CN215525253U

CN215525253U - Dry blood spot preparation facilities

Info

Publication number: CN215525253U
Application number: CN202121004621.9U
Authority: CN
Inventors: 赵蓓蓓; 张婷; 佘旭辉; 陈秀如; 梁嘉威
Original assignee: Guangzhou Kingmed Diagnostics Group Co ltd; Guangzhou Kingmed Diagnostics Central Co Ltd
Current assignee: Guangzhou Kingmed Diagnostics Group Co ltd; Guangzhou Kingmed Diagnostics Central Co Ltd
Priority date: 2021-05-11
Filing date: 2021-05-11
Publication date: 2022-01-14
Anticipated expiration: 2031-05-11

Abstract

The utility model discloses a dried blood spot preparation device, which comprises: operation platform, a blood storage pool for holding blood, a chamber and move liquid control structure that hold for depositing filter paper, blood storage pool all sets up on operation platform with holding the chamber, move liquid control structure including moving liquid subassembly and removal subassembly, remove the subassembly setting on operation platform, move liquid subassembly activity and set up on removing the subassembly, move liquid subassembly along with remove the subassembly and move to blood storage pool position department and absorb blood and move once more and hold chamber position department and with the blood droplet formation dry blood spot on filter paper. The utility model realizes the function that the pipetting assembly can simultaneously manufacture a plurality of dried blood spots at the position of the accommodating cavity, so that the dried blood spots can be prepared in batches. Compared with the prior art, the dry blood spot preparation device has the advantages of large sampling area, more sampling numbers and good uniformity of the dry blood spots, and meets the requirement of batch sample preparation.

Description

Dry blood spot preparation facilities

Technical Field

The utility model relates to the technical field of medical equipment, in particular to a dry blood spot preparation device.

Background

The dry blood spot technology is that whole blood is dripped on a filter paper sheet and naturally dried to obtain a dry blood spot sample. Compared with whole blood and serum samples, the dry blood spot sample has the advantages of convenient blood collection, small wound, easy operation, small storage space, convenient transportation, stable sample and the like. With the development of mass spectrometry and other analysis technologies, the method overcomes the challenges of analysis sensitivity and selectivity caused by a small amount of blood and a complex matrix in a dry blood spot sample, the clinical value of the dry blood spot is rapidly approved, and the dry blood spot has wide application in the fields of newborn screening, gene detection, nutrition monitoring, drug concentration monitoring and the like.

With the increasing application of the technology to clinical detection, the accuracy of the determination method becomes more and more important, and the preparation of dry blood spot reagents (curves, quality control and the like) is a decisive factor of the accuracy of the detection method. At present, commercial reagents for dried blood spots on the market are few and have high value, and most laboratories adopt a self-made scheme to prepare dried blood spot samples. The existing method only aims at clinical sample sampling, has small sampling area, small sampling number and high manual degree, can not meet the requirement of batch sample preparation, and can not carry out batch preparation on the dry blood spot reagent.

SUMMERY OF THE UTILITY MODEL

The embodiment of the utility model provides a dried blood spot preparation device, which is used for solving the technical problems that the prior art is only used for clinical sample sampling, the sampling area is small, the sampling number is small, the batch sample preparation requirement cannot be met, and a dried blood spot reagent cannot be prepared in batches.

In order to solve the above problems, there is provided a dried blood spot preparation device including:

an operating platform;

a blood reservoir for containing blood, the blood reservoir being disposed on the operation platform;

the accommodating cavity is used for storing filter paper and is arranged on the operating platform;

and the liquid transferring control structure comprises a liquid transferring component and a moving component, the moving component is arranged on the operating platform, the liquid transferring component is movably arranged on the moving component, the liquid transferring component moves to the position of the blood storage pool along with the moving component to suck blood and moves to the position of the accommodating cavity again to drop the blood onto the filter paper to form a dried blood spot.

Preferably, the moving assembly moves laterally or longitudinally on the operation platform.

Preferably, the moving assembly includes a first transmission structure, a second transmission structure and a third transmission structure, the first transmission structure is perpendicular to the second transmission structure and the third transmission structure, the second transmission structure is perpendicular to the third transmission structure, the first transmission structure moves in a transverse direction, and the second transmission structure and the third transmission structure move in a longitudinal direction.

Preferably, the pipetting assembly comprises a moving member and a pipettor for temporarily storing blood, the moving member is arranged on the moving assembly, and the pipettor is movably arranged on the moving member.

