CN215427432U - Convenient chromatographic component collector - Google Patents

Convenient chromatographic component collector Download PDF

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Publication number
CN215427432U
CN215427432U CN202121781241.6U CN202121781241U CN215427432U CN 215427432 U CN215427432 U CN 215427432U CN 202121781241 U CN202121781241 U CN 202121781241U CN 215427432 U CN215427432 U CN 215427432U
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China
Prior art keywords
sliding
support
collecting
waste liquid
bottom suspension
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CN202121781241.6U
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Chinese (zh)
Inventor
李岩异
刘容麟
王炜
张卫婷
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Ncpc Genetech Biotechnology Development Co ltd
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Ncpc Genetech Biotechnology Development Co ltd
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Priority to CN202121781241.6U priority Critical patent/CN215427432U/en
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Abstract

The utility model relates to a convenient chromatographic component collector which structurally comprises a base, wherein a waste liquid collecting box and a support are arranged on the base, a sliding frame is arranged on the support, the sliding frame is installed on the support through a height adjusting mechanism, a sliding rod is connected on the sliding frame in a sliding manner, a collecting head is connected on the sliding rod in a sliding manner, and the collecting head is communicated with a liquid guide pipe; the top of box is collected to the waste liquid is provided with two bottom suspension faggings, leaves the gap between two bottom suspension faggings and forms the waste liquid and collect the ditch be provided with the support column on the bottom suspension fagging the top of support column is provided with the backup pad the bottom suspension fagging with it has the accommodation hole that is matrix distribution to open respectively on the backup pad. The utility model has simple structure and convenient use, can reduce the loss of target protein and can be suitable for collecting containers of different models.

