CN215610676U

CN215610676U - Liquid storage vehicle

Info

Publication number: CN215610676U
Application number: CN202120730972.1U
Authority: CN
Inventors: 胡福林; 周程凯; 冯云峰; 梅武威; 韩伟
Original assignee: Zhejiang JYSS Bio Engineering Co Ltd
Current assignee: Zhejiang JYSS Bio Engineering Co Ltd
Priority date: 2021-04-12
Filing date: 2021-04-12
Publication date: 2022-01-25
Anticipated expiration: 2031-04-12

Abstract

The utility model provides a liquid storage vehicle which comprises a barrel body with an upward opening, wherein a liquid storage bag can be mounted in the barrel body, the bottom of the barrel body is connected with a bottom frame, and the bottom frame is detachably connected or fixedly connected with the barrel body; the side surface of the barrel body is provided with a door which can be opened or closed; the shape of staving is cylindric, and the material of staving is stainless steel. Compared with the traditional bioreactor which is directly mixed and stirred with liquid, the bioreactor has the advantages of simple operation, stable production process, short batch preparation time, high production efficiency, no need of accessory facilities such as complex pipelines and the like, no need of cleaning, disinfection and sterilization, low production cost, easy passing verification and the like, and has better application scenes in the development and production of modern biotechnology drugs.

Description

Liquid storage vehicle

Technical Field

The utility model relates to the technical field of biological instruments, in particular to a liquid storage vehicle.

Background

Under the background that the biopharmaceuticals are increasingly hot, the traditional medicine production mode cannot adapt to the requirements of the biopharmaceuticals, and because the probability of developing the biopharmaceuticals from concepts to complete commercialization is extremely low, a flexible, low-cost and reconfigurable production platform is a key for quickly recombining the existing production line for production.

Disclosure of Invention

The utility model aims to provide a liquid storage vehicle, aims to optimize complex stirring application, provides a better solution for laboratories and pilot plants, and can meet all stirring and mixing requirements.

The technical scheme adopted by the utility model is that the liquid storage vehicle comprises a barrel body with an upward opening, wherein a liquid storage bag can be mounted in the barrel body, the liquid storage bag is a disposable flexible plastic container with good biological safety, and the container is fixed in the barrel body, and is simple and safe to use.

Further, in some large-volume barrels, such as a 1000L barrel and a 500L barrel, because of their large volumes, the liquid storage bags are difficult to install, and in order to facilitate the installation of the liquid storage bags, it is preferable that a door capable of being opened or closed is arranged on the side surface of the barrel, and the installation of the liquid storage bags in the barrel can be facilitated through the door; and the side surfaces of the barrels with smaller volumes, namely the 100L barrels, are not provided with doors.

Furthermore, the barrel body is made of stainless steel materials, the shape of the barrel body is cylindrical, the liquid storage bag is convenient to install, meanwhile, the stainless steel materials can resist corrosion of culture solution, and the service life of the device is prolonged.

Furthermore, on some barrel bodies with doors on the side surfaces, two convex strips are arranged on the barrel bodies and are arranged in parallel, the doors are located between the two convex strips, the barrel bodies are hollow at the door positions, the doors are hinged with the convex strips on one side, locking structures capable of being fixed with the doors are arranged on the convex strips on the other side, and when the locking structures are opened, the doors can freely rotate according to the hinged positions; when the locking structure is closed, one side of the door locking structure is clamped with the corresponding convex strip, so that the locking of the door is realized. Specifically, the locking structure can be a rotatable handle and a stop block, and the handle and the stop block are respectively arranged on the door, the convex strip or the convex strip and the door.

Further, the staving bottom is connected with the underframe frame, is equipped with the universal wheel that the stock solution car of being convenient for removed on the underframe frame, underframe frame and staving detachable connection or fixed connection: the detachable connection mode is convenient for the barrel body to be taken down after the barrel body is moved to a designated position, and at the moment, the bottom frame can be continuously used for the movement of other barrel bodies; the mode of fixed connection makes can not separate between staving and the underframe frame, and at the removal in-process, the wholeness is good, and when the underframe frame moved on the inclined plane, the staving still can not separate with the underframe frame. As an optimal technical scheme, a fixed connection mode is adopted, a support column is arranged on the bottom frame, and the support column and the barrel body are welded together. Furthermore, the bottom frame is C-shaped, and part of universal wheels on the bottom frame are provided with locking structures.

