CN215534370U

CN215534370U - Device for non-invasive measurement of animal respiratory index

Info

Publication number: CN215534370U
Application number: CN202121640030.0U
Authority: CN
Inventors: 郭衍俊; 夏海龙; 徐林
Original assignee: Shanghai Tow Int Co ltd
Current assignee: Shanghai Tow Int Co ltd
Priority date: 2021-07-19
Filing date: 2021-07-19
Publication date: 2022-01-18
Anticipated expiration: 2031-07-19

Abstract

The utility model provides a device for non-invasively measuring animal respiratory indexes, which comprises a reference cabin, a test cabin, a pressure sensor, a damper and a data acquisition device, wherein the damper balances the airflow between the test cabin and the reference cabin; the pressure sensor respectively detects the respiratory signal values of the reference cabin and the test cabin, and is connected with the data acquisition device through a wire; and the test cabin is provided with an air path interface. The utility model realizes the non-invasive measurement of the respiration of the animal, and realizes the respiration detection without anesthesia and intubation. The non-invasive method is adopted, when in measurement, the animal can be awake and move freely, and the animal can be monitored for a long time on one animal, and the measurement is repeated. Through setting up the damping structure, realized the balanced function of signal. Through bias flow air supply and continuous ventilation, fresh air is breathed by animals, and carbon dioxide is prevented from being stored. The online atomization function is realized through the atomization dosing port.

Description

Device for non-invasive measurement of animal respiratory index

Technical Field

The utility model relates to the field of respiration detection, in particular to a device for non-invasively measuring animal respiration indexes.

Background

Animal experiments have great significance for researching the etiology, pathogenesis, pathophysiology, treatment and the like of human diseases, and the establishment of animal models has special value. In the research of respiratory animal models, the lung function examination of experimental animals is always a difficult problem. In particular, in large-scale experimental small animals such as mice and rats, the respiration rate of the animals is too small compared with that of the human body, and thus the measurement is very difficult. When the traditional mode of anaesthetizing the tracheal cannula is used for testing the animal respiration, due to the intervention of an anaesthesia operation in the process, the measured signal cannot actually reflect the normal respiration parameter of the animal. And the traditional measurement mode cannot carry out long-term tracking research on animal individuals.

The patent document is the utility model patent of CN211633732U and discloses a respiratory anesthesia system for experimental animal high power microsurgery, the respiratory anesthesia system for experimental animal high power microsurgery include microscopic device and anaesthesia device, its advantage shows: the micro-device can complete more precise microsurgical experimental operation, so that an animal model is more stable, and a breathing mask is adopted as a medium for anesthesia in the micro-device, so that the operating space range of the micro-device is wider, and an operator can conveniently perform experimental operation; the anesthesia system can be used for simultaneously performing anesthesia induction and operation maintenance anesthesia on experimental animals, so that not only can the reagent be saved, the anesthesia effect be improved, but also the air pollution can be reduced, the working efficiency of an operator is improved, and the workload of the operator is reduced. But the above scheme cannot achieve non-invasive detection.

SUMMERY OF THE UTILITY MODEL

Aiming at the defects in the prior art, the utility model aims to provide a device for non-invasively measuring the animal respiratory index.

The device for non-invasively measuring the animal respiratory index comprises a reference cabin, a test cabin, a pressure sensor, a damper and a data acquisition device, wherein:

the damper balances airflow between the test chamber and the reference chamber;

the pressure sensor respectively detects the respiratory signal values of the reference cabin and the test cabin, and is connected with the data acquisition device through a wire;

and the test cabin is provided with an air path interface.

Preferably, the test chamber further comprises a bias flow controller, wherein the bias flow controller is connected with the air channel interface through a pipeline and provides bias flow gas for the test chamber.

Preferably, the test chamber further comprises an atomization dosing port, the atomization dosing port is communicated with the test chamber, and the atomization device atomizes and doses the test chamber through the atomization dosing port.

Preferably, the reference chamber and the test chamber are arranged in an integrated manner or in a split manner.

Preferably, the reference chamber and the test chamber are made of plastic or metal materials.

