CN215535297U - Drug delivery device for non-human primate oral tablets and capsules - Google Patents

Abstract

The utility model discloses a drug delivery device for non-human primate oral tablets and capsules, which comprises a medical silica gel hose, a medical silica gel tube cover, a medical silica gel plug and an injector; the medical silica gel hose comprises a hose body, a clamping table is arranged at the end part of the hose body, and a clamping groove is formed in the inner side wall of an opening of the medical silica gel hose cover; before administration, the medical silica gel plug is plugged into one end of the accommodating cavity in the tube body, which is far away from the medical silica gel tube cover; when the medicine is administered, the medical silica gel plug is pulled out from one end of the holding cavity inside the tube body, which is far away from the medical silica gel tube cover, and the injection port of the injector is plugged into one end of the holding cavity inside the tube body, which is far away from the medical silica gel tube cover. The utility model is convenient for large-scale administration operation in animal houses, improves the success rate of one-time administration, and better protects test administration personnel; the hose, the plug and the pipe cover which are made of medical silica gel materials have good biocompatibility and can be repeatedly used after being cleaned and disinfected.

Description

Drug delivery device for non-human primate oral tablets and capsules

Technical Field

The utility model relates to the technical field of preclinical animal test pharmacokinetic research, in particular to a drug delivery device for non-human primate oral tablets and capsules.

Background

Oral tablets and capsules are the most common general formulations used in preclinical animal testing, and it is a common research procedure to administer tablets to nonhuman primates by gavage, collect plasma samples or collect tissues after capsules, measure blood concentrations in matrices, and further analyze pharmacokinetic characteristics (e.g., distribution, elimination, metabolism, etc.) of drugs or metabolites based on this data.

The most commonly used method at present is the gavage administration, the process of which is briefly described as follows: animal experimenters forcibly open the oral cavity of the non-human primate to go deep into the throat part of the animal, put the prepared solid preparation such as a tablet and a capsule at the back part of the throat of the cynomolgus monkey, and inject a solvent or drinking water into the throat of the cynomolgus monkey by adopting a syringe to assist swallowing. The strong feeding method has the defects that in the test process, the non-human primates have strong rejection consciousness, the experimental animals with larger body sizes are often more violent in sexual conditions, the problems that the position of the experimental animals is inaccurate to manually place and locate, the animals easily spit out tablets or capsules or reject medicinal preparations and the like exist in the direct strong feeding of the tablets or capsules, the machin vomit is easily caused, the failure rate of the administration is high, and the injury of testers is easily caused.

SUMMERY OF THE UTILITY MODEL

In order to solve the technical problems, the utility model provides a drug delivery device for non-human primate oral tablets and capsules, which comprises a medical silica gel hose, a medical silica gel tube cover connected to one end of the medical silica gel hose, a medical silica gel plug corresponding to the other end of the medical silica gel hose, and an injector corresponding to the medical silica gel plug;

the medical silica gel hose comprises a cylindrical tube body, the side part of one end of the tube body is connected with the medical silica gel tube cover, the end part of the tube body is provided with a clamping table corresponding to the medical silica gel tube cover, the inner side wall of the opening of the medical silica gel tube cover is provided with a clamping groove corresponding to the clamping table, and the opening and closing of the medical silica gel tube cover are realized through the separation and clamping of the clamping groove and the clamping table;

before administration, the medical silica gel plug is plugged into one end, far away from the medical silica gel tube cover, of the accommodating cavity in the tube body;

when the medicine is administered, the medical silica gel plug is kept away from in the holding cavity inside the tube body, one end of the medical silica gel tube cover is pulled out, and the injection port of the injector is plugged into the holding cavity inside the tube body, and one end of the medical silica gel tube cover is kept away from in the holding cavity inside the tube body.

Wherein, medical silica gel tube cap is the hemisphere structure of smooth anti-irritation structure, causes the stimulation through the smooth surface of hemisphere in order to prevent to the animal.

Wherein, medical silica gel hose and medical silica gel tube cap realize elastic connection for integrated into one piece and through integrated into one piece's connector.

The outer diameter of the medical silica gel hose is 16-18mm, the inner diameter of the medical silica gel hose is 14mm, the inner volume of the accommodating cavity is 10-15ml, the diameter of the medical silica gel pipe cover is 14-16mm, and the outer diameter of the external injector is 14-16 mm.

The inner wall of the medical silica gel hose is provided with anti-skidding folds so as to prevent the medical silica gel tube cover or the injector from slipping out of the medical silica gel hose in a use state to cause administration failure.