Description

Convenient chromatographic component collector
Technical Field
The utility model relates to a chromatography collection device, in particular to a convenient chromatography component collector.
Background
At present, in a chromatographic system which is not provided with a collector at the purification development optimization stage of recombinant protein, in order to solve the problems that when a target peak is collected in sections, the collecting pipe is easy to run out of a collecting container to cause the loss of collecting liquid, and a collecting pipeline is put into adjacent collecting liquid, so that the possibility of mutual pollution of the solutions collected in each section is increased, and the detection of the components of the solutions collected in each section is unreal, the collecting pipe needs to be held by hands all the time during operation, so that the experiment operation is time-consuming, labor-consuming and easy to make mistakes.
SUMMERY OF THE UTILITY MODEL
The utility model aims to provide a convenient chromatographic component collector to solve the problems that the operation is time-consuming and labor-consuming in the purification, development and optimization stage of recombinant protein, the collecting solution is easy to lose and the sectional collecting solutions are mutually polluted.
The utility model is realized by the following steps: a convenient chromatographic component collector comprises a base, wherein a waste liquid collecting box and a support are arranged on the base, a sliding frame is arranged on the support, the sliding frame is installed on the support through a height adjusting mechanism, a sliding rod is connected onto the sliding frame in a sliding manner, a collecting head is connected onto the sliding rod in a sliding manner, and the collecting head is communicated with a liquid conduit; the top of box is collected to the waste liquid is provided with two bottom suspension faggings, leaves the gap between two bottom suspension faggings and forms the waste liquid and collect the ditch be provided with the support column on the bottom suspension fagging the top of support column is provided with the backup pad the bottom suspension fagging with it has the accommodation hole that is matrix distribution to open respectively on the backup pad.
The height adjusting mechanism comprises a sleeve arranged at the end part of the sliding frame, the sleeve is sleeved on the support, a fixing screw is arranged on the sleeve, and the fixing screw penetrates through the side wall of the sleeve.
The sliding frame is characterized in that a sliding groove is formed in the inner side of the sliding frame, and the end part of the sliding rod is installed in the sliding groove.
The sliding rod is provided with a sliding hole, and the collecting head penetrates through the sliding hole.
Two fixed knobs are screwed on the outer wall of the collecting head, and the fixed knobs are respectively positioned on the upper side and the lower side of the sliding rod.
Scales are respectively arranged on the support, the sliding frame and the sliding rod.
The waste liquid collecting box is used for collecting waste liquid, the liquid collecting pipes are arranged on the upper supporting plate and the lower supporting plate, the accommodating holes are distributed in a matrix mode, the liquid collecting pipes are also distributed in a matrix mode, the upper supporting plate and the lower supporting plate can be replaced to adapt to the liquid collecting pipes with different diameters, and the upper supporting plate can move up and down along with the supporting columns to adapt to the liquid collecting pipes with different heights.
The sliding frame can move up and down along the support, the sliding rod can move back and forth along the sliding frame, and the collecting head can move left and right along the sliding rod, so that the collecting head can move up and down, left and right and front and back, and the collecting head can correspond to different liquid collecting pipes when in use. When the target protein is collected, the collecting head can be quickly moved from one liquid collecting pipe to the next liquid collecting pipe, so that the loss of the volume of the target protein component in the collecting process is avoided. The mutual pollution of adjacent components caused by the fact that the liquid outlet pipeline of each part of collected liquid extends into the collecting container is eliminated, and the detection result of the collection of each component is more real.
The utility model provides great convenience for collecting waste liquid except the target protein, no waste liquid bottle needs to be prepared additionally, and the waste liquid is convenient to discharge and collect.
The position of the collecting head can be accurately determined through the scales and the marks, so that the collecting head corresponds to each liquid collecting pipe.
The utility model has simple structure and convenient use, can reduce the loss of target protein and can be suitable for collecting containers of different models.
Drawings
Fig. 1 is a schematic structural view of the present invention.
Fig. 2 is a side view of the present invention.
Fig. 3 is a top view of the present invention.
In the figure: 1. a base; 2. a waste liquid collection box; 3. a support; 4. a carriage; 5. a slide bar; 6. a collection head; 7. a liquid conduit; 8. a lower support plate; 9. a support pillar; 10. an upper support plate; 11. a waste liquid collection trench; 12. a sleeve; 13. a set screw; 14. a slide hole; 15. an accommodation hole; 16. fixing the knob; 17. a chute.
Detailed Description
As shown in fig. 1, 2 and 3, the present invention comprises a base 1, a waste liquid collecting box 2 and a bracket 3 are arranged on the base 1, a sliding frame 4 is arranged on the bracket 3, the sliding frame 4 is arranged on the bracket 3 through a height adjusting mechanism, a sliding rod 5 is connected on the sliding frame 4 in a sliding way, a collecting head 6 is connected on the sliding rod 5 in a sliding way, and the collecting head 6 is communicated with a liquid conduit 7. Be provided with two bottom suspension faggings 8 at the top of waste liquid collection box 2, leave the gap between two bottom suspension faggings 8 and form waste liquid and collect ditch 11, be provided with support column 9 on bottom suspension fagging 8, be provided with backup pad 10 on the top of support column 9, it has the accommodation hole 15 that is the matrix distribution to open respectively on bottom suspension fagging 8 and last backup pad 10.
The base 1 is the horizontality, and support 3 perpendicular to base 1, support 3 are total two, and two supports 3 are located the both sides at base 1 rear, are connected with the horizontal pole between two supports 3, and the portal frame structure is constituteed with support 3 to the horizontal pole, and the cross section of support 3 is the rectangle.
Box 2 is collected to the waste liquid open-top, and 8 overlap joints of bottom suspension fagging are at the top that box 2 was collected to the waste liquid, and the vertical cross-under of support column 9 is on bottom suspension fagging 8, and thereby support column 9 can reciprocate the height of adjusting upper support plate 10 for bottom suspension fagging 8, and when not artifical external force of exerting, support column 9 can support the weight of upper support plate 10, liquid collecting pipe and liquid.
The waste liquid collecting box 2 is used for collecting waste liquid, a plurality of liquid collecting pipes are arranged on an upper supporting plate 10 and a lower supporting plate 8, the liquid collecting pipes are distributed in a matrix mode due to the fact that the accommodating holes 15 are distributed in the matrix mode, the upper supporting plate 10 and the lower supporting plate 8 can be replaced to adapt to liquid collecting pipes with different diameters, and the upper supporting plate 10 can move up and down along with the supporting columns 9 to adapt to liquid collecting pipes with different heights.
The height adjusting mechanism comprises a sleeve 12 fixed at the end of the sliding frame 4, the sleeve 12 is sleeved on the support 3, a fixing screw 13 is arranged on the sleeve 12, and the fixing screw 13 penetrates through the side wall of the sleeve 12. The sleeve 12 can move up and down along the bracket 3 to drive the sliding rod 5 to move up and down along the bracket 3, and after the height of the sliding rod 5 is determined, the fixing screw 13 is rotated to enable the end part of the fixing screw 13 to tightly push against the bracket 3, so that the position of the sliding rod 5 is fixed.
Be equipped with spout 17 respectively in the inboard of two carriage 4, spout 17 sets up along the length direction of carriage 4, and install in spout 17 at the both ends of slide bar 5, and slide bar 5 can slide around following spout 17 to the realization is to the regulation of collection head 6 front and back position.
The sliding rod 5 is provided with a sliding hole 14, the sliding hole 14 is long and is arranged along the length direction of the sliding rod 5, the collecting head 6 penetrates through the sliding hole 14, and the collecting head 6 can slide in the sliding hole 14 to move left and right.
The sliding frame 4 can move up and down along the support 3, the sliding rod 5 can move back and forth along the sliding frame 4, and the collecting head 6 can move left and right along the sliding rod 5, so that the collecting head 6 can move up and down, left and right and front and back, and the collecting head 6 corresponds to different liquid collecting pipes when in use.
Two fixing knobs 16 are screwed on the outer wall of the collecting head 6, the fixing knobs 16 are respectively positioned on the upper side and the lower side of the sliding rod 5, and when the position of the collecting head 6 needs to be fixed, the sliding rod 5 is clamped by rotating the fixing knobs 16, so that the collecting head 6 is fixed.
Scales or marks are respectively arranged on the support 3, the sliding frame 4 and the sliding rod 5, grooves are arranged in the sliding grooves 17 and the sliding holes 14 corresponding to the digital scales or marks, so that the sliding rod 5 or the collecting head 6 can be accurately and temporarily positioned at the corresponding scales or marks, and the collecting head 6 can be accurately corresponding to the liquid collecting pipe.
When the target protein is collected, the collecting head 6 can be quickly moved from one liquid collecting pipe to the next liquid collecting pipe, so that the loss of the volume of the target protein component in the collecting process is avoided. The mutual pollution of adjacent components caused by the fact that the liquid outlet pipeline of each part of collected liquid extends into the collecting container is eliminated, and the detection result of the collection of each component is more real.
The utility model is provided with the waste liquid collecting box 2, when the waste liquid needs to be discharged, the collecting head 6 is moved to the upper part of the waste liquid collecting groove 11 to discharge the waste liquid, thereby providing great convenience for collecting the waste liquid except the target protein, avoiding the need of additionally preparing a waste liquid bottle and simultaneously facilitating the discharge and collection of the waste liquid.
The utility model has simple structure and convenient use, can reduce the loss of target protein and can be suitable for collecting containers of different models.