Preferably, the pipettor moves in a vertical direction or a horizontal direction with respect to the moving member.

Preferably, the moving member includes a fixed block and a moving bracket movably disposed on the fixed block, the fixed block is disposed on the moving assembly, and the pipette is disposed on the moving bracket.

Preferably, the pipette comprises a pressure lever for controlling the sucking and releasing of blood and one or more suction heads communicated with the pressure lever, and when the pressure lever is pressed down, the suction heads suck blood, and when the pressure lever is pressed down again, the suction heads release blood.

Preferably, the suction head comprises a connecting block and a suction pipe, the connecting block is arranged between the pressing rod and the suction pipe, and the connecting block is respectively communicated with the pressing rod and the suction pipe.

Preferably, the operation platform includes the base and with the base vertically main part, the blood storage pond with it all sets up to hold the chamber on the base, move liquid control structure setting is in on the main part.

Preferably, the pipetting control structure further comprises a control part which is used for controlling the operation of the pipetting assembly and the moving assembly and is connected with the pipetting assembly, and the control part is arranged on the main body.

The embodiment of the utility model has the following beneficial effects:

set up on moving the subassembly through moving the activity of liquid subassembly, move the liquid subassembly along with moving the subassembly and absorb blood and move once more and hold chamber position department and form the dry blood spot with the blood drop on filter paper to blood storage pool position department, thereby realized moving the liquid subassembly and making a plurality of dry blood spots simultaneously holding chamber position department, make the dry blood spot can carry out batch preparation, and move the liquid subassembly and can standard control move the liquid volume, keep the uniformity of beating blood speed, guarantee homogeneity between the blood spot, thereby make the dry blood spot quality of preparing better. Compared with the prior art, the dry blood spot preparation device has the advantages of large sampling area and more sampling numbers, and meets the requirement of batch sample preparation.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.

Wherein:

FIG. 1 is a schematic front view of a dry blood spot preparation device in one embodiment;

FIG. 2 is a schematic side view of the dry blood spot preparation device shown in FIG. 1.

The names and designations of the major components are as follows:

an operating platform-100; a blood storage pool-121; a receiving cavity-122; pipetting control structure-200; a pipetting assembly-220; a moving component-230; a moving member-222; pipette-221; a fixed block-2222; moving the support-2221; a pressure bar-2211; a suction head-2212; connecting block-22121; straw-22122; a base-120; a body-110; control-210; a first transmission structure-231; a second transmission structure-232; a third transport structure-233; gun head box-123; gun head-124; a speed adjusting button-130; blending switch button-140; filter paper-125; gun withdrawing box-126; switching element-300.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Referring to fig. 1 or fig. 2, a dry blood spot preparation apparatus provided by the present invention is now described, which includes an operation platform 100, a blood storage tank 121 for containing blood, a containing cavity 122 for storing filter paper 125, and a liquid-moving control structure 200, wherein the blood storage tank 121 and the containing cavity 122 are both disposed on the operation platform 100, the liquid-moving control structure 200 includes a liquid-moving assembly 220 and a moving assembly 230, the moving assembly 230 is disposed on the operation platform 100, the liquid-moving assembly 220 is movably disposed on the moving assembly 230, the liquid-moving assembly 220 moves to the position of the blood storage tank 121 along with the moving assembly 230 to suck blood and move to the position of the containing cavity 122 again to drop blood onto the filter paper to form a dry blood spot.

In the embodiment, the pipetting assembly 220 is movably arranged on the moving assembly 230, the pipetting assembly 220 moves to the position of the blood storage tank 121 along with the moving assembly 230 to suck blood and moves to the position of the accommodating cavity 122 again to drip the blood onto the filter paper to form a dried blood spot, so that the pipetting assembly 220 can simultaneously make a plurality of dried blood spots at the position of the accommodating cavity 122, and the dried blood spots can be prepared in batches. Compared with the prior art, the dry blood spot preparation device has the advantages of large sampling area and more sampling numbers, and meets the requirement of batch sample preparation.