Preferably, a movable bottom plate or an elastic cabin is arranged inside the test cabin.

Preferably, at least two air path interfaces are provided.

Preferably, the data acquisition device is connected with a plurality of pressure sensors, and each pressure sensor detects one test chamber and one reference chamber.

Preferably, the data acquisition device comprises a computer.

Preferably, the volume of the reference compartment is smaller than the volume of the test compartment.

Compared with the prior art, the utility model has the following beneficial effects:

1. the utility model realizes the non-invasive measurement of the respiration of the animal, and realizes the respiration detection without anesthesia and intubation.

2. The utility model adopts a non-invasive mode, and the animals can be awake and freely move during measurement, and can carry out long-time monitoring and repeated measurement on one animal.

3. The utility model realizes the signal balance function by arranging the damping structure.

4. The utility model supplies air through bias flow and continuously ventilates, so that fresh air is ensured to be breathed by animals, and carbon dioxide is prevented from being stored.

5. The utility model is also provided with an atomization dosing port to realize the online atomization function.

Drawings

Other features, objects and advantages of the utility model will become more apparent upon reading of the detailed description of non-limiting embodiments with reference to the following drawings:

fig. 1 and 2 are schematic structural diagrams of an apparatus for non-invasively measuring an animal respiratory index.

Fig. 3(a) -3 (c) are schematic structural views of different forms of dampers.

Fig. 4 is a system diagram of an apparatus for non-invasively measuring respiratory index of an animal.

Fig. 5(a) -5 (d) are schematic diagrams of different positions of the test chamber and the reference chamber.

Fig. 6(a) -6 (c) are schematic diagrams of different arrangement positions of the atomization device.

FIGS. 7 and 8 are graphs showing the results of the detection of the present invention.

The figures show that:

test chamber 1

Reference chamber 2

Damper 3

Pressure sensor 4

Gas path interface 5

Atomizing medicine feeding port 6

Detailed Description

The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the utility model, but are not intended to limit the utility model in any way. It should be noted that it would be obvious to those skilled in the art that various changes and modifications can be made without departing from the spirit of the utility model. All falling within the scope of the present invention.

As shown in fig. 1 to 8, the present invention discloses a method for measuring animal respiratory index by non-invasive and non-invasive method. The lung function test can be repeated on the same animal. The activity and the eating and drinking of the animals can be unlimited and are easier to operate, the influence of the skill level of an operator on the experiment is relatively small, and the influence of air leakage and struggling of the animals does not exist.

The utility model comprises a reference cabin, a test cabin, a pressure sensor, a damper and a data acquisition device, wherein: the damper balances airflow between the test chamber and the reference chamber; the pressure sensor respectively detects the respiratory signal values of the reference cabin and the test cabin, and is connected with the data acquisition device through a wire; and the test cabin is provided with an air path interface. The test cabin is characterized by further comprising a bias flow controller, wherein the bias flow controller is connected with the air path interface through a pipeline and provides bias flow gas for the test cabin. Still including atomizing dosing port, atomizing dosing port intercommunication test compartment, atomizing equipment passes through atomizing dosing port is to test compartment atomizing and is dosed. The reference cabin and the test cabin are arranged in an integrated or split mode. The reference cabin and the test cabin are made of plastic or metal materials. A movable bottom plate or an elastic cabin is arranged in the test cabin. At least two gas circuit interfaces are arranged. The data acquisition device is connected with a plurality of pressure sensors, and each pressure sensor detects one test chamber and one reference chamber. The data acquisition device comprises a computer. The volume of the reference chamber is smaller than the volume of the test chamber.

Furthermore, an animal is placed in a test chamber, airflow generated by the respiration of the animal changes, the difference value between a signal of the test chamber and a signal of a reference chamber is a respiration signal of the animal, the respiration signal is acquired by a sensor, amplified and filtered, and analyzed and calculated in software to obtain the respiration parameter. When the air channel interface is used for detection, the animal test chamber is ventilated, fresh air is provided for animals, and CO is prevented₂Effects of retention on animal respiration. The utility model can realize online atomization drug delivery by arranging the atomization drug delivery port. The damper of the utility model is used for balancing and stabilizing air flow.

