CN206715368U - A kind of annulus type centrifugal extractor for cephalo-type series parent nucleus production - Google Patents
A kind of annulus type centrifugal extractor for cephalo-type series parent nucleus production Download PDFInfo
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- CN206715368U CN206715368U CN201720247411.XU CN201720247411U CN206715368U CN 206715368 U CN206715368 U CN 206715368U CN 201720247411 U CN201720247411 U CN 201720247411U CN 206715368 U CN206715368 U CN 206715368U
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- outlet pipe
- phase outlet
- cephalo
- inlet pipe
- centrifugal extractor
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Abstract
The utility model discloses a kind of annulus type centrifugal extractor for cephalo-type series parent nucleus production, the rotary cylinder rotated is driven including fixed cylinder and in fixed cylinder and by transmission parts, the annular space for material circulation is left between rotary cylinder and fixed cylinder, the rotary cylinder bottom connects annular space with top, material liquid inlet pipe, extract inlet pipe, light phase outlet pipe and the heavy phase outlet pipe of connection annular space are provided with the outside of fixed cylinder, the light phase outlet pipe and heavy phase outlet pipe are arranged at fixed cylinder top outer；Material liquid screen pack is additionally provided with the material liquid inlet pipe.By annulus type centrifugal extractor of the present utility model, the phenol content in disengaging time and water layer is effectively controlled, extracting and developing and purifying to material, traditional various extraction kettles and extraction tower can be replaced, solvent load can be reduced, saves the operating time, reduces energy consumption.
Description
Technical field
The utility model is related to a kind of centrifugal extractor, particularly for cephalo-type series parent nucleus production circular-gap from
Heart extractor.
Background technology
Cephalosporin analog antibiotic is the important component in anti-infection drug.Although cephalo medicine is various in style, often
The synthetic method of individual product is totally different, but still many common problems be present, as cephalosporins Cefditoren pivoxil Cephalosporins is female
Core 7-ATCA, Cefprozil parent nucleus 7-APCA, Ceftizoxime parent nucleus 7-NACA, Cefdinir and Cefixime parent nucleus 7-AVCA with
And Cefozopran parent nucleus 7-ACP etc. production first sloughs 2- carboxyl-protecting groups using phenol hydrolysis, then passes through penicillin acyl
Change the technique that enzyme sloughs 7- amido protecting groups.The process has that consumption of organic solvent is larger, and extraction time is more, disengaging time
The longer and problem such as cause product yield low, while cephalo-type product is unstable in the basic conditions, causes impurity to raise, extraction
Not exclusively, the problems such as phenol of residual and organic solvent are very big to the activity influence of enzyme.
How effectively to remove the phenol of residual, reduce impurity etc., have important influence to the quality for improving product.
Utility model content
Technical problem to be solved in the utility model is to provide a kind of centrifugal extractor of new circular-gap, effectively goes
Except the phenol, the impurity that are remained in cephalo-type series parent nucleus.
For solve above technical problem, the circular-gap described in the utility model for cephalo-type series parent nucleus production from
Heart extractor, including fixed cylinder and the rotary cylinder that rotation is driven in fixed cylinder and by transmission parts, in rotary cylinder and fixation
The annular space for material circulation is left between cylinder, the rotary cylinder bottom connects annular space, the fixed cylinder outside company of being provided with top
Material liquid inlet pipe, the extract inlet pipe of logical annular space, the top of rotary cylinder is communicated with light phase outlet pipe and heavy phase outlet pipe；In the raw material
Material liquid screen pack is additionally provided with liquid inlet pipe.
Further, the light phase outlet pipe, be respectively arranged with light phase screen pack, heavy phase screen pack in heavy phase outlet pipe, remove
Caused impurity in extraction process.
Further, extract screen pack is provided with the extract inlet pipe, removes the impurity in extract.
Further, the fixed cylinder bottom is provided with drain, and discharge extraction process produces gas.
Further, the fixed cylinder is fixedly installed in shell, material liquid inlet pipe, extract inlet pipe, light phase outlet pipe and
Heavy phase outlet pipe both passes through shell, and transmission parts are fixed on cover top portion.
Further, drive block is provided with the output shaft of the transmission parts, the drive block is interior with rotary cylinder top
Side is fixed.
Further, the outer casing bottom is provided with support block.
