CN215611660U - Reagent container - Google Patents

Abstract

The application relates to the technical field of medical equipment, in particular to a reagent container. The reagent container comprises a body and a cover body, wherein the body is internally provided with at least one cavity with an opening at the top; a groove is arranged between the outer wall of the cavity and the inner wall of the body; the bottom of the cover body is convexly provided with a bulge corresponding to the groove; the protruding end of the protrusion protrudes towards the concave surface of the groove and is provided with an ultrasonic melting part, and the ultrasonic melting part deforms and melts in an ultrasonic environment to fill a gap covered by the groove and the protrusion. The reagent container provided by the application solves the technical problems of poor sealing performance and high cost in the prior art.

Description

Reagent container

Technical Field

The application relates to the technical field of medical equipment, in particular to a reagent container.

Background

In the in vitro diagnostic equipment such as immunochemiluminescence analyzer, reagent such as magnetic bead liquid, enzyme labeling liquid, diluent is subpackaged to each cavity of reagent container usually, when needing to detect and use, install the reagent container on the mounting structure of the reagent storehouse of equipment again, remove the reagent that needs from the cavity through the suction means of equipment such as pipetting needle, a mode of practicing thrift the cost is that the reagent in each cavity can supply to detect many times and use, consequently need each cavity to form airtight space and be convenient for store and prevent that the reagent from revealing, volatilize and prevent that the foreign matter from falling into in the reagent.

However, in the prior art, the reagent container is generally divided into two parts, and then the two parts are locked by the locking structure to form the reagent container with two internal cavities, but in the reagent container with such a structure, during use, especially during transportation, the reagent is likely to leak or permeate from the locking joint, the sealing performance is not good, and in order to enhance the sealing performance, a sealing gasket, a silica gel pad and the like are further arranged at the joint, so that the cost is increased, the cost is high, and the sealing performance is general.

SUMMERY OF THE UTILITY MODEL

The application aims to provide a reagent container to solve the technical problems that the existing reagent container is poor in sealing performance and high in cost.

The application provides a reagent container, includes:

a body having at least one open-topped chamber therein; and

the cover body is covered on the top of the cavity;

a concave groove which is downwards concave from the top opening is arranged between the outer wall of the cavity and the inner wall of the body; the bottom of the cover body is convexly provided with a bulge corresponding to the groove, and the bulge covers the groove;

the protruding end of the protrusion is provided with an ultrasonic melting part protruding towards the concave surface of the groove,

the ultrasonic melting part is in an ultrasonic environment and deforms and melts to fill in a gap covered by the groove and the protrusion.

Furthermore, at least two cavities are arranged in the body;

the groove is arranged between the outer walls of two adjacent cavities, or

A partition is arranged between every two adjacent cavities, and the groove is formed between the outer wall of the partition and the outer wall of each cavity;

the bottom of the cover body is provided with the bulge corresponding to the protrusion of the groove, and the protruding extending end of the bulge is provided with the ultrasonic melting part towards the concave surface of the groove in a protruding mode.

Furthermore, the groove is a U-shaped through groove which extends transversely along the outer wall of the cavity.

Further, the volume of the ultrasonic melting part is less than or equal to the volume of the gap; and/or

The structural shape of the ultrasonic melting part is a conical body with a downward tip; and/or

The ultrasonic melting part is made of plastic or plastics.

Further, the volume of the ultrasonic melting portion is greater than or equal to 0.3 times the volume of the gap and less than or equal to 0.6 times the volume of the gap.

Furthermore, the outer wall of the cover body corresponding to the cover opening formed in the cavity is in threaded connection with the inner wall of the spiral cover.

Furthermore, a PE sealing film is sealed on the opening of the cover opening,

and a silicone membrane is laid between the PE sealing membrane and the top of the screw cap in a sealing manner.

Furthermore, the silicon pellosil is provided with cross slits.

