CN215609902U

CN215609902U - Filtering device for doxorubicin hydrochloride lipidosome injection

Info

Publication number: CN215609902U
Application number: CN202120320469.9U
Authority: CN
Inventors: 朱林林
Original assignee: Changzhou Kinyond Pharmaceutical Manufacturing Co ltd
Current assignee: Changzhou Kinyond Pharmaceutical Manufacturing Co ltd
Priority date: 2021-02-04
Filing date: 2021-02-04
Publication date: 2022-01-25
Anticipated expiration: 2031-02-04

Abstract

The utility model discloses a filtering device for doxorubicin hydrochloride liposome injection, relates to the technical field of injection filtering, and aims to solve the problems that an adopted filtering net is small in pore size, large impurities in the injection easily block the pore size, the filtering capacity is greatly reduced, and the filtering effect is poor. The top of base is provided with support frame and liquid collecting tank, and the support frame passes through bolted connection with the base, the top of support frame is provided with the filtration storehouse, and filters storehouse and support frame joggle, the top of filtering the storehouse is provided with the apron, and apron and filtration storehouse sealing connection, the central point department of putting of apron top is provided with the motor, and the motor passes through bolted connection with the apron, the below of apron is provided with the pivot, and the pivot passes through the coupling joint with the output of motor, the inside of filtering the storehouse is provided with the arc filter frame, the top of arc filter frame is provided with the filter frame, one side of motor is provided with liquid feeding mechanism.

Description

Filtering device for doxorubicin hydrochloride lipidosome injection

Technical Field

The utility model relates to the technical field of injection filtration, in particular to a filtering device for doxorubicin hydrochloride liposome injection.

Background

The injection is a sterile solution for injection into the body and a sterile powder or concentrated solution for preparing a solution or a suspension before use, and the doxorubicin hydrochloride liposome injection is one of the injections and is a liposome preparation, wherein doxorubicin hydrochloride is encapsulated in a liposome containing methoxy polyethylene glycol on the surface, and the process is called pegylation, so that the liposome can be protected from being recognized by a mononuclear macrophage system, and the time of the liposome in blood circulation is prolonged. The injection is required to be stored by a filter device during production.

At present, a filter screen is directly used for filtering doxorubicin hydrochloride liposome injection, the aperture of the adopted filter screen is small, large impurities in the injection easily block the aperture, the filtering capacity is greatly reduced, the filtering effect is poor, and the using requirement cannot be met. Therefore, a filtering device for doxorubicin hydrochloride liposome injection is urgently needed in the market to solve the problems.

SUMMERY OF THE UTILITY MODEL

The utility model aims to provide a filtering device for doxorubicin hydrochloride liposome injection, which aims to solve the problems that the aperture of a filtering net adopted in the background technology is small, the aperture is easily blocked by large impurities in the injection, the filtering capacity is greatly reduced, and the filtering effect is poor.

In order to achieve the purpose, the utility model provides the following technical scheme: a filtering device for doxorubicin hydrochloride liposome injection comprises a base, wherein a supporting frame and a liquid collecting box are arranged above the base, the supporting frame is connected with the base through screws, a filtering bin is arranged above the supporting frame and is in joggle joint with the supporting frame, a cover plate is arranged above the filtering bin, the cover plate is connected with the filter bin in a sealing way, a motor is arranged at the central position above the cover plate and is connected with the cover plate through a screw, a rotating shaft is arranged below the cover plate, the rotating shaft is connected with the output end of the motor through a coupling, an arc-shaped filter frame is arranged inside the filter bin, the arc-shaped filter frame and the filter bin are arranged into an integral structure, a filter frame is arranged above the arc-shaped filter frame, and the filter frame passes through bolted connection with the pivot, one side of motor is provided with the liquid feeding mechanism, and the one end of liquid feeding mechanism runs through the apron and extends to the inside of crossing the filter bin.