Specifically, the blood storage tank 121 and the accommodating cavity 122 are both disposed on the operation platform 100, but the positions of the blood storage tank 121 and the accommodating cavity 122 on the operation platform 100 are different, so that the moving assembly 230 is required to drive the pipetting assembly 220 to sequentially suck blood from the blood storage tank 121 and move the blood to the position of the accommodating cavity 122 again and drop the blood onto the filter paper to form a dried blood spot. In fact, the blood storage tank 121 is provided with the mixing switch button 140 for uniformly mixing the blood in the blood storage tank 121, when the mixing switch button 140 is turned on, the blood in the blood storage tank 121 starts to be mixed, when the blood is mixed for a certain time, the concentration of the blood reaches uniformity, the mixing switch button 140 is turned off, the mixing of the blood is stopped, the rotating speed adjusting button 130 is arranged at the interval of the mixing switch button 140 for adjusting the mixing speed of the blood, the higher the mixing speed is, the higher the mixing force is, the speed of mixing needs to be adjusted according to the concentration of the blood, the finally obtained blood is more standard through the mixing switch button 140 and the rotating speed adjusting button 130, and the quality of the finally prepared dried blood spots is better. Wherein, the size of the accommodating cavity 122 can be designed according to the actual production requirement, so that the dried blood spots can be conveniently produced in large batch.

In one embodiment, the moving assembly 230 moves laterally or longitudinally on the operation platform 100.

In this embodiment, the moving assembly 230 moves transversely or longitudinally relative to the operation platform 100, that is, moves along at least three directions of the transverse direction or the longitudinal direction, and the three directions are perpendicular to each other, and the moving assembly 230 can drive the pipetting assembly 220 to move along the three directions, so that the pipetting assembly 220 finally reaches the position of the blood storage pool 121 to aspirate blood, and also reaches the position of the accommodating cavity 122 to prepare dried blood spots, thereby efficiently realizing mass production of dried blood spots.

In one embodiment, the moving assembly 230 includes a first transmission structure 231, a second transmission structure 232 and a third transmission structure 233, the first transmission structure 231 is perpendicular to the second transmission structure 232 and the third transmission structure 233, respectively, the second transmission structure 232 is perpendicular to the third transmission structure 233, the first transmission structure 231 moves in a lateral direction, and the second transmission structure 232 and the third transmission structure 233 move in a longitudinal direction.

In the present embodiment, the pipetting module 220 moves on the first transfer structure 231, the second transfer structure 232 and the third transfer structure 233 respectively, and the first transfer structure 231, the second transfer structure 232 and the third transfer structure 233 move along three different directions respectively, so that the pipetting module 220 can reach the position of the blood storage pool 121 to aspirate blood and also reach the position of the containing cavity 122 to prepare dried blood spots. In fact, the first, second and

third transport structures

231, 232, 233 can be either a belt transport structure or three slide structures and each can carry the pipetting assembly 220 for movement in three different directions.

In one embodiment, the pipetting assembly 220 includes a moving member 222 and a pipettor 221 for temporarily storing blood, the moving member 222 is disposed on the moving assembly 230, and the pipettor 221 is movably disposed on the moving member 222.

In this embodiment, by disposing the moving member 222 on the moving assembly 230 and moving in various directions along with the moving assembly 230, and by disposing the pipettor 221 on the moving member 222, that is, the pipettor 221 is also movable on the moving member 222, when the pipettor 221 moves along with the moving member 222 to the position of the blood reservoir 121, the pipettor 221 further needs to continue to move into the blood reservoir 121 to aspirate blood, at this time, the pipettor 221 needs to move on the moving member 222 and the pipettor 221 moves toward the blood in the blood reservoir 121, after the pipettor 221 aspirates the blood, the pipettor 221 starts to move in a direction away from the blood reservoir 121 and then moves along with the moving member 222 toward the position of the receiving cavity 122, when the position of the receiving cavity 122 is reached, the pipettor 221 starts to move on the moving member 222, and the pipettor 221 moves toward the filter paper in the receiving cavity 122, and when the filter paper approaches, the pipettor 221 starts to release blood to prepare dried blood spots, after the preparation is completed, the pipettor 221 moves to the next piece of filter paper along with the moving piece 222 in the accommodating cavity 122, the pipettor 221 releases blood to prepare another dried blood spot, the pipettor 221 does not finish releasing blood until all the filter papers are prepared, at this time, the pipettor 221 moves in a direction away from the accommodating cavity 122, and thus, the whole movement process of the pipettor 221 is completed.

In one embodiment, the pipettor 221 moves in a vertical direction or a horizontal direction with respect to the moving member 222.