Further, at least one cavity is internally provided with a reagent bottle which can be detachably connected, and correspondingly, the bottom of at least one cavity is provided with a rotary clamping groove;

the rotary clamping groove is used for correspondingly clamping with the circumferential groove of the reagent bottle,

the bottom of reagent bottle is provided with gear engagement portion, gear engagement portion is used for meshing with the gear drive portion in the equipment.

Further, the inner wall of body is provided with the ladder face to inside lateral protrusion along its circumference, the ladder face indulge on with the interval has between the topside of body, the ladder face with the topside parallel and level of cavity sets up.

Compared with the prior art, set up between reagent container's the body inner wall and the cavity outer wall by the concave recess of open-top side down for close sealedly with the protruding lid that lid bottom protrusion set up, the bellied concave surface protrusion that stretches out the end towards this recess is equipped with ultrasonic melting portion, this ultrasonic melting portion can warp the melting under ultrasonic operating environment, because the arch closes natural decurrent extrusion force with the recess lid, liquid after melting itself can automatic flow to and fill the gap before recess and the arch, secondly because aforementioned extrusion force also can add the mobile trend force of a extrusion of liquid to, impel it to fill this gap. The structure arrangement can ensure that the body and the cover body are completely sealed, effectively prevents the leakage or the permeation of the reagent in the cavity, greatly increases the sealing property of the structure, simultaneously does not need to add a sealing gasket, a sealing strip, a silica gel pad and the like, has lower cost, and has lower material cost for manufacturing the ultrasonic melting part. The technical problems of poor sealing performance and high cost of the conventional reagent container are solved.

Drawings

In order to more clearly illustrate the detailed description of the present application or the technical solutions in the prior art, the drawings needed to be used in the detailed description of the present application or the prior art description will be briefly introduced below, and it is obvious that the drawings in the following description are some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative efforts.

FIG. 1 is a schematic structural diagram of a reagent container provided in an embodiment of the present application;

FIG. 2 is an exploded view of a reagent container provided in an embodiment of the present application;

FIG. 3 is an enlarged view of portion A shown in FIG. 2;

fig. 4 is a schematic structural diagram of a cover provided in the embodiment of the present application;

FIG. 5 is a longitudinal cross-sectional view of a reagent vessel provided in an embodiment of the present application;

fig. 6 is an enlarged view of a portion B shown in fig. 5;

fig. 7 is an enlarged view of the ultrasonic melting portion of portion B shown in fig. 5 before melting.

Reference numerals:

10-a body; 11-a cavity; 12-a groove; 13-separation; 14-step surface; 20-a cover body; 21-bulge; 22-ultrasonic melting section; 221-a liquid; 23-cover opening; 30-a gap; 40-screwing a cover; 50-PE sealing film; 60-silica gel membrane; 70-reagent bottle; 71-gear mesh; 72-circumferential groove.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are some embodiments of the present application, but not all embodiments. The components of the embodiments of the present application, generally described and illustrated in the figures herein, can be arranged and designed in a wide variety of different configurations.

Thus, the following detailed description of the embodiments of the present application, presented in the accompanying drawings, is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.

In the description of the present application, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings or orientations or positional relationships that the products of the application usually place when in use, and are used only for convenience in describing the present application and simplifying the description, but do not indicate or imply that the devices or elements being referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present application. Furthermore, the terms "first," "second," "third," and the like are used solely to distinguish one from another and are not to be construed as indicating or implying relative importance.

Furthermore, the terms "horizontal", "vertical", "overhang" and the like do not imply that the components are required to be absolutely horizontal or overhang, but may be slightly inclined. For example, "horizontal" merely means that the direction is more horizontal than "vertical" and does not mean that the structure must be perfectly horizontal, but may be slightly inclined.

In the description of the present application, it is further noted that, unless expressly stated or limited otherwise, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present application can be understood in a specific case by those of ordinary skill in the art.

Some embodiments of the present application will be described in detail below with reference to the accompanying drawings. The embodiments described below and the features of the embodiments can be combined with each other without conflict.