Further, for the convenience of movement of the liquid storage vehicle, for some large-size barrels, such as a 1000L barrel and a 500L barrel, a transverse handle and a longitudinal handle are arranged on the barrels, the transverse handle and the longitudinal handle are both used for facilitating an operator to drive the liquid storage vehicle to move, the transverse handle facilitates pushing of the liquid storage vehicle, and the longitudinal handle facilitates pulling of the liquid storage vehicle. Specifically, the number of the transverse handles is one, and the number of the longitudinal handles is two. For some staving with smaller volume, for example 100L staving, only one handle is arranged on the staving, the handle is provided with two horizontal sections and two vertical sections, the horizontal section is provided with one, two ends of the horizontal section are respectively connected with the two vertical sections, and the two vertical sections are respectively connected to the staving. The handle has the advantages of a transverse handle and a longitudinal handle, and is convenient for an operator to drive the liquid storage vehicle to move.

Further, be equipped with the observation hole on the side of staving, the observation hole is the strip and vertical arrangement, and the observation hole makes things convenient for operating personnel to observe the condition of the inside cell culture of liquid storage bag from the outside. Preferably, the observation holes are provided with two or more than two, and are positioned on the same straight line in the vertical direction, so that the different height positions of the liquid storage bag can be conveniently observed. Further, when the door is provided on the tub, a part or all of the observation holes are located on the door.

Furthermore, be equipped with the electrode hole on the staving, the electrode hole is strip and level and arranges, and the side that the electrode hole is located the staving is close to the bottom position, lies in the electrode hole position on the staving and is equipped with folding electrode holder, can carry out the installation of electrode through electrode holder, and the electrode can insert the stock solution bag in the staving through the electrode hole.

Furthermore, a liquid outlet is arranged at the bottom of the barrel body, so that liquid can be conveniently discharged from the liquid storage bag in the barrel body.

Furthermore, a stirring device is matched and matched with the liquid storage vehicle, the stirring device comprises a stirrer and a control platform for controlling the stirrer to move, the stirrer is installed at the upper end of the telescopic arm, the control platform can control the telescopic arm to move up and down, so that the stirrer can stir culture liquid in liquid storage bags in the liquid storage vehicles with different sizes, and a scale is fixedly arranged on one side of the telescopic arm, so that when the telescopic arm moves, an operator can quickly know the distance that the telescopic arm contracts at the moment; meanwhile, the angle of the stirrer can be adjusted by the control platform, the stirrer is detachably connected with a stirring paddle, and the stirring angle of the stirring paddle is adjusted by adjusting the angle of the stirrer; moreover, the control platform can be used for controlling the stirring speed of the stirring paddle, so that the stirring paddle is suitable for different culture solutions.

Further, the agitator is installed on control platform, and control platform installs on the chassis, and the chassis bottom also is equipped with the universal wheel, makes things convenient for the holistic removal of agitating unit, still is equipped with the fixed position of stirring rake on the agitating unit, and the stirring rake that dismantles can be inserted on the fixed position of stirring rake, still is equipped with the handle on the chassis, and operating personnel can drive the agitating unit motion through pulling or promotion handle.

Further, when the culture solution in the liquid storage vehicle is stirred by the stirring device, the stirring device and the liquid storage vehicle are preferably ensured to be relatively fixed, if the stirring device and the liquid storage vehicle move relatively in the stirring process, and if the stirring device and the liquid storage vehicle are light, a stirring paddle in the stirring device is in contact with a liquid storage bag in the barrel body, so that the liquid storage bag is broken, and the culture solution leaks; and when the weight is heavy, the stirring paddle hits the inner wall of the barrel body, so that the stirring paddle or the stirrer is damaged. In order to solve the problem, preferably, the stirring device is provided with a fixing structure, and the fixing structure can realize locking between the stirring device and the liquid storage vehicle and avoid moving. As preferred technical scheme, fixed knot constructs for a cardboard, is equipped with the buckle of arranging in pairs on the cardboard, and the buckle can be detained the underframe of stock solution car in the centre, has accomplished the locking between agitating unit and the stock solution car this moment promptly. Because the stock solution car has multiple size, the underframe size of the stock solution car of unidimensional is different, consequently corresponds on the cardboard to be equipped with many buckles different to the interval, pairs with the stock solution car of unidimensional respectively for agitating unit is applicable to the stock solution car of unidimensional, and the suitability is strong.

