CN215388010U

CN215388010U - Purification device for producing Laolatinib intermediate

Info

Publication number: CN215388010U
Application number: CN202121977189.1U
Authority: CN
Inventors: 彭捷; 向世明; 董强; 潘旭; 张翔
Original assignee: Chengdu Better Pharmaceutical Technology Co ltd
Current assignee: Chengdu Better Pharmaceutical Technology Co ltd
Priority date: 2021-08-20
Filing date: 2021-08-20
Publication date: 2022-01-04
Anticipated expiration: 2031-08-20

Abstract

The utility model provides a purification device for producing a Laolatinib intermediate, which comprises a sleeve, a filter cylinder and a cover plate, wherein a rotary table is arranged on the bottom surface of the cover plate, the rotary table is connected with a first motor, the filter cylinder is detachably connected with the rotary table through threads, the size of the filter cylinder is smaller than that of the sleeve, and the filter cylinder is positioned in the sleeve; according to the purification device for producing the Laplace nib intermediate, the filter cylinder is matched with the sleeve, the filter cylinder rotates in the sleeve, materials in the filter cylinder are separated and purified by taking the wall of the filter cylinder as a filter medium under the action of centrifugal force, purified filtrate is stored in the sleeve, residues are left in the filter cylinder, and the purification device is convenient, simple and high in efficiency.

Description

Purification device for producing Laolatinib intermediate

Technical Field

The utility model relates to the technical field of pharmaceutical equipment, in particular to a purification device for producing Laolatinib intermediates.

Background

Laolatinib is a third-generation ALK Tyrosine Kinase Inhibitor (TKI) Lorbrena, is effective on crizotinib and second-generation ALK inhibitor drug-resistant lung cancer, and can play a good role in non-small cell lung cancer with central nervous system metastasis due to high blood brain barrier permeability. Is suitable for treating ALK positive and ROS1 positive advanced NSCLC.

The loratinib is a chemical raw material or a chemical product, and needs to be purified, i.e. separated and purified, during the synthesis process, so that the loratinib drug intermediate reaches a certain grade for the subsequent synthesis of drugs. The traditional separation mode adopts a filter screen to separate, the time consumption is long, the effect is poor, and the working efficiency is low easily.

SUMMERY OF THE UTILITY MODEL

The utility model provides a purification device for producing Laolatinib intermediates, which can efficiently separate and purify drug intermediates.

The embodiment of the utility model is realized by the following technical scheme:

the utility model provides a production loratinib is purification device for intermediate body, includes the sleeve, strains a section of thick bamboo and apron install the carousel on the bottom surface of apron, the carousel is connected with first motor, strain a section of thick bamboo with the connection can be dismantled through the screw thread to the carousel, the size of straining a section of thick bamboo is less than telescopic size, strain a section of thick bamboo and be located telescopic inside strain and overlap on the periphery wall of a section of thick bamboo and be equipped with plastic film.

Further, the cover plate is detachably connected with the sleeve through a buckle.

So set up, when straining a section of thick bamboo and rotate in the sleeve, apron and sleeve can fix, so can prevent that liquid from splashing out in the sleeve.

Further, a bottom cap is threadedly mounted to the bottom of the filter cartridge.

The purpose of setting up the bottom is in order to conveniently clear up the residue in straining a section of thick bamboo, and the material in straining a section of thick bamboo can have a large amount of residues after many times filter separation, can shift out straining a section of thick bamboo this moment, then opens the bottom, can clear up the residue.

Further, still include the pole setting the second motor is installed to the tip of pole setting, the second motor is located the top of apron be equipped with the link on the apron the output department of second motor is equipped with the haulage rope the tip of haulage rope is equipped with the couple, the couple with the link phase-match.

The cover plate can be automatically lifted by the traction of the second motor.

Further, still include the annular transmission band, the sleeve is placed on the annular transmission band.

Further, the number of the sleeves placed on the endless transmission belt is plural.

The automatic assembly line operation is realized by the arrangement.

Furthermore, a plurality of grooves are formed in the annular conveying belt and matched with the sleeves.

The groove can fix the position of the sleeve to prevent the sleeve from displacing.

The technical scheme of the embodiment of the utility model at least has the following advantages and beneficial effects:

according to the purification device for producing the Laplace nib intermediate, the filter cylinder is matched with the sleeve, the filter cylinder rotates in the sleeve, materials in the filter cylinder are separated and purified by taking the wall of the filter cylinder as a filter medium under the action of centrifugal force, purified filtrate is stored in the sleeve, residues are left in the filter cylinder, and the purification device is convenient, simple and high in efficiency.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.

Fig. 1 is a first schematic structural diagram of a purification apparatus for producing a loratinib intermediate provided in embodiment 1 of the present invention;

fig. 2 is a schematic structural diagram ii of a purification apparatus for producing a loratinib intermediate provided in embodiment 1 of the present invention;

fig. 3 is a schematic view of the construction of the filter cartridge shown in fig. 1.