As shown in fig. 1 to 7, the present application provides a reagent container for containing a diagnostic reagent, wherein the diagnostic reagent composition may specifically include a magnetic bead solution, an enzyme labeling solution, a diluent, and the like, and when a detection use is required, the reagent container is mounted on a mounting structure in a reagent chamber of a device, and the required diagnostic reagent is removed by a suction device of the device, such as a pipette needle. The reagent container provided by the embodiment of the application comprises a body 10 and a cover body 20, wherein at least one cavity 11 with an open top is arranged in the body 10, a plurality of cavities 11 can be transversely arranged, and the cover body 20 covers the top of the cavity 11. A groove 12 is formed between the outer wall of at least one of the cavities 11 and the inner wall of the body 10, the groove 12 is formed by a top opening which is recessed downward, a protrusion 21 is formed at the bottom of the cover body 20 corresponding to the protrusion of the groove 12, the protrusion 21 covers the groove 12, an ultrasonic melting part 22 is formed at the protruding end of the protrusion 21 facing the concave surface of the groove 12, the ultrasonic melting part 22 can be deformed and melted in an ultrasonic environment, and the ultrasonic melting part 22 can be made of thermoplastic materials such as plastic and plastics, and the specific principle is as follows: ultrasonic waves act on the contact surface of the ultrasonic melting part 22 made of thermoplastic plastics, plastics and the like, high-frequency vibration of tens of thousands of times per second is generated, the high-frequency vibration reaching a certain amplitude transmits ultrasonic energy to the ultrasonic melting part, large local high temperature is generated due to large acoustic resistance at the gap between the groove 12 and the protrusion 21, and the ultrasonic melting part 22 made of the thermoplastic materials is melted immediately. When the reagent vessel is manufactured, the ultrasonic melting part 22 is deformed and melted in the ultrasonic environment, and the melted liquid 221 fills the gap 30 where the groove 12 and the protrusion 21 are covered, as shown in fig. 6, to achieve better sealing.

The reagent container provided by the embodiment of the application is characterized in that a groove 12 which is downwards concave from an opening at the top is formed between the inner wall of a body 10 of the reagent container and the outer wall of a cavity 11 and is used for covering and sealing a protrusion 21 which is convexly arranged at the bottom of a cover body 20, an ultrasonic melting part 22 is convexly arranged at the extending end of the protrusion 21 towards the concave surface of the groove 12, the ultrasonic melting part 22 can be deformed and melted under an ultrasonic environment, when the reagent container is manufactured, an ultrasonic generator can extrude the cover body 20 towards the body 10 while emitting ultrasonic waves, melted liquid 221 can automatically flow to and fill a gap 30 between the groove 12 and the protrusion 21, and the extruding force can further apply a flowing trend force of the liquid towards the extruding direction to enable the liquid to fill the gap 30. The ultrasonic generator is commercially available, and different types of ultrasonic generators can be selected according to the material characteristics of the ultrasonic melting part, for example, the ultrasonic generator is selected from a flexible L3000 Advanced plastic welding machine, and the ultrasonic melting part is selected from ABS or PE material. Compared with the prior art, this kind of structure setting can make between body 10 and the lid 20 totally sealed, effectively prevents revealing or the infiltration of reagent in the cavity 11, greatly increased the leakproofness of structure, need not simultaneously to add sealed pad, sealing strip, silica gel pad etc. the cost is lower to the material of making ultrasonic melting portion 22 is mostly thermoplastic material such as plastic, plastics, and low cost such as plastic, plastics easily obtains, and the cost is also lower. The technical problems of poor sealing performance and high cost of the conventional reagent container are solved.

As shown in fig. 2, 3 and 5, at least two cavities 11 are provided in the body 10, and the plurality of cavities 11 can increase the reagent capacity and can separately contain a plurality of diagnostic reagents. An alternative embodiment is that the groove 12 is arranged between the outer walls of two adjacent cavities 11, another alternative embodiment is that a partition 13 is arranged between two adjacent cavities 11, the groove 12 is arranged between the outer wall of the partition 13 and the outer wall of the cavity 11, correspondingly, the bottom of the cover body 20 is also convexly provided with a bulge 21 corresponding to the groove 12, and the protruding end of the bulge 21 is also convexly provided with an ultrasonic melting part 22 facing the concave surface of the groove 12. The arrangement can further improve the structural tightness of the reagent container, and further effectively prevent the leakage or the penetration of the reagent.