Claims (6)

1. A convenient chromatographic component collector is characterized by comprising a base, wherein a waste liquid collecting box and a support are arranged on the base, a sliding frame is arranged on the support, the sliding frame is installed on the support through a height adjusting mechanism, a sliding rod is connected onto the sliding frame in a sliding manner, a collecting head is connected onto the sliding rod in a sliding manner, and the collecting head is communicated with a liquid guide pipe; the top of box is collected to the waste liquid is provided with two bottom suspension faggings, leaves the gap between two bottom suspension faggings and forms the waste liquid and collect the ditch be provided with the support column on the bottom suspension fagging the top of support column is provided with the backup pad the bottom suspension fagging with it has the accommodation hole that is matrix distribution to open respectively on the backup pad.
2. The portable chromatography component collector of claim 1, wherein the height adjustment mechanism comprises a sleeve disposed at an end of the carriage, the sleeve being sleeved on the support, and a set screw disposed on the sleeve, the set screw passing through a sidewall of the sleeve.
3. The portable chromatography component collector of claim 1, wherein a chute is provided inside the carriage, and an end of the sliding rod is mounted in the chute.
4. The portable chromatography component collector of claim 1, wherein the sliding rod is provided with a sliding hole, and the collecting head passes through the sliding hole.
5. The portable chromatography component collector of claim 1, wherein two fixing knobs are screwed on the outer wall of the collecting head, and the fixing knobs are respectively positioned on the upper and lower sides of the sliding rod.
6. The portable chromatography component collector of claim 1, wherein scales are provided on the support, the carriage, and the sliding bar, respectively.
CN202121781241.6U 2021-08-02 2021-08-02 Convenient chromatographic component collector Active CN215427432U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202121781241.6U CN215427432U (en) 2021-08-02 2021-08-02 Convenient chromatographic component collector

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202121781241.6U CN215427432U (en) 2021-08-02 2021-08-02 Convenient chromatographic component collector

Publications (1)

Publication Number Publication Date
CN215427432U true CN215427432U (en) 2022-01-07

Family

ID=79690516

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202121781241.6U Active CN215427432U (en) 2021-08-02 2021-08-02 Convenient chromatographic component collector

Country Status (1)

Country Link
CN (1) CN215427432U (en)

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