Through the technical scheme, the drug delivery device provided by the utility model is characterized in that the drug is stored in the medical silica gel hose in advance, two ends of the drug are respectively sealed by the medical silica gel plug and the medical silica gel hose cover so as to ensure that the tablet or the capsule cannot slide out of control during the drug temporary storage period, the drug delivery part is accurately positioned through the slender structure of the medical silica gel hose without manual penetration, and the drug in the medical silica gel hose is injected into the throat of a non-human primate test object such as a cynomolgus monkey through the air pressure and the gravity provided by the external injector, so that the drug delivery device has the following beneficial effects:

1. the large-scale administration operation of the animal room is facilitated, the one-time administration success rate is improved, and test administration personnel are better protected;

2. after the medicament is administered, the syringe can be quickly and seamlessly operated to administer a blank solvent with a specific volume;

3. the medical silica gel hose, the medical silica gel plug and the medical silica gel pipe cover are all formed by processing medical silica gel, have good biocompatibility, have small reaction to animal tissues, have the characteristics of cold resistance, high temperature resistance, weak acid and alkali resistance, harmlessness, nontoxicity, odorlessness, high elasticity, strong ultraviolet resistance, good elasticity, kink resistance, no deformation, softness, electric arc resistance, corona resistance, chemical stability, physiological inertia, no toxicity or irritation to animals, hydrophobicity, air permeability, excellent rebound resilience, difficult deformation and the like, and can be repeatedly utilized after being cleaned and sterilized.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly introduced below.

Fig. 1 is a schematic sectional structure view of a drug delivery device disclosed in an embodiment of the present invention.

In the figure: 10. a medical silica gel hose; 11. a pipe body; 12. an accommodating cavity; 13. clamping a platform; 20. a medical silica gel tube cover; 21. a card slot; 30. a medical silica gel plug; 40. a medicament.

Detailed Description

The technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention.

Referring to fig. 1, the present invention provides a drug delivery device for non-human primate oral tablets and capsules, comprising a medical silicone hose 10, a medical silicone tube cap 20 connected to one end of the medical silicone hose 10, a medical silicone plug 30 corresponding to the other end of the medical silicone hose 10, and an injector corresponding to the medical silicone plug 30; the medical silica gel hose 10 comprises a cylindrical tube body 11, a medical silica gel tube cover 20 is connected to the side part of one end of the tube body 11, a clamping table 13 corresponding to the medical silica gel tube cover 20 is arranged at the end part of the tube body 11, a clamping groove 21 corresponding to the clamping table 13 is arranged on the inner side wall of an opening of the medical silica gel tube cover 20, and the opening and closing of the medical silica gel tube cover 20 are realized through the separation and clamping of the clamping groove 21 and the clamping table 13; before administration, the medical silica gel plug 30 is plugged into one end of the accommodating cavity 12 in the tube body 11, which is far away from the medical silica gel tube cover 20; when the medicine is administered, the medical silicone plug 30 is pulled out from one end of the accommodating cavity 12 inside the tube body 11, which is far away from the medical silicone tube cover 20, and the injection port of the injector is plugged into one end of the accommodating cavity 12 inside the tube body 11, which is far away from the medical silicone tube cover 20.

Wherein, the medical silica gel tube cover 20 is a semispherical structure with a smooth anti-irritation structure, and the semispherical smooth surface is used for preventing irritation to animals; the medical silica gel hose 10 and the medical silica gel tube cover 20 are integrally formed and are elastically connected through an integrally formed connector; the outer diameter of the medical silica gel hose 10 is 16-18mm, the inner diameter of the medical silica gel hose 10 is 14mm, the inner volume of the accommodating cavity 12 is 10-15ml, the diameter of the medical silica gel tube cover 20 is 14-16mm, and the outer diameter of an externally connected injector is 14-16 mm; the inner wall of the medical silica gel hose 10 is provided with anti-slip folds to prevent the medical silica gel tube cap 20 or the syringe from slipping out of the medical silica gel hose 10 in a use state to cause administration failure.