Icon: 1-sleeve, 2-filter cartridge, 21-bottom cover, 3-cover plate, 31-rotary table, 32-first motor, 33-suspension ring, 4-vertical rod, 41-second motor, 42-traction rope, 43-hook, 5-annular transmission belt and 51-groove.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.

Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the utility model, as claimed, but is merely representative of selected embodiments of the utility model. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.

In the description of the present invention, it should be noted that if the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. indicate an orientation or positional relationship based on the orientation or positional relationship shown in the drawings or the orientation or positional relationship which is usually placed when the product of this application is used, the description is merely for convenience and simplicity of description, and it is not intended to indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.

In the description of the present invention, it should be further noted that unless otherwise explicitly stated or limited, the terms "disposed," "mounted," "connected," and "connected" should be interpreted broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.

Example 1

As shown in fig. 1-3, a purification device for producing loratinib intermediates comprises a plurality of sleeves 1, filter cartridges 2, a cover plate 3, a vertical rod 4 and an annular transmission belt 5, wherein a rotary disc 31 is installed on the bottom surface of the cover plate 3, the rotary disc 31 is connected with a first motor 32, the filter cartridges 2 are detachably connected with the rotary disc 31 through threads, the size of the filter cartridges 2 is smaller than that of the sleeves 1, the filter cartridges 2 are positioned in the sleeves 1, a plastic film (not shown) is sleeved on the outer circumferential wall of the filter cartridges 2, a bottom cover 21 is installed at the bottom of the filter cartridges 2 through threads, the cover plate 3 is detachably connected with the sleeves 1 through buckles, a second motor 41 is installed at the end of the vertical rod 4, the second motor 41 is positioned at the top of the cover plate 3, a hanging ring 33 is arranged on the cover plate 3, a traction rope 42 is arranged at the output end of the second motor 41, a hook 43 is arranged at the end of the traction rope 42, the hook 43 is matched with the hanging ring 33, the sleeve 1 is placed on the annular conveying belt 5, the annular conveying belt 5 is provided with a plurality of grooves 51, and the grooves 51 are matched with the sleeve 1.

The use method of the purification device for producing the loratinib intermediate provided by the embodiment is as follows:

firstly, materials are put into a filter cylinder 2, then the filter cylinder 2 and a cover plate 3 are assembled, then the cover plate 3 and the filter cylinder 2 are integrally lifted up through a second motor 41, an annular conveying belt 5 is opened, an empty sleeve 1 is moved to the position right below the filter cylinder 2, a plastic film on the outer circumferential wall of the filter cylinder 2 is taken down, then the second motor 41 is controlled to insert the filter cylinder 2 into the sleeve 1, then the cover plate 3 and the sleeve 1 are tightly fixed through a buckle, then a first motor 32 is started, the filter cylinder 2 rotates in the sleeve 1, after a certain time of working, the first motor 32 is closed, the buckle of the cover plate 3 and the sleeve 1 is opened, the cover plate 3 is lifted up, the annular conveying belt 5 rotates, the next empty sleeve 1 is switched, and then the operation is repeated again. After the separation and purification process is finished, the filter cartridge 2 is lifted, a waste residue storage barrel is prevented from being arranged below the filter cartridge 2, then the bottom cover 21 is opened, and waste residues in the filter cartridge 2 are cleaned out.

The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and various modifications and changes will occur to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. The utility model provides a production purification device for loratinib intermediate body, its characterized in that includes the sleeve, strains a section of thick bamboo and apron install the carousel on the bottom surface of apron, the carousel is connected with first motor, strain a section of thick bamboo with the carousel passes through the screw thread and can dismantle the connection, the size of straining a section of thick bamboo is less than telescopic size, strain a section of thick bamboo and be located telescopic inside strain and overlap on straining the periphery wall and be equipped with plastic film.

2. The purification device for producing Laplace tinib intermediates of claim 1, wherein the cover plate is detachably connected to the sleeve by a snap.

3. The purification device for intermediate bodies in the production of loratinib according to claim 1, characterized in that a bottom cap is screwed on the bottom of the filter cartridge.

4. The purification device for producing Laplace tinib intermediates of claim 1, further comprising a vertical rod, wherein a second motor is mounted at the end of the vertical rod, the second motor is located at the top of the cover plate, a hanging ring is arranged on the cover plate, a traction rope is arranged at the output end of the second motor, a hook is arranged at the end of the traction rope, and the hook is matched with the hanging ring.

5. The purification device for producing loratinib intermediate according to claim 1, further comprising an endless conveyor belt on which said sleeve is placed.

6. The purification device for producing Laolatinib intermediates, as claimed in claim 5, wherein the number of sleeves placed on the endless conveyor is plural.

7. The purification device for producing Laolatinib intermediates, according to claim 5 or 6, wherein the endless conveyor belt is provided with grooves, which are matched with the sleeves.