Centrifugal extractor of the present utility model, using circular-gap structure, organic layer and water layer continuous extraction can be achieved so that
Phenol content in disengaging time and water layer is effectively controlled, and reduces influence, the reduction three wastes, reduction of the phenol residual to product
Extraction separation process two-phase time of contact is produced with reducing impurity, can also reduce solvent load, further reduces the generation of impurity,
It can save the operating time, reduce energy consumption.Some floccules can be produced in preparation process additionally, due to cephalo-type series parent nucleus to consolidate
Body and other impurities, material liquid screen pack is set in material liquid inlet pipe, floccule solid and other impurities can be carried out
Filtering, to improve the quality of product.The filter screen set in other pipelines equally can remove corresponding impurity, yield to product,
Quality increases.
Brief description of the drawings
Fig. 1 is structural representation of the present utility model.
In figure：1- fixed cylinders；1.1- material liquid inlet pipes；1.1.0- material liquid screen pack；1.2- extract inlet pipes；1.2.0-
Extract screen pack；1.3- light phase outlet pipes；1.3.0- light phase screen pack；1.4- heavy phase outlet pipes；1.4.0- heavy phase screen pack；1.5-
Drain；2- rotary cylinders；2.1- mixed liquor imports；3- shells；3.1- support block；4- transmission parts；4.1- drive block；5- rings
Gap.
Embodiment
With reference to embodiment and referring to the drawings, the utility model is further described.
Embodiment 1：
As shown in figure 1, the annulus type centrifugal extractor described in the utility model for cephalo-type series parent nucleus production, main
To include fixed cylinder 1, rotary cylinder 2, shell 3, transmission parts 4.Wherein, branch of the shell 3 as whole annulus type centrifugal extractor
Frame, bottom are provided with support block 3.1.Transmission parts 4 are arranged on the top of shell 3, and biography is provided with the output shaft of transmission parts 4
Motion block 4.1, the inside top of drive block 4.1 and rotary cylinder 2 are fixed.Rotary cylinder 2 is located inside fixed cylinder 1, and rotary cylinder 2 is with consolidating
Space is left between safety barrel 1, for the annular space 5 for material circulation.Drive block 4.1, rotary cylinder 2 and fixed cylinder 1 are respectively positioned on shell 3
It is internal.
The mixed liquor import 2.1 of connection annular space 5 is offered in the bottom of rotary cylinder 2.The outside of fixed cylinder 1 is provided with connected ring
Material liquid inlet pipe 1.1, the extract inlet pipe 1.2 of gap 5, the upper outside of rotary cylinder 2 then connect light phase outlet pipe 1.3 and heavy phase outlet pipe
1.4, and light phase outlet pipe 1.3 connects the opening that the side of rotary cylinder 2 is located at the lower section of drive block 4.1, heavy phase outlet pipe 1.4, which then connects, to be turned
Opening of the dynamic top of cylinder 2 positioned at the top of drive block 4.1.Material liquid inlet pipe 1.1, extract inlet pipe 1.2, the and of light phase outlet pipe 1.3
Heavy phase outlet pipe 1.4 both passes through shell 3.
It is also respectively provided with material liquid inlet pipe 1.1, extract inlet pipe 1.2, light phase outlet pipe 1.3 and heavy phase outlet pipe 1.4
Material liquid screen pack 1.1.0, extract screen pack 1.2.0, light phase screen pack 1.3.0 and heavy phase screen pack 1.4.0.
The bottom of fixed cylinder 1 is provided with drain 1.5.
In use, opening transmission parts 4, the rotation of rotary cylinder 2 is driven by drive block 4.1.Material liquid is from material liquid inlet pipe
1.1 enter, and are filtered by material liquid screen pack 1.1.0, enter after removing floccule and other impurities in annular space 5, extract from
Extract inlet pipe 1.2 enters, and is included in after extract screen pack 1.2.0 filterings in annular space 5, material liquid is with extract in annular space
5 bottoms mix, and turn into mixed liquor, the mixed liquor import 2.1 of mixed liquor from the bottom of rotary cylinder 2 is entered in rotary cylinder 2, rotated
Under the centrifugal action of cylinder 2, separated between different phases.Isolated light phase (i.e. extract organic layer) is pushed up from rotary cylinder 2
The outlet of portion side (lower section of drive block 4.1) is gone out, and is filtered to light phase outlet pipe 1.4, and through light phase screen pack 1.3.0, discharge is received
Collection.Isolated heavy phase (i.e. feed liquid water layer) exports away from the top of rotary cylinder 2 (lower section of drive block 4.1), to heavy phase outlet pipe
1.4, and filtered through heavy phase screen pack 1.4.0, discharge is collected.
Material liquid and extract are continuously entered in annular space 5, are entered after mixing in rotary cylinder 2, after two-phase obtains centrifugation
Each discharge.