Preferably, a sleeve is arranged between the filtering bin and the liquid collecting tank, filter screens are arranged at two ends of the sleeve and between the filtering bin and the liquid collecting tank, the filter screens are in joggle joint with the filtering bin, the liquid collecting tank and the sleeve, a connecting ring is arranged outside the sleeve, and the connecting ring is provided with two connecting rings.

Preferably, one side of crossing the filter house is provided with the booster pump, and the booster pump passes through bolted connection with the support frame, the top of booster pump is provided with explosion-proof trachea, and explosion-proof trachea's one end runs through the apron and extends to the inside of crossing the filter house, explosion-proof trachea sets up structure as an organic whole with the apron, and explosion-proof trachea and booster pump sealing connection.

Preferably, an electric heater is arranged outside the filtering bin, and the electric heater is connected with the filtering bin through screws.

Preferably, the arc-shaped scraper blade is arranged below the filter frame, the arc-shaped scraper blade and the filter frame are arranged into an integral structure, and the arc-shaped scraper blade is attached to the arc-shaped filter frame.

Preferably, the liquid collecting tank is provided with a liquid level observation groove, the liquid level observation groove and the liquid collecting tank are arranged into an integral structure, one side of the liquid collecting tank is provided with a liquid drainage mechanism, and the liquid drainage mechanism and the liquid collecting tank are arranged into an integral structure.

Compared with the prior art, the utility model has the beneficial effects that:

1. the utility model discloses a device passes through the setting of motor, filter frame and arc scraper blade, and it is rotatory to drive the filter frame with the help of the pivot under the effect of motor, along with the filter frame rotates can stir the injection to impurity rejection in the injection in advance, and the arc scraper blade rotates along with the filter frame is synchronous, can get rid of accumulational impurity on the arc filter frame along with the rotation of arc scraper blade, indirect improvement the filter effect. The problem of impurity in the injection raw materials too much directly use the filter screen to carry out the filter effect not good is solved.

2. The utility model discloses a device passes through the setting of booster pump, can increase the atmospheric pressure value in the filtration storehouse with the help of the booster pump with the air injection to the filtration of injection is accelerated to the pressure differential extrusion injection. The problem of injection liquid filter effect not good under the ordinary pressure is solved.

3. The utility model discloses a device passes through electric heater's setting, can heat the filtration storehouse with the help of electric heater to promote the temperature of the inside injection in filtration storehouse, accelerated injection flow speed, indirect improvement the filter effect. Solves the problems of poor fluidity of the injection liquid at normal temperature and reduced filtering effect.

4. The utility model discloses a device passes through telescopic setting, can play a lot of filtration to the injection with the help of the sleeve to improve the filter effect. The problems of insufficient filtering times and poor filtering effect are solved.

Drawings

FIG. 1 is a schematic view of the overall structure of the present invention;

FIG. 2 is a front view of the present invention;

fig. 3 is a partially enlarged view of the area a of fig. 1 according to the present invention.

In the figure: 1. a base; 2. a support frame; 3. a filtering bin; 4. a cover plate; 5. a booster pump; 6. an explosion-proof air pipe; 7. a motor; 8. a rotating shaft; 9. a liquid adding mechanism; 10. an electric heater; 11. a filter frame; 12. a liquid collection tank; 13. a liquid discharge mechanism; 14. a filter screen; 15. a liquid level observation tank; 16. a sleeve; 17. a connecting ring; 18. an arc-shaped filter frame; 19. an arc-shaped scraper.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.

