claim 1, which is characterized in that: the cleaning device comprises a mounting seat (41), wherein an air cylinder (40) is arranged on the mounting seat (41), a first connecting rod (42) is fixedly connected to the output end of the air cylinder (40), the top end of the first connecting rod (42) penetrates through the outer wall of the box body (10), a cleaning plate (43) is arranged, and cleaning cotton is arranged on the cleaning plate (43).
7. The screening mechanism of the milling and uniformly mixing device for producing the valsartan intermediate as claimed in claim 6, which is characterized in that: the mounting seat (41) is fixedly connected with the outer wall of the box body (10).
8. The screening mechanism of the milling and uniformly mixing device for producing the valsartan intermediate as claimed in claim 6, which is characterized in that: the bottom of the box body (10) is fixedly provided with supporting legs (15).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122081480.7U CN215694290U (en) | 2021-08-31 | 2021-08-31 | Screening mechanism of milling and mixing device for valsartan intermediate production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122081480.7U CN215694290U (en) | 2021-08-31 | 2021-08-31 | Screening mechanism of milling and mixing device for valsartan intermediate production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN215694290U true CN215694290U (en) | 2022-02-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202122081480.7U Active CN215694290U (en) | 2021-08-31 | 2021-08-31 | Screening mechanism of milling and mixing device for valsartan intermediate production |
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| CN (1) | CN215694290U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115096044A (en) * | 2022-06-20 | 2022-09-23 | 福建省清流县东莹化工有限公司 | Energy-saving fluorite powder drying furnace |
-
2021
- 2021-08-31 CN CN202122081480.7U patent/CN215694290U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115096044A (en) * | 2022-06-20 | 2022-09-23 | 福建省清流县东莹化工有限公司 | Energy-saving fluorite powder drying furnace |
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