The working principle of the utility model is as follows:

before use, one end of the medical silica gel hose 10 is plugged through the medical silica gel plug 30, then the medicament 40 is stored in the medical silica gel hose 10, and then the inlet and the outlet of the medicament 40 are sealed through the medical silica gel tube cover 20 so as to ensure that tablets or capsules cannot slide out of the medical silica gel hose 10 out of control during temporary storage of the medicament 40;

in the using state, the administration position is accurately positioned through the slender structure of the medical silica gel hose 10, manual penetration is not needed, after the tablet or capsule is confirmed to reach a specific position (such as the back of the throat) of an animal oral cavity, the medical silica gel plug 30 is pulled out and is connected into an externally matched injector, and the medical silica gel hose 10 is ensured not to generate relative displacement in the using process and is only used as air pushing or quantitative dissolution assisting solvent;

the principle similar to gravity or air propulsion is utilized to realize quick and safe administration, and after the quick administration of tablets and capsules is finished, the injection device can be continuously connected with an external injector to administer a solvent; when the solvent is fed, the injector is pushed to compress the air in the medical silica gel hose 10 to press the medical silica gel tube cover 20, the gastric lavage solvent is ejected, and the tablets or capsules also flow into the digestive tract (esophagus and stomach) of the animal along with the waves.

From a more detailed aspect, the external label of the connected external matching injector is provided with accurate volume scale indication corresponding to different volumes, the scale indication is divided into internal volumes with specific specifications such as 5ml, 10ml, 15ml, 20ml and the like, and the menstruum can be given according to the actual required amount.

In addition, the dosage of the medicine is 2-5 tablets or capsules/animals, so that the available volume of about 15ml fixed by the medical silica gel hose 10 can completely meet the administration requirement, and the medicine 40 can be retained in the medical silica gel hose 10 due to the fact that the medicine is excessively large, and the medicine can be administered in a divided manner.

In summary, it can be seen from the detailed description of the structure and method of use of the present invention that the administration device of the present invention is applied: the structure and the principle are relatively simple, the large-scale administration operation of the animal house is convenient, the one-time administration success rate is improved, and the test administration personnel are better protected; after the drug preparation is administered, the injection syringe can be quickly and seamlessly operated to administer a blank solvent with a specific volume; the device is particularly suitable for the administration operation of non-human primate oral tablets and capsules, and the one-time administration success rate of the device is superior to that of a common conventional administration method in daily test practice.

The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to the above-described embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the utility model. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (5)

1. The drug delivery device for the non-human primate oral tablets and capsules is characterized by comprising a medical silica gel hose (10), a medical silica gel tube cover (20) connected to one end of the medical silica gel hose (10), a medical silica gel plug (30) corresponding to the other end of the medical silica gel hose (10) and an injector corresponding to the medical silica gel plug (30);

the medical silica gel hose (10) comprises a cylindrical tube body (11), the medical silica gel tube cover (20) is connected to the lateral part of one end of the tube body (11), a clamping table (13) corresponding to the medical silica gel tube cover (20) is arranged at the end part of the tube body (11), a clamping groove (21) corresponding to the clamping table (13) is arranged on the inner side wall of an opening of the medical silica gel tube cover (20), and the opening and closing of the medical silica gel tube cover (20) are realized through the separation and clamping of the clamping groove (21) and the clamping table (13);

before administration, the medical silica gel plug (30) is plugged into one end, far away from the medical silica gel tube cover (20), of the accommodating cavity (12) in the tube body (11);

when the medicine is administrated, the medical silica gel plug (30) is far away from the inside of the accommodating cavity (12) of the tube body (11), one end of the medical silica gel tube cover (20) is extracted, and the injection port of the injector is plugged into the inside of the accommodating cavity (12) of the tube body (11), and one end of the medical silica gel tube cover (20) is far away from the inside of the accommodating cavity (12) of the tube body (11).

2. The device of claim 1, wherein the silicone cap (20) is a hemispherical structure with a smooth anti-irritation structure to prevent irritation to the animal by the hemispherical smooth surface.

3. The device for administering oral non-human primate tablets and capsules as claimed in claim 1, wherein said tube (11) and said cap (20) are integrally formed and are elastically connected by an integrally formed connecting body.

4. The device according to claim 1, wherein the outer diameter of the tube (11) is 16-18mm, the inner diameter of the tube (11) is 14mm, the inner volume of the containing cavity (12) is 10-15ml, the diameter of the medical silica gel tube cover (20) is 14-16mm, and the outer diameter of the externally connected syringe is 14-16 mm.

5. The device for administering oral non-human primate tablets and capsules as claimed in claim 1, wherein the inner wall of the tube (11) is provided with anti-slip folds to prevent the medical silicone tube cap (20) or syringe from slipping out of the medical silicone tube (10) in the use state and causing administration failure.

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