Referring to fig. 1-3, an embodiment of the present invention is shown: a filtering device for doxorubicin hydrochloride lipidosome injection comprises a base 1, a supporting frame 2 and a liquid collecting box 12 are arranged above the base 1, the supporting frame 2 is connected with the base 1 through screws, a filtering bin 3 is arranged above the supporting frame 2, the filtering bin 3 is joggled with the supporting frame 2, a cover plate 4 is arranged above the filtering bin 3, the cover plate 4 is hermetically connected with the filtering bin 3, a motor 7 is arranged at the central position above the cover plate 4, the motor 7 is connected with the cover plate 4 through screws, a rotating shaft 8 is arranged below the cover plate 4, the rotating shaft 8 is connected with the output end of the motor 7 through a coupler, an arc-shaped filtering frame 18 is arranged inside the filtering bin 3, the arc-shaped filtering frame 18 and the filtering bin 3 are arranged into an integral structure, a filtering frame 11 is arranged above the arc-shaped filtering frame 18, the filtering frame 11 is connected with the rotating shaft 8 through screws, the motor 7 drives the filtering frame 11 to rotate through the rotating shaft 8, along with the injection is stirred in the rotation of pivot 8 to can reject the impurity in the injection in advance, indirect improvement subsequent filtering mechanism's filter effect, one side of motor 7 is provided with liquid feeding mechanism 9, and the one end of liquid feeding mechanism 9 runs through apron 4 and extends to the inside of filtering storehouse 3.

Further, be provided with sleeve 16 between filter bin 3 and the header tank 12, all be provided with filter screen 14 between the both ends of sleeve 16 and filter bin 3 and the header tank 12, and filter screen 14 and filter bin 3, header tank 12 and sleeve 16 joggle, sleeve 16's outside is provided with go-between 17, and go-between 17 is provided with two. The injection can be filtered for a plurality of times through the filter screen 14, so that the injection filtering effect is ensured, and the sleeve 16 and the connecting ring 17 are convenient to disassemble and replace the filter screen 14.

Further, one side of crossing filter bin 3 is provided with booster pump 5, and booster pump 5 passes through bolted connection with support frame 2, and booster pump 5's top is provided with explosion-proof trachea 6, and explosion-proof trachea 6's one end runs through apron 4 and extends to the inside of crossing filter bin 3, and explosion-proof trachea 6 sets up structure as an organic whole with apron 4, and explosion-proof trachea 6 and booster pump 5 sealing connection. Air can be injected into the filter bin 3 through the booster pump 5, and the injection is extruded by utilizing the pressure difference, so that the filtering effect of the injection is improved.

Further, an electric heater 10 is arranged outside the filtering bin 3, and the electric heater 10 is connected with the filtering bin 3 through screws. The electric heater 10 is used for filtering the filtering bin 3, so that the temperature of the injection is indirectly increased, the flowing speed of the injection can be properly accelerated, and the injection is conveniently filtered.

Further, the arc-shaped scraper blade 19 is arranged below the filter frame 11, the arc-shaped scraper blade 19 and the filter frame 11 are arranged into an integral structure, and the arc-shaped scraper blade 19 is attached to the arc-shaped filter frame 18. Through arc scraper blade 19 along with filter frame 11 synchronous rotation, can scrape off the impurity of piling up on arc filter 18 along with arc scraper blade 19's rotation to arc filter 18 filter effect has been ensured.

Further, a liquid level observation groove 15 is formed in the liquid collecting tank 12, the liquid level observation groove 15 and the liquid collecting tank 12 are arranged to be of an integrated structure, a liquid drainage mechanism 13 is arranged on one side of the liquid collecting tank 12, and the liquid drainage mechanism 13 and the liquid collecting tank 12 are arranged to be of an integrated structure. The amount of the liquid stored in the header tank 12 can be observed by the liquid level observing groove 15, and the filtered injection can be discharged by the liquid discharging mechanism 13.