The utility model measures the integrated airflow generated by the respiration of an animal by means of a non-invasive respiration detection chamber (plethysmograph) signal. The signals in the noninvasive breath detection chamber are from the respiratory airflow of the nose and the airflow derived from the change of the chest volume, and are the respiratory signal values generated when the nasal flow and the chest flow are mixed. Since the animal's respiratory signal is very small, the test must be performed to ensure quiet running of the environment, and the reference chamber in the trace serves to reduce the effects of environmental noise.

After raw data is obtained by a pressure sensor, the respiration waveform is analyzed by software. And extracting the characteristic points and automatically obtaining related parameters.

The calculation of the parameter specification comprises: ti: an inspiration time(s); te: expiration time(s); PIF: maximum inspiratory flow rate (ml/s); PEF: maximum expiratory flow rate (ml/s); volbal is respiratory ratio; f: respiratory rate (times/min); vt: tidal volume (ml); mv: minute ventilation (ml); EF 50: expiratory flow rate (ml/s) corresponding to 50% of the gas volume expired; EIP is the last inspiratory pause time(s); EEP: an end-expiratory pause time(s); TR is relaxation time; PenH: an indicator for quantifying the degree of bronchoconstriction.

The whole animal is put into the test chamber by a whole body plethysmography, the respiratory airflow of the animal and the floating superposition of the thoracic cavity generate respiratory signals, and the signal change of the test chamber is traced by the sensor to obtain respiratory data. According to the utility model, stable respiration signals are obtained through the structures of the test chamber and the reference chamber. Through the airflow damping structure, the steady flow effect is realized, and the signal is balanced. The utility model also provides an on-line atomization drug delivery function. Through bias flow air supply and continuous ventilation, fresh air is breathed by animals, and carbon dioxide is prevented from being stored. The procedure of the present invention is conventional and will not be described in detail herein.

The relative position of the reference cabin and the test cabin can be changed, and the test cabin and the reference cabin can be split or integrated. The cabin body can be cylindrical, square or other structures. The cabin body is not limited in material, and can be made of plastics, metals and the like.

In the description of the present application, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience in describing the present application and simplifying the description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present application.

The foregoing description of specific embodiments of the present invention has been presented. It is to be understood that the present invention is not limited to the specific embodiments described above, and that various changes or modifications may be made by one skilled in the art within the scope of the appended claims without departing from the spirit of the utility model. The embodiments and features of the embodiments of the present application may be combined with each other arbitrarily without conflict.

Claims

1. The device for non-invasively measuring the animal respiratory index is characterized by comprising a reference cabin, a test cabin, a pressure sensor, a damper and a data acquisition device, wherein:

the damper balances airflow between the test chamber and the reference chamber;

and the test cabin is provided with an air path interface.

2. The apparatus of claim 1, further comprising a bias flow controller connected to the air circuit interface via a conduit for providing a bias flow gas to the test chamber.

3. The apparatus for non-invasively measuring the respiratory index of an animal according to claim 1, further comprising an atomization dosing port, wherein the atomization dosing port is communicated with the test chamber, and the atomization device atomizes and doses the drug to the test chamber through the atomization dosing port.

4. The apparatus of claim 1, wherein the reference chamber and the test chamber are integrally or separately disposed.

5. The apparatus of claim 1, wherein the reference chamber and the test chamber are made of plastic or metal.

6. The apparatus for non-invasively measuring the respiratory index of the animal according to claim 1, wherein a movable bottom plate or an elastic cabin is arranged inside the test cabin.

7. The apparatus of claim 1, wherein at least two of the air circuit interfaces are provided.

8. The apparatus of claim 1, wherein the data acquisition device is connected to a plurality of pressure sensors, each of the pressure sensors detecting one of the test chamber and one of the reference chamber.

9. The apparatus for non-invasively measuring respiratory indices of an animal of claim 1 wherein the data acquisition device comprises a computer.

10. The apparatus for non-invasively measuring respiratory indices of an animal of claim 1 wherein the reference chamber has a volume less than the volume of the test chamber.