CN215384844U

CN215384844U - Auxiliary device for preparing abdominal aorta constriction model of experimental animal

Info

Publication number: CN215384844U
Application number: CN202120785695.4U
Authority: CN
Inventors: 白晓洁; 郝峻涛; 封启龙; 张升校; 曹茜倩
Original assignee: Shanxi Medical University
Current assignee: Shanxi Medical University
Priority date: 2021-04-16
Filing date: 2021-04-16
Publication date: 2022-01-04
Anticipated expiration: 2031-04-16

Abstract

The utility model belongs to the field of cardiovascular research, and particularly relates to an auxiliary device for preparing an abdominal aorta constriction model of an experimental animal, which comprises a base, a fixed column, a movable rod, an auxiliary needle fixing rod and an auxiliary needle, wherein one end of the fixed column is vertically and fixedly connected to the base, the other end of the fixed column is rotatably connected with one end of the movable rod, the other end of the movable rod is rotatably connected with one end of the auxiliary needle fixing rod, the other end of the auxiliary needle fixing rod is connected with the auxiliary needle, and the auxiliary needle is in a 90-degree right-angle shape.

Description

Auxiliary device for preparing abdominal aorta constriction model of experimental animal

Technical Field

The utility model belongs to the field of cardiovascular research, and particularly relates to an auxiliary device for preparing an abdominal aortic stenosis model of an experimental animal.

Background

The number of hypertension in modern society is increased, and the hypertension presents low-age performance and seriously harms human health. Chronic pressure load increases lead to ventricular remodeling, manifested by myocardial hypertrophy, fibrosis, increased cardiomyocyte apoptosis, and embryonic gene re-expression, which in turn leads to heart failure. When the blood pressure control is actively advocated, the discussion of the occurrence and development mechanisms of the pressure-loaded myocardial hypertrophy/heart failure has great significance for early suppression and even reversal of the disease process. The abdominal aorta coarctation is a common animal model preparation method for the research, peripheral resistance is increased due to abdominal aorta coarctation of different degrees, pressure load is formed on heart pump function, and myocardial hypertrophy and heart failure occur gradually. The model has better clinical relevance, is an ideal animal model for researching the pathophysiological mechanism of cardiac hypertrophy and heart failure, neuroendocrine factor abnormality and pharmacology, does not need to carry out trachea intubation and thoracotomy operation on experimental animals in the preparation process of the model compared with an aortic arch constriction model, and has relatively lower mortality.

The operation steps of abdominal aortic stenosis in the experimental animal, which are currently common and widely accepted, are: after animals are anesthetized, the left upper abdomen is longitudinally cut to expose the abdominal aorta, the abdominal aorta is separated at the position 0.5-1 cm above the renal artery branch, an auxiliary needle (the thickness of the needle head is determined by the requirement of the constriction degree) and the abdominal aorta are jointly ligated, then the auxiliary needle is drawn out, and the abdomen is closed to resist infection.

In practical operation, the above process has some problems as follows: 1. the auxiliary needle jointly ligated with the abdominal aorta is not well placed and fixed before ligation, and often needs an assistant to assist holding, so that the auxiliary needle can deflect in the ligation process when being completed by a single person, the ligation effect is affected, and the injury of the needle head to surrounding tissues can be caused; 2. the placed auxiliary needle needs to be drawn out after ligation, the operation needs a certain space in the abdominal cavity, the auxiliary needle cannot be too long, but the auxiliary needle is too short and is not well placed before ligation; 3. at present, there are no ligature auxiliary needles with uniform specification, and many of them are reformed by clinical injection needles with different calibers according to literature reports, while different experimental animals (such as mice, rats or rabbits) and different arterial constriction requirements (50% or 75%) need to select auxiliary needles with different diameters, so that they need to be uniform and standardized.

SUMMERY OF THE UTILITY MODEL

The utility model provides an auxiliary device for preparing an abdominal aorta constriction model of an experimental animal, which is designed aiming at an auxiliary needle in the preparation of the abdominal aorta constriction model of the experimental animal, so that the auxiliary needle is easier to operate and use, and meanwhile, a corresponding device is added, thereby being beneficial to single-person independent operation.

In order to achieve the purpose, the utility model adopts the following technical scheme:

the utility model provides an auxiliary device for preparation of experimental animals abdominal aorta constriction model, includes base, fixed column, movable rod, supplementary needle dead lever and supplementary needle, the perpendicular fixed connection of one end of fixed column is on the base, the other end of fixed column rotates with the one end of movable rod to be connected, the other end of movable rod rotates with the one end of supplementary needle dead lever to be connected, the other end of supplementary needle dead lever is connected with supplementary needle, supplementary needle is 90 right angle shapes.