In conclusion, the beneficial effects of the utility model are as follows: the liquid storage vehicle provided by the utility model has a rigid container made of stainless steel, disposable flexible plastic with good biological safety and used for contacting with a medium is arranged in the container, and compared with the traditional bioreactor, the mode of directly mixing and stirring the liquid with the liquid has the advantages of simple operation, stable production process, short batch preparation time, high production efficiency, no need of accessory facilities such as complex pipelines, no need of cleaning, disinfection and sterilization, low production cost, easy passing verification and the like, and has better application scenes in the development and production of modern biotechnology drugs; the liquid storage vehicle and the stirring device are matched for use, so that the requirements of stirring and mixing media with different viscosities can be met; the stirring device can be matched with liquid storage vehicles of different sizes for use, and the platform capable of being quickly recombined is flexible in use, low in cost and strong in adaptability; various sensors can be configured, so that key data in the process can be displayed in real time.

Drawings

FIG. 1 is a schematic view of a stirring device stirring a liquid storage vehicle;

FIG. 2 is a schematic view of the structure of the stirring apparatus;

FIG. 3 is a schematic structural diagram of a 1000L liquid storage vehicle;

FIG. 4 is a schematic view of a 500L liquid storage cart;

FIG. 5 is a schematic structural diagram of a 100L liquid storage vehicle;

FIG. 6 is a schematic bottom structure view of a 1000L liquid storage cart.

Detailed Description

Embodiments of the utility model are described in further detail below with reference to the accompanying drawings, it being noted that the examples are merely illustrative of the utility model and should not be considered as limiting, and that all features disclosed in the examples of the utility model, or steps in all methods or processes disclosed, may be combined in any way, except for mutually exclusive features and/or steps.

This embodiment provides a stock solution car, including one and be equipped with upwards open-ended staving 10, can carry out the installation of stock solution bag in the staving 10, the stock solution bag is the disposable flexible plastic container that has good biological safety nature, and this container is fixed inside staving 10, simple to use, safety. Compared with the traditional bioreactor made of stainless steel, the liquid storage vehicle has the advantages of simple operation, stable production process, short batch preparation time, high production efficiency, no need of auxiliary facilities such as complex pipelines, no need of cleaning, disinfection and sterilization, low production cost, easy passing verification and the like, and has better application scene in the development and production of modern biotechnology drugs.

In some large-sized barrels 10, referring to fig. 3 and 4, for example, 1000L barrels and 500L barrels have large sizes, and therefore the liquid storage bags are difficult to install, and in order to facilitate installation of the liquid storage bags, it is preferable that a door 11 capable of being opened or closed is arranged on the side surface of the barrel 10, and installation of the liquid storage bags in the barrel 10 can be facilitated through the door 11; while some smaller size tubs, such as the 100L tub of FIG. 5, do not have doors 11 on the sides.

Preferably, the material of staving 10 is stainless steel, and its shape is cylindricly, makes things convenient for the installation of stock solution bag, and stainless steel material can be able to bear or endure the corruption of culture solution simultaneously, the life of extension device.

On some barrel bodies 10 with doors 11 on the side surfaces, two convex strips 12 are arranged on the barrel bodies 10, the two convex strips 12 are arranged in parallel, the doors 11 are positioned between the two convex strips 12, the positions of the barrel bodies 10, which are positioned at the doors 11, are hollowed, the doors 11 are hinged with the convex strips 12 on one side, locking structures 13 capable of being fixed with the doors 11 are arranged on the convex strips 12 on the other side, and when the locking structures 13 are opened, the doors 11 can freely rotate according to the hinged positions; when the locking structure 13 is closed, one side of the locking structure 13 of the door 11 is locked with the corresponding convex strip 12, so that the door 11 is locked. Specifically, the locking structure 13 may be a rotatable handle 15 and a stopper 16, and the handle 15 and the stopper 16 are respectively disposed on the door 11 and the protruding strip 12.