As a further example, as shown in fig. 2 and 3, the groove 12 may be a U-shaped through groove extending transversely along the outer wall of the cavity 11. This maximizes the sealing interface at the top edge of the cavity 11, thereby maximizing the sealing performance of the structure.

As another further example, in view of the convenience of extrusion and the sensitivity of extrusion reaction, as shown in fig. 7, the ultrasonic melting part 22 may be a cone with a downward tip, so as to facilitate extrusion and melt flow, and the structural shape of the ultrasonic melting part 22 is not particularly limited, and may be a cone, a cylinder, a block, or an irregular shape, as long as it protrudes from the protruding end of the protrusion 21. In addition, when the cover 20 and the body 10 are not covered, i.e. the reagent container is not completely manufactured, as shown in fig. 7, there is a certain distance between the bottom of the cover 20 and the top of the body 10, but the protrusion 21 is at least partially located in the groove 12.

In a further embodiment, the volume of the ultrasonic melting part 22 is smaller than or equal to the volume of the gap 30 between the groove 12 and the protrusion 21, so that the melted liquid 221 can be prevented from overflowing the top surface of the groove 12 and falling into the cavity 11 or other positions in the body 10, and the overflow of the liquid 221 can be effectively prevented while achieving a good sealing effect.

Preferably, the critical curve of the effect of ultrasonic welding is applied to the volume V of the ultrasonic melt section 22₁And volume V of gap 30₂Evaluation was performed in which the ultrasonic generator power P satisfied the relation (1): p is 4 μ SFAf, where μ is the coefficient of friction between the sonotrode and the piece to be welded, S is the weld area, F is the static pressure of the sonotrode, a is the amplitude of the sonotrode, and F is the vibration frequency of the sonotrode. In the formula (1), μ, F, A, f are given by the ultrasonic generator, and S can be considered approximately as the volume V of the ultrasonic melting portion 22₁Volume V of gap 30₂Ratio of (S ≈ V)₁/V₂The applicant accidentally finds that when the value of S is adjusted to be more than or equal to 0.3 and less than or equal to 0.6, the welding effect does not have the condition of weak combination or overlarge deformation, namely when V is more than or equal to 0.3 and less than or equal to V₁/V₂When the critical curve is less than or equal to 0.6, the effect evaluation in the critical curve is positioned at the optimal position in the middle section. So that the volume V of the ultrasonic melting part 22₁Volume V of gap 30 greater than or equal to 0.3 times₂And less than or equal to 0.6 times the volume V of the gap 30₂Namely, satisfies the relation (2): 0.3V₂≤V₁≤0.6V₂(2) By the arrangement, a good sealing effect can be ensured, the melted liquid 221 can be well prevented from overflowing the top surface of the groove 12, and further the liquid 221 is effectively prevented from undesirably falling into the cavity 11 or other positions in the body 10, and the overflow of the liquid 221 is effectively prevented.

In order to make the bottom surface of the cover 20 fit with the top surface of the body 10 more closely to further improve the sealing performance of the structure, as shown in fig. 2 and 3, the inner wall of the body 10 may be provided with a stepped surface 14 protruding laterally inward along the circumferential direction thereof, the stepped surface 14 being spaced apart from the top edge of the body 10 in the longitudinal direction, and the stepped surface 14 being disposed flush with the top edge of the cavity 11.