In this embodiment, when the pipette 221 moves to the position of the blood storage pool 121 along with the moving member 222, the pipette 221 starts to move close to the blood storage pool 121 and suck blood, that is, at this time, the pipette 221 is above the blood storage pool 121 or at a position close to the above, it is required that the pipette 221 further moves into the blood storage pool 121, that is, the pipette 221 needs to move along a vertical direction or a horizontal direction, and then can complete sucking blood by the pipette 221, when the pipette 221 completes sucking blood, the pipette 221 moves along a vertical direction and is far away from the blood storage pool 121, and then prepares to perform a next stage of movement, and similarly, when the pipette 221 moves to the position of the accommodating cavity 122 along with the moving member 222, the pipette starts to move close to the accommodating cavity 122 and releases blood, that is, at this time, the pipette 221 is above the accommodating cavity 122 or at a position close to the above, it is necessary to move the pipette 221 further into the receiving cavity 122, that is, the pipette 221 needs to move in the vertical direction or in the horizontal direction, and only when the pipette 221 releases the blood, the dried blood spot can be prepared, and when the pipette 221 releases the blood, the pipette 221 moves in the vertical direction and is away from the receiving cavity 122.

In one embodiment, the moving member 222 includes a fixed block 2222 and a moving bracket 2221 movably disposed on the fixed block 2222, the fixed block 2222 is disposed on the moving assembly 230, and the pipette 221 is disposed on the moving bracket 2221.

In this embodiment, the movable holder 2221 is movably disposed on the fixed block 2222, so that the pipette 221 moves vertically or horizontally along with the movable holder 2221. In fact, the moving mode of the moving support 2221 on the fixed block 2222 may be a transmission motion or a sliding motion, and of course, these moving modes are uniformly supported by the designed structure, and a transmission mechanism or a sliding mechanism may be designed to realize that the moving support 2221 moves on the fixed block 2222, that is, the support drives the pipettor 221 to move.

In one embodiment, the pipette 221 includes a plunger 2211 for controlling the sucking and discharging of blood, and one or more tips 2212 communicating with the plunger 2211, wherein when the plunger 2211 is pressed down, the tip 2212 sucks blood, and when the plunger 2211 is pressed down again, the tip 2212 discharges blood.

In this embodiment, the suction head 2212 is moved into the blood reservoir 121, the air in the suction head 2212 is exhausted by pressing down the pressing rod 2211, the pressing rod 2211 is pulled up, the pressure in the suction head 2212 is lower than the atmospheric pressure of the outside until the suction head 2212 is full of blood, the pressing rod 2211 stops pulling up, when the suction head 2212 is moved to the position of the accommodating cavity 122 again, the pressing rod 2211 is pressed down again, the blood in the suction head 2212 starts to be released to the filter paper, when no blood is needed on the filter paper, the blood in the

suction head

2211, 2212 can be pulled up again to stop releasing immediately, and thus the suction and release of the blood in the suction head 2212 are perfectly controlled by the pressing rod 2211. In fact, if the yield needs to be increased, a plurality of suction heads 2212 can be arranged on the compression bar 2211, so that a large amount of blood can be sucked in the blood storage tank 121 by the plurality of suction heads 2212 at the same time, when the plurality of suction heads 2212 move to the position of the accommodating cavity 122, the plurality of suction heads 2212 simultaneously release the blood to start releasing on the filter paper, a plurality of dried blood spots are formed simultaneously, the production efficiency of the dried blood spots is greatly improved, and the mass production of the dried blood spots is realized. Wherein, can guarantee homogeneity between the blood spot through depression bar standard control move liquid volume to make the dry blood spot quality of preparing better.

In one embodiment, the suction head 2212 comprises a connecting block 22121 and a suction tube 22122, the connecting block 22121 is disposed between the pressing rod 2211 and the suction tube 22122, and the connecting block 22121 is respectively communicated with the pressing rod 2211 and the suction tube 22122.

In this embodiment, a cavity is formed inside the connecting block 22121, and the end of the pressing rod 2211 is connected to an exhaust plate movable in the cavity, so that when the pressing rod 2211 is pressed down, the exhaust plate exhausts all air in the cavity, and the pressing value of the pressing rod 2211 can be controlled to reduce the amount of blood to be sucked up and released by the suction tube 22122. In fact, the operation platform 100 is further provided with a gun head box 123 and a gun withdrawing box 126, before blood is sucked, the suction head 2212 needs to be moved to the position of the gun head box 123, the suction pipe 22122 needs to be matched with the gun head 124 in the gun head box 123 to suck blood in the blood storage tank 121 in the next step, when blood is sucked, the blood is released in the accommodating position, when dried blood spots are prepared, the suction head 2212 needs to be moved to the gun withdrawing box 126 to withdraw the gun head 124, of course, different types of gun heads 124 suck blood with different concentrations, and therefore, if dried blood spots with different concentrations need to be prepared, the gun heads 124 need to be continuously replaced.