Furthermore, the other end of the auxiliary fixing rod is provided with a socket, and the long right-angle edge of the auxiliary needle is a fixing end and is installed in the socket.

Still further, the end of stiff end is equipped with the same interface, can pull out and insert different auxiliary needles.

Furthermore, the needle head part of the auxiliary needle is subjected to blunt rounding treatment, the end (short end) where the needle head part is located is a ligation end, and the length of the ligation end is as short as possible on the premise of sufficient ligation, so that the auxiliary needle can be conveniently pulled out after the ligation is finished.

Further, the fixed column is hinged with the movable rod, and a fixed bolt is arranged at the hinged position.

Compared with the prior art, the utility model has the following advantages:

the utility model is suitable for auxiliary needles (75% of mice, 50% of mice, 75% of rats, 50% of rats, 75% of rabbits and 50% of rabbits) with abdominal aortic constriction of different common experimental animals (mice, rats and rabbits). Because the operating space of the abdominal cavity is limited, the auxiliary needle is made into a 90-degree right-angle shape, and the needle head part is subjected to blunt rounding treatment.

The movable rod can adjust the height and the auxiliary needle fixing rod can rotate at will, the direction is adjusted, and the operation in a laboratory is more convenient.

The utility model can be used by a single person without the assistance of an assistant.

Drawings

FIG. 1 is a schematic overall view of the apparatus of the present invention;

FIG. 2 is a side view of the apparatus of the present invention;

wherein, the base-1, the fixed column-2, the movable rod-3, the auxiliary needle fixed rod-4, the auxiliary needle-5, the socket-6, the fixed end-7, the interface-8, the ligation end-9 and the fixed bolt-10.

Detailed Description

In order to further illustrate the technical solution of the present invention, the present invention is further illustrated by the following examples.

Example 1

As shown in fig. 1, an auxiliary device for preparing an abdominal aorta constriction model of an experimental animal comprises a base 1, a fixed column 2, a movable rod 3, an auxiliary needle fixing rod 4 and an auxiliary needle 5, wherein one end of the fixed column 2 is vertically and fixedly connected to the base 1, the other end of the fixed column 2 is hinged to one end of the movable rod 3, a fixing bolt 10 is arranged at the hinged position, the other end of the movable rod 3 is rotatably connected to one end of the auxiliary needle fixing rod 4, the other end of the auxiliary needle fixing rod 4 is connected to the auxiliary needle 5, and the auxiliary needle 5 is 90-degree right-angled.

The other end of auxiliary fixing pole 4 is equipped with socket 6, the long right-angle limit of auxiliary needle 5 is stiff end 7, installs in socket 6, and the stiff end 7 of different auxiliary needles 5 is equipped with same interface 8, can pull out and insert auxiliary needle 5.

The needle head part of the auxiliary needle 5 is subjected to blunt rounding treatment, the end where the needle head part is located is a ligation end 9, and the length of the ligation end 9 is as short as possible on the premise of sufficient ligation.

While there have been shown and described what are at present considered to be the essential features and advantages of the utility model, it will be apparent to those skilled in the art that the utility model is not limited to the details of the foregoing exemplary embodiments, but is capable of other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the utility model being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.

Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.

Claims

1. The utility model provides an auxiliary device for experimental animals abdominal aorta constriction model preparation, its characterized in that, includes base (1), fixed column (2), movable rod (3), supplementary needle dead lever (4) and supplementary needle (5), the perpendicular fixed connection of one end of fixed column (2) is on base (1), the other end of fixed column (2) is rotated with the one end of movable rod (3) and is connected, the other end of movable rod (3) is rotated with the one end of supplementary needle dead lever (4) and is connected, the other end of supplementary needle dead lever (4) is connected with supplementary needle (5), supplementary needle (5) are 90 right angles.

2. The auxiliary device for preparing the abdominal aorta constriction model of the experimental animal as claimed in claim 1, wherein the other end of the auxiliary needle fixing rod (4) is provided with a socket (6), and the long right-angle side of the auxiliary needle (5) is a fixing end (7) and is arranged in the socket (6).

3. An auxiliary device for the preparation of models of constriction of the abdominal aorta of laboratory animals according to claim 2, characterized in that the ends of said fixed ends (7) are provided with the same interface (8).

4. The auxiliary device for the preparation of abdominal aortic constriction model of experimental animal of claim 1, wherein the needle head of the auxiliary needle (5) is blunt rounded, the end of the needle head is a ligation end (9), and the length of the ligation end (9) is as short as possible under the condition of sufficient ligation.

5. The auxiliary device for the preparation of the abdominal aorta constriction model of the experimental animal as claimed in claim 1, wherein the fixed column (2) is hinged with the movable rod (3), and a fixed bolt (10) is arranged at the hinged position.