The working principle is as follows: when the injection filtering device is used, injection stock solution is added into the filtering bin 3 through the liquid adding mechanism 9, the electric heater 10 is started to heat the filtering bin 3, the heating temperature cannot influence the activity of the injection, the motor 7 is started, the filter frame 11 is driven to rotate by the aid of the rotating shaft 8 under the action of the motor 7, the injection is stirred along with the rotation of the filter frame 11, impurities can be removed in advance by combining the arc-shaped filter frame 18, the arc-shaped scraper 19 synchronously rotates along with the filter frame 11 to scrape the impurities accumulated on the arc-shaped filter frame 18, and the filtering effect of the arc-shaped filter frame 18 is ensured; starting a booster pump 5 to inject air into the filter bin 3 through an explosion-proof air pipe 6, increasing the air pressure value inside the filter bin 3, and extruding the injection under the action of pressure difference, so that the injection is filtered more quickly; the injection liquid flowing through is filtered several times by the filter net 14, thereby improving the injection liquid filtering effect, and the filtered injection liquid falls into the header tank 12, and the injection liquid can be discharged by the liquid discharge mechanism 13.

It will be evident to those skilled in the art that the utility model is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the utility model being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.

Claims

1. A doxorubicin hydrochloride lipidosome filter equipment for injection, includes base (1), its characterized in that: the filter is characterized in that a support frame (2) and a liquid collecting tank (12) are arranged above the base (1), the support frame (2) is connected with the base (1) through screws, a filter bin (3) is arranged above the support frame (2), the filter bin (3) is joggled with the support frame (2), a cover plate (4) is arranged above the filter bin (3), the cover plate (4) is hermetically connected with the filter bin (3), a motor (7) is arranged at the central position above the cover plate (4), the motor (7) is connected with the cover plate (4) through screws, a rotating shaft (8) is arranged below the cover plate (4), the rotating shaft (8) is connected with the output end of the motor (7) through a coupler, an arc-shaped filter frame (18) is arranged inside the filter bin (3), the arc-shaped filter frame (18) and the filter bin (3) are arranged into an integral structure, and a filter frame (11) is arranged above the arc-shaped filter frame (18), and the filter frame (11) is connected with the rotating shaft (8) through screws, one side of the motor (7) is provided with a liquid adding mechanism (9), and one end of the liquid adding mechanism (9) penetrates through the cover plate (4) and extends to the inside of the filter bin (3).

2. The filtering device for doxorubicin hydrochloride liposome injection according to claim 1, wherein: be provided with sleeve (16) between filter bin (3) and header tank (12), all be provided with filter screen (14) between the both ends of sleeve (16) and filter bin (3) and header tank (12), and filter screen (14) and filter bin (3), header tank (12) and sleeve (16) joggle, the outside of sleeve (16) is provided with go-between (17), and go-between (17) are provided with two.

3. The filtering device for doxorubicin hydrochloride liposome injection according to claim 1, wherein: one side of crossing filter bin (3) is provided with booster pump (5), and booster pump (5) passes through the screw connection with support frame (2), the top of booster pump (5) is provided with explosion-proof trachea (6), and the one end of explosion-proof trachea (6) runs through apron (4) and extends to the inside of crossing filter bin (3), explosion-proof trachea (6) set up structure as an organic whole with apron (4), and explosion-proof trachea (6) and booster pump (5) sealing connection.

4. The filtering device for doxorubicin hydrochloride liposome injection according to claim 1, wherein: an electric heater (10) is arranged outside the filtering bin (3), and the electric heater (10) is connected with the filtering bin (3) through screws.

5. The filtering device for doxorubicin hydrochloride liposome injection according to claim 1, wherein: the arc-shaped scraper blade (19) is arranged below the filter frame (11), the arc-shaped scraper blade (19) and the filter frame (11) are arranged into an integral structure, and the arc-shaped scraper blade (19) is attached to the arc-shaped filter frame (18).

6. The filtering device for doxorubicin hydrochloride liposome injection according to claim 1, wherein: the liquid level observation tank (15) is arranged on the liquid collection tank (12), the liquid level observation tank (15) and the liquid collection tank (12) are arranged to be of an integrated structure, the liquid drainage mechanism (13) is arranged on one side of the liquid collection tank (12), and the liquid drainage mechanism (13) and the liquid collection tank (12) are arranged to be of an integrated structure.