Preferably, staving 10 bottom is connected with bottom frame 14, is equipped with the universal wheel 17 that the stock solution car of being convenient for removed on bottom frame 14, bottom frame 14 and staving 10 detachable connections or fixed connection: the detachable connection mode is convenient for the barrel 10 to be taken down after the barrel 10 moves to a designated position, and at the moment, the bottom frame 14 can be used for the movement of other barrel 10 continuously; the fixed connection is such that the tub 10 is not separated from the base frame 14, the integrity is good during movement, and the tub 10 is not separated from the base frame 14 when the base frame 14 moves on the inclined surface 38. In this embodiment, preferably, the base frame 14 is provided with a support column 18, and the support column 18 is welded to the barrel 10. Further, the bottom frame 14 is in a C shape, and part of the universal wheels 17 on the bottom frame 14 is provided with a locking structure.

Preferably, for the convenience of movement of the liquid storage vehicle, for some large-sized barrels 10, such as the 1000L barrel and the 500L barrel in fig. 3 and 4, a transverse handle 22 and a longitudinal handle 23 are arranged on the barrels, both the transverse handle 22 and the longitudinal handle 23 are used for facilitating an operator to drive the liquid storage vehicle to move, the transverse handle 22 facilitates pushing of the liquid storage vehicle, and the longitudinal handle 23 facilitates pulling of the liquid storage vehicle. Specifically, one transverse handle 22 is provided, and two longitudinal handles 23 are provided. Referring to fig. 5, for some smaller-sized tubs 10, such as the 100L tub of fig. 5, only one handle 24 is provided thereon, the handle 24 is provided with two horizontal sections 25 and two vertical sections 26, the vertical section 26 is provided with two, the horizontal section 25 is provided with one, two ends of the horizontal section 25 are respectively connected to the two vertical sections 26, and the two vertical sections 26 are respectively connected to the tub 10. The handle 24 has the advantages of the transverse handle 22 and the longitudinal handle 23, and is convenient for an operator to drive the liquid storage vehicle to move.

Be equipped with on the side of staving 10 and observe hole 19, observe hole 19 and be the strip and vertically arrange, observe hole 19 and make things convenient for operating personnel to observe the condition of the inside cell culture of liquid storage bag from the outside. Preferably, the observation holes 19 are two or more than two and are positioned on the same straight line in the vertical direction, so that different height positions of the liquid storage bag can be conveniently observed. Further, when the tub 10 is provided with the door 11, a part or all of the viewing hole 19 is located on the door 11.

Preferably, be equipped with electrode hole 20 on the staving 10, electrode hole 20 is strip and level and arranges, and electrode hole 20 is located the side of staving 10 and is close to the bottom position, and it is equipped with folding electrode holder 21 to lie in electrode hole 20 position on the staving 10, can carry out the installation of electrode through electrode holder 21, and the electrode can insert the stock solution bag in the staving 10 through electrode hole 20.

Preferably, the bottom of the barrel body 10 is provided with a liquid outlet 27, which is convenient for the liquid storage bag in the barrel body 10 to discharge liquid.

The stirring device is matched with the liquid storage vehicle and comprises a stirrer 28 and a control platform 29 for controlling the stirrer 28 to move, the stirrer 28 is mounted at the upper end of a telescopic arm 30, the control platform 29 can control the telescopic arm 30 to move up and down, so that the stirrer 28 can stir culture liquid in liquid storage bags in the liquid storage vehicle with different sizes, and a scale 35 is fixedly arranged on one side of the telescopic arm 30, so that an operator can quickly know the distance that the telescopic arm 30 contracts when the telescopic arm 30 moves; meanwhile, the angle of the stirrer 28 can be adjusted by the control platform 29, the stirrer 28 is detachably connected with a stirring paddle 31, and the stirring angle of the stirring paddle 31 is adjusted by adjusting the angle of the stirrer 28; furthermore, the control platform 29 can be used to control the stirring speed of the stirring paddle 31 so that different culture solutions can be applied.

Preferably, agitator 28 installs on control platform 29, and control platform 29 installs on chassis 32, and chassis 32 bottom also is equipped with the universal wheel, makes things convenient for the holistic removal of agitating unit, still is equipped with the fixed position 33 of stirring rake on the agitating unit, and the stirring rake 31 of dismantling can be inserted on the fixed position 33 of stirring rake, still is equipped with handle 34 on chassis 32, and operating personnel can drive the agitating unit motion through pulling or pushing handle 34.