In one embodiment, the operation platform 100 comprises a base 120 and a main body 110 perpendicular to the base 120, the blood reservoir 121 and the receiving cavity 122 are disposed on the base 120, and the pipetting control structure 200 is disposed on the main body 110.

In this embodiment, the operation platform 100 is composed of two parts, which are a base 120 and a main body 110 perpendicular to the base 120, the pipetting control structure 200 is disposed on the main body 110, and the pipetting control structure 200 is movable on the main body 110, so that the moving component 230 drives the pipetting component 220 to move on the main body 110 and can move to the positions of the blood storage tank 121 and the accommodating cavity 122 on the base 120, thereby facilitating the preparation of the dried blood spot and improving the efficiency of the preparation of the dried blood spot.

In one embodiment, the pipetting control structure 200 further comprises a control member 210 for controlling the operation of the pipetting assembly 220 and the moving assembly 230 and connected to the pipetting assembly 220, the control member 210 being disposed on the body 110.

In this embodiment, the control element 210 controls the pipetting assembly 220 and the moving assembly 230 to operate, so that the dry blood spots can be automatically prepared, of course, a whole set of programs for controlling the pipetting assembly 220 and the moving assembly 230 to operate are installed on the control element 210, the control element 210 can sequentially control the control element 210, the control element 210 can also store and monitor the data quality of the dry blood spots, if an accident or quality problem occurs during the production of the dry blood spots, the control element 210 can immediately interrupt the production, and when the production is normal, the normal process production is performed, so that the dry blood spots can be continuously produced in batches. In fact, the switch 300 of the whole device is also provided on the main body 110, and the normal production of dried blood spots can be performed only by opening the switch 300.

The above disclosure is only for the purpose of illustrating the preferred embodiments of the present invention, and it is therefore to be understood that the utility model is not limited by the scope of the appended claims.

Claims

1. A dried blood spot preparation device, comprising:

an operating platform;

2. The dry blood spot preparation device according to claim 1, wherein the moving assembly moves laterally or longitudinally on the operation platform.

3. The dried blood spot preparation device according to claim 2, wherein the moving assembly comprises a first transport structure, a second transport structure and a third transport structure, the first transport structure being mutually perpendicular to the second transport structure and the third transport structure, respectively, the second transport structure being mutually perpendicular to the third transport structure, the first transport structure being in a lateral motion and the second transport structure being in a longitudinal motion.

4. The dry blood spot preparation device according to claim 1, wherein the pipetting assembly comprises a moving member and a pipette for temporarily storing blood, the moving member being disposed on the moving assembly, the pipette being movably disposed on the moving member.

5. The dry blood spot preparation device according to claim 4, wherein the pipette is moved in a vertical direction or a horizontal direction with respect to the moving member.

6. The dried blood spot preparation device according to claim 5, wherein the moving member comprises a fixed block and a moving bracket movably disposed on the fixed block, the fixed block is disposed on the moving assembly, and the pipette is disposed on the moving bracket.

7. The dry blood spot preparation device according to claim 6, wherein the pipette comprises a plunger for controlling the sucking and discharging of blood and one or more tips communicating with the plunger, and when the plunger is depressed, the tip sucks up blood, and when the plunger is depressed again, the tip discharges blood.

8. The dry blood spot preparation device according to claim 7, wherein the suction head comprises a connection block and a suction tube, the connection block is disposed between the pressure lever and the suction tube, and the connection block is respectively communicated with the pressure lever and the suction tube.

9. The dry blood spot preparation device according to any one of claims 1 to 8, wherein the operation platform comprises a base and a main body perpendicular to the base, the blood reservoir and the receiving chamber are both disposed on the base, and the pipetting control structure is disposed on the main body.

10. The dry blood spot preparation device according to claim 9, wherein the pipetting control structure further comprises a control member for controlling operation of and connection with the pipetting assembly and the movement assembly, the control member being disposed on the main body.