In centrifugal process, meeting creating pockets of air etc., it can be discharged from drain 1.5.
By annulus type centrifugal extractor of the present utility model, the phenol content in disengaging time and water layer is effectively controlled
System, extracting and developing and purifying to material, can replace traditional various extraction kettles and extraction tower, can reduce solvent load, save
Operating time, reduce energy consumption.
Claims (7)
1. a kind of annulus type centrifugal extractor for cephalo-type series parent nucleus production, including fixed cylinder（1）With positioned at fixation
Cylinder（1）It is interior and by transmission parts（4）Drive the rotary cylinder rotated（2）, in rotary cylinder（2）With fixed cylinder（1）Between leave for thing
The logical annular space of stream（5）, it is characterised in that：The rotary cylinder（2）Bottom connects annular space with top（5）, fixed cylinder（1）Outside
It is provided with connection annular space（5）Material liquid inlet pipe（1.1）, extract inlet pipe（1.2）, rotary cylinder（2）Top be communicated with light phase
Outlet pipe（1.3）With heavy phase outlet pipe（1.4）；In the material liquid inlet pipe（1.1）Inside it is additionally provided with material liquid screen pack（1.1.0）.
2. it is used for the annulus type centrifugal extractor of cephalo-type series parent nucleus production according to claim 1, it is characterised in that：
The light phase outlet pipe（1.3）, heavy phase outlet pipe（1.4）Inside it is respectively arranged with light phase screen pack（1.3.0）, heavy phase screen pack
（1.4.0）.
3. it is used for the annulus type centrifugal extractor of cephalo-type series parent nucleus production according to claim 2, it is characterised in that：
The extract inlet pipe（1.2）Inside it is provided with extract screen pack（1.2.0）.
4. it is used for the annulus type centrifugal extractor of cephalo-type series parent nucleus production according to claim 1, it is characterised in that：
The fixed cylinder（1）Bottom is provided with drain（1.5）.
5. it is used for the annulus type centrifugal extractor of cephalo-type series parent nucleus production according to claim 1, it is characterised in that：
The fixed cylinder（1）It is fixedly installed on shell（3）It is interior, material liquid inlet pipe（1.1）, extract inlet pipe（1.2）, light phase outlet pipe
（1.3）With heavy phase outlet pipe（1.4）Both pass through shell（3）, transmission parts（4）It is fixed on shell（3）Top.
6. it is used for the annulus type centrifugal extractor of cephalo-type series parent nucleus production according to claim 1, it is characterised in that：
The transmission parts（4）Output shaft on be provided with drive block（4.1）, the drive block（4.1）With rotary cylinder（2）The inner side on top
It is fixed.
7. it is used for the annulus type centrifugal extractor of cephalo-type series parent nucleus production according to claim 5, it is characterised in that：
The shell（3）Bottom is provided with support block（3.1）.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720247411.XU CN206715368U (en) | 2017-03-14 | 2017-03-14 | A kind of annulus type centrifugal extractor for cephalo-type series parent nucleus production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720247411.XU CN206715368U (en) | 2017-03-14 | 2017-03-14 | A kind of annulus type centrifugal extractor for cephalo-type series parent nucleus production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206715368U true CN206715368U (en) | 2017-12-08 |
Family
ID=60501958
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720247411.XU Expired - Fee Related CN206715368U (en) | 2017-03-14 | 2017-03-14 | A kind of annulus type centrifugal extractor for cephalo-type series parent nucleus production |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206715368U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108745253A (en) * | 2018-08-02 | 2018-11-06 | 潍坊奥通药业有限公司 | The matching used automatic continuous mixing of continuous reaction device and Liquid liquid Separation device and method |
| CN110465112A (en) * | 2019-08-15 | 2019-11-19 | 清华大学 | It is a kind of to handle the annulus type centrifugal extractor containing a small amount of solid particle feed liquid |
-
2017
- 2017-03-14 CN CN201720247411.XU patent/CN206715368U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108745253A (en) * | 2018-08-02 | 2018-11-06 | 潍坊奥通药业有限公司 | The matching used automatic continuous mixing of continuous reaction device and Liquid liquid Separation device and method |
| CN110465112A (en) * | 2019-08-15 | 2019-11-19 | 清华大学 | It is a kind of to handle the annulus type centrifugal extractor containing a small amount of solid particle feed liquid |
| CN110465112B (en) * | 2019-08-15 | 2020-08-21 | 清华大学 | Annular gap type centrifugal extractor capable of treating feed liquid containing a small amount of solid particles |
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|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20171208 |
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| CF01 | Termination of patent right due to non-payment of annual fee |