In a preferred embodiment, as shown in fig. 2, the cover body 20 is provided with a cover opening 23 corresponding to each cavity 11, and the outer wall of the cover opening 23 is provided with threads capable of being in threaded connection with both inner walls of the screw cap 40. The connection mode has better sealing performance. Further, a PE sealing film 50 may be sealingly laid on the opening of the cap opening 23 to further improve the sealing performance of the opening. Preferably, a silicone membrane 60 is further disposed between the PE sealing membrane 50 and the top of the screw cap 40 to further improve the sealing performance of the opening. Furthermore, the silicone membrane 60 may be scribed with cross-cuts, which may be preferably cross-cuts, so as to facilitate the puncturing mechanism or the suction device of the apparatus, such as a pipette needle, to more easily penetrate the silicone membrane 60 and suck the reagent in the cavity 11.

Further, as shown in fig. 2, in at least one cavity 11 of the embodiment of the present application, a detachably connected reagent bottle 70 is disposed, correspondingly, a rotary clamping groove is disposed at the bottom of at least one cavity 11, the rotary clamping groove is used for being connected with a circumferential groove 72 of the reagent bottle 70, a gear engaging portion 71 is further disposed at the bottom end of the reagent bottle 70, the gear engaging portion 71 is engaged with a gear driving portion in the apparatus, so that the reagent bottle 70 can rotate relative to the body 10 in the cavity 11, so as to uniformly mix the reagents in the reagent bottle 70.

Finally, it should be noted that: the above embodiments are only used for illustrating the technical solutions of the present application, and not for limiting the same; although the present application has been described in detail with reference to the foregoing embodiments, it should be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present application.

Claims (10)

1. A reagent container, comprising:

a body having at least one open-topped chamber therein; and

the cover body is covered on the top of the cavity;

a concave groove which is downwards concave from the top opening is arranged between the outer wall of the cavity and the inner wall of the body; the bottom of the cover body is convexly provided with a bulge corresponding to the groove, and the bulge covers the groove;

the protruding end of the protrusion is provided with an ultrasonic melting part protruding towards the concave surface of the groove,

the ultrasonic melting part is in an ultrasonic environment and deforms and melts to fill in a gap covered by the groove and the protrusion.

2. Reagent vessel according to claim 1,

at least two cavities are arranged in the body;

the groove is arranged between the outer walls of two adjacent cavities, or

A partition is arranged between every two adjacent cavities, and the groove is formed between the outer wall of the partition and the outer wall of each cavity;

the bottom of the cover body is provided with the bulge corresponding to the protrusion of the groove, and the protruding extending end of the bulge is provided with the ultrasonic melting part towards the concave surface of the groove in a protruding mode.

3. Reagent vessel according to claim 1 or 2,

the groove is a U-shaped through groove and transversely extends along the outer wall of the cavity.

4. Reagent vessel according to claim 1 or 2,

the volume of the ultrasonic melting part is less than or equal to the volume of the gap; and/or

The structural shape of the ultrasonic melting part is a conical body with a downward tip; and/or

The ultrasonic melting part is made of plastic or plastics.

5. Reagent vessel according to claim 4,

the volume of the ultrasonic melting part is greater than or equal to 0.3 times the volume of the gap and less than or equal to 0.6 times the volume of the gap.

6. Reagent vessel according to claim 1,

the outer wall of the cover body corresponding to the cover opening formed in the cavity is in threaded connection with the inner wall of the spiral cover.

7. Reagent vessel according to claim 6,

a PE sealing film is sealed on the opening of the cover opening,

and a silicone membrane is laid between the PE sealing membrane and the top of the screw cap in a sealing manner.

8. Reagent vessel according to claim 7,

the silicon pellicles are provided with crossed scoring seams.

9. The reagent container of claim 2, wherein at least one of the cavities is provided with a reagent bottle which can be detachably connected, and correspondingly, the bottom of at least one of the cavities is provided with a rotary clamping groove;

the rotary clamping groove is used for correspondingly clamping with the circumferential groove of the reagent bottle,

the bottom of reagent bottle is provided with gear engagement portion, gear engagement portion is used for meshing with the gear drive portion in the equipment.

10. Reagent vessel according to claim 2,

the inner wall of body is provided with the ladder face to inside lateral protrusion along its circumference, the ladder face indulge upward with the interval has between the topside of body, the ladder face with the topside parallel and level of cavity sets up.

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