When the stirring device is used for stirring the culture solution in the liquid storage vehicle, the stirring device and the liquid storage vehicle are preferably ensured to be relatively fixed, if the stirring device and the liquid storage vehicle move relatively in the stirring process, the stirring paddle 31 in the stirring device is in contact with the liquid storage bag in the barrel body 10 to break the liquid storage bag, so that the culture solution leaks; heavy, the paddle 31 hits the inner wall of the tub 10, causing damage to the paddle 31 or the stirrer 28. In order to solve the problem, preferably, the stirring device is provided with a fixing structure 36, and the fixing structure 36 can lock the stirring device and the liquid storage vehicle, so as to avoid moving. In this embodiment, fixed knot constructs 36 is a cardboard 36, is equipped with the buckle 37 of arranging in pairs on the cardboard 36, and buckle 37 can detain the bottom frame 14 of stock solution car in the middle of, has accomplished the locking between agitating unit and the stock solution car this moment promptly. Because the stock solution car has multiple size, the underframe 14 size of the stock solution car of equidimension not is different, consequently correspond on the cardboard 36 and be equipped with many buckles 37 different to the interval, pair with the stock solution car of equidimension not respectively for agitating unit is applicable to the stock solution car of equidimension not, and the suitability is strong.

The above description is only the specific embodiments of the present invention, but the protection scope of the present invention is not limited thereto, and any changes or substitutions that are not thought of through creative work should be covered within the protection scope of the present invention, and therefore, the protection scope of the present invention should be subject to the protection scope defined by the claims.

Claims

1. A liquid storage vehicle is characterized by comprising a barrel body with an upward opening, wherein a liquid storage bag can be mounted in the barrel body, the bottom of the barrel body is connected with a bottom frame, and the bottom frame is detachably connected or fixedly connected with the barrel body;

the side surface of the barrel body is provided with a door which can be opened or closed;

the barrel body is provided with two convex strips which are arranged in parallel, the door is positioned between the two convex strips, the position of the barrel body, which is positioned in the door, is hollowed, the door is hinged with the convex strips on one side, the convex strips on the other side are provided with a locking structure which can be fixed with the door, and when the locking structure is opened, the door can freely rotate according to the hinged position; when the locking structure is closed, one side of the door locking structure is clamped with the corresponding convex strip, so that the locking of the door is realized.

2. The liquid storage vehicle of claim 1, wherein the barrel is cylindrical and is made of stainless steel.

3. The liquid storage vehicle of claim 1, wherein the locking structure is a rotatable handle and a stop, and the handle and the stop are respectively disposed on the door, the protrusion strip or the protrusion strip, and the door.

4. The liquid storage vehicle as claimed in claim 1, wherein the bottom frame is provided with universal wheels for facilitating movement of the liquid storage vehicle, and part of the universal wheels on the bottom frame is provided with locking structures.

5. The liquid storage vehicle of claim 1, wherein the bottom frame is C-shaped, and the bottom frame is provided with a support pillar, and the support pillar is welded to the barrel body.

6. A liquid storage vehicle according to claim 1, wherein the tank body is provided with one transverse handle and two longitudinal handles.

7. The liquid storage vehicle as claimed in claim 1, wherein the barrel body is provided with only one handle, the handle is provided with two horizontal sections and two vertical sections, the horizontal section is provided with one horizontal section, two ends of the horizontal section are respectively connected with the two vertical sections, and the two vertical sections are respectively connected with the barrel body.

8. The liquid storage vehicle as claimed in claim 1, wherein the side surface of the tank body is provided with observation holes, the observation holes are strip-shaped and vertically arranged, two or more observation holes are provided, and the observation holes are positioned on the same straight line in the vertical direction;

when the door is arranged on the barrel body, part or all of the observation holes are positioned on the door;

the electrode hole is arranged on the barrel body, the electrode hole is in a strip shape and is horizontally arranged, the electrode hole is positioned on the side surface of the barrel body and is close to the bottom, a foldable electrode support is arranged on the barrel body and is positioned at the electrode hole, the electrode can be installed through the electrode support, and the electrode can be inserted into a liquid storage bag in the barrel body through the electrode hole;

the bottom of the barrel body is provided with a liquid outlet which is convenient for the liquid storage bag in the barrel body to discharge liquid.